Detailed information for compound 135643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 979.781 | Formula: C34H48N9O17P3S--
  • H donors: 9 H acceptors: 15 LogP: -3.94 Rotable bonds: 27
    Rule of 5 violations (Lipinski): 4
  • SMILES: O=C(NCCSC(C(=O)NCCc1c[nH]c2c1cccc2)C)CCNC(=O)C(C(COP(=O)(OP(=O)(OCC1OC(C(C1OP(=O)([O-])[O-])O)n1cnc2c1ncnc2N)O)O)(C)C)O
  • InChi: 1S/C34H50N9O17P3S/c1-19(31(47)37-10-8-20-14-39-22-7-5-4-6-21(20)22)64-13-12-36-24(44)9-11-38-32(48)28(46)34(2,3)16-57-63(54,55)60-62(52,53)56-15-23-27(59-61(49,50)51)26(45)33(58-23)43-18-42-25-29(35)40-17-41-30(25)43/h4-7,14,17-19,23,26-28,33,39,45-46H,8-13,15-16H2,1-3H3,(H,36,44)(H,37,47)(H,38,48)(H,52,53)(H,54,55)(H2,35,40,41)(H2,49,50,51)/p-2
  • InChiKey: FDMGWGASOWLEIB-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0623 0.2048
Brugia malayi Bromodomain containing protein 0.0164 0.1192 0.1435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.0682 0.2246
Brugia malayi Papain family cysteine protease containing protein 0.0102 0.0682 0.0821
Schistosoma mansoni hypothetical protein 0.0045 0.0207 0.0249
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0095 0.0284
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0046 0.0055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0536 0.1758
Loa Loa (eye worm) hypothetical protein 0.0162 0.1177 0.1416
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0625 0.0484
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0042 0.0088
Schistosoma mansoni ran 0.0021 0.0011 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.043 0.0518
Loa Loa (eye worm) hypothetical protein 0.0268 0.206 0.2478
Plasmodium falciparum serine repeat antigen 7 0.0095 0.0623 0.2939
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0625 0.0484
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Brugia malayi RNA binding protein 0.0067 0.0393 0.0473
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Plasmodium vivax heterochromatin protein 1, putative 0.0025 0.0042 0.0199
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0102 0.0682 0.0821
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Brugia malayi Protein cec-1. 0.0025 0.0042 0.0051
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.0682 0.3186
Brugia malayi CXXC zinc finger family protein 0.0028 0.0074 0.0089
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0073 0.0439 0.2073
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0073 0.0439 0.0529
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1444 0.1738
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0524 0.4175 0.5024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Brugia malayi CHD4 protein 0.003 0.009 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0095 0.0623 0.2048
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0597 0.4776 1
Giardia lamblia Cathepsin B precursor 0.0382 0.3001 0.6274
Trypanosoma cruzi ISWI complex protein 0.0033 0.0112 0.0134
Echinococcus granulosus GPCR family 2 0.0033 0.0108 0.0129
Plasmodium vivax vivapain-3 0.0102 0.0682 0.322
Leishmania major importin beta-1 subunit, putative 0.0023 0.0028 0.0094
Mycobacterium tuberculosis Probable lipase LipD 0.0192 0.1429 0.1299
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0046 0.0055
Loa Loa (eye worm) hypothetical protein 0.0311 0.2415 0.2905
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0085 0.0102
Echinococcus multilocularis cathepsin L cysteine protease 0.0276 0.2119 0.255
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0835 0.1004
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0071 0.0201
Loa Loa (eye worm) hypothetical protein 0.014 0.0996 0.1198
Loa Loa (eye worm) hypothetical protein 0.1024 0.8311 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0623 0.2048
Echinococcus granulosus tar DNA binding protein 0.0067 0.0393 0.0473
Leishmania major hypothetical protein, conserved 0.0025 0.0045 0.0151
Trichomonas vaginalis D-aminoacylase, putative 0.0192 0.1429 0.4743
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0042 0.0199
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus granulosus Chromobox protein 3 0.0025 0.0042 0.0051
Echinococcus multilocularis glutamate receptor 2 0.0072 0.0434 0.0522
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0153 0.0184
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0439 0.1464
Loa Loa (eye worm) hypothetical protein 0.0104 0.0697 0.0839
Schistosoma mansoni chromobox protein 0.0025 0.0042 0.0051
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni hypothetical protein 0.0302 0.2338 0.2813
Trichomonas vaginalis Heterochromatin protein, putative 0.0025 0.0042 0.0105
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0085 0.0102
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0143 0.0172
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0597 0.4776 1
Mycobacterium ulcerans beta-lactamase 0.0192 0.1429 1
Echinococcus granulosus cpg binding protein 0.0034 0.0121 0.0146
Onchocerca volvulus 0.0276 0.2119 0.5218
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0492 0.0592
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Brugia malayi Pre-SET motif family protein 0.0238 0.1809 0.2177
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Brugia malayi hypothetical protein 0.009 0.0581 0.0699
Plasmodium vivax vivapain-1 0.0102 0.0682 0.322
Echinococcus multilocularis cathepsin L cysteine protease 0.0276 0.2119 0.255
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0218 0.1642 0.5471
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Echinococcus multilocularis Chromo domain 0.0025 0.0042 0.0051
Mycobacterium tuberculosis Probable reductase 0.0086 0.0546 0.0404
Plasmodium vivax vivapain-2 0.0276 0.2119 1
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0589 0.1935
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0073 0.0439 0.0529
Trichomonas vaginalis set domain proteins, putative 0.0271 0.2081 0.6924
Trypanosoma brucei trypanothione reductase 0.0037 0.0149 0.0495
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0042 0.0199
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0085 0.0102
Brugia malayi Importin beta-1 subunit 0.0028 0.0072 0.0087
Giardia lamblia Cathepsin L-like protease 0.0095 0.0623 0.1285
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0073 0.0439 0.0529
