Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0162 | 0.5079 |
Echinococcus granulosus | single minded 2 | 0.0046 | 0.1819 | 0.2357 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0318 | 0.0444 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0917 | 0.0768 |
Plasmodium falciparum | cytochrome b | 0.0064 | 0.2919 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.5026 | 0.7016 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0162 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0021 | 0.0318 | 0.0568 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0021 | 0.0318 | 1 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0134 | 0.7197 | 0.9452 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0162 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0021 | 0.0318 | 0.0179 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0624 | 0.078 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0917 | 0.1485 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0021 | 0.0318 | 0.0568 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0624 | 0.101 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0318 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.7164 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1257 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0917 | 0.1167 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2876 | 0.2759 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0021 | 0.0318 | 0.0568 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2876 | 0.2759 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.6212 | 0.8672 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0134 | 0.7197 | 0.8065 |
Schistosoma mansoni | cytochrome b | 0.0064 | 0.2919 | 0.2803 |
Leishmania major | UDP-galactopyranose mutase | 0.0021 | 0.0318 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0021 | 0.0318 | 0.0377 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0917 | 0.1167 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0021 | 0.0318 | 0.0377 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0162 | 0.0145 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1257 | 1 |
Schistosoma mansoni | amine oxidase | 0.0021 | 0.0318 | 0.0159 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0162 | 0.017 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1257 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0624 | 0.0666 |
Schistosoma mansoni | single-minded | 0.0062 | 0.2803 | 0.2685 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0595 | 0.083 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.5026 | 0.8134 |
Brugia malayi | cytochrome b | 0.0064 | 0.2919 | 0.4723 |
Plasmodium vivax | cytochrome b | 0.0064 | 0.2919 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0318 | 0.0444 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2876 | 0.4014 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.0318 | 0.021 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2876 | 0.3751 |
Mycobacterium ulcerans | monoamine oxidase | 0.0021 | 0.0318 | 0.0179 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1257 | 1 |
Onchocerca volvulus | 0.0026 | 0.0624 | 0.0447 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.3125 | 0.5056 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0318 | 0.0444 |
Onchocerca volvulus | 0.0046 | 0.1852 | 0.224 | |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0141 | 0.7612 | 1 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2876 | 0.4653 |
Mycobacterium ulcerans | dehydrogenase | 0.0021 | 0.0318 | 0.0179 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0162 | 0.8915 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0624 | 0.101 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0021 | 0.0318 | 0.0568 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1257 | 0.1113 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0162 | 0.8915 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.0624 | 0.078 |
Schistosoma mansoni | cytochrome b | 0.0064 | 0.2919 | 0.2803 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0021 | 0.0318 | 0.021 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0917 | 0.1485 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0021 | 0.0318 | 1 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0017 | 0.0033 | 0.0046 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0162 | 0.5079 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1257 | 0.2033 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0162 | 0.5 |
Echinococcus multilocularis | 0.0021 | 0.0318 | 0.0321 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0021 | 0.0318 | 0.0568 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0064 | 0.2919 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0624 | 0.0871 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0917 | 0.0996 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0624 | 0.047 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.3125 | 0.3012 |
Echinococcus granulosus | cytochrome B | 0.0064 | 0.2919 | 0.3808 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1257 | 0.1113 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0162 | 0.5079 |
Schistosoma mansoni | lamin | 0.0026 | 0.0624 | 0.047 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0162 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2876 | 0.4653 |
Brugia malayi | SWIRM domain containing protein | 0.0021 | 0.0318 | 0.0515 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0046 | 0.1819 | 0.2011 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0021 | 0.0318 | 0.0568 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0021 | 0.0318 | 0.0179 |
Onchocerca volvulus | 0.0133 | 0.7164 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.5026 | 0.7016 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1257 | 0.1615 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0162 | 0.8915 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2876 | 0.4653 |
Schistosoma mansoni | amine oxidase | 0.0021 | 0.0318 | 0.0159 |
Loa Loa (eye worm) | cytochrome b | 0.0064 | 0.2919 | 0.4074 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0162 | 0.0226 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0624 | 0.0666 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2876 | 0.3201 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0162 | 0.8915 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2876 | 0.2759 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0021 | 0.0318 | 0.0515 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0021 | 0.0318 | 0.0321 |
Plasmodium vivax | hypothetical protein, conserved | 0.0021 | 0.0318 | 0.0568 |
Brugia malayi | bHLH-PAS transcription factor | 0.0046 | 0.1819 | 0.2943 |
Toxoplasma gondii | cytochrome b | 0.0064 | 0.2919 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0624 | 0.078 |
Onchocerca volvulus | 0.0026 | 0.0624 | 0.0447 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0318 | 0.0444 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2876 | 0.2759 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2876 | 0.4014 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0624 | 0.0666 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0917 | 0.1281 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0917 | 0.1167 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0624 | 0.0871 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0917 | 0.0768 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0021 | 0.0318 | 0.0179 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.5026 | 0.8134 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0021 | 0.0318 | 0.0568 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0162 | 0.8915 | 0.8897 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0917 | 0.0996 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0917 | 0.0768 |
Brugia malayi | PAS domain containing protein | 0.0062 | 0.2803 | 0.4536 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0117 | 0.618 | 1 |
Toxoplasma gondii | apocytochrome b, putative | 0.0064 | 0.2919 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0917 | 0.0768 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0021 | 0.0318 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0624 | 0.0871 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3125 | 0.4361 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0318 | 0.0444 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0162 | 0.0262 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0141 | 0.7612 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1257 | 0.1378 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2876 | 0.2759 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0917 | 0.1281 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0318 | 0.0515 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0021 | 0.0318 | 0.0159 |
Mycobacterium ulcerans | putative regulatory protein | 0.0046 | 0.1819 | 0.1893 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0162 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2876 | 0.4014 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.618 | 0.8626 |
Schistosoma mansoni | lamin | 0.0026 | 0.0624 | 0.047 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0917 | 0.0996 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.