Detailed information for compound 1370669

Basic information

Technical information
  • TDR Targets ID: 1370669
  • Name: 4-(4-butan-2-ylphenyl)-1-sulfanylidene-2H-[1, 2,4]triazolo[4,3-a]quinazolin-5-one
  • MW: 350.437 | Formula: C19H18N4OS
  • H donors: 0 H acceptors: 3 LogP: 4.22 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(c1ccc(cc1)n1c(=O)c2ccccc2n2c1nnc2S)C
  • InChi: 1S/C19H18N4OS/c1-3-12(2)13-8-10-14(11-9-13)22-17(24)15-6-4-5-7-16(15)23-18(22)20-21-19(23)25/h4-12H,3H2,1-2H3,(H,21,25)
  • InChiKey: VYKRXNSTDHIOKN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-sec-butylphenyl)-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0101 0.1309 0.1309
Plasmodium vivax plasmepsin IV, putative 0.0054 0.0493 0.3314
Schistosoma mansoni cathepsin F (C01 family) 0.0101 0.1309 0.1309
Echinococcus granulosus calpain 5 0.0087 0.1063 0.0963
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0089
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0682 0.0682
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.023 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0152 0.0178
Entamoeba histolytica hypothetical protein 0.0035 0.0152 0.1044
Onchocerca volvulus 0.0101 0.1309 0.1416
Loa Loa (eye worm) hypothetical protein 0.0058 0.055 0.055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0243 0.0134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0152
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0152 0.0474
Onchocerca volvulus 0.0101 0.1309 0.1416
Schistosoma mansoni cathepsin F (C01 family) 0.0101 0.1309 0.1309
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0035 0.0152 0.1163
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0152 0.0178
Entamoeba histolytica cysteine protease, putative 0.0101 0.1309 0.8974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0087 0.1063 0.1063
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Echinococcus granulosus calpain 0.0087 0.1063 0.0963
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0101 0.1309 0.1527
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0035 0.0152 0.0136
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0365 0.0258
Giardia lamblia Hypothetical protein 0.0035 0.0152 0.0136
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0035 0.0152 0.1044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Giardia lamblia Cathepsin L precursor 0.0035 0.0152 0.0136
Plasmodium vivax serine-repeat antigen (SERA) 0.0035 0.0152 0.052
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0152
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0035 0.0152 0.0152
Brugia malayi calpain family protein 1 0.0231 0.3572 0.3572
Brugia malayi cathepsin L-like precursor 0.007 0.0764 0.0764
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.1459 0.1459
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0037 0.0037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.011 0.1459 0.1459
Leishmania major cathepsin L-like protease 0.0101 0.1309 0.4094
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0682 0.0682
Brugia malayi cathepsin Z-like cysteine proteinase 0.0035 0.0152 0.0152
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0152 0.0042
Plasmodium falciparum plasmepsin II 0.0054 0.0493 0.3767
Echinococcus multilocularis cathepsin b 0.0598 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Plasmodium falciparum serine repeat antigen 4 0.0035 0.0152 0.1163
Entamoeba histolytica cysteine proteinase 1, putative 0.0066 0.0698 0.4784
Schistosoma mansoni Mername-AA248 (C02 family) 0.0087 0.1063 0.1063
Plasmodium falciparum phd finger protein, putative 0.0032 0.011 0.0843
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.023 0.023
Entamoeba histolytica cysteine protease, putative 0.0035 0.0152 0.1044
Leishmania major cathepsin L-like protease 0.0101 0.1309 0.4094
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0152 0.0474
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0209 0.3198 0.3729
Entamoeba histolytica cysteine protease, putative 0.0035 0.0152 0.1044
Giardia lamblia Encystation-specific protease 0.0035 0.0152 0.0136
Plasmodium vivax vivapain-1 0.0066 0.0698 0.4991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Giardia lamblia Cathepsin B precursor 0.0035 0.0152 0.0136
Brugia malayi PHD-finger family protein 0.0032 0.011 0.011
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0035 0.0152 0.1044
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0087 0.1063 0.1063
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0101 0.1309 0.1212
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0066 0.0698 0.0698
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0682 0.2131
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0035 0.0152 0.052
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0035 0.0152 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0035 0.0152 0.0178
Leishmania major cathepsin L-like protease 0.0101 0.1309 0.4094
Onchocerca volvulus 0.0101 0.1309 0.1416
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0209 0.3198 0.3198
Onchocerca volvulus 0.0101 0.1309 0.1416
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0698 0.0698
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0152
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0241 0.3754 0.3754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.1309 0.1527
Loa Loa (eye worm) calpain 0.0087 0.1063 0.1063
Brugia malayi Cathepsin L-like precursor 0.0031 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0101 0.1309 0.1527
Trypanosoma cruzi kinesin, putative 0.0061 0.0606 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Trypanosoma cruzi cysteine protease, putative 0.0066 0.0698 0.0698
Leishmania major cathepsin L-like protease 0.0101 0.1309 0.4094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Loa Loa (eye worm) ctsf protein 0.0101 0.1309 0.1309
Echinococcus multilocularis calpain 0.0087 0.1063 0.0963
Loa Loa (eye worm) hypothetical protein 0.007 0.0764 0.0764
Brugia malayi Pre-SET motif family protein 0.0454 0.748 0.748
Plasmodium falciparum cysteine proteinase falcipain 1 0.0066 0.0698 0.5331
Brugia malayi Cathepsin L-like precursor 0.0101 0.1309 0.1309
Echinococcus granulosus cathepsin b 0.0598 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Entamoeba histolytica hypothetical protein 0.004 0.0243 0.1667
Loa Loa (eye worm) hypothetical protein 0.0598 1 1
Plasmodium vivax unspecified product 0.0035 0.0152 0.052
Trypanosoma cruzi cysteine proteinase, putative 0.0066 0.0698 0.0698
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0089