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Schistosoma mansoni cathepsin F (C01 family) 0.0268 0.206 0.2478
Mycobacterium tuberculosis Conserved protein 0.0192 0.1429 0.1299
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0395 0.0475
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0154 0.0185
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1464
Echinococcus multilocularis glutamate receptor 2 0.0063 0.0357 0.043
Brugia malayi cathepsin Z-like cysteine proteinase 0.0095 0.0623 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0623 0.2048
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Schistosoma mansoni cathepsin S (C01 family) 0.0095 0.0623 0.0749
Onchocerca volvulus 0.0276 0.2119 0.5218
Trypanosoma cruzi major cysteine proteinase, putative 0.0095 0.0623 0.0749
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0102 0.0682 0.2274
Entamoeba histolytica hypothetical protein 0.0075 0.0459 0.2126
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0382 0.3001 0.361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Echinococcus granulosus cathepsin b 0.1024 0.8311 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0073 0.0439 0.0529
Entamoeba histolytica hypothetical protein 0.0095 0.0623 0.2904
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.1873 0.2254
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0095 0.0623 0.0749
Entamoeba histolytica hypothetical protein 0.0075 0.0459 0.2126
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Loa Loa (eye worm) hypothetical protein 0.009 0.0581 0.0699
Plasmodium vivax importin-beta 2, putative 0.0028 0.0072 0.0342
Trypanosoma brucei hypothetical protein, conserved 0.0192 0.1429 0.4761
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Brugia malayi Pre-SET motif family protein 0.0035 0.0125 0.0151
Loa Loa (eye worm) fibroinase 0.0276 0.2119 0.255
Brugia malayi PHD-finger family protein 0.0061 0.0339 0.0408
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0192 0.1429 0.1299
Echinococcus granulosus glutamate receptor 2 0.0063 0.0357 0.043
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0149
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0597 0.4776 0.5747
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0102 0.0682 0.0821
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0095 0.0623 0.0749
Brugia malayi beta-lactamase family protein 0.0192 0.1429 0.1719
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0025 0.0048 0.0057
Schistosoma mansoni importin beta-1 0.0028 0.0072 0.0087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0192 0.1429 0.1299
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0192 0.1429 0.1719
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Echinococcus multilocularis geminin 0.069 0.5552 0.668
Onchocerca volvulus Cathepsin F homolog 0.0276 0.2119 0.5218
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0149
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.043 0.0518
Toxoplasma gondii preprocathepsin c precursor, putative 0.0095 0.0623 0.1304
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0002 0.0004
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0042 0.0051
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0071 0.0201
Onchocerca volvulus 0.0066 0.0386 0.0863
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Mycobacterium ulcerans lipase LipD 0.0192 0.1429 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0198 0.1479 0.178
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0095 0.0623 0.0749
Giardia lamblia Hypothetical protein 0.0095 0.0623 0.1285
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0125 0.0263
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Plasmodium vivax serine-repeat antigen (SERA) 0.0095 0.0623 0.2939
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0042 0.0088
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Leishmania major cysteine peptidase A (CPA) 0.0276 0.2119 0.7062
Echinococcus granulosus chromobox protein 2 0.0025 0.0042 0.0051
Giardia lamblia Cathepsin B precursor 0.0382 0.3001 0.6274
Leishmania major trypanothione reductase 0.0037 0.0149 0.0495
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0095 0.0623 0.2939
Giardia lamblia Cathepsin B precursor 0.0382 0.3001 0.6274
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0025 0.0042 0.0199
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0055
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0028 0.0059
Loa Loa (eye worm) beta-lactamase 0.0192 0.1429 0.1719
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Echinococcus granulosus cathepsin l cysteine peptidase 0.0276 0.2119 0.255
Schistosoma mansoni cathepsin B (C01 family) 0.0095 0.0623 0.0749
Loa Loa (eye worm) hypothetical protein 0.0268 0.206 0.2478
Mycobacterium tuberculosis Conserved protein 0.0192 0.1429 0.1299
Schistosoma mansoni hypothetical protein 0.0033 0.0108 0.0129
Echinococcus granulosus intermediate filament protein 0.0085 0.0542 0.0652
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0095 0.0623 0.2939
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0046 0.0055
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0268 0.206 0.6853
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0149 0.0701
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.0682 0.3186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0268 0.206 0.2478
Plasmodium vivax unspecified product 0.0095 0.0623 0.2939
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0546 0.0404
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0149 0.0179
Schistosoma mansoni eyes absent homolog 0.009 0.0581 0.0699
Echinococcus granulosus lysine specific demethylase 5A 0.0079 0.0492 0.0592
Toxoplasma gondii cathepsin CPC1 0.0095 0.0623 0.1304
Brugia malayi Valyl-tRNA synthetase 0.0025 0.0042 0.0051
Plasmodium vivax SET domain protein, putative 0.0035 0.0125 0.0592
Echinococcus granulosus geminin 0.069 0.5552 0.668
Echinococcus granulosus glutamate receptor 2 0.0072 0.0434 0.0522
Echinococcus granulosus beta LACTamase domain containing family member 0.0192 0.1429 0.1719
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0153 0.0184
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0074 0.0089
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0393 0.0473
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Brugia malayi Cathepsin L-like precursor 0.0268 0.206 0.2478
