Detailed information for compound 1339028

Basic information

Technical information
  • TDR Targets ID: 1339028
  • Name: 2,3-dimethyl-N-[(5-methylfuran-2-yl)methyl]-1 -(phenylmethyl)indole-5-carboxamide
  • MW: 372.46 | Formula: C24H24N2O2
  • H donors: 1 H acceptors: 1 LogP: 4.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(o1)CNC(=O)c1ccc2c(c1)c(C)c(n2Cc1ccccc1)C
  • InChi: 1S/C24H24N2O2/c1-16-9-11-21(28-16)14-25-24(27)20-10-12-23-22(13-20)17(2)18(3)26(23)15-19-7-5-4-6-8-19/h4-13H,14-15H2,1-3H3,(H,25,27)
  • InChiKey: DVGKGVWSODBSQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,3-dimethyl-N-[(5-methyl-2-furyl)methyl]-1-(phenylmethyl)indole-5-carboxamide
  • 2,3-dimethyl-N-[(5-methyl-2-furyl)methyl]-1-(phenylmethyl)-5-indolecarboxamide
  • 1-(benzyl)-2,3-dimethyl-N-[(5-methyl-2-furyl)methyl]indole-5-carboxamide
  • G119-1214
  • NCGC00128936-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0171 0.0439 0.0439
Brugia malayi cathepsin L-like cysteine proteinase 0.0316 0.1015 0.0555
Schistosoma mansoni hypothetical protein 0.0171 0.0439 0.0439
Echinococcus granulosus cathepsin b 0.2584 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2584 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.1402 0.5315 0.4786
Onchocerca volvulus Cathepsin F homolog 0.1402 0.5315 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1402 0.5315 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.1018 0.3794 0.4049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Brugia malayi cathepsin F-like cysteine proteinase 0.044 0.1507 0.1073
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0316 0.1015 0.1015
Onchocerca volvulus 0.0316 0.1015 0.1909
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0962 0.3572 0.2846
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1402 0.5315 1
Entamoeba histolytica cysteine proteinase, putative 0.1402 0.5315 1
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Toxoplasma gondii cathepsin CPL 0.1402 0.5315 1
Echinococcus granulosus cathepsin L 0.0756 0.2758 0.2426
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1018 0.3794 0.3794
Leishmania major cathepsin L-like protease 0.1402 0.5315 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0316 0.1015 0.0555
Loa Loa (eye worm) fibroinase 0.1402 0.5315 0.5315
Echinococcus granulosus tachykinin peptides receptor 99D 0.0599 0.2135 0.1774
Entamoeba histolytica cysteine proteinase, putative 0.1402 0.5315 1
Giardia lamblia Cathepsin B precursor 0.1018 0.3794 1
Schistosoma mansoni cathepsin F (C01 family) 0.0962 0.3572 0.3572
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0756 0.2758 0.2758
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Brugia malayi Cathepsin L-like precursor 0.1402 0.5315 0.5076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Entamoeba histolytica cysteine proteinase, putative 0.0756 0.2758 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0756 0.2758 0.4054
Loa Loa (eye worm) ctsf protein 0.1402 0.5315 0.5315
Onchocerca volvulus Cathepsin L homolog 0.1402 0.5315 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.044 0.1507 0.1507
Loa Loa (eye worm) hypothetical protein 0.0316 0.1015 0.1015
Leishmania major cathepsin L-like protease 0.1402 0.5315 1
Brugia malayi Papain family cysteine protease containing protein 0.0316 0.1015 0.0555
Echinococcus multilocularis cathepsin b 0.2584 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1402 0.5315 0.4786
Brugia malayi Papain family cysteine protease containing protein 0.0756 0.2758 0.2388
Leishmania major cathepsin L-like protease 0.1402 0.5315 1
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0756 0.2758 0.2758
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2584 1 1
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Echinococcus granulosus cathepsin l1 0.0962 0.3572 0.3277
Loa Loa (eye worm) hypothetical protein 0.0316 0.1015 0.1015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Schistosoma mansoni cathepsin F (C01 family) 0.1402 0.5315 0.5315
Schistosoma mansoni cathepsin C 0.0316 0.1015 0.1015
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Echinococcus granulosus cathepsin l1 0.1402 0.5315 0.51
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1402 0.5315 1
Loa Loa (eye worm) cathepsin B 0.1018 0.3794 0.3794
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1402 0.5315 0.5315
Schistosoma mansoni cathepsin S (C01 family) 0.0316 0.1015 0.1015
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0316 0.1015 0.1015
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Brugia malayi cathepsin L-like precursor 0.0962 0.3572 0.3243
