TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.486 | Formula: C24H24N6O3
H donors: 1 H acceptors: 6 LogP: 3.01 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Cn1nnc2c1nc(nc2O)C1CCCN(C1)C(=O)c1ccccc1
InChi: 1S/C24H24N6O3/c1-33-19-11-9-16(10-12-19)14-30-22-20(27-28-30)23(31)26-21(25-22)18-8-5-13-29(15-18)24(32)17-6-3-2-4-7-17/h2-4,6-7,9-12,18H,5,8,13-15H2,1H3,(H,25,26,31)
InChiKey: QETAKCIILWAFLQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	No references
Homo sapiens	hydroxyprostaglandin dehydrogenase 15-(NAD)	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxyprostaglandin dehydrogenase 15-(NAD)	266 aa	216 aa	22.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	hypothetical protein	0.0255	0.6067	0.5918
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0066	0.1197	0.1425
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.2059	0.2761
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0261	0.6203	1
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.2515	1
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.01	0.2059	0.2902
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.2515	0.3969
Trichomonas vaginalis	cyclins, putative	0.0034	0.0365	0.0453
Echinococcus multilocularis	dual specificity	0.0117	0.2515	0.2232
Onchocerca volvulus		0.006	0.1028	1
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0117	0.2515	0.3683
Echinococcus multilocularis	dual specificity	0.0117	0.2515	0.2232
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0066	0.1197	0.1425
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0261	0.6203	0.954
Echinococcus multilocularis	cyclin dependent kinase 5 activator 1	0.0272	0.6502	0.637
Echinococcus granulosus	cyclin dependent kinase 5 activator 1	0.0272	0.6502	0.637
Entamoeba histolytica	protein kinase, putative	0.01	0.2059	0.7879
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.1966	0.2608
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.1028	0.1081
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0261	0.6203	1
Brugia malayi	cell division control protein 2 homolog	0.0096	0.1966	0.2742
Brugia malayi	Protein kinase domain containing protein	0.0261	0.6203	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0365	0.0561
Trichomonas vaginalis	cyclins, putative	0.0034	0.0365	0.0453
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0096	0.1966	0.3023
Entamoeba histolytica	protein kinase domain containing protein	0.01	0.2059	0.7879
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0066	0.1197	0.1425
Loa Loa (eye worm)	hypothetical protein	0.0272	0.6502	1
Echinococcus granulosus	cyclin dependent kinase 1	0.0096	0.1966	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1923	0.2957
Leishmania major	protein kinase, putative	0.0261	0.6203	1
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0096	0.1966	0.2742
Trypanosoma brucei	cdc2-related kinase 1	0.0096	0.1966	0.2742
Echinococcus multilocularis	cyclin dependent kinase 9	0.0061	0.1071	0.0733
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0066	0.1197	0.1425
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.2515	0.3969
Trichomonas vaginalis	CMGC family protein kinase	0.0096	0.1966	0.307
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0066	0.1197	0.1425
Trichomonas vaginalis	CMGC family protein kinase	0.0096	0.1966	0.307
Trypanosoma cruzi	cdc2-related kinase 1	0.0096	0.1966	0.2742
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.1966	0.2608
Echinococcus granulosus	cyclin dependent kinase 5	0.0096	0.1966	0.1661
Echinococcus granulosus	dual specificity	0.0117	0.2515	0.2232
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0066	0.1197	0.1425
Giardia lamblia	Kinase, CMGC CDK	0.0096	0.1966	0.2742
Giardia lamblia	Kinase, CMGC MAPK	0.0066	0.1197	0.1425
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0117	0.2515	0.3683
Trichomonas vaginalis	CMGC family protein kinase	0.0261	0.6203	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0096	0.1966	0.1661
Brugia malayi	hypothetical protein	0.013	0.2847	0.4251
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.01	0.2059	0.2902
Loa Loa (eye worm)	hypothetical protein	0.006	0.1028	0.1581
Entamoeba histolytica	hypothetical protein	0.01	0.2059	0.7879
Loa Loa (eye worm)	hypothetical protein	0.013	0.2847	0.4378
Echinococcus multilocularis	mitogen activated protein kinase	0.0066	0.1197	0.0864
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0117	0.2515	0.3683
Echinococcus granulosus	mitogen activated protein kinase	0.0066	0.1197	0.0864
Echinococcus granulosus	mitogen activated protein kinase 3	0.0066	0.1197	0.0864
Brugia malayi	Protein kinase domain containing protein	0.01	0.2059	0.2902
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1923	0.2957
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0365	0.0561
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0117	0.2515	0.3683
Trypanosoma cruzi	cdc2-related kinase 1	0.0096	0.1966	0.2742
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0066	0.1197	0.1841
Echinococcus granulosus	cyclin dependent kinase 9	0.0061	0.1071	0.0733
Trichomonas vaginalis	cyclin A, putative	0.0034	0.0365	0.0453
Trichomonas vaginalis	CMGC family protein kinase	0.0066	0.1197	0.1813