Brugia malayi Cathepsin L-like cysteine proteinase 0.0268 0.206 0.2478
Schistosoma mansoni cathepsin F (C01 family) 0.0276 0.2119 0.255
Brugia malayi hypothetical protein 0.0075 0.0459 0.0552
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0194 0.1444 0.1738
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0276 0.2119 0.7051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0042 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0597 0.4776 0.5747
Echinococcus multilocularis GPCR, family 2 0.0033 0.0108 0.0129
Entamoeba histolytica cysteine proteinase, putative 0.0268 0.206 0.9718
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0071 0.0085
Brugia malayi RNA, U transporter 1 0.008 0.0504 0.0607
Trypanosoma brucei ISWI complex protein 0.0033 0.0112 0.0372
Echinococcus multilocularis lamin 0.0085 0.0542 0.0652
Echinococcus granulosus glutamate receptor 4 0.0042 0.0188 0.0226
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Echinococcus multilocularis cathepsin L 0.0095 0.0623 0.0749
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Schistosoma mansoni ran 0.0021 0.0011 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Brugia malayi cathepsin L-like cysteine proteinase 0.0095 0.0623 0.0749
Brugia malayi Thioredoxin reductase 0.0037 0.0149 0.0179
Echinococcus multilocularis cysteine protease 0.0276 0.2119 0.255
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Loa Loa (eye worm) hypothetical protein 0.0072 0.043 0.0518
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.043 0.0518
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.0682 0.3186
Echinococcus multilocularis muscleblind protein 0.0311 0.2415 0.2905
Trichomonas vaginalis penicillin-binding protein, putative 0.0192 0.1429 0.4743
Brugia malayi PHD-finger family protein 0.0055 0.0297 0.0357
Loa Loa (eye worm) hypothetical protein 0.009 0.0581 0.0699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.0255 0.0306
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Loa Loa (eye worm) hypothetical protein 0.0042 0.0188 0.0226
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0689 0.0829
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0835 0.1747
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0546 0.0404
Brugia malayi Muscleblind-like protein 0.0311 0.2415 0.2905
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0095 0.0284
Trichomonas vaginalis hypothetical protein 0.0025 0.0042 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0333 0.1077
Giardia lamblia PHD finger protein 15 0.0061 0.0339 0.069
Trypanosoma cruzi cysteine peptidase, putative 0.0102 0.0682 0.0821
Schistosoma mansoni cathepsin F (C01 family) 0.0276 0.2119 0.255
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0108 0.0129
Echinococcus granulosus cathepsin b 0.1024 0.8311 1
Schistosoma mansoni cpg binding protein 0.0028 0.0074 0.0089
Leishmania major hypothetical protein, conserved 0.0073 0.0439 0.1464
Mycobacterium ulcerans esterase/lipase LipP 0.0192 0.1429 1
Schistosoma mansoni chromobox protein 0.0025 0.0042 0.0051
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0095 0.0623 0.2939
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0042 0.0105
Schistosoma mansoni hypothetical protein 0.0033 0.0108 0.0129
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Brugia malayi chromobox protein homolog 3 0.0084 0.0536 0.0645
Onchocerca volvulus 0.0276 0.2119 0.5218
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Trypanosoma cruzi ISWI complex protein 0.0033 0.0112 0.0134
Loa Loa (eye worm) glutamate receptor 1 0.0067 0.0395 0.0475
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0218 0.1642 0.1975
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.0445 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0623 0.2048
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Plasmodium falciparum cysteine proteinase falcipain 1 0.0102 0.0682 0.322
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0073 0.0439 0.0529
Brugia malayi AF-10 protein 0.002 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0536 0.1758
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0623 0.2048
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus granulosus cathepsin l1 0.0276 0.2119 0.255
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0072 0.0087
Leishmania major cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1464
Brugia malayi MH2 domain containing protein 0.0246 0.1873 0.2254
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0105
Schistosoma mansoni lamin 0.0085 0.0542 0.0652
Loa Loa (eye worm) hypothetical protein 0.0153 0.1102 0.1326
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Onchocerca volvulus Huntingtin homolog 0.014 0.0996 0.2396
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0546 0.0404
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.2119 0.255
Echinococcus granulosus chromobox protein 1 0.015 0.1084 0.1304
Trichomonas vaginalis chromobox protein, putative 0.015 0.1084 0.3588
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0198 0.1479 0.178
Schistosoma mansoni hypothetical protein 0.0033 0.0112 0.0134
Brugia malayi cathepsin L-like precursor 0.0268 0.206 0.2478
Plasmodium falciparum serine repeat antigen 8 0.0095 0.0623 0.2939
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Loa Loa (eye worm) hypothetical protein 0.0083 0.0529 0.0636
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0102 0.0682 0.2246
Giardia lamblia Hypothetical protein 0.0095 0.0623 0.1285
Toxoplasma gondii cathepsin CPC2 0.0095 0.0623 0.1304
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0348 0.0419
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.0042 0.0051
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Echinococcus granulosus Chromo domain 0.0025 0.0042 0.0051
Echinococcus granulosus cysteine protease 0.0102 0.0682 0.0821
Plasmodium falciparum thioredoxin reductase 0.0037 0.0149 0.0701
Loa Loa (eye worm) hypothetical protein 0.0073 0.0439 0.0529
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0028 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Plasmodium falciparum serine repeat antigen 5 0.0095 0.0623 0.2939
Trichomonas vaginalis D-aminoacylase, putative 0.0192 0.1429 0.4743
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0095 0.0623 0.2904
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0095 0.0623 0.0749