Leishmania major cathepsin L-like protease 0.1402 0.5315 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2584 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0756 0.2758 0.4054
Loa Loa (eye worm) cysteine protease 0.1402 0.5315 0.5315
Onchocerca volvulus 0.1402 0.5315 1
Entamoeba histolytica cysteine proteinase, putative 0.0962 0.3572 0.5946
Plasmodium vivax vivapain-3 0.0756 0.2758 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1402 0.5315 1
Echinococcus granulosus cathepsin L cysteine protease 0.0756 0.2758 0.2426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1402 0.5315 1
Onchocerca volvulus 0.1402 0.5315 1
Onchocerca volvulus Cathepsin L homolog 0.1402 0.5315 1
Brugia malayi Cathepsin L-like precursor 0.1402 0.5315 0.5076
Plasmodium vivax unspecified product 0.044 0.1507 0.1145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Trypanosoma cruzi cysteine peptidase, putative 0.044 0.1507 0.0548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Toxoplasma gondii cathepsin B 0.1018 0.3794 0.6462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Onchocerca volvulus 0.1402 0.5315 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1018 0.3794 0.3093
Trypanosoma cruzi cysteine peptidase, putative 0.1402 0.5315 0.4786
Entamoeba histolytica cysteine proteinase, putative 0.0756 0.2758 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0756 0.2758 0.4054
Plasmodium vivax unspecified product 0.0756 0.2758 0.4054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1402 0.5315 0.51
Onchocerca volvulus 0.1402 0.5315 1
Loa Loa (eye worm) hypothetical protein 0.044 0.1507 0.1507
Giardia lamblia Cathepsin B precursor 0.1018 0.3794 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0316 0.1015 0.0555
Brugia malayi Papain family cysteine protease containing protein 0.1402 0.5315 0.5076
Entamoeba histolytica cysteine proteinase, putative 0.0756 0.2758 0.4054
Brugia malayi Cathepsin L-like cysteine proteinase 0.0962 0.3572 0.3243
Plasmodium falciparum cysteine proteinase falcipain 1 0.0756 0.2758 0.4054
Loa Loa (eye worm) hypothetical protein 0.0316 0.1015 0.1015
Onchocerca volvulus 0.1402 0.5315 1
Brugia malayi cathepsin L precursor 0.0316 0.1015 0.0555
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1402 0.5315 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0962 0.3572 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1018 0.3794 0.6462
Trypanosoma cruzi cruzipain precursor, putative 0.044 0.1507 0.0548
Echinococcus multilocularis cathepsin L 0.0316 0.1015 0.0602
Trypanosoma cruzi cysteine peptidase, putative 0.0756 0.2758 0.194
Echinococcus multilocularis cathepsin L cysteine protease 0.1402 0.5315 0.51
Leishmania major cathepsin L-like protease 0.1402 0.5315 1
Loa Loa (eye worm) hypothetical protein 0.0962 0.3572 0.3572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0962 0.3572 0.5946
Loa Loa (eye worm) hypothetical protein 0.044 0.1507 0.1507
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0316 0.1015 0.1015
Brugia malayi Cathepsin L-like precursor 0.1402 0.5315 0.5076
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0316 0.1015 0.1015
Loa Loa (eye worm) hypothetical protein 0.0316 0.1015 0.1015
Plasmodium vivax vivapain-1 0.0756 0.2758 0.4054
Schistosoma mansoni cathepsin B (C01 family) 0.0316 0.1015 0.1015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0316 0.1015 0.1015
Onchocerca volvulus 0.0182 0.0486 0.0915
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.0644 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.1402 0.5315 0.5315
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1402 0.5315 1
Brugia malayi Papain family cysteine protease containing protein 0.0316 0.1015 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Echinococcus multilocularis cysteine protease 0.1402 0.5315 0.51
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1402 0.5315 1
Onchocerca volvulus 0.0962 0.3572 0.672
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0599 0.2135 0.1774
Echinococcus granulosus cathepsin L 0.0316 0.1015 0.0602
Loa Loa (eye worm) hypothetical protein 0.0962 0.3572 0.3572
Trypanosoma cruzi cysteine proteinase, putative 0.0756 0.2758 0.194
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0756 0.2758 0.2758
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.044 0.1507 0.1073
Plasmodium vivax vivapain-2 0.1402 0.5315 1
Leishmania major cysteine peptidase A (CPA) 0.1402 0.5315 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.1402 0.5315 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0316 0.1015 0.1015
