Detailed information for compound 1340069

Basic information

Technical information
  • TDR Targets ID: 1340069
  • Name: N-(4-methylphenyl)-4-[[[3-(trifluoromethyl)ph enyl]sulfonylamino]methyl]benzamide
  • MW: 448.458 | Formula: C22H19F3N2O3S
  • H donors: 2 H acceptors: 3 LogP: 4.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NC(=O)c1ccc(cc1)CNS(=O)(=O)c1cccc(c1)C(F)(F)F
  • InChi: 1S/C22H19F3N2O3S/c1-15-5-11-19(12-6-15)27-21(28)17-9-7-16(8-10-17)14-26-31(29,30)20-4-2-3-18(13-20)22(23,24)25/h2-13,26H,14H2,1H3,(H,27,28)
  • InChiKey: IWGUZRFEGUIQSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00630954
  • AQ-750/42210428
  • MLS000540661
  • N-(4-methylphenyl)-4-[({[3-(trifluoromethyl)phenyl]sulfonyl}amino)methyl]benzamide
  • SMR000162594

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.3962 1
Trypanosoma cruzi cysteine proteinase, putative 0.0083 0.1994 0.1734
Brugia malayi cathepsin Z-like cysteine proteinase 0.0035 0.0653 0.0401
Echinococcus granulosus cathepsin l1 0.0152 0.3962 0.4337
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Leishmania major DNA polymerase eta, putative 0.0054 0.1188 0.0901
Plasmodium vivax serine-repeat antigen (SERA) 0.0035 0.0653 0.1647
Trypanosoma cruzi cysteine peptidase, putative 0.0152 0.3962 0.3766
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.3962 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0047 0.0996 0.0809
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.455 0.4373
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0653 0.0925
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.455 0.4373
Entamoeba histolytica cysteine proteinase 2 0.0083 0.1994 0.5033
Entamoeba histolytica cysteine protease, putative 0.0035 0.0653 0.1647
Toxoplasma gondii hypothetical protein 0.0059 0.1323 0.3338
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Giardia lamblia Cathepsin L precursor 0.0035 0.0653 0.1191
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0653 0.0401
Onchocerca volvulus Cathepsin F homolog 0.0152 0.3962 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0035 0.0653 0.0401
Entamoeba histolytica cysteine proteinase 1, putative 0.0083 0.1994 0.5033
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0333 0.0021
Brugia malayi cathepsin L-like cysteine proteinase 0.0035 0.0653 0.0401
Schistosoma mansoni DNA helicase recq5 0.0024 0.0333 0.0021
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0333 0.0225
Plasmodium falciparum serine repeat antigen 9 0.0035 0.0653 0.0881
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.3962 1
Leishmania major cathepsin L-like protease 0.0152 0.3962 0.3766
Onchocerca volvulus 0.0152 0.3962 1
Brugia malayi Cathepsin L-like precursor 0.0105 0.262 0.2741
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0653 0.0925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.262 0.6321
Echinococcus granulosus cathepsin l1 0.0105 0.262 0.2741
Brugia malayi Cathepsin L-like precursor 0.0152 0.3962 0.4337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1994 0.1905
Loa Loa (eye worm) hypothetical protein 0.0054 0.1188 0.1038
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0333 0.0049
Plasmodium vivax vivapain-1 0.0083 0.1994 0.5033
Loa Loa (eye worm) hypothetical protein 0.0047 0.0996 0.0809
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0333 0.0021
Echinococcus multilocularis cathepsin L 0.0083 0.1994 0.1997
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0035 0.0653 0.1647
Echinococcus granulosus cathepsin b 0.032 0.8725 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0047 0.0996 0.0809
Echinococcus granulosus cathepsin L cysteine proteinase 0.0152 0.3962 0.4337
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0152 0.3962 0.4337
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0333 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0653 0.0925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.262 0.6614
Loa Loa (eye worm) RecQ helicase 0.0024 0.0333 0.0021
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Giardia lamblia Cysteine protease 0.0035 0.0653 0.1191
Echinococcus granulosus bloom syndrome protein 0.0024 0.0333 0.0021
Entamoeba histolytica cysteine protease, putative 0.0035 0.0653 0.1647
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0123 0.3149 0.7771
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0996 0.0703
Plasmodium vivax unspecified product 0.0047 0.0996 0.2513
Mycobacterium ulcerans hypothetical protein 0.0192 0.5104 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0653 0.0925
Brugia malayi Cathepsin L-like precursor 0.0105 0.262 0.2741
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.1109 0.0819
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Schistosoma mansoni DNA helicase recq1 0.0024 0.0333 0.0021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0996 0.0809
Schistosoma mansoni cathepsin s 0.0047 0.0996 0.0809
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Loa Loa (eye worm) hypothetical protein 0.0024 0.0333 0.0021
Brugia malayi Cathepsin L-like precursor 0.0152 0.3962 0.4337
Plasmodium falciparum cysteine proteinase falcipain 1 0.0083 0.1994 0.4578
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Leishmania major cathepsin L-like protease 0.0152 0.3962 0.3766
Loa Loa (eye worm) hypothetical protein 0.032 0.8725 1
Brugia malayi cathepsin L-like precursor 0.0105 0.262 0.2741