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0042 0.0199
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Schistosoma mansoni cpg binding protein 0.0034 0.0121 0.0146
Echinococcus granulosus cathepsin l1 0.0268 0.206 0.2478
Echinococcus granulosus glutamate receptor 1 0.0042 0.0188 0.0226
Echinococcus multilocularis snurportin 1 0.0302 0.2338 0.2813
Entamoeba histolytica hypothetical protein 0.0023 0.0028 0.0083
Loa Loa (eye worm) hypothetical protein 0.014 0.0996 0.1198
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0045 0.0151
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0085 0.0102
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.0119 0.0143
Schistosoma mansoni chromobox protein 0.015 0.1084 0.1304
Trypanosoma cruzi major cysteine proteinase, putative 0.0095 0.0623 0.0749
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Brugia malayi TAR-binding protein 0.0067 0.0393 0.0473
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0073 0.0439 0.0529
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0072 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0028 0.0059
Schistosoma mansoni intermediate filament proteins 0.0085 0.0542 0.0652
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0095 0.0623 0.2939
Schistosoma mansoni zinc finger protein 0.0033 0.0112 0.0134
Loa Loa (eye worm) RNA binding protein 0.0067 0.0393 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1444 0.1738
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0073 0.0439 0.1464
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.0919 0.1106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0218 0.1642 0.1975
Echinococcus multilocularis transcription factor Dp 1 0.0126 0.0882 0.1061
Echinococcus granulosus PHD finger protein rhinoceros 0.0061 0.0339 0.0408
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Trichomonas vaginalis D-aminoacylase, putative 0.0192 0.1429 0.4743
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0178 0.0214
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0108 0.0129
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Plasmodium falciparum serine repeat antigen 1 0.0095 0.0623 0.2939
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0623 0.2048
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.011 0.0132
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0339 0.071
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0073 0.0439 0.0529
Brugia malayi cathepsin Z-like cysteine proteinase 0.0095 0.0623 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Brugia malayi M-phase phosphoprotein, mpp8 0.0025 0.0042 0.0051
Echinococcus granulosus glutamate receptor subunit protein glur 0.0051 0.0264 0.0318
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Onchocerca volvulus 0.0271 0.2081 0.5123
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0042 0.0105
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0095 0.0623 0.2939
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Echinococcus granulosus glutamate NMDA receptor subunit 0.0025 0.0046 0.0055
Schistosoma mansoni hypothetical protein 0.069 0.5552 0.668
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Brugia malayi hypothetical protein 0.0505 0.4022 0.484
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0073 0.0439 0.0529
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0393 0.0473
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni lamin 0.0085 0.0542 0.0652
Plasmodium vivax hypothetical protein, conserved 0.0192 0.1429 0.6743
Mycobacterium ulcerans hypothetical protein 0.0192 0.1429 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Echinococcus granulosus importin subunit beta 1 0.0028 0.0072 0.0087
Echinococcus multilocularis zinc finger protein 0.0044 0.0202 0.0243
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0125 0.0151
Plasmodium falciparum phosphodiesterase gamma, putative 0.0073 0.0439 0.2073
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0072 0.0241
Schistosoma mansoni hypothetical protein 0.0033 0.0108 0.0129
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0073 0.0439 0.0529
Onchocerca volvulus 0.0192 0.1429 0.3484
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0524 0.4175 0.5024
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0046 0.0055
Schistosoma mansoni hypothetical protein 0.0033 0.0108 0.0129
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Plasmodium falciparum cysteine proteinase falcipain 3 0.0276 0.2119 1
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Entamoeba histolytica hypothetical protein 0.0025 0.0042 0.0149
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1464
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0102 0.0682 0.0821
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0597 0.4776 0.5747
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Echinococcus multilocularis beta LACTamase domain containing family member 0.0192 0.1429 0.1719
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) cathepsin B 0.0382 0.3001 0.361
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0835 0.2781
Loa Loa (eye worm) hypothetical protein 0.0083 0.0524 0.0631
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0625 0.0895
Plasmodium falciparum importin beta, putative 0.0028 0.0072 0.0342
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.2073
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0623 0.2048
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0045 0.0095
Onchocerca volvulus 0.0025 0.0042 0.000000029675
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0073 0.0439 0.2073
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0025 0.0048 0.0057
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0623 0.0749
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0073 0.0439 0.0529
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0459 0.0552
Echinococcus multilocularis muscleblind protein 1 0.0311 0.2415 0.2905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0102 0.0682 0.2274
Echinococcus multilocularis cathepsin b 0.1024 0.8311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Loa Loa (eye worm) hypothetical protein 0.0042 0.0188 0.0226
Echinococcus multilocularis musashi 0.0085 0.0542 0.0652
Entamoeba histolytica cysteine proteinase, putative 0.0102 0.0682 0.3186
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Loa Loa (eye worm) ctsf protein 0.0276 0.2119 0.255
