Detailed information for compound 1330637

Basic information

Technical information
  • TDR Targets ID: 1330637
  • Name: methyl 2-[[3-(trifluoromethyl)phenyl]amino]ac etate
  • MW: 233.187 | Formula: C10H10F3NO2
  • H donors: 1 H acceptors: 1 LogP: 2.71 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CNc1cccc(c1)C(F)(F)F
  • InChi: 1S/C10H10F3NO2/c1-16-9(15)6-14-8-4-2-3-7(5-8)10(11,12)13/h2-5,14H,6H2,1H3
  • InChiKey: NXDJBFSBMWZWMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[3-(trifluoromethyl)phenyl]amino]acetic acid methyl ester
  • methyl 2-[[3-(trifluoromethyl)phenyl]amino]ethanoate
  • (3-Trifluoromethyl-phenylamino)-acetic acid methyl ester
  • BAS 04211008
  • STK281591
  • MLS000688266
  • SMR000283900
  • ZINC00416150
  • NCIOpen2_003348
  • NSC71558

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0233 0.0978 0.0916
Entamoeba histolytica cysteine proteinase 2 0.054 0.2373 0.4243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0233 0.0978 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0254 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Entamoeba histolytica cysteine proteinase, putative 0.0957 0.4265 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.054 0.2373 0.1546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0957 0.4265 1
Plasmodium vivax unspecified product 0.0307 0.1316 0.1026
Brugia malayi Papain family cysteine protease containing protein 0.054 0.2373 0.2373
Echinococcus multilocularis cysteine protease 0.0957 0.4265 0.4226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0957 0.4265 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0957 0.4265 0.4226
Giardia lamblia Cathepsin B precursor 0.0848 0.3769 1
Plasmodium vivax unspecified product 0.054 0.2373 0.4243
Echinococcus granulosus cathepsin b 0.2221 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Onchocerca volvulus 0.0957 0.4265 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0233 0.0978 0.0916
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0957 0.4265 0.4226
Brugia malayi Papain family cysteine protease containing protein 0.0233 0.0978 0.0978
Loa Loa (eye worm) ctsf protein 0.0957 0.4265 0.4265
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.065 0.2871 0.2097
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0957 0.4265 1
Schistosoma mansoni cathepsin F (C01 family) 0.0957 0.4265 0.4226
Echinococcus multilocularis cathepsin L cysteine protease 0.0957 0.4265 0.4226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Toxoplasma gondii cathepsin CPC1 0.0233 0.0978 0.1807
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Echinococcus multilocularis cathepsin L 0.054 0.2373 0.2321
Trypanosoma cruzi cysteine protease, putative 0.054 0.2373 0.1546
Toxoplasma gondii preprocathepsin c precursor, putative 0.0233 0.0978 0.1807
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.054 0.2373 0.2321
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0957 0.4265 1
Entamoeba histolytica cysteine proteinase, putative 0.054 0.2373 0.4243
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2221 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0233 0.0978 0.0978
Entamoeba histolytica cysteine proteinase, putative 0.054 0.2373 0.4243
Brugia malayi Cathepsin L-like precursor 0.0957 0.4265 0.4265
Entamoeba histolytica cysteine proteinase, putative 0.0957 0.4265 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.0978 0.0978
Echinococcus multilocularis cathepsin b 0.2221 1 1
Onchocerca volvulus 0.0957 0.4265 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0254 0.0186
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0254 0.5
Entamoeba histolytica cysteine proteinase, putative 0.054 0.2373 0.4243
Entamoeba histolytica cysteine protease, putative 0.0957 0.4265 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.054 0.2373 0.4243
Trypanosoma cruzi cysteine peptidase, putative 0.0307 0.1316 0.0374
Onchocerca volvulus 0.0957 0.4265 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0069 0.0069
Toxoplasma gondii cathepsin CPC2 0.0233 0.0978 0.1807
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Loa Loa (eye worm) hypothetical protein 0.0233 0.0978 0.0978
Loa Loa (eye worm) fibroinase 0.0957 0.4265 0.4265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.065 0.2871 0.5757
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2221 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0233 0.0978 0.0916
Leishmania major cathepsin L-like protease 0.0957 0.4265 1
Loa Loa (eye worm) hypothetical protein 0.065 0.2871 0.2871
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Brugia malayi Cathepsin L-like precursor 0.0957 0.4265 0.4265
