TDR Targets

Basic information

Technical information

TDR Targets ID: 1344928
Name: [1-[(3-chlorophenyl)amino]-1-oxopropan-2-yl] 1,3-benzothiazole-6-carboxylate
MW: 360.815 | Formula: C17H13ClN2O3S
H donors: 1 H acceptors: 3 LogP: 4.16 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)NC(=O)C(OC(=O)c1ccc2c(c1)scn2)C
InChi: 1S/C17H13ClN2O3S/c1-10(16(21)20-13-4-2-3-12(18)8-13)23-17(22)11-5-6-14-15(7-11)24-9-19-14/h2-10H,1H3,(H,20,21)
InChiKey: DSPATMKPDQEBRR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[2-[(3-chlorophenyl)amino]-1-methyl-2-oxo-ethyl] 1,3-benzothiazole-6-carboxylate
1,3-benzothiazole-6-carboxylic acid [2-[(3-chlorophenyl)amino]-1-methyl-2-oxoethyl] ester
1,3-benzothiazole-6-carboxylic acid [2-[(3-chlorophenyl)amino]-2-keto-1-methyl-ethyl] ester
[1-[(3-chlorophenyl)amino]-1-oxo-propan-2-yl] 1,3-benzothiazole-6-carboxylate
T5379342

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glutaminase	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	glutaminase, putative	Get druggable targets OG5_129245	All targets in OG5_129245
Loa Loa (eye worm)	glutaminase 2	Get druggable targets OG5_129245	All targets in OG5_129245
Brugia malayi	glutaminase DH11.1	Get druggable targets OG5_129245	All targets in OG5_129245
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium ulcerans	glutaminase	Get druggable targets OG5_129245	All targets in OG5_129245
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0473	0.0462	0.0462
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2983	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1497	0.4351	0.4351
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1023	0.2551	0.2551
Echinococcus granulosus	cathepsin L cysteine protease	0.0825	0.18	0.18
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0565	0.0809	0.0809
Brugia malayi	Cathepsin L-like precursor	0.1497	0.4351	0.4351
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2983	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0825	0.18	0.18
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0549	0.0749	0.1142
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1497	0.4351	1
Loa Loa (eye worm)	ctsf protein	0.1497	0.4351	0.4351
Brugia malayi	Cathepsin L-like precursor	0.1023	0.2551	0.2551
Trypanosoma cruzi	cysteine proteinase, putative	0.0825	0.18	0.18
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1497	0.4351	1
Brugia malayi	Cathepsin L-like precursor	0.1497	0.4351	0.4351
Echinococcus multilocularis	cathepsin L	0.0825	0.18	0.18
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0565	0.0809	0.186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0565	0.0809	0.186
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0427	0.0284	0.0918
Trypanosoma cruzi	cysteine peptidase, putative	0.1892	0.5854	0.5854
Entamoeba histolytica	cysteine proteinase 2	0.0825	0.18	0.4136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0473	0.0462	0.0462
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1892	0.5854	0.5854
Trypanosoma cruzi	cruzipain precursor, putative	0.1892	0.5854	0.5854
Echinococcus granulosus	cathepsin l1	0.1497	0.4351	0.4351
Schistosoma mansoni	cathepsin F (C01 family)	0.1497	0.4351	0.4351
Entamoeba histolytica	cysteine proteinase, putative	0.1023	0.2551	0.5864
Trypanosoma cruzi	major cysteine proteinase, putative	0.0747	0.1503	0.1503
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1023	0.2551	0.5864
Trypanosoma cruzi	cysteine protease, putative	0.0825	0.18	0.18
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0549	0.0749	0.172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1497	0.4351	0.4351
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Loa Loa (eye worm)	cysteine protease	0.1497	0.4351	0.4351
Onchocerca volvulus		0.1497	0.4351	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0473	0.0462	0.0462
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0473	0.0462	0.0462
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1418	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Loa Loa (eye worm)	hypothetical protein	0.2983	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1497	0.4351	1
Entamoeba histolytica	cysteine protease, putative	0.1497	0.4351	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0473	0.0462	0.0462
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1497	0.4351	0.4351
Onchocerca volvulus		0.1497	0.4351	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0565	0.0809	0.186
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1497	0.4351	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0825	0.18	0.18
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Leishmania major	cathepsin L-like protease	0.1497	0.4351	0.4558
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1497	0.4351	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Brugia malayi	Cathepsin L-like precursor	0.1497	0.4351	0.4351
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0462	0.0462
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Onchocerca volvulus	Cathepsin L homolog	0.1497	0.4351	1
Toxoplasma gondii	cathepsin CPC1	0.0549	0.0749	0.1142
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0825	0.18	0.4136
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0427	0.0284	0.0653
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2983	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1497	0.4351	1
Leishmania major	cysteine peptidase A (CPA)	0.1497	0.4351	0.4558
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.2983	1	1
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1497	0.4351	0.4351
Onchocerca volvulus		0.1497	0.4351	1
Schistosoma mansoni	cathepsin s	0.0473	0.0462	0.0462
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Trypanosoma cruzi	cysteine proteinase, putative	0.0825	0.18	0.18
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0825	0.18	0.18
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0427	0.0284	0.0918
Entamoeba histolytica	cysteine proteinase, putative	0.0825	0.18	0.4136
Echinococcus multilocularis	cysteine protease	0.1497	0.4351	0.4351
Entamoeba histolytica	cysteine proteinase, putative	0.0825	0.18	0.4136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1497	0.4351	1
Echinococcus granulosus	cathepsin l1	0.1023	0.2551	0.2551
