Detailed information for compound 1318512

Basic information

Technical information
  • TDR Targets ID: 1318512
  • Name: [2-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethylam ino]-2-oxoethyl] 3-(methoxymethyl)-1-benzofur an-2-carboxylate
  • MW: 406.41 | Formula: C18H18N2O7S
  • H donors: 1 H acceptors: 4 LogP: 1.53 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1c(oc2c1cccc2)C(=O)OCC(=O)NCCN1C(=O)SCC1=O
  • InChi: 1S/C18H18N2O7S/c1-25-8-12-11-4-2-3-5-13(11)27-16(12)17(23)26-9-14(21)19-6-7-20-15(22)10-28-18(20)24/h2-5H,6-10H2,1H3,(H,19,21)
  • InChiKey: CILKFIYEBUKDOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[2-(2,4-dioxothiazolidin-3-yl)ethylamino]-2-oxo-ethyl] 3-(methoxymethyl)benzofuran-2-carboxylate
  • 3-(methoxymethyl)-2-benzofurancarboxylic acid [2-[2-(2,4-dioxo-3-thiazolidinyl)ethylamino]-2-oxoethyl] ester
  • 3-(methoxymethyl)benzofuran-2-carboxylic acid [2-[2-(2,4-diketothiazolidin-3-yl)ethylamino]-2-keto-ethyl] ester
  • [2-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethylamino]-2-oxo-ethyl] 3-(methoxymethyl)-1-benzofuran-2-carboxylate
  • MLS000417496
  • SMR000264483
  • ZINC03416316

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0098 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Schistosoma mansoni ap endonuclease 0.0038 0.0082 0.0082
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0015 0.0501
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0449 0.1986 0.1986
Loa Loa (eye worm) hypothetical protein 0.0449 0.1986 0.1986
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0082 0.0082
Giardia lamblia Cysteine protease 0.0449 0.1986 0.4847
Echinococcus granulosus GPCR family 2 0.0047 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0449 0.1986 0.1986
Brugia malayi Papain family cysteine protease containing protein 0.0449 0.1986 0.1986
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0449 0.1986 0.1986
Onchocerca volvulus Cathepsin L homolog 0.218 1 1
Echinococcus granulosus adam 0.0023 0.0011 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0002 0.0002
Brugia malayi cathepsin L-like cysteine proteinase 0.0449 0.1986 0.1986
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0449 0.1986 0.1986
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0543 0.0543
Schistosoma mansoni hypothetical protein 0.0063 0.0198 0.0198
Echinococcus multilocularis cathepsin L cysteine protease 0.218 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0082 0.0082
Brugia malayi hypothetical protein 0.0032 0.0053 0.0053
Brugia malayi cathepsin Z-like cysteine proteinase 0.0449 0.1986 0.1986
Loa Loa (eye worm) hypothetical protein 0.1456 0.665 0.665
Echinococcus multilocularis histone deacetylase 1 0.0066 0.0209 0.0209
Loa Loa (eye worm) papain family cysteine protease containing protein 0.218 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0231 0.0974 0.0974
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0098 0.0098
Echinococcus granulosus histone deacetylase 1 0.0066 0.0209 0.0209
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0449 0.1986 0.4847
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0261 0.0261
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1923 0.8813 0.8813
Loa Loa (eye worm) ctsf protein 0.218 1 1
Leishmania major histone deacetylase, putative 0.0074 0.0247 0.0247
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0449 0.1986 0.1986
Brugia malayi Matrixin family protein 0.0045 0.0112 0.0112
Echinococcus multilocularis cathepsin L cysteine protease 0.218 1 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0449 0.1986 0.1986
Schistosoma mansoni histone deacetylase hda2 0.0032 0.0052 0.0052
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0449 0.1986 0.1986
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0054 0.0157 0.0157
Onchocerca volvulus 0.218 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Trypanosoma cruzi cysteine protease, putative 0.1173 0.5336 0.5336
Brugia malayi cathepsin L precursor 0.0449 0.1986 0.1986
Plasmodium vivax unspecified product 0.0449 0.1986 0.1986
Leishmania major hypothetical protein, conserved 0.005 0.0135 0.0135
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0082 0.02
Echinococcus multilocularis histone deacetylase 8 0.0032 0.0052 0.0052
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0002 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0124 0.0124
Plasmodium vivax vivapain-2 0.218 1 1
Leishmania major hypothetical protein, conserved 0.0206 0.0857 0.0857
Loa Loa (eye worm) hypothetical protein 0.0032 0.0052 0.0052
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0449 0.1986 0.1986
Loa Loa (eye worm) hypothetical protein 0.0449 0.1986 0.1986
Loa Loa (eye worm) histone deacetylase 3 0.0066 0.0209 0.0209
Echinococcus multilocularis disintegrin and metalloproteinase 0.0048 0.0128 0.0128
Loa Loa (eye worm) matrixin family protein 0.0108 0.0405 0.0405
Entamoeba histolytica cysteine proteinase 2 0.1173 0.5336 0.5336
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1173 0.5336 0.5336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.0974 0.0974
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0124 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.018 0.074 0.074