Plasmodium vivax unspecified product 0.0035 0.0653 0.1647
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0152 0.3962 0.4337
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0732 0.1847
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.455 0.449
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0152 0.3962 0.4337
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Loa Loa (eye worm) hypothetical protein 0.0047 0.0996 0.0809
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0035 0.0653 0.0881
Loa Loa (eye worm) hypothetical protein 0.0105 0.262 0.2741
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0333 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.1994 0.5033
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0152 0.3962 1
Schistosoma mansoni cathepsin B (C01 family) 0.0035 0.0653 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0035 0.0653 0.0925
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0035 0.0653 0.0401
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0105 0.262 0.238
Echinococcus multilocularis cysteine protease 0.0152 0.3962 0.4337
Schistosoma mansoni cathepsin S (C01 family) 0.0035 0.0653 0.0401
Brugia malayi Cathepsin L-like precursor 0.0152 0.3962 0.4337
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0333 0.0021
Giardia lamblia Cathepsin B precursor 0.0123 0.3149 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0035 0.0653 0.0401
Trypanosoma brucei cysteine peptidase C (CPC) 0.0123 0.3149 0.3073
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.1188 0.109
Leishmania major cathepsin L-like protease 0.0152 0.3962 0.3766
Loa Loa (eye worm) hypothetical protein 0.0152 0.3962 0.4337
Plasmodium falciparum serine repeat antigen 5 0.0035 0.0653 0.0881
Plasmodium falciparum cysteine proteinase falcipain 3 0.0152 0.3962 1
Brugia malayi Cathepsin L-like precursor 0.0152 0.3962 0.4337
Leishmania major cathepsin L-like protease 0.0152 0.3962 0.3766
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Leishmania major cathepsin L-like protease 0.0152 0.3962 0.3766
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0035 0.0653 0.0881
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.1994 0.1997
Onchocerca volvulus Cathepsin L homolog 0.0152 0.3962 1
Leishmania major cathepsin L-like protease 0.0152 0.3962 0.3766
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0315 0.0207
Schistosoma mansoni cathepsin F (C01 family) 0.0152 0.3962 0.4337
Giardia lamblia Cathepsin B precursor 0.0035 0.0653 0.1191
Giardia lamblia Cathepsin B precursor 0.0123 0.3149 1
Trypanosoma cruzi cysteine peptidase, putative 0.0083 0.1994 0.1734
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0035 0.0653 0.1647
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Entamoeba histolytica cysteine protease, putative 0.0035 0.0653 0.1647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.3962 1
Onchocerca volvulus 0.0152 0.3962 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0333 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.1994 0.1997
Brugia malayi cathepsin L precursor 0.0035 0.0653 0.0401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Giardia lamblia Encystation-specific protease 0.0035 0.0653 0.1191
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0035 0.0653 0.1647
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0035 0.0653 0.0925
Leishmania major cathepsin L-like protease 0.0152 0.3962 0.3766
Entamoeba histolytica cysteine protease, putative 0.0035 0.0653 0.1647
Giardia lamblia Cysteine protease 0.0035 0.0653 0.1191
Giardia lamblia Cathepsin B precursor 0.0035 0.0653 0.1191
Loa Loa (eye worm) hypothetical protein 0.0035 0.0653 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.262 0.6321
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0315 0.0207
Giardia lamblia Cathepsin L precursor 0.0035 0.0653 0.1191
Onchocerca volvulus 0.0152 0.3962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0653 0.0925
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0333 0.084
Schistosoma mansoni cathepsin F (C01 family) 0.0105 0.262 0.2741
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Echinococcus multilocularis cathepsin L 0.0035 0.0653 0.0401
Echinococcus multilocularis cathepsin b 0.032 0.8725 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1994 0.4604
Loa Loa (eye worm) hypothetical protein 0.0035 0.0653 0.0401
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0035 0.0653 0.1647
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0333 0.0021
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0653 0.0925
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.3962 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.1109 0.101
Entamoeba histolytica cysteine protease, putative 0.0035 0.0653 0.1647
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0035 0.0653 0.1191
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0653 0.0925
Schistosoma mansoni DNA polymerase eta 0.0054 0.1188 0.1038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0653 0.0925
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0653 0.0401
Plasmodium falciparum serine repeat antigen 4 0.0035 0.0653 0.0881
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.3962 1
Echinococcus granulosus dna polymerase eta 0.0054 0.1188 0.1038
Trypanosoma cruzi cruzipain precursor, putative 0.0152 0.3962 0.3766
