TDR Targets

Basic information

Technical information

TDR Targets ID: 1333552
Name: ethyl 4-[2-(phenoxy)ethyl]-1-(1,3-thiazole-5- carbonyl)piperidine-4-carboxylate
MW: 388.481 | Formula: C20H24N2O4S
H donors: 0 H acceptors: 3 LogP: 3.31 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1(CCOc2ccccc2)CCN(CC1)C(=O)c1cncs1
InChi: 1S/C20H24N2O4S/c1-2-25-19(24)20(10-13-26-16-6-4-3-5-7-16)8-11-22(12-9-20)18(23)17-14-21-15-27-17/h3-7,14-15H,2,8-13H2,1H3
InChiKey: JHQZFCRHIYACDW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 4-[2-(phenoxy)ethyl]-1-(thiazole-5-carbonyl)piperidine-4-carboxylate
1-[oxo-(5-thiazolyl)methyl]-4-[2-(phenoxy)ethyl]-4-piperidinecarboxylic acid ethyl ester
4-[2-(phenoxy)ethyl]-1-(thiazole-5-carbonyl)isonipecotic acid ethyl ester
ethyl 4-[2-(phenoxy)ethyl]-1-(1,3-thiazol-5-ylcarbonyl)piperidine-4-carboxylate
ethyl 4-(2-phenoxyethyl)-1-(1,3-thiazol-5-ylcarbonyl)piperidine-4-carboxylate
MLS000735127
SMR000318130