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0015 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0139 0.0139
Mycobacterium ulcerans hypothetical protein 0.007 0.0231 0.8836
Schistosoma mansoni ap endonuclease 0.0038 0.0082 0.0082
Schistosoma mansoni hypothetical protein 0.0111 0.0417 0.0417
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0002 0.0002
Giardia lamblia Cathepsin B precursor 0.0449 0.1986 0.4847
Giardia lamblia Cathepsin L precursor 0.0449 0.1986 0.4847
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Brugia malayi Cathepsin L-like precursor 0.0723 0.3255 0.3255
Plasmodium vivax histone deacetylase, putative 0.0032 0.0052 0.0052
Loa Loa (eye worm) disintegrin family protein 0.0035 0.0067 0.0067
Schistosoma mansoni cathepsin S (C01 family) 0.0449 0.1986 0.1986
Plasmodium falciparum cysteine proteinase falcipain 1 0.1173 0.5336 0.5336
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0124 0.0124
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0066 0.0209 0.0209
Mycobacterium ulcerans hydrolase 0.0054 0.0157 0.5979
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0723 0.3255 0.3255
Echinococcus multilocularis histone deacetylase 7 0.0074 0.0247 0.0247
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Mycobacterium tuberculosis Conserved protein 0.007 0.0231 0.1155
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Mycobacterium ulcerans hypothetical protein 0.0024 0.0015 0.0501
Giardia lamblia Cathepsin L-like protease 0.0449 0.1986 0.4847
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0261 0.0261
Toxoplasma gondii exonuclease III APE 0.0038 0.0082 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0857 0.0857
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0597 0.0597
Onchocerca volvulus Matrilysin homolog 0.0099 0.0364 0.0314
Onchocerca volvulus 0.0449 0.1986 0.1945
Giardia lamblia Cathepsin L precursor 0.0449 0.1986 0.4847
Brugia malayi Cathepsin L-like precursor 0.218 1 1
Plasmodium vivax unspecified product 0.1173 0.5336 0.5336
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0449 0.1986 0.1986
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0082 0.0082
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0261 0.0261
Leishmania major DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0417 0.0417
Echinococcus granulosus histone deacetylase 3 0.0066 0.0209 0.0209
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0135 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0231 0.0974 0.0974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1173 0.5336 0.5336
Echinococcus granulosus histone deacetylase 0.0074 0.0247 0.0247
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.007 0.0231 0.1155
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0231 0.0231
Plasmodium falciparum serine repeat antigen 7 0.0449 0.1986 0.1986
Plasmodium falciparum serine repeat antigen 4 0.0449 0.1986 0.1986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.007 0.0231 0.0231
Schistosoma mansoni cathepsin s 0.0723 0.3255 0.3255
Trypanosoma brucei histone deacetylase 3 0.0074 0.0247 0.0247
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0905 0.4098 0.4098
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0032 0.0053 0.0053
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0135 0.0135
Brugia malayi cathepsin Z-like cysteine proteinase 0.0449 0.1986 0.1986
Onchocerca volvulus 0.0062 0.0192 0.0141
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0209 0.0209
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0449 0.1986 0.1986
Schistosoma mansoni cathepsin F (C01 family) 0.1456 0.665 0.665
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0082 0.0082
Echinococcus multilocularis histone deacetylase 0.0074 0.0247 0.0247
Mycobacterium leprae Probable lipase LipE 0.007 0.0231 0.8705
Schistosoma mansoni histone deacetylase 4 5 0.0074 0.0247 0.0247
Schistosoma mansoni histone deacetylase 0.0066 0.0209 0.0209
Brugia malayi hypothetical protein 0.005 0.0135 0.0135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.0974 0.0974
Echinococcus granulosus disintegrin and metalloproteinase 0.0048 0.0128 0.0128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0449 0.1986 0.1986
Brugia malayi Cathepsin L-like cysteine proteinase 0.1456 0.665 0.665
Brugia malayi cathepsin F-like cysteine proteinase 0.0723 0.3255 0.3255
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0002 0.0002
Entamoeba histolytica histone deacetylase, putative 0.0066 0.0209 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1456 0.665 0.665
Schistosoma mansoni cathepsin C 0.0449 0.1986 0.1986
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0261 0.0261
Leishmania major cathepsin L-like protease 0.218 1 1
Plasmodium vivax hypothetical protein, conserved 0.007 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.218 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0432 0.1907 0.1907
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0449 0.1986 0.1986
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0053
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0449 0.1986 0.1986