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0333 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Plasmodium vivax vivapain-2 0.0152 0.3962 1
Giardia lamblia Cathepsin B precursor 0.0035 0.0653 0.1191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0653 0.0925
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0035 0.0653 0.0881
Loa Loa (eye worm) cysteine protease 0.0152 0.3962 0.4337
Trypanosoma cruzi cysteine peptidase, putative 0.0152 0.3962 0.3766
Echinococcus granulosus cathepsin L 0.0035 0.0653 0.0401
Loa Loa (eye worm) ctsf protein 0.0152 0.3962 0.4337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.8725 1
Giardia lamblia Cathepsin L precursor 0.0035 0.0653 0.1191
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0333 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.3962 1
Giardia lamblia Cathepsin L precursor 0.0035 0.0653 0.1191
Plasmodium vivax unspecified product 0.0083 0.1994 0.5033
Trypanosoma cruzi cysteine peptidase, putative 0.0152 0.3962 0.3766
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.3962 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0653 0.0401
Trypanosoma cruzi cysteine peptidase, putative 0.0152 0.3962 0.3766
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0035 0.0653 0.1191
Leishmania major DNA polymerase eta, putative 0.0038 0.0732 0.043
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.032 0.8725 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0152 0.3962 0.4337
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0333 0.0021
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0035 0.0653 0.0401
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0653 0.0401
Giardia lamblia Cysteine protease 0.0035 0.0653 0.1191
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Plasmodium falciparum serine repeat antigen 6 0.0035 0.0653 0.0881
Giardia lamblia Cathepsin L-like protease 0.0035 0.0653 0.1191
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0315 0.0795
Trypanosoma cruzi cruzipain precursor, putative 0.0047 0.0996 0.0703
Echinococcus granulosus cathepsin b 0.032 0.8725 1
Trypanosoma brucei unspecified product 0.0023 0.0315 0.0207
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.032 0.8725 0.8683
Plasmodium vivax vivapain-2 0.0152 0.3962 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0653 0.0925
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0333 0.084
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0653 0.0401
Toxoplasma gondii cathepsin CPL 0.0152 0.3962 1
Brugia malayi Cathepsin L-like precursor 0.0152 0.3962 0.4337
Giardia lamblia Hypothetical protein 0.0035 0.0653 0.1191
Entamoeba histolytica hypothetical protein 0.0035 0.0653 0.1647
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.3962 1
Giardia lamblia Cathepsin B precursor 0.0035 0.0653 0.1191
Plasmodium falciparum serine repeat antigen 7 0.0035 0.0653 0.0881
Loa Loa (eye worm) cathepsin B 0.0123 0.3149 0.337
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0035 0.0653 0.0925
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0152 0.3962 1
Toxoplasma gondii cathepsin CPC1 0.0035 0.0653 0.1647
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0035 0.0653 0.1647
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0035 0.0653 0.0401
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0035 0.0653 0.0401
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0083 0.1994 0.1997
Onchocerca volvulus 0.0152 0.3962 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0333 0.0049
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0035 0.0653 0.1191
Loa Loa (eye worm) hypothetical protein 0.0035 0.0653 0.0401
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0035 0.0653 0.1647
Brugia malayi Cathepsin L-like cysteine proteinase 0.0105 0.262 0.2741
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.1188 0.0901
Plasmodium falciparum serine repeat antigen 8 0.0035 0.0653 0.0881
Brugia malayi cathepsin Z-like cysteine proteinase 0.0035 0.0653 0.0401
Trypanosoma cruzi major cysteine proteinase, putative 0.0035 0.0653 0.0349
Giardia lamblia Cathepsin L precursor 0.0035 0.0653 0.1191
Giardia lamblia Cathepsin L-like protease 0.0035 0.0653 0.1191
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0732 0.043
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0333 0.0018
Entamoeba histolytica cysteine protease, putative 0.0152 0.3962 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0035 0.0653 0.1647
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0653 0.0925
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Onchocerca volvulus 0.0152 0.3962 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0152 0.3962 0.4337
Echinococcus multilocularis dna polymerase eta 0.0054 0.1188 0.1038
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0653 0.0925
Toxoplasma gondii cathepsin CPC2 0.0035 0.0653 0.1647
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0333 0.0021
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.1109 0.0819
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.5104 1
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.1994 0.5033
Echinococcus granulosus cathepsin L 0.0083 0.1994 0.1997
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1427 0.1148
Entamoeba histolytica cysteine protease, putative 0.0035 0.0653 0.1647
Brugia malayi fibroinase precursor 0.0035 0.0653 0.0401
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Toxoplasma gondii cathepsin B 0.0123 0.3149 0.7948
