Detailed information for compound 1345754

Basic information

Technical information
  • TDR Targets ID: 1345754
  • Name: 5-chloro-2-methoxy-N'-[2-([1,2,4]triazolo[4,5 -a]pyridin-3-ylsulfanyl)acetyl]benzohydrazide
  • MW: 391.832 | Formula: C16H14ClN5O3S
  • H donors: 2 H acceptors: 4 LogP: 3.13 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C(=O)NNC(=O)CSc1nnc2n1cccc2)Cl
  • InChi: 1S/C16H14ClN5O3S/c1-25-12-6-5-10(17)8-11(12)15(24)20-19-14(23)9-26-16-21-18-13-4-2-3-7-22(13)16/h2-8H,9H2,1H3,(H,19,23)(H,20,24)
  • InChiKey: OAPIPRFUFZQVRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-chloro-2-methoxy-N'-[1-oxo-2-([1,2,4]triazolo[4,5-a]pyridin-3-ylthio)ethyl]benzohydrazide
  • 5-chloro-2-methoxy-N'-[2-([1,2,4]triazolo[4,5-a]pyridin-3-ylthio)acetyl]benzohydrazide
  • 5-chloro-2-methoxy-N'-[2-([1,2,4]triazolo[4,5-a]pyridin-3-ylsulfanyl)ethanoyl]benzohydrazide
  • MLS000772751
  • SMR000377304
  • ZINC02639292