Schistosoma mansoni chromodomain helicase DNA binding protein 0.003 0.009 0.0108
Echinococcus granulosus peregrin 0.0066 0.0382 0.0459
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0192 0.1429 1
Onchocerca volvulus 0.0028 0.0074 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.2119 0.255
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Echinococcus granulosus cathepsin L 0.0102 0.0682 0.0821
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Entamoeba histolytica cysteine proteinase 1, putative 0.0102 0.0682 0.3186
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.0013
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0072 0.0434 0.0522
Schistosoma mansoni bromodomain containing protein 0.0138 0.0983 0.1183
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0102 0.0682 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0333 0.1077
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0011 0.005
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Giardia lamblia hypothetical protein 0.0073 0.0439 0.09
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0192 0.1429 0.1719
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0066 0.0386 0.0464
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Brugia malayi glutathione reductase 0.0037 0.0149 0.0179
Onchocerca volvulus 0.0085 0.0542 0.1255
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0042 0.0051
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0492 0.0592
Onchocerca volvulus 0.0095 0.0623 0.1459
Toxoplasma gondii thioredoxin reductase 0.0037 0.0149 0.0311
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0095 0.0623 0.2939
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0016 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Trypanosoma cruzi hypothetical protein, conserved 0.0192 0.1429 0.1719
Brugia malayi cathepsin F-like cysteine proteinase 0.0095 0.0623 0.0749
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0625 0.0484
Brugia malayi hypothetical protein 0.0162 0.1177 0.1416
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Loa Loa (eye worm) heterochromatin protein 1 0.015 0.1084 0.1304
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0546 0.0404
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0095 0.0623 0.2939
Brugia malayi Intermediate filament tail domain containing protein 0.0085 0.0542 0.0652
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1024 0.8311 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0218 0.1642 0.1975
Schistosoma mansoni hypothetical protein 0.0075 0.0459 0.0552
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0073 0.0439 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Echinococcus multilocularis chromobox protein 1 0.015 0.1084 0.1304
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Plasmodium vivax unspecified product 0.0102 0.0682 0.322
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.0042 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0095 0.0623 0.2939
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Giardia lamblia Cysteine protease 0.0095 0.0623 0.1285
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0072 0.0241
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0095 0.0623 0.1285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0192 0.1429 0.1299
Echinococcus multilocularis cathepsin L 0.0102 0.0682 0.0821
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0218 0.1642 0.1975
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0393 0.0473
Schistosoma mansoni ATP-binding cassette transporter 0.0025 0.0046 0.0055
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0337 0.0706
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Brugia malayi Bromodomain containing protein 0.0083 0.0523 0.0629
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0073 0.0439 0.1464
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0085 0.0102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0192 0.1429 0.1719
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1444 0.1738
Brugia malayi SET domain containing protein 0.0026 0.0058 0.0069
Loa Loa (eye worm) hypothetical protein 0.007 0.042 0.0505
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Loa Loa (eye worm) hypothetical protein 0.0094 0.0614 0.0739
Onchocerca volvulus Huntingtin homolog 0.014 0.0996 0.2396
Schistosoma mansoni jumonji domain containing protein 0.0158 0.1142 0.1374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Onchocerca volvulus Alhambra homolog 0.0061 0.0339 0.0747
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1444 0.1738
Onchocerca volvulus Cathepsin L homolog 0.0276 0.2119 0.5218
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Entamoeba histolytica cysteine proteinase, putative 0.0276 0.2119 1
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Mycobacterium tuberculosis Conserved protein 0.0192 0.1429 0.1299
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0095 0.0623 0.2939
Echinococcus multilocularis cysteine protease 0.0276 0.2119 0.255
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0016 0.0077
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.0013
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0218 0.1642 0.1975
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0073 0.0439 0.0529
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0011 0.0022
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0039 0.0165 0.0198
Entamoeba histolytica cysteine protease, putative 0.0276 0.2119 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Giardia lamblia Cathepsin B precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0073 0.0439 0.1464
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.0042 0.0051
Brugia malayi Glutamate receptor 1 precursor 0.0067 0.0395 0.0475
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.042 0.0505
Loa Loa (eye worm) glutathione reductase 0.0037 0.0149 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Plasmodium falciparum glutathione reductase 0.0037 0.0149 0.0701
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0028 0.0067 0.0188
Loa Loa (eye worm) cysteine protease 0.0276 0.2119 0.255
Brugia malayi Papain family cysteine protease containing protein 0.0102 0.0682 0.0821
Loa Loa (eye worm) CHromoDomain protein family member 0.003 0.009 0.0108