Toxoplasma gondii preprocathepsin c precursor, putative 0.0035 0.0653 0.1647
Giardia lamblia Cathepsin L precursor 0.0035 0.0653 0.1191
Loa Loa (eye worm) hypothetical protein 0.0105 0.262 0.2741
Leishmania major cathepsin L-like protease 0.0152 0.3962 0.3766
Giardia lamblia Cathepsin B precursor 0.0123 0.3149 1
Plasmodium falciparum serine repeat antigen 3 0.0035 0.0653 0.0881
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0035 0.0653 0.1647
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0653 0.0401
Giardia lamblia Hypothetical protein 0.0035 0.0653 0.1191
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0035 0.0653 0.0401
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.3962 1
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0035 0.0653 0.1191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0123 0.3149 0.337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Plasmodium vivax vivapain-3 0.0083 0.1994 0.5033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0653 0.0925
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.1188 0.1038
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0083 0.1994 0.1997
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0123 0.3149 0.2926
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0315 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0653 0.0925
Entamoeba histolytica cysteine protease, putative 0.0083 0.1994 0.5033
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0653 0.0401
Echinococcus multilocularis cathepsin b 0.032 0.8725 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Echinococcus granulosus cathepsin L cysteine protease 0.0083 0.1994 0.1997
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0653 0.0401
Loa Loa (eye worm) hypothetical protein 0.0035 0.0653 0.0401
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0035 0.0653 0.1647
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0333 0.084
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0047 0.0996 0.0809
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.3962 0.4337
Brugia malayi Cathepsin L-like precursor 0.0152 0.3962 0.4337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.1994 0.4604
Onchocerca volvulus 0.0152 0.3962 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0035 0.0653 0.1647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0035 0.0653 0.1647
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0035 0.0653 0.1647
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0083 0.1994 0.1734
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.3962 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0315 0.0207
Loa Loa (eye worm) fibroinase 0.0152 0.3962 0.4337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Onchocerca volvulus Cathepsin L homolog 0.0152 0.3962 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0083 0.1994 0.1905
Trypanosoma cruzi cysteine protease, putative 0.0083 0.1994 0.1734
Onchocerca volvulus 0.0152 0.3962 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0152 0.3962 0.4337
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0123 0.3149 0.2926
Loa Loa (eye worm) hypothetical protein 0.0035 0.0653 0.0401
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0333 0.0021
Schistosoma mansoni cathepsin C 0.0035 0.0653 0.0401
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0035 0.0653 0.1647
Trypanosoma cruzi cysteine proteinase, putative 0.0083 0.1994 0.1734
Brugia malayi cathepsin B-like cysteine proteinase 0.032 0.8725 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.8725 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0653 0.0401
Leishmania major cysteine peptidase A (CPA) 0.0152 0.3962 0.3766
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.1109 0.0819
Brugia malayi Cathepsin L-like precursor 0.0047 0.0996 0.0809
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0083 0.1994 0.1997
Plasmodium falciparum serine repeat antigen 2 0.0035 0.0653 0.0881
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0653 0.0925
Echinococcus granulosus cysteine protease 0.0083 0.1994 0.1997
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0653 0.0401
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.032 0.8725 1
Plasmodium falciparum serine repeat antigen 1 0.0035 0.0653 0.0881
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.3962 1
Schistosoma mansoni cathepsin F (C01 family) 0.0152 0.3962 0.4337
Loa Loa (eye worm) hypothetical protein 0.0105 0.262 0.2741
Trypanosoma cruzi major cysteine proteinase, putative 0.0035 0.0653 0.0349
Giardia lamblia Cysteine protease 0.0035 0.0653 0.1191
Echinococcus multilocularis cysteine protease 0.0152 0.3962 0.4337
Giardia lamblia Cathepsin B precursor 0.0035 0.0653 0.1191
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0152 0.3962 0.3895
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.1994 0.5033
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0152 0.3962 0.4337
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0035 0.0653 0.0925
Onchocerca volvulus 0.0105 0.262 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0152 0.3962 1
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0653 0.0401
Entamoeba histolytica cysteine proteinase, putative 0.0083 0.1994 0.5033
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0152 0.3962 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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