Leishmania major cathepsin L-like protease 0.1402 0.5315 1
Brugia malayi fibroinase precursor 0.0316 0.1015 0.0555
Brugia malayi cathepsin F-like cysteine proteinase 0.0316 0.1015 0.0555
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0316 0.1015 0.1015
Brugia malayi Papain family cysteine protease containing protein 0.0316 0.1015 0.0555
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0316 0.1015 0.1015
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2584 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Loa Loa (eye worm) hypothetical protein 0.0962 0.3572 0.3572
Entamoeba histolytica cysteine proteinase 2 0.0756 0.2758 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.1402 0.5315 0.4786
Schistosoma mansoni cathepsin s 0.044 0.1507 0.1507
Echinococcus granulosus cathepsin b 0.2584 1 1
Plasmodium vivax vivapain-2 0.1402 0.5315 1
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Loa Loa (eye worm) hypothetical protein 0.0316 0.1015 0.1015
Echinococcus multilocularis tumor protein p63 0.0408 0.138 0.0984
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Onchocerca volvulus 0.1402 0.5315 1
Brugia malayi Cathepsin L-like precursor 0.0962 0.3572 0.3243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0756 0.2758 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1402 0.5315 1
Echinococcus multilocularis cysteine protease 0.1402 0.5315 0.51
Echinococcus multilocularis cathepsin L 0.0756 0.2758 0.2426
Loa Loa (eye worm) hypothetical protein 0.044 0.1507 0.1507
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1402 0.5315 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0316 0.1015 0.1015
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2584 1 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.0486 0.0486
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1402 0.5315 1
Brugia malayi Cathepsin L-like precursor 0.1402 0.5315 0.5076
Loa Loa (eye worm) hypothetical protein 0.2584 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0316 0.1015 0.1015
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Leishmania major cathepsin L-like protease 0.1402 0.5315 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0316 0.1015 0.0555
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0756 0.2758 0.194
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Loa Loa (eye worm) hypothetical protein 0.0316 0.1015 0.1015
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Entamoeba histolytica cysteine protease, putative 0.0756 0.2758 0.4054
Echinococcus granulosus cathepsin l cysteine peptidase 0.1402 0.5315 0.51
Brugia malayi Cathepsin L-like precursor 0.0962 0.3572 0.3243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0316 0.1015 0.1015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1402 0.5315 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1402 0.5315 0.51
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Entamoeba histolytica cysteine protease, putative 0.1402 0.5315 1
Giardia lamblia Cathepsin B precursor 0.1018 0.3794 1
Brugia malayi Papain family cysteine protease containing protein 0.0756 0.2758 0.2388
Echinococcus multilocularis cathepsin b 0.2584 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1402 0.5315 0.4786
Echinococcus granulosus cathepsin L cysteine proteinase 0.1402 0.5315 0.51
Onchocerca volvulus Cathepsin L homolog 0.0316 0.1015 0.1909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1402 0.5315 1
Brugia malayi Cathepsin L-like precursor 0.044 0.1507 0.1073
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0756 0.2758 0.194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Brugia malayi Cathepsin L-like precursor 0.1402 0.5315 0.5076
Onchocerca volvulus 0.1402 0.5315 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1402 0.5315 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1402 0.5315 1
Brugia malayi Cathepsin L-like precursor 0.1402 0.5315 0.5076
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0316 0.1015 0.1015
Trypanosoma cruzi cysteine protease, putative 0.0756 0.2758 0.194
Leishmania major cathepsin L-like protease 0.1402 0.5315 1
Echinococcus granulosus tumor protein p63 0.0408 0.138 0.0984
Echinococcus multilocularis cathepsin L cysteine protease 0.1402 0.5315 0.51
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1402 0.5315 0.5315
Echinococcus granulosus cysteine protease 0.0756 0.2758 0.2426
Loa Loa (eye worm) hypothetical protein 0.1402 0.5315 0.5315

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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