Detailed information for compound 1343739

Basic information

Technical information
  • TDR Targets ID: 1343739
  • Name: ethyl 4-(propanoylamino)-3-prop-2-enyl-2-sulf anylidene-1,3-thiazole-5-carboxylate
  • MW: 300.397 | Formula: C12H16N2O3S2
  • H donors: 1 H acceptors: 2 LogP: 2.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1sc(=S)n(c1NC(=O)CC)CC=C
  • InChi: 1S/C12H16N2O3S2/c1-4-7-14-10(13-8(15)5-2)9(19-12(14)18)11(16)17-6-3/h4H,1,5-7H2,2-3H3,(H,13,15)
  • InChiKey: AMOPNKGGBHSYQV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 3-allyl-4-(propanoylamino)-2-thioxo-thiazole-5-carboxylate
  • 3-allyl-4-(1-oxopropylamino)-2-thioxo-5-thiazolecarboxylic acid ethyl ester
  • 3-allyl-4-propionamido-2-thioxo-thiazole-5-carboxylic acid ethyl ester
  • ZINC03207352
  • MLS000536716
  • SMR000155548
  • T0504-9168

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.5 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0005 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0005 0.5 0.5
Echinococcus multilocularis oxidoreductase 0.0005 0.5 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0005 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0005 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Echinococcus granulosus oxidoreductase 0.0005 0.5 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0005 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Brugia malayi oxidoreductase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0005 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0005 0.5 0.5
Leishmania major dehydrogenase-like protein 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0005 0.5 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0005 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0005 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.5 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Giardia lamblia Reductase, putative 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.0005 0.5 0.5
Echinococcus granulosus steroid dehydrogenase 0.0005 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0005 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Mycobacterium ulcerans carveol-like dehydrogenase 0.0005 0.5 0.5
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0005 0.5 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0005 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0005 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0005 0.5 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Brugia malayi hypothetical protein 0.0005 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Giardia lamblia Hypothetical protein 0.0005 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0005 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0005 0.5 0.5
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0005 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0005 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0005 0.5 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0005 0.5 0.5
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0005 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0005 0.5 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0005 0.5 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0005 0.5 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0005 0.5 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0005 0.5 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0005 0.5 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Mycobacterium ulcerans dehydrogenase 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0005 0.5 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0005 0.5 0.5
Brugia malayi hypothetical protein 0.0005 0.5 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0005 0.5 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0005 0.5 0.5
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0005 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0005 0.5 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.0005 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0005 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0005 0.5 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0005 0.5 0.5
Onchocerca volvulus Sepiapterin reductase homolog 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 9 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0005 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0005 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0005 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0005 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0005 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0005 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0005 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0005 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0005 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0005 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0005 0.5 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0005 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0005 0.5 0.5
Leishmania major oxidoreductase-like protein 0.0005 0.5 0.5
Leishmania major pteridine reductase 1 0.0005 0.5 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0005 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 2 0.0005 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0005 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0005 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0005 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0005 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Echinococcus multilocularis conserved hypothetical protein 0.0005 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0005 0.5 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0005 0.5 0.5
Brugia malayi Retinol dehydrogenase 12 0.0005 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.5 0.5
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0005 0.5 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0005 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0005 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0005 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Schistosoma mansoni retinal dehydrogenase 0.0005 0.5 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0005 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0005 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0005 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0005 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0005 0.5 0.5
Mycobacterium leprae Probable oxidoreductase 0.0005 0.5 0.5
Plasmodium vivax hypothetical protein, conserved 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.5 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0005 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0005 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0005 0.5 0.5
Leishmania major short chain dehydrogenase-like protein 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0005 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0005 0.5 0.5
Onchocerca volvulus 0.0005 0.5 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0005 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0005 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0005 0.5 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0005 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0005 0.5 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0005 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0005 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0005 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0005 0.5 0.5
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0005 0.5 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0005 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0005 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0005 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0005 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0005 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0005 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0005 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0005 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0005 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0005 0.5 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0005 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0005 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0005 0.5 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0005 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0005 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0005 0.5 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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