Trichomonas vaginalis	CMGC family protein kinase	0.0066	0.1197	0.1813
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0096	0.1966	0.1535
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0096	0.1966	0.3023
Brugia malayi	cyclin-dependent kinase 9	0.0053	0.0856	0.0841
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0261	0.6203	1
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0096	0.1966	0.3023
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0066	0.1197	0.0864
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0053	0.0856	0.1316
Trichomonas vaginalis	cyclins, putative	0.0034	0.0365	0.0453
Trichomonas vaginalis	CMGC family protein kinase	0.0096	0.1966	0.307
Entamoeba histolytica	protein kinase, putative	0.01	0.2059	0.7879
Echinococcus multilocularis	cyclin dependent kinase	0.0096	0.1966	0.1661
Echinococcus granulosus	cyclin dependent kinase	0.0096	0.1966	0.1661
Entamoeba histolytica	cell division protein kinase 2, putative	0.0096	0.1966	0.7444
Trichomonas vaginalis	CMGC family protein kinase	0.0066	0.1197	0.1813
Leishmania major	protein kinase, putative	0.0261	0.6203	1
Trichomonas vaginalis	cyclin B, putative	0.0034	0.0365	0.0453
Echinococcus granulosus	cyclin dependent kinase 9	0.0053	0.0856	0.0509
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0261	0.6203	1
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.2515	0.3969
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0261	0.6203	1
Brugia malayi	MAP kinase sur-1	0.0066	0.1197	0.1425
Echinococcus multilocularis	cyclin dependent kinase 1	0.0096	0.1966	0.1661
Entamoeba histolytica	protein kinase, putative	0.0117	0.2515	1
Trichomonas vaginalis	cyclin B, putative	0.0034	0.0365	0.0453
Plasmodium vivax	serine/threonine kinase-1, putative	0.0261	0.6203	1
Schistosoma mansoni	kinase	0.0053	0.0856	0.08
Echinococcus multilocularis	dual specificity	0.0117	0.2515	0.2232
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0856	0.08
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0096	0.1966	0.2742
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.2515	0.3969
Giardia lamblia	Kinase, CMGC CDK	0.0096	0.1966	0.2742
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.2515	0.3969
Trichomonas vaginalis	CMGC family protein kinase	0.0066	0.1197	0.1813
Trypanosoma cruzi	cdc2-related kinase 3	0.0096	0.1966	0.2742
Echinococcus multilocularis		0.0255	0.6067	0.5918
Schistosoma mansoni	cyclin-dependent kinase 5 activator	0.0272	0.6502	1
Echinococcus multilocularis	cyclin dependent kinase 5	0.0096	0.1966	0.1661
Echinococcus multilocularis	tumor protein p63	0.0408	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.1197	0.1356
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0117	0.2515	0.3868
Echinococcus granulosus	dual specificity	0.0117	0.2515	0.2232
Entamoeba histolytica	cell division protein kinase 2, putative	0.0104	0.2181	0.8446
Echinococcus multilocularis	cyclin dependent kinase 9	0.0053	0.0856	0.0509
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.01	0.2059	0.2902
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0261	0.6203	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0096	0.1966	0.2742
Echinococcus granulosus	dual specificity	0.01	0.2059	0.1759
Echinococcus multilocularis	dual specificity	0.01	0.2059	0.1759
Trichomonas vaginalis	cyclin B, putative	0.0034	0.0365	0.0453
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0.0856	0.2283
Echinococcus multilocularis	cyclin dependent kinase 1	0.0096	0.1966	0.1661
Loa Loa (eye worm)	hypothetical protein	0.013	0.2847	0.4378
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0261	0.6203	1
Schistosoma mansoni	serine/threonine protein kinase	0.0261	0.6203	0.9513
Echinococcus granulosus	dual specificity	0.0117	0.2515	0.2232
Loa Loa (eye worm)	hypothetical protein	0.0091	0.1829	0.2813
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.01	0.2059	0.3167
Loa Loa (eye worm)	hypothetical protein	0.0255	0.6067	0.933
Trichomonas vaginalis	cyclin B, putative	0.0034	0.0365	0.0453
Schistosoma mansoni	serine/threonine protein kinase	0.0261	0.6203	0.9513
Giardia lamblia	Kinase, CMGC CLK	0.0261	0.6203	1
Trypanosoma brucei	cdc2-related kinase 3	0.0096	0.1966	0.2742
Plasmodium falciparum	protein serine/threonine kinase-1	0.0261	0.6203	1
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0261	0.6203	0.606
Giardia lamblia	Kinase, CMGC DYRK	0.0117	0.2515	0.3683
Brugia malayi	Protein kinase domain containing protein	0.0096	0.1966	0.2742
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.01	0.2059	0.2902
Trichomonas vaginalis	cyclins, putative	0.0034	0.0365	0.0453
Schistosoma mansoni	serine/threonine protein kinase	0.0117	0.2515	0.3504
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0117	0.2515	0.2633
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.2515	0.3969
Echinococcus granulosus	dual specificity protein kinase clk2	0.0261	0.6203	0.606
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0066	0.1197	0.1425
Trypanosoma brucei	protein kinase, putative	0.0075	0.1412	0.1794

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.1 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1495730

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1366189