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0098 0.0098
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0082 0.2316
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0135 0.0135
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1173 0.5336 0.5336
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0139 0.0689
Trypanosoma cruzi cysteine peptidase, putative 0.218 1 1
Giardia lamblia Cathepsin B precursor 0.0449 0.1986 0.4847
Loa Loa (eye worm) hypothetical protein 0.007 0.0231 0.0231
Toxoplasma gondii cathepsin CPC1 0.0449 0.1986 0.1986
Trichomonas vaginalis importin beta-1, putative 0.0023 0.001 0.001
Mycobacterium ulcerans lipase LipD 0.007 0.0231 0.8836
Trypanosoma cruzi cysteine peptidase, putative 0.218 1 1
Plasmodium falciparum serine repeat antigen 9 0.0449 0.1986 0.1986
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.007 0.0231 0.8836
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.001 0.001
Schistosoma mansoni histone deacetylase hda2 0.0078 0.0268 0.0268
Echinococcus multilocularis histone deacetylase 6 0.0078 0.0268 0.0268
Echinococcus granulosus importin subunit beta 1 0.0028 0.0034 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0192 0.0192
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0124 0.0124
Onchocerca volvulus 0.1456 0.665 0.6632
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Brugia malayi Muscleblind-like protein 0.018 0.074 0.074
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0905 0.4098 0.4098
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1923 0.8813 0.8813
Schistosoma mansoni dihydroceramide desaturase 0.0048 0.0128 0.0128
Echinococcus multilocularis cathepsin l cysteine peptidase 0.218 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.218 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0082 0.0082
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0209 0.0209
Brugia malayi histone deacetylase 1 (HD1) 0.0066 0.0209 0.0209
Trypanosoma cruzi cysteine proteinase, putative 0.1173 0.5336 0.5336
Loa Loa (eye worm) matrix metalloproteinase 0.0045 0.0112 0.0112
Echinococcus multilocularis cathepsin L 0.1173 0.5336 0.5336
Trypanosoma cruzi major cysteine proteinase, putative 0.0449 0.1986 0.1986
Brugia malayi Pre-SET motif family protein 0.0062 0.0192 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.218 1 1
Echinococcus multilocularis cathepsin b 0.1923 0.8813 0.8813
Echinococcus granulosus cathepsin L 0.0449 0.1986 0.1986
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0023 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.218 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0002 0.0002
Plasmodium vivax histone deacetylase 1, putative 0.0066 0.0209 0.0209
Onchocerca volvulus 0.007 0.0231 0.018
Loa Loa (eye worm) hypothetical protein 0.018 0.074 0.074
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1173 0.5336 0.5336
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0449 0.1986 0.1986
Onchocerca volvulus 0.218 1 1
Brugia malayi Matrixin family protein 0.0045 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.007 0.0231 0.0231
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0231 0.0974 0.0974
Trichomonas vaginalis conserved hypothetical protein 0.0449 0.1986 0.1986
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0162 0.0657 0.0657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1173 0.5336 0.5336
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0231 0.0231
Trypanosoma cruzi cysteine proteinase, putative 0.1173 0.5336 0.5336
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Loa Loa (eye worm) histone deacetylase 0.0074 0.0247 0.0247
Trypanosoma brucei histone deacetylase 1 0.0066 0.0209 0.0209
Brugia malayi Papain family cysteine protease containing protein 0.1173 0.5336 0.5336
Loa Loa (eye worm) hypothetical protein 0.0042 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0047 0.0124 0.0124
Entamoeba histolytica cysteine protease, putative 0.0449 0.1986 0.1986
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.218 1 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0015 0.0015
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0121 0.0121
Mycobacterium ulcerans esterase/lipase LipP 0.007 0.0231 0.8836
Echinococcus granulosus histone deacetylase 6 0.0074 0.0247 0.0247
Schistosoma mansoni cathepsin F (C01 family) 0.218 1 1
Plasmodium vivax vivapain-1 0.1173 0.5336 0.5336
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.007 0.0231 0.0231
Brugia malayi Histone deacetylase family protein 0.0074 0.0247 0.0247
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0261 1
Trypanosoma cruzi cysteine peptidase, putative 0.0723 0.3255 0.3255
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0449 0.1986 0.1986
Loa Loa (eye worm) hypothetical protein 0.0449 0.1986 0.1986
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0857 0.0857
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0192 0.0192
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0449 0.1986 0.1986
Brugia malayi Papain family cysteine protease containing protein 0.0449 0.1986 0.1986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1173 0.5336 0.5336
Giardia lamblia Cathepsin L precursor 0.0449 0.1986 0.4847
