Detailed information for compound 1344929

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 313.315 | Formula: C14H15N7O2
  • H donors: 2 H acceptors: 3 LogP: 2.41 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NN=Nc1nc2c([nH]1)n(C)c(=O)n(c2=O)C
  • InChi: 1S/C14H15N7O2/c1-8-4-6-9(7-5-8)17-19-18-13-15-10-11(16-13)20(2)14(23)21(3)12(10)22/h4-7H,1-3H3,(H2,15,16,17,18)
  • InChiKey: GSDVDCFDIVEOAH-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0036 0.0064 0.0064
Echinococcus granulosus pyruvate kinase 0.0021 0.0006 0.0006
Brugia malayi Putative carbonic anhydrase 5 precursor 0.02 0.0677 0.0677
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0234
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Echinococcus multilocularis carbonic anhydrase 0.0094 0.028 0.028
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0121 0.0084
Schistosoma mansoni pyruvate kinase 0.004 0.0079 0.0079
Mycobacterium ulcerans pyruvate kinase 0.004 0.0079 0.0612
Echinococcus granulosus cathepsin l1 0.1379 0.5086 0.5086
Giardia lamblia Cathepsin B precursor 0.0322 0.1134 0.2914
Echinococcus multilocularis pyruvate kinase 0.004 0.0079 0.0079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0059 0.0059
Plasmodium falciparum serine repeat antigen 8 0.0322 0.1134 0.2219
Brugia malayi cathepsin Z-like cysteine proteinase 0.0553 0.1997 0.1997
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0105 0.0195
Onchocerca volvulus 0.1379 0.5086 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.02 0.0677 0.0677
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0227 0.0223
Loa Loa (eye worm) hypothetical protein 0.0094 0.028 0.028
Trypanosoma cruzi cruzipain precursor, putative 0.1807 0.669 0.6663
Echinococcus granulosus tumor protein p63 0.0408 0.1455 0.1455
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1379 0.5086 0.5086
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0036
Loa Loa (eye worm) cysteine protease 0.1379 0.5086 0.5086
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0079 0.0144
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Onchocerca volvulus 0.0322 0.1134 0.2174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.1134 0.2106
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0203 0.0203
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0203 0.1682
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2693 1 1
Brugia malayi cathepsin L precursor 0.0322 0.1134 0.1134
Brugia malayi Cathepsin L-like cysteine proteinase 0.0945 0.3465 0.3465
Loa Loa (eye worm) glutaminase 0.033 0.1164 0.1164
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0034
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0094 0.028 0.028
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Giardia lamblia Cathepsin B precursor 0.1055 0.3876 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.1134 0.2106
Brugia malayi cathepsin Z-like cysteine proteinase 0.0553 0.1997 0.1997
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0036
Toxoplasma gondii preprocathepsin c precursor, putative 0.0536 0.1932 0.3792
Loa Loa (eye worm) hypothetical protein 0.0945 0.3465 0.3465
Echinococcus multilocularis pyruvate kinase 0.004 0.0079 0.0079
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0322 0.1134 0.2177
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0154 0.0154
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0064 0.0064
Echinococcus multilocularis cathepsin L cysteine protease 0.1379 0.5086 0.5086
Onchocerca volvulus 0.006 0.0152 0.023
Trypanosoma cruzi cysteine peptidase, putative 0.0755 0.2754 0.2696
Brugia malayi Papain family cysteine protease containing protein 0.0322 0.1134 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1055 0.3876 0.7583
Plasmodium vivax vivapain-3 0.0755 0.2754 0.541
Echinococcus multilocularis cathepsin L 0.0322 0.1134 0.1134
Giardia lamblia PHD finger protein 15 0.0035 0.006 0.014
Loa Loa (eye worm) hypothetical protein 0.0322 0.1134 0.1134
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.02 0.0677 0.0677
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0121 0.0227
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0105 0.0256
Brugia malayi Cathepsin L-like precursor 0.0945 0.3465 0.3465
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0322 0.1134 0.2219
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.02 0.0677 0.0677
Entamoeba histolytica cysteine protease, putative 0.0322 0.1134 0.2177
Chlamydia trachomatis pyruvate kinase 0.004 0.0079 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0945 0.3465 0.6763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0101 0.0101
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0079 0.0086
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0036 0.0234
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0036 0.0234
Trypanosoma cruzi cysteine proteinase, putative 0.0755 0.2754 0.2696
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0322 0.1134 0.2219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1379 0.5086 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0755 0.2754 0.2754