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.005 0.0425 0.0425
Trypanosoma cruzi cysteine peptidase, putative 0.0159 0.41 0.41
Trypanosoma cruzi cruzipain precursor, putative 0.0159 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.3093 0.7543
Leishmania major cathepsin L-like protease 0.0159 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Loa Loa (eye worm) hypothetical protein 0.011 0.2438 0.2438
Onchocerca volvulus 0.0159 0.41 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0086 0.1662 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Leishmania major cathepsin L-like protease 0.0159 0.41 1
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.1662 0.1662
Loa Loa (eye worm) cysteine protease 0.0159 0.41 0.41
Brugia malayi Cathepsin L-like cysteine proteinase 0.011 0.2438 0.2438
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0335 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0159 0.41 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0159 0.41 0.41
Trypanosoma cruzi cysteine protease, putative 0.0086 0.1662 0.1662
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Loa Loa (eye worm) hypothetical protein 0.0159 0.41 0.41
Onchocerca volvulus 0.0159 0.41 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0159 0.41 0.41
Giardia lamblia Cathepsin B precursor 0.0129 0.3093 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Plasmodium vivax vivapain-2 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.011 0.2438 0.5946
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.011 0.2438 0.2438
Onchocerca volvulus Cathepsin L homolog 0.0159 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0425 0.0425
Echinococcus granulosus cathepsin l1 0.011 0.2438 0.2438
Toxoplasma gondii cathepsin B 0.0129 0.3093 0.7543
Echinococcus granulosus cysteine protease 0.0086 0.1662 0.1662
Loa Loa (eye worm) cathepsin B 0.0129 0.3093 0.3093
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0425 0.0425
Leishmania major cathepsin L-like protease 0.0159 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Echinococcus granulosus cathepsin L cysteine protease 0.0086 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0086 0.1662 0.1662
Loa Loa (eye worm) hypothetical protein 0.011 0.2438 0.2438
Brugia malayi Cathepsin L-like precursor 0.0159 0.41 0.41
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.1662 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Giardia lamblia Cathepsin B precursor 0.0129 0.3093 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0086 0.1662 0.4054
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0129 0.3093 0.3093
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0159 0.41 0.41
Schistosoma mansoni cathepsin s 0.005 0.0425 0.0425
Schistosoma mansoni cathepsin F (C01 family) 0.0159 0.41 0.41
Onchocerca volvulus 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1662 0.4054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0159 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.41 1
Echinococcus multilocularis cathepsin L 0.0086 0.1662 0.1662
Echinococcus multilocularis cathepsin L cysteine protease 0.0159 0.41 0.41
Onchocerca volvulus Cathepsin L homolog 0.0159 0.41 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0129 0.3093 0.3093
Brugia malayi Cathepsin L-like precursor 0.005 0.0425 0.0425
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Brugia malayi Cathepsin L-like precursor 0.011 0.2438 0.2438
Echinococcus granulosus cathepsin b 0.0335 1 1
Echinococcus multilocularis cathepsin b 0.0335 1 1
Brugia malayi Cathepsin L-like precursor 0.0159 0.41 0.41
Brugia malayi Cathepsin L-like precursor 0.0159 0.41 0.41
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.1662 0.4054
Plasmodium vivax vivapain-1 0.0086 0.1662 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.011 0.2438 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Trypanosoma cruzi cysteine peptidase, putative 0.0159 0.41 0.41
Onchocerca volvulus 0.0159 0.41 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0425 0.0425
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Echinococcus granulosus cathepsin b 0.0335 1 1
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Leishmania major cysteine peptidase A (CPA) 0.0159 0.41 1
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.1662 0.1662
Brugia malayi Cathepsin L-like precursor 0.0159 0.41 0.41
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0086 0.1662 0.1662
Trypanosoma cruzi cysteine peptidase, putative 0.0159 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Schistosoma mansoni cathepsin F (C01 family) 0.011 0.2438 0.2438
Giardia lamblia Cathepsin B precursor 0.0129 0.3093 1
Entamoeba histolytica cysteine proteinase, putative 0.0159 0.41 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.1662 0.4054
Leishmania major cathepsin L-like protease 0.0159 0.41 1
Plasmodium vivax vivapain-2 0.0159 0.41 1
Brugia malayi cathepsin L-like precursor 0.011 0.2438 0.2438
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.41 1
Brugia malayi Papain family cysteine protease containing protein 0.0159 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Trypanosoma cruzi cysteine proteinase, putative 0.0086 0.1662 0.1662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.1662 0.4054
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.41 1
Entamoeba histolytica cysteine proteinase 2 0.0086 0.1662 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0086 0.1662 0.1662
Trypanosoma cruzi cysteine peptidase, putative 0.0159 0.41 0.41
Entamoeba histolytica cysteine proteinase, putative 0.0159 0.41 1
Loa Loa (eye worm) hypothetical protein 0.0335 1 1
Loa Loa (eye worm) ctsf protein 0.0159 0.41 0.41
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0159 0.41 1
Echinococcus granulosus cathepsin L 0.0086 0.1662 0.1662
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0159 0.41 0.41
Plasmodium vivax vivapain-3 0.0086 0.1662 0.4054
Echinococcus granulosus cathepsin l1 0.0159 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Echinococcus multilocularis cysteine protease 0.0159 0.41 0.41
Plasmodium vivax unspecified product 0.0086 0.1662 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.005 0.0425 0.0425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.41 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0159 0.41 0.41
Toxoplasma gondii cathepsin CPL 0.0159 0.41 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0335 1 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0129 0.3093 0.5868
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0086 0.1662 0.1662
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Onchocerca volvulus 0.0159 0.41 1
Echinococcus multilocularis cysteine protease 0.0159 0.41 0.41
Leishmania major cathepsin L-like protease 0.0159 0.41 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Brugia malayi Cathepsin L-like precursor 0.0159 0.41 0.41
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Brugia malayi Cathepsin L-like precursor 0.011 0.2438 0.2438
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0159 0.41 0.41
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0159 0.41 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0425 0.0425
Onchocerca volvulus 0.011 0.2438 0.5946
Schistosoma mansoni cathepsin F (C01 family) 0.0159 0.41 0.41
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0086 0.1662 0.1662
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0159 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Leishmania major cathepsin L-like protease 0.0159 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0159 0.41 1
Plasmodium vivax unspecified product 0.005 0.0425 0.1037
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.41 1
Loa Loa (eye worm) fibroinase 0.0159 0.41 0.41
Loa Loa (eye worm) papain family cysteine protease containing protein 0.005 0.0425 0.0425
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.1662 0.1662
Onchocerca volvulus 0.0159 0.41 1
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Onchocerca volvulus Cathepsin F homolog 0.0159 0.41 1
Leishmania major cathepsin L-like protease 0.0159 0.41 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2438 0.2438
Brugia malayi Cathepsin L-like precursor 0.0159 0.41 0.41
Echinococcus multilocularis cathepsin b 0.0335 1 1
Entamoeba histolytica cysteine protease, putative 0.0086 0.1662 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.011 0.2438 0.5946
Trypanosoma cruzi cruzipain precursor, putative 0.005 0.0425 0.0425
Leishmania major cathepsin L-like protease 0.0159 0.41 1
Onchocerca volvulus 0.0159 0.41 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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