Entamoeba histolytica cysteine protease, putative 0.0449 0.1986 0.1986
Toxoplasma gondii histone deacetylase HDAC1 0.0074 0.0247 0.0247
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0231 0.0974 0.0974
Leishmania major cathepsin L-like protease 0.218 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1923 0.8813 0.8813
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0561 0.0561
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0015 0.0015
Entamoeba histolytica cysteine protease, putative 0.0449 0.1986 0.1986
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0002 0.0002
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.1986 0.1986
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.007 0.0231 0.0231
Brugia malayi RNA, U transporter 1 0.0079 0.0272 0.0272
Toxoplasma gondii hypothetical protein 0.0027 0.0028 0.0028
Echinococcus multilocularis cysteine protease 0.218 1 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0015 0.0065
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0561 0.0561
Giardia lamblia Cathepsin B precursor 0.0905 0.4098 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Brugia malayi Papain family cysteine protease containing protein 0.218 1 1
Brugia malayi Hemopexin family protein 0.0063 0.0198 0.0198
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0162 0.0657 0.0657
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1456 0.665 0.665
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0261 0.0261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0231 0.0974 0.0974
Trypanosoma brucei histone deacetylase 4 0.0074 0.0247 0.0247
Onchocerca volvulus Matrilysin homolog 0.0045 0.0112 0.006
Loa Loa (eye worm) hypothetical protein 0.0062 0.0192 0.0192
Schistosoma mansoni DNA polymerase eta 0.0021 0.0002 0.0002
Onchocerca volvulus Cathepsin L homolog 0.0449 0.1986 0.1945
Mycobacterium leprae conserved hypothetical protein 0.007 0.0231 0.8705
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0597 0.0597
Trypanosoma brucei histone deacetylase 2 0.0032 0.0052 0.0052
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0002 0.0002
Onchocerca volvulus 0.218 1 1
Trypanosoma cruzi histone deacetylase, putative 0.0074 0.0247 0.0247
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0082 0.0082
Trypanosoma cruzi histone deacetylase, putative 0.0074 0.0247 0.0247
Toxoplasma gondii cathepsin B 0.0905 0.4098 0.4098
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0082 0.02
Mycobacterium tuberculosis Probable lipase LipD 0.007 0.0231 0.1155
Echinococcus granulosus cathepsin b 0.1923 0.8813 0.8813
Onchocerca volvulus 0.007 0.0231 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.218 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.1173 0.5336 0.5336
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0032 0.0053 0.0053
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0449 0.1986 0.1986
Brugia malayi Cathepsin L-like precursor 0.1456 0.665 0.665
Loa Loa (eye worm) hypothetical protein 0.0723 0.3255 0.3255
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0066 0.0209 0.0209
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Echinococcus granulosus snurportin 1 0.0297 0.1282 0.1282
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.1986 0.1986
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0905 0.4098 0.4098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0449 0.1986 0.1986
Leishmania major cathepsin L-like protease 0.218 1 1
Giardia lamblia Cathepsin L precursor 0.0449 0.1986 0.4847
Trypanosoma cruzi histone deacetylase, putative 0.0032 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0023 0.001 0.001
Brugia malayi Cathepsin L-like precursor 0.218 1 1
Schistosoma mansoni hypothetical protein 0.0047 0.0124 0.0124
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0139 0.4744
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0082 0.0082
Leishmania major cathepsin L-like protease 0.218 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0231 0.0231
Giardia lamblia Cathepsin B precursor 0.0449 0.1986 0.4847
Giardia lamblia Cysteine protease 0.0449 0.1986 0.4847
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.1986 0.1986
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.1282 0.1282
Echinococcus granulosus cathepsin l1 0.218 1 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0449 0.1986 0.1986
Trypanosoma cruzi cysteine peptidase, putative 0.218 1 1
Leishmania major cysteine peptidase A (CPA) 0.218 1 1
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0561 0.0561
Echinococcus multilocularis geminin 0.0685 0.3079 0.3079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0231 0.0231
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0082 0.0082
Leishmania major importin beta-1 subunit, putative 0.0023 0.001 0.001
Brugia malayi Importin beta-1 subunit 0.0028 0.0034 0.0034
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0449 0.1986 0.1986
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0449 0.1986 0.1986
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0449 0.1986 0.1986
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0449 0.1986 0.1986
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0448 0.0448