Trypanosoma cruzi cruzipain precursor, putative 0.0307 0.1316 0.0374
Echinococcus granulosus cathepsin b 0.2221 1 1
Echinococcus granulosus cathepsin l1 0.0957 0.4265 0.4226
Brugia malayi cathepsin L precursor 0.0233 0.0978 0.0978
Leishmania major cathepsin L-like protease 0.0957 0.4265 1
Trypanosoma cruzi cysteine peptidase, putative 0.0957 0.4265 0.3644
Leishmania major cathepsin L-like protease 0.0957 0.4265 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.0978 0.0978
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Brugia malayi Papain family cysteine protease containing protein 0.0233 0.0978 0.0978
Brugia malayi Papain family cysteine protease containing protein 0.0233 0.0978 0.0978
Schistosoma mansoni cathepsin C 0.0233 0.0978 0.0916
Echinococcus multilocularis cysteine protease 0.0957 0.4265 0.4226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0957 0.4265 1
Toxoplasma gondii cathepsin CPL 0.0957 0.4265 1
Echinococcus granulosus cathepsin l1 0.065 0.2871 0.2821
Entamoeba histolytica cysteine proteinase 1, putative 0.054 0.2373 0.4243
Brugia malayi fibroinase precursor 0.0233 0.0978 0.0978
Brugia malayi Cathepsin L-like cysteine proteinase 0.065 0.2871 0.2871
Echinococcus multilocularis cathepsin L 0.0233 0.0978 0.0916
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.054 0.2373 0.2321
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Echinococcus granulosus cathepsin L 0.0233 0.0978 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.2373 0.4243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0233 0.0978 0.0978
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0233 0.0978 0.0978
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0254 0.5
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0254 0.0186
Brugia malayi cathepsin L-like cysteine proteinase 0.0233 0.0978 0.0978
Plasmodium vivax vivapain-2 0.0957 0.4265 1
Brugia malayi Cathepsin L-like precursor 0.0957 0.4265 0.4265
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0233 0.0978 0.0916
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0069 0.0069
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0307 0.1316 0.1316
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0233 0.0978 0.0916
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Brugia malayi Cathepsin L-like precursor 0.065 0.2871 0.2871
Toxoplasma gondii cathepsin B 0.0848 0.3769 0.8762
Brugia malayi Papain family cysteine protease containing protein 0.0957 0.4265 0.4265
Onchocerca volvulus Cathepsin L homolog 0.0957 0.4265 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0233 0.0978 0.0916
Loa Loa (eye worm) hypothetical protein 0.0032 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.065 0.2871 0.2871
Giardia lamblia Cathepsin B precursor 0.0848 0.3769 1
Brugia malayi Cathepsin L-like precursor 0.0307 0.1316 0.1316
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0233 0.0978 0.0916
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Trypanosoma cruzi cysteine peptidase, putative 0.0957 0.4265 0.3644
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0848 0.3769 0.8488
Brugia malayi cathepsin Z-like cysteine proteinase 0.0233 0.0978 0.0978
Schistosoma mansoni cathepsin s 0.0307 0.1316 0.1256
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.065 0.2871 0.5757
Brugia malayi cathepsin L-like precursor 0.065 0.2871 0.2871
Trypanosoma cruzi cysteine proteinase, putative 0.054 0.2373 0.1546
Loa Loa (eye worm) hypothetical protein 0.0233 0.0978 0.0978
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Leishmania major cathepsin L-like protease 0.0957 0.4265 1
Loa Loa (eye worm) cathepsin B 0.0848 0.3769 0.3769
Echinococcus granulosus cysteine protease 0.054 0.2373 0.2321
Leishmania major cathepsin L-like protease 0.0957 0.4265 1
Trypanosoma cruzi cysteine peptidase, putative 0.054 0.2373 0.1546
Trypanosoma cruzi cysteine proteinase, putative 0.054 0.2373 0.1546
Brugia malayi cathepsin F-like cysteine proteinase 0.0307 0.1316 0.1316
Trypanosoma cruzi cysteine peptidase, putative 0.0957 0.4265 0.3644
Trypanosoma cruzi cruzipain precursor, putative 0.0957 0.4265 0.3644
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0307 0.1316 0.1316
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0848 0.3769 0.3726
Leishmania major cathepsin L-like protease 0.0957 0.4265 1
Entamoeba histolytica cysteine proteinase, putative 0.065 0.2871 0.5757
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Onchocerca volvulus 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Echinococcus granulosus cathepsin L 0.054 0.2373 0.2321
Brugia malayi Cathepsin L-like precursor 0.0957 0.4265 0.4265
Onchocerca volvulus 0.0957 0.4265 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0957 0.4265 1
