Detailed information for compound 1339659

Basic information

Technical information
  • TDR Targets ID: 1339659
  • Name: 2-ethoxy-N-(2-hydroxyphenyl)benzamide
  • MW: 257.284 | Formula: C15H15NO3
  • H donors: 2 H acceptors: 2 LogP: 2.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1C(=O)Nc1ccccc1O
  • InChi: 1S/C15H15NO3/c1-2-19-14-10-6-3-7-11(14)15(18)16-12-8-4-5-9-13(12)17/h3-10,17H,2H2,1H3,(H,16,18)
  • InChiKey: IRLUOHGSVLDVLW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • AN-652/41713898
  • ZINC00363589
  • STK259766
  • MLS000064279
  • SMR000076355

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.1309 1 1
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0133 0.0755 0.0755
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0052 0.0052
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7407 0.7407
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.1309 1 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0311 0.0311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0148 0.0874 0.092
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0194 0.0194
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0194 0.0204
Loa Loa (eye worm) hypothetical protein 0.0044 0.0055 0.0055
Plasmodium falciparum subtilisin-like protease 1 0.0201 0.1288 0.1288
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0144 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Entamoeba histolytica hypothetical protein 0.0043 0.0052 0.5
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0045 0.0064 0.0068
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0382 0.2714 0.2714
Loa Loa (eye worm) hypothetical protein 0.0587 0.4324 0.4324
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0133 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Brugia malayi ribonucleotide reductase 2 0.0133 0.0755 0.0755
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Echinococcus multilocularis neuroendocrine convertase 2 0.0373 0.2646 0.2646
Entamoeba histolytica hypothetical protein 0.0043 0.0052 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.0052 0.5
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0045 0.0064 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0311 0.0311
Schistosoma mansoni hypothetical protein 0.0043 0.0052 0.0052
Toxoplasma gondii subtilisin SUB1 0.0201 0.1288 0.1288
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0055 0.0055
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.1309 1 1
Schistosoma mansoni furin-1 (S08 family) 0.0262 0.1772 0.1772
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0045 0.0064 0.0064
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0111 0.0584 0.0615
Brugia malayi proprotein convertase 2 0.0373 0.2646 0.2646
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0362 0.2552 0.2552
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0311 0.0311
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0044 0.0055 0.0055
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.1246 0.9502 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0148 0.0874 0.092
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0052 0.0052
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0133 0.0755 0.0755
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.1309 1 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0133 0.0755 0.0755
Loa Loa (eye worm) reprolysin 0.0044 0.0055 0.0055
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0194 0.0194
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0311 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.1246 0.9502 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0133 0.0755 0.0755
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0111 0.0584 0.0615
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0133 0.0755 0.0795
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0362 0.2552 0.2552
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Loa Loa (eye worm) hypothetical protein 0.0225 0.1482 0.1482
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0311 0.0311
Giardia lamblia Furin precursor putative serine protease 0.0111 0.0584 0.3265
Echinococcus granulosus neuroendocrine convertase 2 0.0373 0.2646 0.2646
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0057 0.0162 0.0162
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0311 0.0311
Trypanosoma brucei protein kinase, putative 0.0062 0.0194 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0148 0.0874 0.092
Brugia malayi RNA binding protein 0.0076 0.0311 0.0311
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0133 0.0755 0.0755
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0144 0.0144
Echinococcus multilocularis Furin 1 0.0148 0.0874 0.0874
Plasmodium vivax subtilisin-like protease 1 0.0201 0.1288 0.1288
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.1246 0.9502 1
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0311 0.0311
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0194 0.0194
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0362 0.2552 0.2686
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.1309 1 1
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0133 0.0755 0.0755
Brugia malayi MAP kinase sur-1 0.0062 0.0194 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0144 0.0144
Loa Loa (eye worm) endoprotease bli-4 0.0587 0.4324 0.4324
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Entamoeba histolytica hypothetical protein 0.0043 0.0052 0.5
Mycobacterium leprae conserved hypothetical protein 0.0063 0.0209 0.022
Brugia malayi neuroendocrine convertase 1 precursor 0.0373 0.2646 0.2646
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0311 0.0311
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0194 0.0194
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0194 0.0194
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0111 0.0584 0.0615
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.1309 1 1
Echinococcus granulosus adam 0.0057 0.0162 0.0162
Echinococcus multilocularis adam 0.0057 0.0162 0.0162
Mycobacterium ulcerans transcriptional regulator NrdR 0.0063 0.0209 0.022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0144 0.0144
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.1246 0.9502 1
Brugia malayi celfurPC protein 0.0476 0.345 0.345
Brugia malayi hypothetical protein 0.0057 0.0162 0.0162
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0133 0.0755 0.0558
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0148 0.0874 0.092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0144 0.0144
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0133 0.0755 0.0755
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0194 0.0204
Brugia malayi endoprotease bli-4 precursor 0.0587 0.4324 0.4324
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.1309 1 1
Brugia malayi TAR-binding protein 0.0076 0.0311 0.0311
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.1309 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0362 0.2552 0.2686
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0194 0.0194
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0148 0.0874 0.0874
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0052 0.0052
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0133 0.0755 0.0755
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0133 0.0755 0.0755
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.1309 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0194 0.0194
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0587 0.4324 0.4324
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0311 0.0311
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0133 0.0755 0.0755
Giardia lamblia High cysteine membrane protein Group 2 0.0214 0.1389 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0194 0.0194
Echinococcus multilocularis 0.0476 0.345 0.345
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0448 0.3231 0.34
Echinococcus granulosus Furin 1 0.0148 0.0874 0.0874
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0194 0.0194
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.1246 0.9502 1
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0055 0.0055
Trichomonas vaginalis hypothetical protein 0.0111 0.0584 0.0615
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0148 0.0874 0.092
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0584 0.0615
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0044 0.0055 0.0055
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0133 0.0755 0.0755
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0144 0.0144
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0144 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0194 0.0204
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0133 0.0755 0.0755
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0194 0.0194
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0194 0.0194
Brugia malayi hypothetical protein 0.0043 0.0052 0.0052
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0194 0.0194
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0133 0.0755 0.0795
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0144 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0144 0.0144
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0045 0.0064 0.0064
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0194 0.0204
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0194 0.0194
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0133 0.0755 0.0755
Onchocerca volvulus 0.0037 0 0.5
Loa Loa (eye worm) RNA binding protein 0.0076 0.0311 0.0311
Echinococcus granulosus furin 0.0587 0.4324 0.4324
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.1309 1 1
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0133 0.0755 0.0755
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0045 0.0064 0.0068
Schistosoma mansoni hypothetical protein 0.0111 0.0584 0.0584
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0063 0.0209 0.022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0148 0.0874 0.092
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.1309 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0311 0.0311
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.1309 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0194 0.0194
Loa Loa (eye worm) proprotein convertase 2 0.0148 0.0874 0.0874

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.