Brugia malayi Matrixin family protein 0.0108 0.0405 0.0405
Echinococcus granulosus cathepsin L 0.1173 0.5336 0.5336
Echinococcus multilocularis adam 0.0023 0.0011 0.0011
Onchocerca volvulus 0.218 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0135
Echinococcus multilocularis muscleblind protein 0.018 0.074 0.074
Brugia malayi Probable ClpP-like protease 0.0077 0.0261 0.0261
Brugia malayi Histone deacetylase 1 0.0066 0.0209 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0449 0.1986 0.1986
Onchocerca volvulus 0.007 0.0231 0.018
Brugia malayi Matrixin family protein 0.0045 0.0112 0.0112
Plasmodium falciparum cysteine proteinase falcipain 2a 0.218 1 1
Brugia malayi Pre-SET motif family protein 0.0432 0.1907 0.1907
Plasmodium vivax serine-repeat antigen (SERA) 0.0449 0.1986 0.1986
Plasmodium falciparum serine repeat antigen 8 0.0449 0.1986 0.1986
Entamoeba histolytica hypothetical protein 0.0111 0.0417 0.0417
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0449 0.1986 0.1986
Entamoeba histolytica cysteine proteinase, putative 0.218 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0139 0.0689
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0192 0.0192
Echinococcus multilocularis GPCR, family 2 0.0047 0.0124 0.0124
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0449 0.1986 0.4847
Giardia lamblia Hypothetical protein 0.0449 0.1986 0.4847
Entamoeba histolytica hypothetical protein 0.0111 0.0417 0.0417
Loa Loa (eye worm) fibroinase 0.218 1 1
Loa Loa (eye worm) acetyltransferase 0.0142 0.0561 0.0561
Entamoeba histolytica hypothetical protein 0.0449 0.1986 0.1986
Plasmodium vivax histone deacetylase, putative 0.0074 0.0247 0.0247
Echinococcus granulosus cathepsin l cysteine peptidase 0.218 1 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0209 0.0209
Toxoplasma gondii cathepsin CPC2 0.0449 0.1986 0.1986
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0135 0.0135
Trypanosoma brucei cysteine peptidase C (CPC) 0.0905 0.4098 0.4098
Plasmodium falciparum histone deacetylase 2 0.0074 0.0247 0.0247
Loa Loa (eye worm) histone deacetylase 7A 0.0074 0.0247 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Onchocerca volvulus 0.0045 0.0112 0.006
Brugia malayi Cathepsin L-like precursor 0.218 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0448 0.0448
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0417 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0192 0.0192
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.218 1 1
Brugia malayi histone deacetylase 11 0.0032 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.1923 0.8813 0.8813
Trichomonas vaginalis D-aminoacylase, putative 0.007 0.0231 0.0231
Mycobacterium ulcerans hypothetical protein 0.0024 0.0015 0.0501
Leishmania major cathepsin L-like protease 0.218 1 1
Plasmodium falciparum histone deacetylase 1 0.0066 0.0209 0.0209
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0261 0.0261
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0449 0.1986 0.1986
Mycobacterium tuberculosis Probable hydrolase 0.007 0.0231 0.1155
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0082 0.0082
Echinococcus granulosus histone deacetylase 6 0.0078 0.0268 0.0268
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0261 1
Brugia malayi hypothetical protein 0.0111 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0034
Plasmodium falciparum serine repeat antigen 6 0.0449 0.1986 0.1986
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0082 0.0082
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.007 0.0231 0.1155
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0449 0.1986 0.1986
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0002
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0723 0.3255 0.3255
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0449 0.1986 0.1986
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0449 0.1986 0.1986
Giardia lamblia Cathepsin B precursor 0.0449 0.1986 0.4847
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0449 0.1986 0.1986
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0045 0.0112 0.0112
Trichomonas vaginalis set domain proteins, putative 0.0492 0.2184 0.2184
Onchocerca volvulus 0.218 1 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0297 0.1282 0.1282
Loa Loa (eye worm) hypothetical protein 0.0149 0.0597 0.0597
Brugia malayi Histone deacetylase family protein 0.0074 0.0247 0.0247
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0002 0.0002
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0034 0.0034
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0015 0.0015
Trichomonas vaginalis esterase, putative 0.007 0.0231 0.0231
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0124 0.0124
Giardia lamblia DINP protein human, muc B family 0.0021 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.1986 0.1986
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.007 0.0231 0.0231
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0449 0.1986 0.4847
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0135 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.218 1 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0002 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0449 0.1986 0.1986