Plasmodium vivax	vivapain-2	0.1497	0.4351	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1497	0.4351	0.4351
Trypanosoma cruzi	cysteine peptidase, putative	0.1892	0.5854	0.5854
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1497	0.4351	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1166	0.3093	0.3093
Loa Loa (eye worm)	hypothetical protein	0.1023	0.2551	0.2551
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1497	0.4351	1
Entamoeba histolytica	cysteine proteinase, putative	0.0825	0.18	0.4136
Brugia malayi	Cathepsin L-like precursor	0.1497	0.4351	0.4351
Onchocerca volvulus	Cathepsin F homolog	0.1497	0.4351	1
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Echinococcus granulosus	cysteine protease	0.0825	0.18	0.18
Leishmania major	cathepsin L-like protease	0.1892	0.5854	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1497	0.4351	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1497	0.4351	0.4351
Giardia lamblia	Cathepsin B precursor	0.0565	0.0809	0.2617
Brugia malayi	Cathepsin L-like precursor	0.0473	0.0462	0.0462
Onchocerca volvulus		0.1497	0.4351	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0427	0.0284	0.0653
Echinococcus multilocularis	cathepsin b	0.2983	1	1
Leishmania major	cathepsin L-like protease	0.1497	0.4351	0.4558
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1497	0.4351	1
Plasmodium vivax	vivapain-1	0.0825	0.18	0.4136
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2983	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0825	0.18	0.4136
Schistosoma mansoni	cathepsin F (C01 family)	0.1023	0.2551	0.2551
Toxoplasma gondii	cathepsin CPL	0.1497	0.4351	1
Leishmania major	cathepsin L-like protease	0.1892	0.5854	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0549	0.0749	0.172
Echinococcus multilocularis	cathepsin b	0.2983	1	1
Echinococcus granulosus	cathepsin b	0.2983	1	1
Leishmania major	cathepsin L-like protease	0.1497	0.4351	0.4558
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1497	0.4351	0.4351
Loa Loa (eye worm)	hypothetical protein	0.1497	0.4351	0.4351
Giardia lamblia	Cathepsin B precursor	0.1166	0.3093	1
Entamoeba histolytica	cysteine proteinase, putative	0.1497	0.4351	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0565	0.0809	0.0809
Leishmania major	cathepsin L-like protease	0.1892	0.5854	1
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0462	0.0462
Loa Loa (eye worm)	hypothetical protein	0.1023	0.2551	0.2551
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1497	0.4351	0.4351
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1497	0.4351	0.4351
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1497	0.4351	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0825	0.18	0.18
Giardia lamblia	Cathepsin B precursor	0.1166	0.3093	1
Onchocerca volvulus	Cathepsin L homolog	0.1497	0.4351	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0474	0.0465	0.1068
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0565	0.0809	0.0809
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Giardia lamblia	Cathepsin B precursor	0.1166	0.3093	1
Echinococcus granulosus	cathepsin L	0.0825	0.18	0.18
Onchocerca volvulus		0.1497	0.4351	1
Brugia malayi	Papain family cysteine protease containing protein	0.0825	0.18	0.18
Brugia malayi	Papain family cysteine protease containing protein	0.0825	0.18	0.18
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1497	0.4351	1
Brugia malayi	Cathepsin L-like precursor	0.1497	0.4351	0.4351
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0565	0.0809	0.186
Loa Loa (eye worm)	hypothetical protein	0.0473	0.0462	0.0462
Toxoplasma gondii	cathepsin B	0.1166	0.3093	0.6906
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Brugia malayi	Cathepsin L-like precursor	0.1023	0.2551	0.2551
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0825	0.18	0.4136
Brugia malayi	Cathepsin L-like precursor	0.1497	0.4351	0.4351
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0549	0.0749	0.242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0549	0.0749	0.172
Onchocerca volvulus		0.1023	0.2551	0.5864
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1166	0.3093	0.3093
Plasmodium vivax	unspecified product	0.0473	0.0462	0.1061
Entamoeba histolytica	cysteine proteinase, putative	0.0825	0.18	0.4136
Leishmania major	cathepsin L-like protease	0.1497	0.4351	0.4558
Onchocerca volvulus		0.1497	0.4351	1
Brugia malayi	cathepsin L-like precursor	0.1023	0.2551	0.2551
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1166	0.3093	0.7108
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0825	0.18	0.18
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Plasmodium vivax	vivapain-3	0.0825	0.18	0.4136
Echinococcus multilocularis	cysteine protease	0.1497	0.4351	0.4351
Loa Loa (eye worm)	cathepsin B	0.1166	0.3093	0.3093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1892	0.5854	1
Giardia lamblia	Encystation-specific protease	0.0427	0.0284	0.0918
Plasmodium vivax	unspecified product	0.0825	0.18	0.4136
Loa Loa (eye worm)	hypothetical protein	0.1023	0.2551	0.2551
Onchocerca volvulus		0.1497	0.4351	1
Echinococcus granulosus	cathepsin b	0.2983	1	1
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Plasmodium vivax	vivapain-2	0.1497	0.4351	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1023	0.2551	0.5864
Entamoeba histolytica	cysteine protease, putative	0.0825	0.18	0.4136
Entamoeba histolytica	cysteine proteinase, putative	0.1497	0.4351	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0825	0.18	0.4136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1
Brugia malayi	Papain family cysteine protease containing protein	0.1497	0.4351	0.4351
Loa Loa (eye worm)	fibroinase	0.1497	0.4351	0.4351
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1497	0.4351	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0549	0.0749	0.172
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0549	0.0749	0.0749
Schistosoma mansoni	cathepsin F (C01 family)	0.1497	0.4351	0.4351
Leishmania major	cathepsin L-like protease	0.1497	0.4351	0.4558
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1166	0.3093	0.3189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1497	0.4351	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.5481 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1442772

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1344928