Brugia malayi Cathepsin L-like precursor 0.1379 0.5086 0.5086
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0121 0.0227
Giardia lamblia Hypothetical protein 0.0322 0.1134 0.2914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0064 0.0064
Loa Loa (eye worm) pyruvate kinase 0.004 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0755 0.2754 0.5343
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1379 0.5086 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Loa Loa (eye worm) pyruvate kinase 0.004 0.0079 0.0079
Echinococcus multilocularis cysteine protease 0.1379 0.5086 0.5086
Onchocerca volvulus 0.0286 0.0999 0.1907
Echinococcus multilocularis cathepsin b 0.2693 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.1134 0.2106
Loa Loa (eye worm) hypothetical protein 0.0945 0.3465 0.3465
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0322 0.1134 0.1134
Brugia malayi glutaminase DH11.1 0.033 0.1164 0.1164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0322 0.1134 0.1134
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.006 0.0107
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0009 0.022
Toxoplasma gondii cathepsin B 0.1055 0.3876 0.7618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1379 0.5086 1
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Echinococcus granulosus cathepsin l cysteine peptidase 0.1379 0.5086 0.5086
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0322 0.1134 0.2219
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0322 0.1134 0.2106
Leishmania major cysteine peptidase A (CPA) 0.1379 0.5086 0.759
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0433 0.1549 0.1549
Brugia malayi cathepsin F-like cysteine proteinase 0.0433 0.1549 0.1549
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1379 0.5086 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Trichomonas vaginalis glutaminase, putative 0.033 0.1164 0.2165
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0755 0.2754 0.2696
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2693 1 1
Giardia lamblia Cathepsin L precursor 0.0322 0.1134 0.2914
Loa Loa (eye worm) hypothetical protein 0.0322 0.1134 0.1134
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0227 0.0287
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0227 0.0227
Plasmodium falciparum pyruvate kinase 0.004 0.0079 0.0144
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0755 0.2754 0.5385
Brugia malayi Cathepsin L-like precursor 0.1379 0.5086 0.5086
Giardia lamblia Cathepsin B precursor 0.1055 0.3876 1
Brugia malayi cathepsin L-like precursor 0.0945 0.3465 0.3465
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0322 0.1134 0.2106
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0583 0.0583
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1379 0.5086 0.5086
Leishmania major cathepsin L-like protease 0.1807 0.669 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1379 0.5086 1
Echinococcus granulosus cathepsin L cysteine protease 0.0755 0.2754 0.2754
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0234
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0322 0.1134 0.1134
Plasmodium falciparum serine repeat antigen 9 0.0322 0.1134 0.2219
Brugia malayi Cathepsin L-like precursor 0.1379 0.5086 0.5086
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0322 0.1134 0.1134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0322 0.1134 0.1134
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0088 0.0088
Brugia malayi jmjC domain containing protein 0.0043 0.0088 0.0088
Brugia malayi fibroinase precursor 0.0322 0.1134 0.1134
Echinococcus multilocularis carbonic anhydrase 0.0094 0.028 0.028
Brugia malayi Cathepsin L-like precursor 0.1379 0.5086 0.5086
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1379 0.5086 1
Loa Loa (eye worm) hypothetical protein 0.1379 0.5086 0.5086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Echinococcus granulosus carbonic anhydrase 0.0094 0.028 0.028
Giardia lamblia Cathepsin L precursor 0.0322 0.1134 0.2914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.1134 0.2106
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0094 0.028 0.028
Trypanosoma cruzi cysteine peptidase, putative 0.0433 0.1549 0.1482
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2693 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0322 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Schistosoma mansoni carbonic anhydrase-related 0.0094 0.028 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Giardia lamblia Cathepsin B precursor 0.0322 0.1134 0.2914
Giardia lamblia Cathepsin B precursor 0.0322 0.1134 0.2914
Echinococcus granulosus carbonic anhydrase 0.0094 0.028 0.028
Entamoeba histolytica hypothetical protein 0.0322 0.1134 0.2177
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0403 0.1437 0.2816
Echinococcus multilocularis pyruvate kinase 0.0032 0.0048 0.0048
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0088 0.0088
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2693 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1807 0.669 0.6663