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0261 0.5
Giardia lamblia Encystation-specific protease 0.0449 0.1986 0.4847
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0449 0.1986 0.1986
Plasmodium vivax importin-beta 2, putative 0.0028 0.0034 0.0034
Plasmodium vivax unspecified product 0.0723 0.3255 0.3255
Echinococcus granulosus dna polymerase kappa 0.0021 0.0002 0.0002
Giardia lamblia Cathepsin L-like protease 0.0449 0.1986 0.4847
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.218 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0209 0.0209
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0192 0.0192
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0082 0.0082
Loa Loa (eye worm) cysteine protease 0.218 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0449 0.1986 0.1986
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.007 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.218 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0261 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0112 0.0112
Schistosoma mansoni cathepsin B (C01 family) 0.0449 0.1986 0.1986
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0209 0.0209
Brugia malayi Papain family cysteine protease containing protein 0.1173 0.5336 0.5336
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Mycobacterium leprae PROBABLE HYDROLASE 0.0054 0.0157 0.5528
Toxoplasma gondii cathepsin CPL 0.218 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0417 0.0417
Mycobacterium tuberculosis Conserved protein 0.007 0.0231 0.1155
Toxoplasma gondii histone deacetylase HDAC3 0.0066 0.0209 0.0209
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0098 0.0098
Mycobacterium tuberculosis Probable conserved lipoprotein 0.007 0.0231 0.1155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Brugia malayi Cathepsin L-like precursor 0.1456 0.665 0.665
Plasmodium vivax serine-repeat antigen (SERA) 0.0449 0.1986 0.1986
Schistosoma mansoni importin beta-1 0.0028 0.0034 0.0034
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0231 0.0974 0.0974
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0124 0.0124
Giardia lamblia Cathepsin L precursor 0.0449 0.1986 0.4847
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0002 0.0002
Plasmodium falciparum histone deacetylase, putative 0.0074 0.0247 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0066 0.0209 0.0209
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0449 0.1986 0.1986
Entamoeba histolytica cysteine proteinase, putative 0.1173 0.5336 0.5336
Mycobacterium ulcerans beta-lactamase 0.007 0.0231 0.8836
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1173 0.5336 0.5336
Schistosoma mansoni hypothetical protein 0.0685 0.3079 0.3079
Mycobacterium tuberculosis Probable lipase LipE 0.007 0.0231 0.1155
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1923 0.8813 0.8813
Mycobacterium tuberculosis Probable esterase LipL 0.007 0.0231 0.1155
Leishmania major DNA polymerase eta, putative 0.0021 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0077 0.0261 0.0261
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.007 0.0231 0.0231
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0002 0.0002
Echinococcus multilocularis histone deacetylase 3 0.0066 0.0209 0.0209
Brugia malayi Disintegrin family protein 0.0048 0.0128 0.0128
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0015 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Echinococcus granulosus cathepsin l1 0.1456 0.665 0.665
Onchocerca volvulus 0.0063 0.0198 0.0147
Leishmania major cathepsin L-like protease 0.218 1 1
Brugia malayi fibroinase precursor 0.0449 0.1986 0.1986
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0905 0.4098 0.4098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.218 1 1
Echinococcus granulosus histone deacetylase 7 0.0074 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.218 1 1
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Trypanosoma cruzi histone deacetylase, putative 0.0032 0.0052 0.0052
Echinococcus multilocularis dna polymerase eta 0.0021 0.0002 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0082 0.0082
Giardia lamblia Cathepsin B precursor 0.0905 0.4098 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0028 0.0028
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0034 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Leishmania major histone deacetylase, putative 0.0074 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.007 0.0231 0.0231
Plasmodium falciparum serine repeat antigen 3 0.0449 0.1986 0.1986
Giardia lamblia Hypothetical protein 0.0449 0.1986 0.4847
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.218 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0449 0.1986 0.1986
Brugia malayi hypothetical protein 0.0023 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1173 0.5336 0.5336
Plasmodium falciparum importin beta, putative 0.0028 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0054 0.0157 0.0157
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0449 0.1986 0.1986
