Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | norepinephrine transporter | 0.0277 | 0.039 | 0.039 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0277 | 0.039 | 0.039 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0105 | 0.0098 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0047 | 0 | 0.5 |
Onchocerca volvulus | 0.0277 | 0.039 | 0.039 | |
Brugia malayi | Cytochrome P450 family protein | 0.0105 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.0063 | 0.0063 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.0063 | 0.0063 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.0063 | 0.0063 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0105 | 0.0098 | 0.0098 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0047 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0105 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.039 | 0.039 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.5955 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.039 | 0.039 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0063 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0277 | 0.039 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0277 | 0.039 | 0.039 |
Plasmodium falciparum | transporter, putative | 0.0047 | 0 | 0.5 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0105 | 0.0098 | 0.0098 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0047 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0105 | 0.0098 | 0.5 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.0063 | 0.0063 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0047 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0277 | 0.039 | 0.039 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5955 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0006 | 0.0969 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.5955 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5955 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0084 | 0.0063 | 0.0063 |
Leishmania major | cytochrome p450-like protein | 0.0105 | 0.0098 | 0.5 |
Giardia lamblia | Ceramide glucosyltransferase | 0.27 | 0.449 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.0063 | 0.0063 |
Plasmodium vivax | hypothetical protein, conserved | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0277 | 0.039 | 0.039 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0277 | 0.039 | 0.039 |
Plasmodium falciparum | amino acid transporter, putative | 0.0047 | 0 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.5955 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0105 | 0.0098 | 0.0098 |
Echinococcus multilocularis | chromobox protein 1 | 0.0084 | 0.0063 | 0.0063 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0105 | 0.0098 | 0.5 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.5955 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0006 | 0.0969 |
Trypanosoma brucei | cytochrome P450, putative | 0.0105 | 0.0098 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0277 | 0.039 | 0.039 |
Echinococcus granulosus | serotonin transporter | 0.0277 | 0.039 | 0.039 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0063 | 1 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.039 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0047 | 0.0047 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0047 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.