Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0187 | 0.2552 | 0.5 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0187 | 0.2552 | 0.5 |
Echinococcus granulosus | protein kinase | 0.0447 | 0.6889 | 0.6915 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0189 | 0.259 | 0.259 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.2552 | 0.2562 |
Schistosoma mansoni | protein kinase | 0.0189 | 0.259 | 0.259 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.9962 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0189 | 0.259 | 0.376 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0189 | 0.259 | 0.26 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0189 | 0.259 | 0.26 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1841 | 0.1841 |
Schistosoma mansoni | vam6/vps39 related | 0.0187 | 0.2552 | 0.2552 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1841 | 0.1848 |
Onchocerca volvulus | 0.0187 | 0.2552 | 1 | |
Schistosoma mansoni | rap gtpase-activating protein | 0.0187 | 0.2552 | 0.2552 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.0187 | 0.2552 | 0.2562 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0189 | 0.259 | 0.376 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.0189 | 0.259 | 0.26 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.2552 | 0.2562 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.0187 | 0.2552 | 0.2552 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0189 | 0.259 | 0.376 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0189 | 0.259 | 0.259 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.0187 | 0.2552 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.2552 | 0.2562 |
Brugia malayi | Protein kinase domain containing protein | 0.0189 | 0.259 | 0.259 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.0187 | 0.2552 | 0.3705 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0189 | 0.259 | 0.26 |
Schistosoma mansoni | protein kinase | 0.0447 | 0.6889 | 0.6889 |
Brugia malayi | hypothetical protein | 0.0187 | 0.2552 | 0.2552 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.0447 | 0.6889 | 0.6915 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0187 | 0.2552 | 0.2552 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.0187 | 0.2552 | 0.2552 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.0632 | 0.9962 | 1 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.0187 | 0.2552 | 0.5 |
Echinococcus multilocularis | 0.0447 | 0.6889 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0187 | 0.2552 | 0.2552 |
Schistosoma mansoni | protein kinase | 0.0634 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1841 | 0.1848 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.