Detailed information for compound 1359333

Basic information

Technical information
  • TDR Targets ID: 1359333
  • Name: N-(2-methyl-1,3-benzothiazol-6-yl)-2-(2-methy lphenoxy)acetamide
  • MW: 312.386 | Formula: C17H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)sc(n2)C)COc1ccccc1C
  • InChi: 1S/C17H16N2O2S/c1-11-5-3-4-6-15(11)21-10-17(20)19-13-7-8-14-16(9-13)22-12(2)18-14/h3-9H,10H2,1-2H3,(H,19,20)
  • InChiKey: BMJKAEIBCFDRQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-methyl-1,3-benzothiazol-6-yl)-2-(2-methylphenoxy)ethanamide
  • MLS001007699
  • SMR000384832
  • T5238381
  • ZINC02644117

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0306 0.1829 0.1829
Entamoeba histolytica cysteine proteinase, putative 0.0817 0.5239 0.4173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Echinococcus granulosus cathepsin l1 0.153 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1829 0.1826
Brugia malayi cathepsin B-like cysteine proteinase 0.098 0.6327 0.6326
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Brugia malayi cathepsin Z-like cysteine proteinase 0.0306 0.1829 0.1826
Leishmania major cathepsin L-like protease 0.153 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0817 0.5239 0.4173
Entamoeba histolytica cysteine proteinase 2 0.0817 0.5239 0.4173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1019 0.659 0.5827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Plasmodium vivax vivapain-1 0.0817 0.5239 0.4173
Echinococcus granulosus cathepsin b 0.098 0.6327 0.6326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1019 0.659 0.5827
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0817 0.5239 0.2978
Onchocerca volvulus 0.1019 0.659 0.6589
Onchocerca volvulus 0.153 1 1
Brugia malayi Cathepsin L-like precursor 0.153 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Schistosoma mansoni cathepsin s 0.0511 0.3196 0.3194
Plasmodium vivax unspecified product 0.0511 0.3196 0.1673
Echinococcus multilocularis cathepsin b 0.098 0.6327 0.6326
Onchocerca volvulus 0.153 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0514 0.322 0.1703
Onchocerca volvulus Cathepsin L homolog 0.153 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0514 0.322 0.1703
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.098 0.6327 0.6326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0817 0.5239 0.2978
Trypanosoma cruzi cysteine proteinase, putative 0.0817 0.5239 0.4173
Loa Loa (eye worm) hypothetical protein 0.098 0.6327 0.6327
Giardia lamblia Cathepsin B precursor 0.0514 0.322 1
Brugia malayi Papain family cysteine protease containing protein 0.0306 0.1829 0.1826
Brugia malayi Cathepsin L-like precursor 0.153 1 1
Leishmania major cathepsin L-like protease 0.153 1 1
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Loa Loa (eye worm) ctsf protein 0.153 1 1
Plasmodium vivax unspecified product 0.0817 0.5239 0.4173
Echinococcus granulosus cathepsin b 0.098 0.6327 0.6326
Schistosoma mansoni cathepsin C 0.0306 0.1829 0.1826
Loa Loa (eye worm) hypothetical protein 0.0306 0.1829 0.1829
Entamoeba histolytica cysteine proteinase, putative 0.153 1 1
Onchocerca volvulus 0.153 1 1
Onchocerca volvulus Cathepsin L homolog 0.0306 0.1829 0.1826
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5351 0.5349
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0004 0.0004
Echinococcus multilocularis cathepsin b 0.098 0.6327 0.6326
Trypanosoma cruzi cysteine peptidase, putative 0.0511 0.3196 0.1673
Trypanosoma cruzi cysteine protease, putative 0.0817 0.5239 0.4173
Leishmania major cathepsin L-like protease 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.1019 0.659 0.659
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.098 0.6327 0.6326
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.098 0.6327 0.5505
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0297 0.0293
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0297 0.0293
Loa Loa (eye worm) hypothetical protein 0.0306 0.1829 0.1829
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0004 0.0004
Plasmodium vivax vivapain-2 0.153 1 1
Toxoplasma gondii cathepsin CPL 0.153 1 1
Leishmania major cysteine peptidase A (CPA) 0.153 1 1
Onchocerca volvulus 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1019 0.659 0.5827
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.153 1 1
Brugia malayi TAR-binding protein 0.0076 0.0297 0.0293
Giardia lamblia Cathepsin B precursor 0.0514 0.322 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.153 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1829 0.1826
Entamoeba histolytica cysteine proteinase, putative 0.0817 0.5239 0.4173
Brugia malayi cathepsin L-like cysteine proteinase 0.0306 0.1829 0.1826
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.153 1 1
Loa Loa (eye worm) cysteine protease 0.153 1 1
Entamoeba histolytica cysteine proteinase, putative 0.153 1 1
Giardia lamblia Cathepsin B precursor 0.0514 0.322 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.153 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Echinococcus granulosus cysteine protease 0.0817 0.5239 0.5237
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.098 0.6327 0.6326
Leishmania major cathepsin L-like protease 0.153 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0514 0.322 0.3218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.1829 0.1829
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0297 0.0297
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Brugia malayi cathepsin L-like precursor 0.1019 0.659 0.6589
Brugia malayi Papain family cysteine protease containing protein 0.0817 0.5239 0.5237
Trypanosoma cruzi cruzipain precursor, putative 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0004
Echinococcus granulosus cathepsin l1 0.1019 0.659 0.6589
Echinococcus multilocularis cysteine protease 0.153 1 1
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Echinococcus multilocularis cathepsin l cysteine peptidase 0.153 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.1019 0.659 0.6589
Brugia malayi Papain family cysteine protease containing protein 0.153 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1829 0.1826
Onchocerca volvulus 0.0306 0.1829 0.1826
Leishmania major cathepsin L-like protease 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.0511 0.3196 0.3196
Loa Loa (eye worm) hypothetical protein 0.1019 0.659 0.659
Plasmodium vivax vivapain-2 0.153 1 1
Echinococcus granulosus cathepsin L 0.0817 0.5239 0.5237
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0297 0.0293
