Detailed information for compound 1318601

Basic information

Technical information
  • TDR Targets ID: 1318601
  • Name: 6-methyl-7-[3-(2-methylpiperidin-1-yl)-3-oxop ropyl]sulfonyl-4H-1,4-benzoxazin-3-one
  • MW: 380.459 | Formula: C18H24N2O5S
  • H donors: 1 H acceptors: 4 LogP: 1.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1COc2c(N1)cc(c(c2)S(=O)(=O)CCC(=O)N1CCCCC1C)C
  • InChi: 1S/C18H24N2O5S/c1-12-9-14-15(25-11-17(21)19-14)10-16(12)26(23,24)8-6-18(22)20-7-4-3-5-13(20)2/h9-10,13H,3-8,11H2,1-2H3,(H,19,21)
  • InChiKey: WQUZSSIPDNYBIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-methyl-7-[3-(2-methyl-1-piperidyl)-3-oxo-propyl]sulfonyl-4H-1,4-benzoxazin-3-one
  • 6-methyl-7-[3-(2-methyl-1-piperidinyl)-3-oxopropyl]sulfonyl-4H-1,4-benzoxazin-3-one
  • 7-[3-keto-3-(2-methyl-1-piperidyl)propyl]sulfonyl-6-methyl-4H-1,4-benzoxazin-3-one
  • 6-methyl-7-[3-(2-methylpiperidin-1-yl)-3-oxo-propyl]sulfonyl-4H-1,4-benzoxazin-3-one
  • E511-0076
  • NCGC00121800-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0243 0.3374
Loa Loa (eye worm) hypothetical protein 0.0028 0.0138 0.0138
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.008 0.0155
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0234 0.2529 0.2529
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0464 0.5192 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0645 0.12
Schistosoma mansoni thyroid hormone receptor 0.0023 0.008 0.0155
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.008 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0983 0.1893
Schistosoma mansoni coup transcription factor 0.0023 0.008 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0048 0.0372 0.0716
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.5095 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0645 0.12
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0645 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0172 0.2198
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0645 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0248 0.3457
Brugia malayi ecdysteroid receptor 0.0023 0.008 0.008
Brugia malayi nuclear receptor NHR-88 0.0023 0.008 0.008
Brugia malayi follicle stimulating hormone receptor 0.0459 0.5131 0.5131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.008 0.0155
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0243 1
Echinococcus multilocularis hormone sensitive lipase 0.0464 0.5192 1
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.008 0.008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0243 0.3374
Echinococcus granulosus tar DNA binding protein 0.0063 0.0545 0.105
Echinococcus multilocularis lamin dm0 0.0028 0.0144 0.0277
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0144 0.0144
Schistosoma mansoni survival motor neuron protein 0.0048 0.0372 0.0716
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0645 0.1242
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0545 0.105
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0243 0.3374
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.008 0.0155
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.039 0.039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.008 0.0155
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0243 0.0468
Brugia malayi hypothetical protein 0.002 0.0047 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.008 0.0155
Echinococcus multilocularis lamin 0.0028 0.0144 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0645 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0248 0.3457
Echinococcus granulosus intermediate filament protein 0.0028 0.0144 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.008 0.008
Loa Loa (eye worm) runx1 0.011 0.1096 0.1096
Onchocerca volvulus Huntingtin homolog 0.0241 0.2613 0.2553
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0074
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.008 0.008
Schistosoma mansoni inositol monophosphatase 0.0037 0.0243 0.0468
Mycobacterium ulcerans lipase LipD 0.0071 0.0645 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.008 0.0155
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0243 0.3374
Schistosoma mansoni inositol monophosphatase 0.0037 0.0243 0.0468
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0645 1
Leishmania major hypothetical protein, conserved 0.003 0.0172 0.2198
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.008
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0248 0.0478
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.008
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0243 0.976
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0645 0.12
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0243 0.3374
Loa Loa (eye worm) inositol-1 0.0037 0.0243 0.0243
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0248 0.0478
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0144 0.0144
Brugia malayi hypothetical protein 0.0234 0.2529 0.2529
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.008 0.008
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0545 0.105
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0172 0.2198
Loa Loa (eye worm) hypothetical protein 0.0037 0.0248 0.0248
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0645 1
Onchocerca volvulus 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0038 0.0038
Schistosoma mansoni lamin 0.0028 0.0144 0.0277
Onchocerca volvulus 0.006 0.0511 0.0434
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0464 0.5192 1
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0645 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0464 0.5192 1
Mycobacterium ulcerans hypothetical protein 0.0071 0.0645 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0243 0.3374
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.008 0.0155
Loa Loa (eye worm) hypothetical protein 0.0049 0.039 0.039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.008 0.008
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0545 0.0545
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0645 1
Brugia malayi TAR-binding protein 0.0063 0.0545 0.0545
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.008 0.0155
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.008 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.008 0.008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.008 0.0155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0645 0.1242
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2529 0.4871
Onchocerca volvulus 0.0071 0.0645 0.0569
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0038 0.0074
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0248 0.0248
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.008 0.0155
Onchocerca volvulus Huntingtin homolog 0.0241 0.2613 0.2553
Loa Loa (eye worm) hypothetical protein 0.0071 0.0645 0.0645
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0645 0.1242
Loa Loa (eye worm) hypothetical protein 0.0071 0.0645 0.0645
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.008 0.008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0372 0.0372
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0248 0.0478
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0645 0.0645
Schistosoma mansoni lozenge 0.011 0.1096 0.2112
Echinococcus multilocularis Protein lozenge 0.011 0.1096 0.2112
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0248 0.3457
Onchocerca volvulus 0.0071 0.0645 0.0569
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0248 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0248 0.0478
Trichomonas vaginalis esterase, putative 0.0071 0.0645 1