Plasmodium falciparum serine repeat antigen 4 0.0322 0.1134 0.2219
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0322 0.1134 0.1134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Plasmodium vivax vivapain-2 0.1379 0.5086 1
Entamoeba histolytica cysteine protease, putative 0.0322 0.1134 0.2177
Plasmodium falciparum cysteine proteinase falcipain 1 0.0755 0.2754 0.541
Plasmodium falciparum serine repeat antigen 5 0.0322 0.1134 0.2219
Plasmodium falciparum carbonic anhydrase 0.0094 0.028 0.054
Echinococcus multilocularis pyruvate kinase 0.0021 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.02 0.0677 0.0677
Leishmania major cathepsin L-like protease 0.1379 0.5086 0.759
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1374 0.5069 0.5029
Echinococcus multilocularis cathepsin b 0.2693 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0322 0.1134 0.1134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0036 0.1583
Leishmania major cathepsin L-like protease 0.1379 0.5086 0.759
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0203 1
Giardia lamblia Cysteine protease 0.0322 0.1134 0.2914
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1379 0.5086 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0203 0.1682
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0322 0.1134 0.2177
Schistosoma mansoni pyruvate kinase 0.004 0.0079 0.0079
Onchocerca volvulus 0.0036 0.0064 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.0755 0.2754 0.5385
Entamoeba histolytica cysteine proteinase 2 0.0755 0.2754 0.5385
Echinococcus multilocularis carbonic anhydrase II 0.02 0.0677 0.0677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0553 0.1997 0.3831
Plasmodium vivax serine-repeat antigen (SERA) 0.0322 0.1134 0.2219
Echinococcus granulosus cathepsin l1 0.0945 0.3465 0.3465
Schistosoma mansoni carbonic anhydrase-related 0.0094 0.028 0.028
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0079 0.0079
Trypanosoma cruzi cysteine peptidase, putative 0.1807 0.669 0.6663
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0583 0.0583
Schistosoma mansoni cathepsin C 0.0322 0.1134 0.1134
Loa Loa (eye worm) glutaminase 2 0.033 0.1164 0.1164
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0536 0.1932 0.3792
Trypanosoma cruzi cruzipain precursor, putative 0.0433 0.1549 0.1482
Plasmodium falciparum cysteine proteinase falcipain 3 0.1379 0.5086 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1379 0.5086 0.5086
Loa Loa (eye worm) hypothetical protein 0.0094 0.028 0.028
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0203 0.0203
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0227 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.1134 0.2106
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0583 0.0583
Loa Loa (eye worm) fibroinase 0.1379 0.5086 0.5086
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0322 0.1134 0.2914
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0322 0.1134 0.2106
Plasmodium falciparum phd finger protein, putative 0.0035 0.006 0.0107
Giardia lamblia Hypothetical protein 0.0322 0.1134 0.2914
Echinococcus granulosus pyruvate kinase 0.004 0.0079 0.0079
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0403 0.1437 0.3697
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0203 0.0203
Trypanosoma cruzi major cysteine proteinase, putative 0.0322 0.1134 0.1063
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.006 0.006
Brugia malayi Papain family cysteine protease containing protein 0.0322 0.1134 0.1134
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.1134 0.2106
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0536 0.1932 0.3792
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0553 0.1997 0.3831
Loa Loa (eye worm) hypothetical protein 0.0322 0.1134 0.1134
Schistosoma mansoni cathepsin F (C01 family) 0.0945 0.3465 0.3465
Giardia lamblia Cathepsin L precursor 0.0322 0.1134 0.2914
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0203 0.0251
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.036 0.036
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0999 0.1836
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0088 0.0088
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0079 0.0086
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0094 0.028 0.028
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.006 0.0107
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0322 0.1134 0.1134
Echinococcus granulosus peregrin 0.0039 0.0076 0.0076
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0322 0.1134 0.2219
Giardia lamblia Cathepsin L-like protease 0.0322 0.1134 0.2914
Onchocerca volvulus Cathepsin L homolog 0.1379 0.5086 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0322 0.1134 0.2106
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0553 0.1997 0.1997
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0945 0.3465 0.6763
Loa Loa (eye worm) hypothetical protein 0.2693 1 1
Mycobacterium ulcerans glutaminase 0.033 0.1164 1