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0449 0.1986 0.4847
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Entamoeba histolytica cysteine protease, putative 0.0449 0.1986 0.1986
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0034 0.0034
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Echinococcus granulosus cathepsin L cysteine proteinase 0.218 1 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.074 0.074
Echinococcus multilocularis cathepsin b 0.1923 0.8813 0.8813
Brugia malayi Cathepsin L-like precursor 0.218 1 1
Giardia lamblia Cysteine protease 0.0449 0.1986 0.4847
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.0857 0.0857
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0449 0.1986 0.1986
Schistosoma mansoni hypothetical protein 0.0047 0.0124 0.0124
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0449 0.1986 0.1986
Plasmodium vivax histone deacetylase 2, putative 0.0074 0.0247 0.0247
Trypanosoma cruzi cruzipain precursor, putative 0.218 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.045 0.1988 1
Leishmania major hypothetical protein, conserved 0.007 0.0231 0.0231
Trypanosoma brucei unspecified product 0.0021 0.0002 0.0002
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0066 0.0209 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Toxoplasma gondii histone deacetylase HDAC4 0.0032 0.0052 0.0052
Giardia lamblia Cysteine protease 0.0449 0.1986 0.4847
Onchocerca volvulus 0.0492 0.2184 0.2143
Schistosoma mansoni histone deacetylase 0.0066 0.0209 0.0209
Echinococcus granulosus cysteine protease 0.1173 0.5336 0.5336
Schistosoma mansoni hypothetical protein 0.0102 0.0378 0.0378
Entamoeba histolytica hypothetical protein 0.0111 0.0417 0.0417
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0054 0.0157 0.0782
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0449 0.1986 0.1986
Trypanosoma cruzi cruzipain precursor, putative 0.0723 0.3255 0.3255
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Onchocerca volvulus Matrix metalloproteinase homolog 0.0099 0.0364 0.0314
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0261 0.0261
Loa Loa (eye worm) histone deacetylase 11 0.0032 0.0052 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.218 1 1
Entamoeba histolytica cysteine proteinase, putative 0.218 1 1
Leishmania major histone deacetylase, putative 0.0066 0.0209 0.0209
Entamoeba histolytica cysteine proteinase, putative 0.1173 0.5336 0.5336
Onchocerca volvulus Cathepsin F homolog 0.218 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0449 0.1986 0.1986
Entamoeba histolytica cysteine protease, putative 0.0449 0.1986 0.1986
Trypanosoma brucei histone deacetylase, putative 0.0074 0.0247 0.0247
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0723 0.3255 0.3255
Leishmania major histone deacetylase, putative 0.0066 0.0209 0.0209
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.218 1 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0261 1
Toxoplasma gondii ABC1 family protein 0.007 0.0231 0.0231
Entamoeba histolytica cysteine protease, putative 0.0449 0.1986 0.1986
Schistosoma mansoni histone deacetylase 4 5 0.0074 0.0247 0.0247
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0082 0.309
Schistosoma mansoni cathepsin F (C01 family) 0.218 1 1
Leishmania major cathepsin L-like protease 0.218 1 1
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Toxoplasma gondii histone deacetylase HDAC2 0.0066 0.0209 0.0209
Loa Loa (eye worm) cathepsin B 0.0905 0.4098 0.4098
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0209 0.0209
Giardia lamblia Histone deacetylase 0.0066 0.0209 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.001 0.001
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0098 0.0098
Loa Loa (eye worm) histone deacetylase 1 0.0066 0.0209 0.0209
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0135 0.0135
Echinococcus multilocularis cysteine protease 0.218 1 1
Giardia lamblia Cathepsin L precursor 0.0449 0.1986 0.4847
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0192 0.0192
Echinococcus granulosus histone deacetylase 6 0.0074 0.0247 0.0247
Brugia malayi Papain family cysteine protease containing protein 0.0449 0.1986 0.1986
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Echinococcus granulosus muscleblind protein 0.018 0.074 0.074
Entamoeba histolytica cysteine protease, putative 0.1173 0.5336 0.5336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Brugia malayi Cathepsin L-like precursor 0.218 1 1
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0015 0.0015
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0449 0.1986 0.1986
Loa Loa (eye worm) hypothetical protein 0.1456 0.665 0.665
Echinococcus multilocularis histone deacetylase 6 0.0074 0.0247 0.0247
Trypanosoma cruzi cysteine peptidase, putative 0.1173 0.5336 0.5336
Plasmodium vivax vivapain-2 0.218 1 1
Echinococcus granulosus cathepsin b 0.1923 0.8813 0.8813
Echinococcus multilocularis beta LACTamase domain containing family member 0.007 0.0231 0.0231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.218 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1923 0.8813 0.8813
Echinococcus multilocularis snurportin 1 0.0297 0.1282 0.1282