Echinococcus granulosus muscleblind protein 0.0311 0.2415 0.2905
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0073 0.0439 0.0529
Trichomonas vaginalis chromobox protein, putative 0.015 0.1084 0.3588
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0459 0.0552
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0087
Onchocerca volvulus 0.0276 0.2119 0.5218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Loa Loa (eye worm) hypothetical protein 0.0505 0.4022 0.484
Brugia malayi Cathepsin L-like precursor 0.0268 0.206 0.2478
Giardia lamblia Encystation-specific protease 0.0095 0.0623 0.1285
Trichomonas vaginalis chromobox protein, putative 0.0091 0.0589 0.1935
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0276 0.2119 0.255
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0215 0.0259
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0073 0.0439 0.0529
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Leishmania major hypothetical protein, conserved 0.0033 0.0112 0.0372
Loa Loa (eye worm) hypothetical protein 0.0311 0.2415 0.2905
Entamoeba histolytica cysteine proteinase, putative 0.0276 0.2119 1
Loa Loa (eye worm) hypothetical protein 0.0505 0.4022 0.484
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0108 0.0129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0623 0.2048
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0268 0.206 0.6853
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0524 0.4175 0.5024
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus multilocularis glutamate receptor 4 0.0042 0.0188 0.0226
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Echinococcus multilocularis chromobox protein 1 0.015 0.1084 0.1304
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0108 0.0129
Loa Loa (eye worm) hypothetical protein 0.0042 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0085 0.0542 0.0652
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0129
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) hypothetical protein 0.0039 0.0165 0.0198
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.0255 0.0306
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0011 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0459 0.0552
Loa Loa (eye worm) intermediate filament protein 0.0085 0.0542 0.0652
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.043 0.0518
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.1809 0.2177
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0481 0.0578
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.003 0.009 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Schistosoma mansoni hypothetical protein 0.069 0.5552 0.668
Plasmodium vivax glutathione reductase, putative 0.0037 0.0149 0.0701
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0382 0.3001 1
Trypanosoma cruzi cruzipain precursor, putative 0.0276 0.2119 0.255
Echinococcus granulosus jumonji domain containing protein 0.0084 0.0536 0.0644
Mycobacterium leprae conserved hypothetical protein 0.0192 0.1429 1
Echinococcus multilocularis lamin dm0 0.0085 0.0542 0.0652
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0095 0.0623 0.2939
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0108 0.0129
Mycobacterium leprae Probable lipase LipE 0.0192 0.1429 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0218 0.1642 0.1975
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0095 0.0623 0.2939
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0108 0.0129
Onchocerca volvulus 0.0276 0.2119 0.5218
Loa Loa (eye worm) hypothetical protein 0.0084 0.0536 0.0645
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0597 0.4776 0.5747
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0597 0.4776 0.5747
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Schistosoma mansoni zinc finger protein 0.0044 0.0202 0.0243
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0192 0.1429 0.1719
Toxoplasma gondii cathepsin CPL 0.0276 0.2119 0.4437
Loa Loa (eye worm) hypothetical protein 0.0041 0.0178 0.0214
Plasmodium falciparum phd finger protein, putative 0.0061 0.0339 0.1601
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1464
Brugia malayi fibroinase precursor 0.0095 0.0623 0.0749
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus granulosus cathepsin L 0.0095 0.0623 0.0749
Schistosoma mansoni hypothetical protein 0.0025 0.0042 0.0051
Echinococcus multilocularis peregrin 0.0066 0.0382 0.0459
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0218 0.1642 0.1975
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Brugia malayi Heterochromatin protein 1 0.015 0.1084 0.1304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0194 0.1444 0.1738
Onchocerca volvulus Cathepsin L homolog 0.0095 0.0623 0.1459
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.0536 0.0644
Leishmania major cathepsin L-like protease 0.0276 0.2119 0.7062
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0339 0.1601
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0073 0.0439 0.0529
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0042 0.0051
Brugia malayi Papain family cysteine protease containing protein 0.0276 0.2119 0.255
Echinococcus granulosus lamin dm0 0.0085 0.0542 0.0652
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0091 0.0589 0.1375
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0194 0.1444 0.1738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0095 0.0623 0.0749
Schistosoma mansoni cathepsin C 0.0095 0.0623 0.0749
Echinococcus granulosus cathepsin L cysteine protease 0.0102 0.0682 0.0821
Loa Loa (eye worm) hypothetical protein 0.0276 0.2119 0.255
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0835 0.0696
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.2338 0.2813
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0002 0.0004
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1024 0.8311 1
Brugia malayi PHD-finger family protein 0.0026 0.005 0.006
Echinococcus granulosus cathepsin L cysteine proteinase 0.0276 0.2119 0.255
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0439 0.0529
Onchocerca volvulus 0.0059 0.0329 0.0721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0835 0.1004
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Onchocerca volvulus 0.0192 0.1429 0.3484
Schistosoma mansoni lozenge 0.0063 0.0363 0.0437
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0046 0.0055