Onchocerca volvulus Cathepsin L homolog 0.1379 0.5086 1
Onchocerca volvulus 0.1379 0.5086 1
Leishmania major cathepsin L-like protease 0.1379 0.5086 0.759
Brugia malayi Pre-SET motif family protein 0.0251 0.0869 0.0869
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0064 0.0064
Schistosoma mansoni cathepsin F (C01 family) 0.1379 0.5086 0.5086
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.006 0.006
Toxoplasma gondii cathepsin CPL 0.1379 0.5086 1
Plasmodium falciparum serine repeat antigen 3 0.0322 0.1134 0.2219
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1055 0.3876 0.3827
Schistosoma mansoni pyruvate kinase 0.0021 0.0006 0.0006
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Entamoeba histolytica cysteine protease, putative 0.0322 0.1134 0.2177
Giardia lamblia Cathepsin B precursor 0.1055 0.3876 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0227 0.0382
Giardia lamblia Cathepsin B precursor 0.0553 0.1997 0.5146
Onchocerca volvulus Cathepsin F homolog 0.1379 0.5086 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1055 0.3876 0.3876
Loa Loa (eye worm) hypothetical protein 0.006 0.0154 0.0154
Brugia malayi cathepsin F-like cysteine proteinase 0.0322 0.1134 0.1134
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Brugia malayi Cathepsin L-like precursor 0.1379 0.5086 0.5086
Schistosoma mansoni cathepsin F (C01 family) 0.1379 0.5086 0.5086
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0121 0.0121
Entamoeba histolytica cysteine proteinase, putative 0.0755 0.2754 0.5385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1379 0.5086 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0064 0.0064
Schistosoma mansoni cathepsin B (C01 family) 0.0322 0.1134 0.1134
Onchocerca volvulus 0.0945 0.3465 0.6791
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0536 0.1932 0.4978
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1379 0.5086 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1055 0.3876 0.5771
Giardia lamblia Cathepsin L precursor 0.0322 0.1134 0.2914
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Giardia lamblia Cathepsin L precursor 0.0322 0.1134 0.2914
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0094 0.028 0.028
Echinococcus multilocularis cathepsin L 0.0755 0.2754 0.2754
Echinococcus granulosus carbonic anhydrase II 0.02 0.0677 0.0677
Onchocerca volvulus 0.1379 0.5086 1
Echinococcus granulosus pyruvate kinase 0.0021 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0755 0.2754 0.4047
Onchocerca volvulus 0.1379 0.5086 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0064 0.0113
Leishmania major carbonic anhydrase-like protein 0.02 0.0677 0.0963
Loa Loa (eye worm) pyruvate kinase 0.004 0.0079 0.0079
Entamoeba histolytica cysteine protease, putative 0.0322 0.1134 0.2177
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0322 0.1134 0.2106
Loa Loa (eye worm) hypothetical protein 0.006 0.0155 0.0155
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Schistosoma mansoni carbonic anhydrase-related 0.0094 0.028 0.028
Leishmania major cathepsin L-like protease 0.1807 0.669 1
Entamoeba histolytica cysteine proteinase, putative 0.1379 0.5086 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.1055 0.3876 0.5743
Loa Loa (eye worm) hypothetical protein 0.0433 0.1549 0.1549
Plasmodium vivax vivapain-1 0.0755 0.2754 0.541
Loa Loa (eye worm) hypothetical protein 0.0094 0.028 0.028
Loa Loa (eye worm) ctsf protein 0.1379 0.5086 0.5086
Leishmania major cathepsin L-like protease 0.1807 0.669 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0079 1
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0101 0.0101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0536 0.1932 0.3792
Brugia malayi Bromodomain containing protein 0.0039 0.0076 0.0076
Echinococcus granulosus pyruvate kinase 0.004 0.0079 0.0079
Loa Loa (eye worm) cathepsin B 0.1055 0.3876 0.3876
Plasmodium vivax pyruvate kinase, putative 0.004 0.0079 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0036 0.0234
Echinococcus granulosus cathepsin b 0.2693 1 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0079 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.1134 0.2106
Schistosoma mansoni cathepsin S (C01 family) 0.0322 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0322 0.1134 0.1134
Entamoeba histolytica cysteine protease, putative 0.0322 0.1134 0.2177
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0536 0.1932 0.1932
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0869 0.0869
Plasmodium vivax unspecified product 0.0433 0.1549 0.3038
Plasmodium falciparum serine repeat antigen 1 0.0322 0.1134 0.2219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0755 0.2754 0.5343
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0322 0.1134 0.2106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Giardia lamblia Cysteine protease 0.0322 0.1134 0.2914
Giardia lamblia Cysteine protease 0.0322 0.1134 0.2914
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0565 0.0565
Onchocerca volvulus Alhambra homolog 0.0035 0.006 0.0049