Brugia malayi Inositol-1 0.0037 0.0243 0.0243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.008 0.008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.008 0.0155
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.008
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0243 0.3374
Schistosoma mansoni thyroid hormone receptor 0.0023 0.008 0.0155
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.008 0.0155
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.008 0.0155
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0248 0.0478
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.008 0.0155
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0645 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0511 0.0511
Brugia malayi hypothetical protein 0.003 0.0172 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.008 0.008
Mycobacterium leprae Probable lipase LipE 0.0071 0.0645 1
Loa Loa (eye worm) hypothetical protein 0.0879 1 1
Brugia malayi steroid hormone receptor 0.0023 0.008 0.008
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0199 0.0317
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.008 0.0155
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.008
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.008 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0983 0.1893
Brugia malayi RNA binding protein 0.0063 0.0545 0.0545
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0983 0.1893
Loa Loa (eye worm) beta-lactamase 0.0071 0.0645 0.0645
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0243 0.0468
Loa Loa (eye worm) hypothetical protein 0.0241 0.2613 0.2613
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0459 0.5131 0.5131
Echinococcus multilocularis musashi 0.0028 0.0144 0.0277
Loa Loa (eye worm) hypothetical protein 0.0879 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.0172
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0645 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0248 0.3457
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.021 0.021
Toxoplasma gondii ABC1 family protein 0.0071 0.0645 1
Echinococcus granulosus lamin dm0 0.0028 0.0144 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0545 0.105
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.008 0.0155
Schistosoma mansoni lamin 0.0028 0.0144 0.0277
Loa Loa (eye worm) hypothetical protein 0.0071 0.0645 0.0645
Onchocerca volvulus 0.0048 0.0372 0.0294
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.008 0.0155
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0645 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.008 0.008
Brugia malayi hypothetical protein 0.0241 0.2613 0.2613
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0983 0.1893
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.008 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.008 0.008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0071 0.0645 0.0645
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0645 0.12
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0172 0.2198
Loa Loa (eye worm) RNA binding protein 0.0063 0.0545 0.0545
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0248 0.0478
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0248 0.0478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.008 0.008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.008 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0983 0.1893
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.008 0.0155
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0172 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.008 0.0155
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0172 0.2198
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0038 0.0074
Brugia malayi beta-lactamase 0.0071 0.0645 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0545 0.105
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.008 0.0155
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.008 0.008
Echinococcus multilocularis tumor protein p63 0.0408 0.4545 0.8754
Mycobacterium ulcerans beta-lactamase 0.0071 0.0645 1
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0645 0.12
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0243 0.3374
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.008 0.008
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.008 0.008
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0645 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0983 0.1893
Echinococcus granulosus hormone sensitive lipase 0.0464 0.5192 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0144 0.0144
Echinococcus granulosus lamin 0.0028 0.0144 0.0277
Onchocerca volvulus 0.0028 0.0144 0.0064
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0248 0.0478
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0248 0.3457
Brugia malayi intermediate filament protein 0.0028 0.0144 0.0144
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0645 0.12
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0248 0.3457
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0545 0.105
Schistosoma mansoni intermediate filament proteins 0.0028 0.0144 0.0277
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.039 0.039
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0172 1
Leishmania major hypothetical protein, conserved 0.0071 0.0645 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.008 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0983 0.1893
Loa Loa (eye worm) hypothetical protein 0.0028 0.0144 0.0144
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2529 0.4871
Mycobacterium tuberculosis Conserved protein 0.0071 0.0645 0.12
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.008
Brugia malayi beta-lactamase family protein 0.0071 0.0645 0.0645
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0172 0.2198
Echinococcus granulosus tumor protein p63 0.0408 0.4545 0.8754
Schistosoma mansoni hypothetical protein 0.0034 0.021 0.0404
Onchocerca volvulus 0.0028 0.0144 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0464 0.5192 0.5192
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0645 0.12
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0248 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.008 0.0155
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0038 0.5
Onchocerca volvulus 0.0071 0.0645 0.0569
Brugia malayi nuclear hormone receptor 0.0023 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0071 0.0645 0.0645
Mycobacterium tuberculosis Conserved protein 0.0071 0.0645 0.12
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0645 1
Echinococcus granulosus FTZ F1 alpha 0.0023 0.008 0.0155
Schistosoma mansoni ap endonuclease 0.0019 0.0038 0.0074
Loa Loa (eye worm) hypothetical protein 0.0241 0.2613 0.2613
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0511 0.0984
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0645 0.12
Schistosoma mansoni nuclear hormone receptor 0.0023 0.008 0.0155
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0243 0.3374
Loa Loa (eye worm) hypothetical protein 0.0071 0.0645 0.0645
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0545 0.105
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0983 0.0983
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0645 0.0645
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.039 0.039
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0248 0.3457
Brugia malayi beta-lactamase family protein 0.0071 0.0645 0.0645
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0645 0.1242
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0983 0.0983
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.008 0.008

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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