Entamoeba histolytica cysteine proteinase, putative 0.1456 0.665 0.665
Plasmodium falciparum serine repeat antigen 1 0.0449 0.1986 0.1986
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0082 0.0082
Plasmodium vivax SET domain protein, putative 0.0062 0.0192 0.0192
Trypanosoma cruzi cysteine peptidase, putative 0.218 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Loa Loa (eye worm) matrixin family protein 0.0099 0.0364 0.0364
Toxoplasma gondii histone deacetylase HDAC5 0.0032 0.0052 0.0052
Plasmodium falciparum cysteine proteinase falcipain 3 0.218 1 1
Schistosoma mansoni hypothetical protein 0.0022 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0047 0.0124 0.0124
Onchocerca volvulus 0.218 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0135 0.0135
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0098 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0231 0.0974 0.0974
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0139 0.0139
Brugia malayi beta-lactamase family protein 0.007 0.0231 0.0231
Entamoeba histolytica hypothetical protein 0.0111 0.0417 0.0417
Plasmodium vivax vivapain-3 0.1173 0.5336 0.5336
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0449 0.1986 0.1986
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0261 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.218 1 1
Echinococcus granulosus histone deacetylase 8 0.0032 0.0052 0.0052
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0787 0.3549 0.3549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1456 0.665 0.665
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0082 0.0082
Onchocerca volvulus 0.218 1 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0028 0.0028
Entamoeba histolytica cysteine proteinase, putative 0.1173 0.5336 0.5336
Echinococcus granulosus geminin 0.0685 0.3079 0.3079
Giardia lamblia Cathepsin B precursor 0.0449 0.1986 0.4847
Loa Loa (eye worm) hypothetical protein 0.007 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.1456 0.665 0.665
Echinococcus granulosus dna polymerase eta 0.0021 0.0002 0.0002
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0082 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.1986 0.1986
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0597 0.0597
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.218 1 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0066 0.0209 0.0209
Mycobacterium tuberculosis Conserved protein 0.0024 0.0015 0.0065
Mycobacterium tuberculosis Conserved protein 0.007 0.0231 0.1155
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0685 0.3079 0.3079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.1986 0.1986
Schistosoma mansoni histone deacetylase 1 2 3 0.0032 0.0052 0.0052
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0449 0.1986 0.1986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.1986 0.1986
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0002 0.0002
Giardia lamblia Cathepsin B precursor 0.0905 0.4098 1
Brugia malayi Matrixin family protein 0.0045 0.0112 0.0112
Trichomonas vaginalis penicillin-binding protein, putative 0.007 0.0231 0.0231
Trypanosoma cruzi histone deacetylase, putative 0.0074 0.0247 0.0247
Brugia malayi cathepsin L-like precursor 0.1456 0.665 0.665
Loa Loa (eye worm) hypothetical protein 0.007 0.0231 0.0231
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0449 0.1986 0.1986
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0082 0.0082
Plasmodium falciparum serine repeat antigen 2 0.0449 0.1986 0.1986
Brugia malayi cathepsin B-like cysteine proteinase 0.1923 0.8813 0.8813
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0182 0.0182
Onchocerca volvulus Cathepsin L homolog 0.218 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0192 0.0192
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0015 0.0501
Brugia malayi beta-lactamase 0.007 0.0231 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0002 0.0002
Plasmodium falciparum serine repeat antigen 5 0.0449 0.1986 0.1986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0449 0.1986 0.1986
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0723 0.3255 0.3255
Trypanosoma brucei hypothetical protein, conserved 0.007 0.0231 0.0231
Echinococcus multilocularis cathepsin l cysteine peptidase 0.218 1 1
Echinococcus multilocularis histone deacetylase 6 0.0074 0.0247 0.0247
Loa Loa (eye worm) beta-lactamase 0.007 0.0231 0.0231
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1173 0.5336 0.5336
Brugia malayi MH2 domain containing protein 0.0117 0.0448 0.0448
Echinococcus multilocularis cathepsin L 0.0449 0.1986 0.1986
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0261 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0047 0.0123 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0378 0.0378
Brugia malayi histone deacetylase 3 (HD3) 0.0066 0.0209 0.0209
Trichomonas vaginalis histone deacetylase, putative 0.0066 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0102 0.0378 0.0378
Entamoeba histolytica cysteine proteinase 1, putative 0.1173 0.5336 0.5336

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) 3.1623 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.