Schistosoma mansoni cathepsin S (C01 family) 0.0233 0.0978 0.0916
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Onchocerca volvulus 0.065 0.2871 0.6677
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0957 0.4265 0.4265
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2221 1 1
Entamoeba histolytica cysteine proteinase, putative 0.054 0.2373 0.4243
Echinococcus granulosus cathepsin L cysteine proteinase 0.0957 0.4265 0.4226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0233 0.0978 0.0978
Onchocerca volvulus Cathepsin F homolog 0.0957 0.4265 1
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Plasmodium vivax vivapain-3 0.054 0.2373 0.4243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0957 0.4265 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0848 0.3769 0.7374
Echinococcus granulosus cathepsin l cysteine peptidase 0.0957 0.4265 0.4226
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0233 0.0978 0.0978
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.054 0.2373 0.4243
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2221 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0233 0.0978 0.0916
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0254 0.0186
Loa Loa (eye worm) hypothetical protein 0.065 0.2871 0.2871
Trypanosoma cruzi cysteine peptidase, putative 0.0957 0.4265 0.3644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0957 0.4265 0.4265
Loa Loa (eye worm) hypothetical protein 0.0307 0.1316 0.1316
Loa Loa (eye worm) hypothetical protein 0.0233 0.0978 0.0978
Onchocerca volvulus 0.0233 0.0978 0.2168
Echinococcus multilocularis cathepsin b 0.2221 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Echinococcus granulosus cathepsin L cysteine protease 0.054 0.2373 0.2321
Brugia malayi intermediate filament protein 0.0033 0.0069 0.0069
Plasmodium vivax vivapain-1 0.054 0.2373 0.4243
Leishmania major cathepsin L-like protease 0.0957 0.4265 1
Brugia malayi Cathepsin L-like precursor 0.0957 0.4265 0.4265
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.054 0.2373 0.2321
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0957 0.4265 1
Leishmania major cathepsin L-like protease 0.0957 0.4265 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0848 0.3769 0.8762
Plasmodium vivax vivapain-2 0.0957 0.4265 1
Schistosoma mansoni cathepsin F (C01 family) 0.065 0.2871 0.2821
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0069 0.0069
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Leishmania major cysteine peptidase A (CPA) 0.0957 0.4265 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0957 0.4265 1
Giardia lamblia Cathepsin B precursor 0.0848 0.3769 1
Loa Loa (eye worm) cysteine protease 0.0957 0.4265 0.4265
Schistosoma mansoni cathepsin F (C01 family) 0.0957 0.4265 0.4226
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0233 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0307 0.1316 0.1316
Onchocerca volvulus 0.0957 0.4265 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0957 0.4265 0.4226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0957 0.4265 1
Entamoeba histolytica cysteine protease, putative 0.054 0.2373 0.4243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0957 0.4265 1
Brugia malayi Papain family cysteine protease containing protein 0.054 0.2373 0.2373
Onchocerca volvulus Cathepsin L homolog 0.0957 0.4265 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0848 0.3769 0.3093
Onchocerca volvulus 0.0957 0.4265 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0957 0.4265 1
Loa Loa (eye worm) hypothetical protein 0.0307 0.1316 0.1316
Loa Loa (eye worm) hypothetical protein 0.0233 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0033 0.0069 0.0069
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0233 0.0978 0.0916
Brugia malayi Cathepsin L-like precursor 0.065 0.2871 0.2871
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0254 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0254 0.5
Onchocerca volvulus Cathepsin L homolog 0.0233 0.0978 0.2168
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2221 1 1
Loa Loa (eye worm) hypothetical protein 0.2221 1 1
Brugia malayi Cathepsin L-like precursor 0.0957 0.4265 0.4265
Loa Loa (eye worm) hypothetical protein 0.0957 0.4265 0.4265

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) > 300 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of Mex-5 Binding to TCR-2. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
EC50 (binding) > 300 um PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of POS-1 Binding to mex-3-RNA. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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