Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.005 | 0 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.0028 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.0028 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.0028 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.426 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.0028 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.426 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.0028 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.0028 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0233 | 0.0233 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0233 | 0.0233 |
Brugia malayi | hypothetical protein | 0.0148 | 0.0233 | 0.0233 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.0028 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.0028 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.0028 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.426 | 1 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.426 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.0028 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.0028 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.0028 | 0.5 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.426 | 1 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.426 | 1 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1931 | 0.4469 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.0028 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.0028 | 0.0028 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.