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0075	0.1458	0.139
Leishmania major	cathepsin L-like protease	0.0137	0.3481	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.1458	0.4189
Entamoeba histolytica	cysteine proteinase 1, putative	0.0075	0.1458	0.4054
Giardia lamblia	Cathepsin B precursor	0.0126	0.3148	1
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Onchocerca volvulus		0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0095	0.2102	0.2102
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0137	0.3481	0.3481
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0042	0.0382	0.0382
Plasmodium falciparum	serine repeat antigen 9	0.0033	0.0079	0.0228
Toxoplasma gondii	cathepsin B	0.0126	0.3148	0.9042
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0033	0.0079	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.2102	0.5946
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0075	0.1458	0.139
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0126	0.3148	0.9042
Trypanosoma cruzi	cruzipain precursor, putative	0.0042	0.0382	0.0382
Entamoeba histolytica	cysteine proteinase, putative	0.0095	0.2102	0.5946
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0033	0.0079	0.0079
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0137	0.3481	1
Plasmodium falciparum	serine repeat antigen 4	0.0033	0.0079	0.0228
Onchocerca volvulus		0.0137	0.3481	1
Entamoeba histolytica	cysteine proteinase, putative	0.0075	0.1458	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3481	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0126	0.3148	0.3093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0095	0.2102	0.5946
Onchocerca volvulus		0.0137	0.3481	1
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Echinococcus granulosus	cysteine protease	0.0075	0.1458	0.139
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0033	0.0079	0.0228
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0126	0.3148	0.902
Schistosoma mansoni	cathepsin F (C01 family)	0.0137	0.3481	0.3429
Brugia malayi	cathepsin L precursor	0.0033	0.0079	0.0079
Loa Loa (eye worm)	ctsf protein	0.0137	0.3481	0.3481
Brugia malayi	Cathepsin L-like precursor	0.0095	0.2102	0.2102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Plasmodium vivax	unspecified product	0.0033	0.0079	0.0228
Echinococcus granulosus	cathepsin L	0.0075	0.1458	0.139
Schistosoma mansoni	cathepsin F (C01 family)	0.0137	0.3481	0.3429
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0336	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0075	0.1458	0.4054
Onchocerca volvulus		0.0137	0.3481	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2102	0.2102
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Loa Loa (eye worm)	cysteine protease	0.0137	0.3481	0.3481
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0137	0.3481	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0137	0.3481	1
Brugia malayi	Cathepsin L-like precursor	0.0042	0.0382	0.0382
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0042	0.0382	0.0382
Trypanosoma cruzi	cysteine peptidase, putative	0.0137	0.3481	0.3481
Trypanosoma cruzi	cruzipain precursor, putative	0.0137	0.3481	0.3481
Leishmania major	cathepsin L-like protease	0.0137	0.3481	1
Loa Loa (eye worm)	cathepsin B	0.0126	0.3148	0.3148
Trypanosoma cruzi	cysteine proteinase, putative	0.0075	0.1458	0.1458
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0137	0.3481	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0137	0.3481	0.3429
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0126	0.3148	0.3148
Onchocerca volvulus		0.0095	0.2102	0.5946
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0033	0.0079	0.0228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0137	0.3481	0.3481
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3481	0.3481
Trypanosoma cruzi	cysteine peptidase, putative	0.0137	0.3481	0.3481
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Echinococcus granulosus	cathepsin b	0.0336	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Plasmodium vivax	unspecified product	0.0042	0.0382	0.1097
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0033	0.0079	0.0228
Brugia malayi	cathepsin L-like cysteine proteinase	0.0033	0.0079	0.0079
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3481	0.3481
Plasmodium vivax	unspecified product	0.0075	0.1458	0.4189
Entamoeba histolytica	cysteine proteinase, putative	0.0075	0.1458	0.4054
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0033	0.0079	0.0228
Echinococcus multilocularis	cathepsin L	0.0075	0.1458	0.139
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0075	0.1458	0.139
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0336	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0137	0.3481	0.3481
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0033	0.0079	0.0079
Echinococcus granulosus	cathepsin l1	0.0095	0.2102	0.2039
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0033	0.0079	0.0079
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0033	0.0079	0.0228
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0079	0.0079
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3481	0.3481
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Echinococcus multilocularis	cathepsin b	0.0336	1	1
Loa Loa (eye worm)	hypothetical protein	0.0336	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0137	0.3481	1
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0079	0.0079
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0033	0.0079	0.0228
Giardia lamblia	Cathepsin B precursor	0.0126	0.3148	1
Onchocerca volvulus		0.0137	0.3481	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0137	0.3481	0.3429
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0033	0.0079	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2102	0.2102
Onchocerca volvulus		0.0137	0.3481	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0075	0.1458	0.4189
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0137	0.3481	0.3429
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3481	1
Entamoeba histolytica	cysteine proteinase, putative	0.0075	0.1458	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0137	0.3481	1
Entamoeba histolytica	cysteine proteinase, putative	0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Giardia lamblia	Cathepsin B precursor	0.0126	0.3148	1
Plasmodium falciparum	serine repeat antigen 5	0.0033	0.0079	0.0228
Toxoplasma gondii	cathepsin CPL	0.0137	0.3481	1
