TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 300.392 | Formula: C19H24O3
H donors: 1 H acceptors: 2 LogP: 4.21 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1C[C@@H]2C(=O)O)C
InChi: 1S/C19H24O3/c1-19-8-7-14-13-6-4-12(22-2)9-11(13)3-5-15(14)16(19)10-17(19)18(20)21/h4,6,9,14-17H,3,5,7-8,10H2,1-2H3,(H,20,21)/t14-,15-,16+,17-,19+/m1/s1
InChiKey: PPXFNZLONONBHR-ILYVXUQDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0238	0.1753	0.1753
Schistosoma mansoni	alpha-glucosidase	0.0138	0.0861	0.0861
Schistosoma mansoni	alpha-glucosidase	0.0138	0.0861	0.0861
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0315	0.0315
Echinococcus granulosus	cathepsin b	0.1162	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1162	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1104	0.9486	1
Onchocerca volvulus		0.1104	0.9486	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1104	0.9486	0.9486
Brugia malayi	Cathepsin L-like precursor	0.073	0.6145	0.6145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Brugia malayi	Papain family cysteine protease containing protein	0.0238	0.1753	0.1753
Loa Loa (eye worm)	hypothetical protein	0.0374	0.2974	0.2974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0238	0.1753	0.1753
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Entamoeba histolytica	cysteine proteinase, putative	0.1104	0.9486	1
Brugia malayi	TAR-binding protein	0.0076	0.0315	0.0315
Entamoeba histolytica	cysteine proteinase, putative	0.1104	0.9486	1
Toxoplasma gondii	cathepsin B	0.0523	0.4304	0.3298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Loa Loa (eye worm)	ctsf protein	0.1104	0.9486	0.9486
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1104	0.9486	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0612	0.5094	0.4051
Entamoeba histolytica	cysteine proteinase, putative	0.073	0.6145	0.5679
Leishmania major	cathepsin L-like protease	0.1104	0.9486	1
Loa Loa (eye worm)	fibroinase	0.1104	0.9486	0.9486
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1753	0.1753
Giardia lamblia	Cathepsin B precursor	0.0523	0.4304	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1104	0.9486	1
Echinococcus granulosus	cathepsin l1	0.073	0.6145	0.6019
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0315	0.0315
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0612	0.5094	0.1525
Trypanosoma cruzi	cysteine peptidase, putative	0.1104	0.9486	0.9377
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0315	0.0315
Echinococcus multilocularis	cathepsin L cysteine protease	0.1104	0.9486	0.9469
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0612	0.5094	0.1525
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Brugia malayi	Cathepsin L-like precursor	0.1104	0.9486	0.9486
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0374	0.2974	0.2974
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0238	0.1753	0.1753
Leishmania major	cathepsin L-like protease	0.1104	0.9486	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0238	0.1753	0.1753
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1162	1	1
Onchocerca volvulus	Cathepsin L homolog	0.1104	0.9486	1
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Trypanosoma cruzi	cysteine peptidase, putative	0.1104	0.9486	0.9377
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0612	0.5094	0.4321
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1162	1	1
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.017	0.017
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Brugia malayi	MH2 domain containing protein	0.0117	0.0678	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1753	0.1753
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1104	0.9486	0.9486
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0238	0.1753	0.1753
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0523	0.4304	0.3093
Echinococcus granulosus	cathepsin l1	0.1104	0.9486	0.9469
Entamoeba histolytica	cysteine proteinase 2	0.0612	0.5094	0.4321
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1104	0.9486	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.073	0.6145	0.5679
Plasmodium vivax	vivapain-2	0.1104	0.9486	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0238	0.1753	0.1753
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0238	0.1753	0.1753
Echinococcus granulosus	cathepsin L	0.0612	0.5094	0.4934
Entamoeba histolytica	cysteine proteinase, putative	0.0612	0.5094	0.4321
Leishmania major	cathepsin L-like protease	0.1104	0.9486	1
Echinococcus granulosus	cathepsin b	0.1162	1	1
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Loa Loa (eye worm)	hypothetical protein	0.1104	0.9486	0.9486
Onchocerca volvulus		0.1104	0.9486	1
Schistosoma mansoni	cathepsin F (C01 family)	0.073	0.6145	0.6145