Mycobacterium ulcerans hypothetical protein 0.0029 0.0036 0.0234
Giardia lamblia Cathepsin L precursor 0.0322 0.1134 0.2914
Echinococcus granulosus cathepsin b 0.2693 1 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0152 0.0152
Brugia malayi PHD-finger family protein 0.0035 0.006 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0553 0.1997 0.3831
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0203 0.0203
Entamoeba histolytica cysteine proteinase, putative 0.1379 0.5086 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0036 0.0234
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0036 0.1583
Brugia malayi Cathepsin L-like precursor 0.0945 0.3465 0.3465
Echinococcus multilocularis carbonic anhydrase 0.0094 0.028 0.028
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0322 0.1134 0.1134
Leishmania major pyruvate kinase 0.004 0.0079 0.0066
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0227 0.0227
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0201 0.0201
Plasmodium falciparum serine repeat antigen 7 0.0322 0.1134 0.2219
Giardia lamblia Cathepsin L-like protease 0.0322 0.1134 0.2914
Brugia malayi Papain family cysteine protease containing protein 0.0755 0.2754 0.2754
Plasmodium falciparum serine repeat antigen 6 0.0322 0.1134 0.2219
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0227 0.0227
Giardia lamblia Cathepsin B precursor 0.0322 0.1134 0.2914
Entamoeba histolytica cysteine protease, putative 0.0322 0.1134 0.2177
Echinococcus multilocularis cysteine protease 0.1379 0.5086 0.5086
Onchocerca volvulus Cathepsin L homolog 0.0322 0.1134 0.2174
Plasmodium falciparum serine repeat antigen 2 0.0322 0.1134 0.2219
Plasmodium vivax serine-repeat antigen (SERA) 0.0322 0.1134 0.2219
Brugia malayi Papain family cysteine protease containing protein 0.0322 0.1134 0.1134
Echinococcus multilocularis cathepsin L cysteine protease 0.1379 0.5086 0.5086
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Schistosoma mansoni carbonic anhydrase 0.0094 0.028 0.028
Schistosoma mansoni hypothetical protein 0.0094 0.028 0.028
Entamoeba histolytica cysteine proteinase, putative 0.0755 0.2754 0.5385
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0079 0.3778
Entamoeba histolytica cysteine protease, putative 0.1379 0.5086 1
Echinococcus granulosus cathepsin L 0.0755 0.2754 0.2754
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.036 0.036
Loa Loa (eye worm) hypothetical protein 0.0433 0.1549 0.1549
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0064 0.0064
Trypanosoma cruzi cysteine proteinase, putative 0.0755 0.2754 0.2696
Schistosoma mansoni hypothetical protein 0.0041 0.0083 0.0083
Trypanosoma cruzi cysteine protease, putative 0.0755 0.2754 0.2696
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0036 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0455 0.1629 0.3096
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0079 0.0079
Entamoeba histolytica cysteine proteinase 1, putative 0.0755 0.2754 0.5385
Echinococcus granulosus cathepsin L cysteine proteinase 0.1379 0.5086 0.5086
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0036 0.0004
Giardia lamblia Encystation-specific protease 0.0403 0.1437 0.3697
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1379 0.5086 0.5086
Entamoeba histolytica cysteine proteinase, putative 0.0945 0.3465 0.6792
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0468 0.0468
Leishmania major cathepsin L-like protease 0.1379 0.5086 0.759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1379 0.5086 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0322 0.1134 0.1134
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0036 0.0064 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0468 0.0468
Onchocerca volvulus 0.1379 0.5086 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0322 0.1134 0.2219
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Loa Loa (eye worm) carbonic anhydrase 3 0.02 0.0677 0.0677
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0322 0.1134 0.2219
Brugia malayi cathepsin L-like cysteine proteinase 0.0322 0.1134 0.1134
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0121 0.0227
Trypanosoma brucei carbonic anhydrase-like protein 0.02 0.0677 0.0904
Plasmodium vivax hypothetical protein, conserved 0.0035 0.006 0.0107
Giardia lamblia Pyruvate kinase 0.004 0.0079 0.019
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.006 0.0152 0.0152
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0227 0.0149
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0227 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Loa Loa (eye worm) hypothetical protein 0.0322 0.1134 0.1134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0036 0.0234
Echinococcus granulosus cathepsin L 0.0322 0.1134 0.1134
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0755 0.2754 0.2754
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0536 0.1932 0.3792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0433 0.1549 0.1549
Giardia lamblia Cysteine protease 0.0322 0.1134 0.2914
