Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Glucosylceramidase homolog | 0.0164 | 0.2132 | 0.2132 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0202 | 0.3754 | 0.3432 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.034 | 0.9724 | 0.971 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2515 | 0.3712 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.034 | 0.9724 | 0.971 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0346 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4771 |
Onchocerca volvulus | Putative nachr subunit | 0.0346 | 1 | 1 |
Onchocerca volvulus | 0.0228 | 0.4904 | 0.4904 | |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4914 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0346 | 1 | 1 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.0126 | 0.0491 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.034 | 0.9724 | 0.971 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 1 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0202 | 0.3754 | 0.3432 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0346 | 1 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0202 | 0.3754 | 0.3432 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0346 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0346 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.034 | 0.9724 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2515 | 0.3712 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4914 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4771 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0346 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0202 | 0.3754 | 0.3432 |
Schistosoma mansoni | alpha-glucosidase | 0.034 | 0.9724 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0346 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.034 | 0.9724 | 0.971 |
Brugia malayi | Ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4771 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.0919 | 0.045 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0231 | 0.5028 | 0.5028 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0202 | 0.3754 | 0.3534 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0164 | 0.2132 | 0.2992 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0202 | 0.3754 | 0.3534 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.025 | 0.5854 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0231 | 0.5028 | 0.4771 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.025 | 0.5854 | 0.564 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.025 | 0.5854 | 0.564 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.034 | 0.9724 | 0.971 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.