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0073 0.0439 0.0529
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.0013
Schistosoma mansoni chromobox protein 0.015 0.1084 0.1304
Brugia malayi hypothetical protein 0.014 0.0996 0.1198
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0143 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0095 0.0623 0.2048
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0276 0.2119 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0072 0.0434 0.0522
Echinococcus granulosus zinc finger protein 0.0044 0.0202 0.0243
Mycobacterium tuberculosis Probable hydrolase 0.0192 0.1429 0.1299
Trypanosoma brucei cysteine peptidase C (CPC) 0.0382 0.3001 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0218 0.1642 0.7736
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0073 0.0439 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0623 0.2048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0276 0.2119 0.7051
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0073 0.0439 0.0529
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0073 0.0439 0.0529
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0276 0.2119 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0073 0.0439 0.2073
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0095 0.0623 0.2939
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0382 0.3001 0.361
Plasmodium vivax vivapain-2 0.0276 0.2119 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.1873 0.2254
Loa Loa (eye worm) runx1 0.0063 0.0363 0.0437
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.0255 0.0306
Brugia malayi Glutamate receptor 2 precursor 0.0067 0.0395 0.0475
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0814 0.6579 0.7915
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0045 0.0214
Leishmania major hypothetical protein, conserved 0.0192 0.1429 0.4761
Entamoeba histolytica hypothetical protein 0.0075 0.0459 0.2126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Brugia malayi Bromodomain containing protein 0.0066 0.0382 0.0459
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0143 0.0172
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Schistosoma mansoni hypothetical protein 0.007 0.042 0.0505
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Brugia malayi intermediate filament protein 0.0085 0.0542 0.0652
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0149
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.003 0.009 0.0108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0025 0.0046 0.0055
Giardia lamblia Cathepsin L-like protease 0.0095 0.0623 0.1285
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0276 0.2119 0.7051
Loa Loa (eye worm) hypothetical protein 0.0061 0.0339 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0025 0.0042 0.0088
Onchocerca volvulus 0.0276 0.2119 0.5218
Entamoeba histolytica hypothetical protein 0.0025 0.0042 0.0149
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0194 0.1444 0.1738
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0095 0.0623 0.1285
Echinococcus multilocularis PHD finger protein rhinoceros 0.0061 0.0339 0.0408
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0835 0.1004
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Schistosoma mansoni cpg binding protein 0.0034 0.0121 0.0146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Trypanosoma cruzi cysteine proteinase, putative 0.0102 0.0682 0.0821
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0536 0.1242
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0276 0.2119 0.255
Entamoeba histolytica cysteine proteinase 2 0.0102 0.0682 0.3186
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0143 0.0172
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0276 0.2119 0.255
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0178 0.0214
Entamoeba histolytica hypothetical protein 0.0025 0.0042 0.0149
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Schistosoma mansoni hypothetical protein 0.0061 0.0339 0.0408
Trypanosoma cruzi cysteine proteinase, putative 0.0102 0.0682 0.0821
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0073 0.0439 0.0529
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Giardia lamblia Cysteine protease 0.0095 0.0623 0.1285
Brugia malayi hypothetical protein 0.0025 0.0045 0.0055
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0276 0.2119 0.7051
Plasmodium falciparum heterochromatin protein 1 0.0025 0.0042 0.0199
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0492 0.0592
Loa Loa (eye worm) hypothetical protein 0.0088 0.0566 0.0682
Echinococcus multilocularis cpg binding protein 0.0034 0.0121 0.0146
Plasmodium falciparum serine repeat antigen 9 0.0095 0.0623 0.2939
Toxoplasma gondii cathepsin B 0.0382 0.3001 0.6283
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0085 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0095 0.0623 0.2048
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Brugia malayi cathepsin B-like cysteine proteinase 0.1024 0.8311 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0439 0.1434
Onchocerca volvulus Cathepsin L homolog 0.0276 0.2119 0.5218
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0268 0.206 0.2478
Brugia malayi jmjC domain containing protein 0.0079 0.0492 0.0592
Onchocerca volvulus 0.0192 0.1429 0.3484
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0329 0.0396
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0524 0.4175 0.5024
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0073 0.0439 0.1464
Echinococcus granulosus lamin 0.0085 0.0542 0.0652
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.2119 0.255
Giardia lamblia Cysteine protease 0.0095 0.0623 0.1285
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0045 0.0055
Brugia malayi beta-lactamase family protein 0.0192 0.1429 0.1719
Echinococcus multilocularis Protein lozenge 0.0063 0.0363 0.0437
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0218 0.1642 0.5471
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0042 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0276 0.2119 0.7062
Trypanosoma cruzi hypothetical protein, conserved 0.0192 0.1429 0.1719
Loa Loa (eye worm) glutamate receptor 2 0.0025 0.0046 0.0055
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0095 0.0623 0.2939