Echinococcus granulosus cathepsin L cysteine protease 0.0817 0.5239 0.5237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0817 0.5239 0.5237
Loa Loa (eye worm) RNA binding protein 0.0076 0.0297 0.0297
Brugia malayi Papain family cysteine protease containing protein 0.0306 0.1829 0.1826
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Echinococcus multilocularis cysteine protease 0.153 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0306 0.1829 0.1826
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1019 0.659 0.5827
Leishmania major cathepsin L-like protease 0.153 1 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0297 0.0293
Loa Loa (eye worm) hypothetical protein 0.0306 0.1829 0.1829
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Echinococcus multilocularis cathepsin L cysteine protease 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.153 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0306 0.1829 0.1829
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Onchocerca volvulus Cathepsin F homolog 0.153 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0817 0.5239 0.5237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0817 0.5239 0.4173
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0306 0.1829 0.1826
Trypanosoma cruzi cysteine peptidase, putative 0.153 1 1
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Echinococcus multilocularis cathepsin L 0.0817 0.5239 0.5237
Onchocerca volvulus 0.153 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0306 0.1829 0.1826
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.153 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.153 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Entamoeba histolytica cysteine protease, putative 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Brugia malayi Cathepsin L-like precursor 0.1019 0.659 0.6589
Brugia malayi Papain family cysteine protease containing protein 0.0817 0.5239 0.5237
Schistosoma mansoni cathepsin F (C01 family) 0.1019 0.659 0.6589
Schistosoma mansoni cathepsin F (C01 family) 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0306 0.1829 0.1826
Trypanosoma cruzi cysteine peptidase, putative 0.153 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.153 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0817 0.5239 0.4173
Loa Loa (eye worm) hypothetical protein 0.0511 0.3196 0.3196
Loa Loa (eye worm) hypothetical protein 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Brugia malayi Cathepsin L-like precursor 0.1019 0.659 0.6589
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.153 1 1
Brugia malayi cathepsin L precursor 0.0306 0.1829 0.1826
Trypanosoma cruzi cysteine peptidase, putative 0.153 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0817 0.5239 0.5237
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0511 0.3196 0.3194
Leishmania major cathepsin L-like protease 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.153 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0817 0.5239 0.4173
Echinococcus multilocularis cathepsin L cysteine protease 0.153 1 1
Brugia malayi Cathepsin L-like precursor 0.153 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0297 0.0297
Brugia malayi RNA binding protein 0.0076 0.0297 0.0293
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0511 0.3196 0.3196
Schistosoma mansoni cathepsin S (C01 family) 0.0306 0.1829 0.1826
Echinococcus multilocularis cathepsin l cysteine peptidase 0.153 1 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0306 0.1829 0.1826
Echinococcus granulosus cathepsin L 0.0306 0.1829 0.1826
Plasmodium falciparum cysteine proteinase falcipain 1 0.0817 0.5239 0.4173
Echinococcus granulosus tar DNA binding protein 0.0076 0.0297 0.0293
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1829 0.1826
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0297 0.0293
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0306 0.1829 0.1826
Onchocerca volvulus 0.153 1 1
Brugia malayi fibroinase precursor 0.0306 0.1829 0.1826
Echinococcus granulosus cathepsin L cysteine proteinase 0.153 1 1
Entamoeba histolytica cysteine protease, putative 0.0817 0.5239 0.4173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.1019 0.659 0.659
Brugia malayi Cathepsin L-like precursor 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.153 1 1
Toxoplasma gondii cathepsin B 0.0514 0.322 0.1703
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5351 0.5349
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0306 0.1829 0.1829
Echinococcus granulosus cathepsin l cysteine peptidase 0.153 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0817 0.5239 0.4173
Trypanosoma cruzi cruzipain precursor, putative 0.0511 0.3196 0.1673
Plasmodium vivax vivapain-3 0.0817 0.5239 0.4173
Onchocerca volvulus 0.153 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.153 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0306 0.1829 0.1826
Brugia malayi cathepsin F-like cysteine proteinase 0.0306 0.1829 0.1826
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0306 0.1829 0.1829
Brugia malayi cathepsin Z-like cysteine proteinase 0.0306 0.1829 0.1826
Echinococcus multilocularis cathepsin L 0.0306 0.1829 0.1826
Plasmodium falciparum cysteine proteinase falcipain 3 0.153 1 1
Loa Loa (eye worm) hypothetical protein 0.0306 0.1829 0.1829
Brugia malayi Cathepsin L-like precursor 0.153 1 1
Loa Loa (eye worm) cathepsin B 0.0514 0.322 0.322
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5351 0.5349
Onchocerca volvulus Cathepsin L homolog 0.153 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0511 0.3196 0.3194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.153 1 1
Loa Loa (eye worm) fibroinase 0.153 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0817 0.5239 0.4173
Brugia malayi Cathepsin L-like precursor 0.0511 0.3196 0.3194
Brugia malayi Papain family cysteine protease containing protein 0.0306 0.1829 0.1826
Leishmania major cathepsin L-like protease 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.098 0.6327 0.6326
Entamoeba histolytica cysteine proteinase, putative 0.0817 0.5239 0.4173
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0297 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0817 0.5239 0.4173
Loa Loa (eye worm) hypothetical protein 0.0511 0.3196 0.3196
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0297 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.153 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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