Echinococcus granulosus	cysteine protease	0.0612	0.5094	0.4934
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Entamoeba histolytica	cysteine proteinase, putative	0.0612	0.5094	0.4321
Brugia malayi	Cathepsin L-like precursor	0.1104	0.9486	0.9486
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1104	0.9486	0.9377
Onchocerca volvulus		0.1104	0.9486	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0374	0.2974	0.2974
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Loa Loa (eye worm)	hypothetical protein	0.0374	0.2974	0.2974
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Loa Loa (eye worm)	hypothetical protein	0.073	0.6145	0.6145
Onchocerca volvulus	Cathepsin F homolog	0.1104	0.9486	1
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0315	0.0315
Giardia lamblia	Cathepsin B precursor	0.0523	0.4304	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1104	0.9486	1
Brugia malayi	cathepsin L-like precursor	0.073	0.6145	0.6145
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0523	0.4304	0.4304
Trypanosoma cruzi	cruzipain precursor, putative	0.1104	0.9486	0.9377
Entamoeba histolytica	cysteine proteinase, putative	0.0612	0.5094	0.4321
Trypanosoma cruzi	cysteine peptidase, putative	0.0612	0.5094	0.4051
Leishmania major	cathepsin L-like protease	0.1104	0.9486	1
Brugia malayi	Cathepsin L-like precursor	0.1104	0.9486	0.9486
Loa Loa (eye worm)	hypothetical protein	0.0374	0.2974	0.2974
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1753	0.1753
Brugia malayi	Cathepsin L-like cysteine proteinase	0.073	0.6145	0.6145
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1104	0.9486	0.9469
Brugia malayi	Papain family cysteine protease containing protein	0.0612	0.5094	0.5094
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.073	0.6145	0.5325
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0612	0.5094	0.4051
Brugia malayi	Glycosyl hydrolases family 31 protein	0.016	0.1059	0.1059
Onchocerca volvulus		0.1104	0.9486	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1104	0.9486	1
Onchocerca volvulus		0.0238	0.1753	0.1434
Trypanosoma cruzi	cruzipain precursor, putative	0.0374	0.2974	0.1481
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0612	0.5094	0.4321
Brugia malayi	RNA binding protein	0.0076	0.0315	0.0315
Onchocerca volvulus		0.073	0.6145	0.6299
Brugia malayi	Papain family cysteine protease containing protein	0.0238	0.1753	0.1753
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0612	0.5094	0.4321
Onchocerca volvulus		0.1104	0.9486	1
Leishmania major	cathepsin L-like protease	0.1104	0.9486	1
Brugia malayi	Cathepsin L-like precursor	0.073	0.6145	0.6145
Loa Loa (eye worm)	hypothetical protein	0.073	0.6145	0.6145
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Schistosoma mansoni	cathepsin s	0.0374	0.2974	0.2974
Echinococcus granulosus	cathepsin L	0.0238	0.1753	0.1484
Trypanosoma cruzi	cysteine proteinase, putative	0.0612	0.5094	0.4051
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0238	0.1753	0.1753
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0238	0.1753	0.1753
Echinococcus multilocularis	cysteine protease	0.1104	0.9486	0.9469
Echinococcus multilocularis	lysosomal alpha glucosidase	0.016	0.1059	0.0768
Echinococcus multilocularis	lysosomal alpha glucosidase	0.016	0.1059	0.0768
Schistosoma mansoni	cathepsin B (C01 family)	0.0238	0.1753	0.1753
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0238	0.1753	0.1753
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1104	0.9486	1
Brugia malayi	Papain family cysteine protease containing protein	0.0238	0.1753	0.1753
Leishmania major	cathepsin L-like protease	0.1104	0.9486	1
Brugia malayi	Cathepsin L-like precursor	0.1104	0.9486	0.9486
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1104	0.9486	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0612	0.5094	0.4321
Giardia lamblia	Cathepsin B precursor	0.0523	0.4304	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0238	0.1753	0.1753
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.073	0.6145	0.5679
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0612	0.5094	0.5094
Plasmodium vivax	unspecified product	0.0374	0.2974	0.1579
Trypanosoma cruzi	cysteine protease, putative	0.0612	0.5094	0.4051
Brugia malayi	Cathepsin L-like precursor	0.1104	0.9486	0.9486
Leishmania major	cathepsin L-like protease	0.1104	0.9486	1
Leishmania major	cysteine peptidase A (CPA)	0.1104	0.9486	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0238	0.1753	0.1753
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1104	0.9486	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0238	0.1753	0.1753
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0238	0.1753	0.1753
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0238	0.1753	0.1753
Onchocerca volvulus	Cathepsin L homolog	0.0238	0.1753	0.1434