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0126	0.3148	0.9042
Entamoeba histolytica	cysteine proteinase, putative	0.0075	0.1458	0.4054
Echinococcus multilocularis	cathepsin b	0.0336	1	1
Plasmodium falciparum	serine repeat antigen 6	0.0033	0.0079	0.0228
Echinococcus multilocularis	cysteine protease	0.0137	0.3481	0.3429
Onchocerca volvulus		0.0137	0.3481	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0382	0.0382
Echinococcus multilocularis	cysteine protease	0.0137	0.3481	0.3429
Plasmodium vivax	vivapain-1	0.0075	0.1458	0.4189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3481	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Plasmodium vivax	vivapain-3	0.0075	0.1458	0.4189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Plasmodium falciparum	serine repeat antigen 1	0.0033	0.0079	0.0228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3481	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0079	0.0079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Plasmodium vivax	vivapain-2	0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	0.1458	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3481	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0042	0.0382	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0079	0.0079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Onchocerca volvulus	Cathepsin L homolog	0.0137	0.3481	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0033	0.0079	0.0228
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0336	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0336	1	1
Plasmodium falciparum	serine repeat antigen 8	0.0033	0.0079	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0137	0.3481	0.3481
Leishmania major	cathepsin L-like protease	0.0137	0.3481	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0075	0.1458	0.139
Trypanosoma cruzi	cysteine peptidase, putative	0.0075	0.1458	0.1458
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0075	0.1458	0.1458
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0137	0.3481	1
Plasmodium falciparum	serine repeat antigen 7	0.0033	0.0079	0.0228
Brugia malayi	Papain family cysteine protease containing protein	0.0075	0.1458	0.1458
Loa Loa (eye worm)	fibroinase	0.0137	0.3481	0.3481
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Plasmodium falciparum	serine repeat antigen 2	0.0033	0.0079	0.0228
Leishmania major	cathepsin L-like protease	0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2102	0.2102
Echinococcus multilocularis	cathepsin L cysteine protease	0.0137	0.3481	0.3429
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0033	0.0079	0.0228
Brugia malayi	Papain family cysteine protease containing protein	0.0137	0.3481	0.3481
Onchocerca volvulus	Cathepsin F homolog	0.0137	0.3481	1
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0079	0.0079
Brugia malayi	cathepsin L-like precursor	0.0095	0.2102	0.2102
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0033	0.0079	0.0228
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0336	1	1
Leishmania major	cathepsin L-like protease	0.0137	0.3481	1
Echinococcus granulosus	cathepsin b	0.0336	1	1
Plasmodium vivax	vivapain-2	0.0137	0.3481	1
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3481	0.3481
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0382	0.0382
Brugia malayi	Papain family cysteine protease containing protein	0.0075	0.1458	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0079	0.0079
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0033	0.0079	0.0228
Brugia malayi	Cathepsin L-like precursor	0.0095	0.2102	0.2102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0137	0.3481	0.3481
Echinococcus granulosus	cathepsin l1	0.0137	0.3481	0.3429
Leishmania major	cathepsin L-like protease	0.0137	0.3481	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0033	0.0079	0.0228
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0075	0.1458	0.4189
Onchocerca volvulus	Cathepsin L homolog	0.0137	0.3481	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0033	0.0079	0.0228
Brugia malayi	cathepsin F-like cysteine proteinase	0.0042	0.0382	0.0382
Trypanosoma cruzi	cysteine protease, putative	0.0075	0.1458	0.1458
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0382	0.0382
Brugia malayi	fibroinase precursor	0.0033	0.0079	0.0079
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0033	0.0079	0.0079
Trypanosoma cruzi	major cysteine proteinase, putative	0.0033	0.0079	0.0079
Toxoplasma gondii	cathepsin CPC2	0.0033	0.0079	0.0228
Toxoplasma gondii	cathepsin CPC1	0.0033	0.0079	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0079	0.0079
Trypanosoma cruzi	cysteine proteinase, putative	0.0075	0.1458	0.1458
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0033	0.0079	0.0228
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0033	0.0079	0.0079
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3481	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0137	0.3481	0.3429
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0033	0.0079	0.0079
Leishmania major	cysteine peptidase A (CPA)	0.0137	0.3481	1
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3481	1
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3481	0.3481
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.3481	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0137	0.3481	0.3429
Schistosoma mansoni	cathepsin F (C01 family)	0.0095	0.2102	0.2039
Entamoeba histolytica	cysteine protease, putative	0.0075	0.1458	0.4054
Schistosoma mansoni	cathepsin s	0.0042	0.0382	0.0305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0075	0.1458	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0137	0.3481	0.3481
Trypanosoma cruzi	major cysteine proteinase, putative	0.0033	0.0079	0.0079
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0095	0.2102	0.2102
Leishmania major	cathepsin L-like protease	0.0137	0.3481	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0033	0.0079	0.0228
Leishmania major	cathepsin L-like protease	0.0137	0.3481	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0137	0.3481	1
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0079	0.0079
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.3481	1
Plasmodium falciparum	serine repeat antigen 3	0.0033	0.0079	0.0228

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.2993 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1431443

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1333552