Toxoplasma gondii cathepsin CPC1 0.0536 0.1932 0.3792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0036
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0271 0.0271
Echinococcus multilocularis peregrin 0.0039 0.0076 0.0076
Echinococcus granulosus carbonic anhydrase 0.0094 0.028 0.028
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0154 0.0154
Trypanosoma cruzi major cysteine proteinase, putative 0.0751 0.2737 0.2679
Echinococcus granulosus cysteine protease 0.0755 0.2754 0.2754
Brugia malayi Papain family cysteine protease containing protein 0.1379 0.5086 0.5086
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0322 0.1134 0.2219
Plasmodium vivax vivapain-2 0.1379 0.5086 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.02 0.0677 0.0602
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0403 0.1437 0.3697
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0154 0.0154
Echinococcus multilocularis pyruvate kinase 0.0021 0.0006 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0755 0.2754 0.4047
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0112 0.0112
Leishmania major cathepsin L-like protease 0.1379 0.5086 0.759
Trypanosoma cruzi cysteine peptidase, putative 0.1379 0.5086 0.5047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Loa Loa (eye worm) hypothetical protein 0.0945 0.3465 0.3465
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0094 0.028 0.028
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0009 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0036 0.0004
Toxoplasma gondii cathepsin CPC2 0.0403 0.1437 0.2816
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1379 0.5086 1
Loa Loa (eye worm) acetyltransferase 0.0175 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0433 0.1549 0.1549
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0553 0.1997 0.3831
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0121 0.0084
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0036 0.0036
Schistosoma mansoni cathepsin s 0.0433 0.1549 0.1549
Onchocerca volvulus 0.1379 0.5086 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0403 0.1437 0.2816
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.006 0.006
Echinococcus multilocularis tumor protein p63 0.0408 0.1455 0.1455
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0203 0.0388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1807 0.669 1
Schistosoma mansoni glutaminase 0.033 0.1164 0.1164
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0755 0.2754 0.2754
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3592 0.3592
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0203 0.1682
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.02 0.0677 0.0602
Brugia malayi jmjC domain containing protein 0.0115 0.036 0.036
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0105 0.0141
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0088 0.0088
Brugia malayi Cathepsin L-like precursor 0.1379 0.5086 0.5086
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1379 0.5086 1
Echinococcus multilocularis pyruvate kinase 0.0021 0.0006 0.0006
Echinococcus granulosus pyruvate kinase 0.0021 0.0006 0.0006
Brugia malayi MH2 domain containing protein 0.0144 0.0468 0.0468
Entamoeba histolytica cysteine protease, putative 0.0755 0.2754 0.5385
Plasmodium vivax unspecified product 0.0322 0.1134 0.2219
Loa Loa (eye worm) hypothetical protein 0.0322 0.1134 0.1134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1379 0.5086 1
Plasmodium vivax unspecified product 0.0755 0.2754 0.541
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1379 0.5086 1
Onchocerca volvulus 0.1379 0.5086 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0088 0.0088
Leishmania major pyruvate kinase 0.004 0.0079 0.0066
Toxoplasma gondii hypothetical protein 0.0094 0.028 0.054
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0064 0.0113
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0009 0.0005
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.006
Brugia malayi Cathepsin L-like precursor 0.0433 0.1549 0.1549
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2693 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1807 0.669 0.6663
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0227 0.0149
Brugia malayi Papain family cysteine protease containing protein 0.0755 0.2754 0.2754
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0094 0.028 0.028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0322 0.1134 0.2106

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 24.66 uM PUBCHEM_BIOASSAY: GASC-1 histone demethylase dose retest Measured in Cell-Free Homogeneous System Using Plate Reader - 2043-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2123] ChEMBL. No reference
Potency (functional) = 0.1778 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.1778 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (binding) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 13.4591 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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