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1753	0.1753
Loa Loa (eye worm)	hypothetical protein	0.1162	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0523	0.4304	0.3298
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.017	0.017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Brugia malayi	Cathepsin L-like precursor	0.0374	0.2974	0.2974
Echinococcus multilocularis	cathepsin b	0.1162	1	1
Plasmodium vivax	vivapain-2	0.1104	0.9486	1
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1753	0.1753
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0612	0.5094	0.5094
Echinococcus granulosus	lysosomal alpha glucosidase	0.016	0.1059	0.0768
Trypanosoma cruzi	cysteine peptidase, putative	0.1104	0.9486	0.9377
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Loa Loa (eye worm)	hypothetical protein	0.073	0.6145	0.6145
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0678	0.0678
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Onchocerca volvulus		0.1104	0.9486	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0374	0.2974	0.1481
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1104	0.9486	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0238	0.1753	0.1753
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1162	1	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.016	0.1059	0.1059
Onchocerca volvulus	Cathepsin L homolog	0.1104	0.9486	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1104	0.9486	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1162	1	1
Schistosoma mansoni	cathepsin C	0.0238	0.1753	0.1753
Plasmodium vivax	vivapain-1	0.0612	0.5094	0.4321
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1104	0.9486	0.9486
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Echinococcus multilocularis	cysteine protease	0.1104	0.9486	0.9469
Plasmodium vivax	vivapain-3	0.0612	0.5094	0.4321
Echinococcus multilocularis	cathepsin L	0.0238	0.1753	0.1484
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Entamoeba histolytica	cysteine proteinase, putative	0.0612	0.5094	0.4321
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1753	0.1753
Loa Loa (eye worm)	cathepsin B	0.0523	0.4304	0.4304
Echinococcus granulosus	cathepsin L cysteine protease	0.0612	0.5094	0.4934
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1104	0.9486	0.9469
Loa Loa (eye worm)	hypothetical protein	0.006	0.017	0.017
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0238	0.1753	0.1753
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Entamoeba histolytica	cysteine protease, putative	0.0612	0.5094	0.4321
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1104	0.9486	1
Entamoeba histolytica	cysteine protease, putative	0.1104	0.9486	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1104	0.9486	0.9469
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1104	0.9486	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Plasmodium vivax	unspecified product	0.0612	0.5094	0.4321
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0789	0.667	0.6562
Echinococcus multilocularis	cathepsin b	0.1162	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1104	0.9486	0.9469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Brugia malayi	cathepsin L precursor	0.0238	0.1753	0.1753
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1104	0.9486	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0374	0.2974	0.2974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1104	0.9486	1
Echinococcus multilocularis	cathepsin L	0.0612	0.5094	0.4934
Brugia malayi	Papain family cysteine protease containing protein	0.1104	0.9486	0.9486
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.017	0.017
Brugia malayi	Cathepsin L-like precursor	0.1104	0.9486	0.9486
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1104	0.9486	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0315	0.0315
Echinococcus multilocularis	cathepsin L cysteine protease	0.1104	0.9486	0.9469
Onchocerca volvulus		0.1104	0.9486	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0238	0.1753	0.1753
Brugia malayi	Papain family cysteine protease containing protein	0.0612	0.5094	0.5094
Leishmania major	cathepsin L-like protease	0.1104	0.9486	1
Brugia malayi	fibroinase precursor	0.0238	0.1753	0.1753
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1104	0.9486	0.9486
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0678	0.0678
Loa Loa (eye worm)	cysteine protease	0.1104	0.9486	0.9486
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0612	0.5094	0.5094
Toxoplasma gondii	cathepsin CPL	0.1104	0.9486	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Saccharomyces cerevisiae	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1474406

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1359200