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0835 0.1004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0689 0.0829
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0108 0.0129
Giardia lamblia Hypothetical protein 0.0073 0.0439 0.09
Echinococcus multilocularis chromobox protein 2 0.0025 0.0042 0.0051
Brugia malayi beta-lactamase 0.0192 0.1429 0.1719
Loa Loa (eye worm) jmjC domain-containing protein 0.0125 0.0873 0.105
Giardia lamblia Cathepsin L precursor 0.0095 0.0623 0.1285
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0046 0.0055
Loa Loa (eye worm) hypothetical protein 0.0192 0.1429 0.1719
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0393 0.0473
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0073 0.0439 0.0529
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0125 0.0151
Brugia malayi Cathepsin L-like precursor 0.0276 0.2119 0.255
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1024 0.8311 1
Leishmania major hypothetical protein, conserved 0.0073 0.0439 0.1464
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0339 0.0408
Plasmodium vivax serine-repeat antigen (SERA) 0.0095 0.0623 0.2939
Trypanosoma cruzi cysteine protease, putative 0.0102 0.0682 0.0821
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0393 0.0473
Plasmodium vivax phosphodiesterase gamma, putative 0.0073 0.0439 0.2073
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0546 0.0404
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0339 0.071
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0194 0.1444 0.1738
Echinococcus granulosus transcription factor Dp 1 0.0126 0.0882 0.1061
Trichomonas vaginalis penicillin-binding protein, putative 0.0192 0.1429 0.4743
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Toxoplasma gondii ABC1 family protein 0.0192 0.1429 0.2991
Loa Loa (eye worm) hypothetical protein 0.0026 0.005 0.006
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus multilocularis Chromobox protein 3 0.0025 0.0042 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0276 0.2119 0.255
Entamoeba histolytica cysteine protease, putative 0.0102 0.0682 0.3186
Brugia malayi jmjC domain containing protein 0.0198 0.1479 0.178
Onchocerca volvulus 0.0276 0.2119 0.5218
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0061 0.0339 0.0408
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0028 0.0059
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0073 0.0439 0.0529
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0149 0.0179
Echinococcus granulosus chromobox protein 1 0.015 0.1084 0.1304
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0095 0.0623 0.1285
Trichomonas vaginalis esterase, putative 0.0192 0.1429 0.4743
Plasmodium falciparum serine repeat antigen 3 0.0095 0.0623 0.2939
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0095 0.0623 0.2904
Entamoeba histolytica cysteine protease, putative 0.0095 0.0623 0.2904
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0073 0.0439 0.0529
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0042 0.0105
Loa Loa (eye worm) helicase 0.0025 0.0042 0.0051
Loa Loa (eye worm) PDE1B protein 0.0073 0.0439 0.0529
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0042 0.0105
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0095 0.0284
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0002 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0207 0.0249
Schistosoma mansoni hypothetical protein 0.002 0.0002 0.0002
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0045 0.0214
Onchocerca volvulus 0.0162 0.1177 0.2851
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0481 0.0578
Giardia lamblia Cysteine protease 0.0095 0.0623 0.1285
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0439 0.1434
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0085 0.0102
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0597 0.4776 0.5747
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0623 0.0749
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0051 0.0264 0.0318
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0073 0.0439 0.0529
Onchocerca volvulus 0.0085 0.0542 0.1255
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0276 0.2119 0.255
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0095 0.0623 0.0749
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0382 0.3001 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0073 0.0439 0.0529
Echinococcus granulosus snurportin 1 0.0302 0.2338 0.2813
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0073 0.0439 0.1434
Plasmodium falciparum serine repeat antigen 2 0.0095 0.0623 0.2939
Echinococcus multilocularis cathepsin b 0.1024 0.8311 1
Onchocerca volvulus 0.0268 0.206 0.5069
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0689 0.0829
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0073 0.0439 0.092
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0215 0.0259
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0095 0.0623 0.0749
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0623 0.2048
Brugia malayi hypothetical protein 0.0025 0.0042 0.0051
Onchocerca volvulus 0.0505 0.4022 1
Brugia malayi cathepsin L precursor 0.0095 0.0623 0.0749
Plasmodium falciparum serine repeat antigen 6 0.0095 0.0623 0.2939
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.0919 0.1106
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0085 0.0542 0.0652
Mycobacterium tuberculosis Probable esterase LipL 0.0192 0.1429 0.1299
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1024 0.8311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0095 0.0623 0.2048
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0439 0.1434
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1024 0.8311 1
Plasmodium falciparum serine repeat antigen 4 0.0095 0.0623 0.2939
Mycobacterium tuberculosis Probable lipase LipE 0.0192 0.1429 0.1299
Loa Loa (eye worm) hypothetical protein 0.0103 0.0689 0.0829
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0073 0.0439 0.1434
Leishmania major GTP-binding protein, putative 0.0021 0.0011 0.0035
Entamoeba histolytica hypothetical protein 0.0075 0.0459 0.2126

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) < 17 nM Inhibition of serotonin N-acetyltransferase ChEMBL. 11448230

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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