Onchocerca volvulus 0.0101 0.1309 0.1416
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0054 0.0493 0.0387
Onchocerca volvulus 0.0517 0.8576 1
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0698 0.4784
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.011 0.011
Entamoeba histolytica calpain large subunit domain III containing protein 0.0061 0.0606 0.4154
Leishmania major cathepsin L-like protease 0.0101 0.1309 0.4094
Loa Loa (eye worm) hypothetical protein 0.017 0.2509 0.2509
Echinococcus granulosus cathepsin l cysteine peptidase 0.0101 0.1309 0.1212
Plasmodium vivax aspartyl proteinase, putative 0.0054 0.0493 0.3314
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0087 0.1063 0.3323
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.1401 0.1305
Loa Loa (eye worm) cathepsin B 0.0209 0.3198 0.3198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0152 0.0178
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.2281 0.2195
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0698 0.4784
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0152 0.0178
Giardia lamblia Cathepsin L precursor 0.0035 0.0152 0.0136
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0087 0.1063 0.1063
Loa Loa (eye worm) cysteine protease 0.0101 0.1309 0.1309
Giardia lamblia Cathepsin B precursor 0.0035 0.0152 0.0136
Schistosoma mansoni hypothetical protein 0.0045 0.0336 0.0336
Schistosoma mansoni cathepsin D (A01 family) 0.016 0.2344 0.2344
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0035 0.0152 0.052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.023 0.023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Brugia malayi cathepsin F-like cysteine proteinase 0.0031 0.0089 0.0089
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0037 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Echinococcus granulosus cathepsin b 0.0598 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Loa Loa (eye worm) calpain 5 0.0061 0.0606 0.0606
Plasmodium vivax vivapain-3 0.0066 0.0698 0.4991
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0152 0.0474
Giardia lamblia Cathepsin B precursor 0.0209 0.3198 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0241 0.3754 0.3684
Brugia malayi cathepsin L precursor 0.0035 0.0152 0.0152
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0365 0.0258
Echinococcus granulosus cathepsin L 0.0035 0.0152 0.0042
Giardia lamblia Cysteine protease 0.0035 0.0152 0.0136
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0241 0.3754 0.3754
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0333 0.0225
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Loa Loa (eye worm) calpain family protein 1 0.0231 0.3572 0.3572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Schistosoma mansoni hypothetical protein 0.0045 0.0336 0.0336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.1309 0.1527
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0066 0.0698 0.0698
Brugia malayi Cathepsin L-like precursor 0.007 0.0764 0.0764
Plasmodium falciparum serine repeat antigen 3 0.0035 0.0152 0.1163
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0598 1 1
Plasmodium falciparum plasmepsin I 0.0054 0.0493 0.3767
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0035 0.0152 0.052
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0209 0.3198 0.3198
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0682 0.0682
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.064 0.0535
Schistosoma mansoni hypothetical protein 0.004 0.0243 0.0243
Plasmodium falciparum serine repeat antigen 5 0.0035 0.0152 0.1163
Onchocerca volvulus 0.007 0.0764 0.0772
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0035 0.0152 0.0136
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0598 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0031 0.0089 0.0089
Schistosoma mansoni patched 1 0.0047 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0047 0.0365 0.0365
Trypanosoma brucei calpain-like protein, putative 0.0087 0.1063 0.3323
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.1459 0.1363
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0365 0.0258
Loa Loa (eye worm) hypothetical protein 0.0054 0.0493 0.0493
Giardia lamblia Cathepsin B precursor 0.0035 0.0152 0.0136
Giardia lamblia Cathepsin B precursor 0.0035 0.0152 0.0136
Trypanosoma brucei cysteine peptidase C (CPC) 0.0209 0.3198 1
Brugia malayi fibroinase precursor 0.0035 0.0152 0.0152
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0054 0.0493 0.0387
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.1459 1
Plasmodium falciparum serine repeat antigen 9 0.0035 0.0152 0.1163
Trichomonas vaginalis set domain proteins, putative 0.0517 0.8576 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.1401 0.1305
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0698 0.4784
Brugia malayi hypothetical protein 0.004 0.0243 0.0243
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0035 0.0152 0.0152
Giardia lamblia Cathepsin L precursor 0.0035 0.0152 0.0136
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0035 0.0152 0.0152
Onchocerca volvulus 0.0035 0.0152 0.0049
Schistosoma mansoni hypothetical protein 0.0032 0.011 0.011
Leishmania major kinesin, putative 0.0061 0.0606 0.1895
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0152 0.0178
Trypanosoma cruzi kinesin, putative 0.0061 0.0606 0.0606
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.1309 0.1527
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0087 0.1063 0.3323
Loa Loa (eye worm) hypothetical protein 0.0065 0.0682 0.0682
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0698 0.2182
Onchocerca volvulus 0.0101 0.1309 0.1416
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0598 1 1
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.1309 0.1527
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0035 0.0152 0.0152
Trypanosoma brucei kinesin, putative 0.0061 0.0606 0.1895
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0031 0.0089 0.0089
Plasmodium falciparum plasmepsin VI 0.0054 0.0493 0.3767
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0152 0.0178
Plasmodium vivax calpain, putative 0.0087 0.1063 0.7981
Echinococcus multilocularis cathepsin L 0.0066 0.0698 0.0594
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0035 0.0152 0.0136
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0087 0.1063 0.3323
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Plasmodium vivax SET domain protein, putative 0.0065 0.0682 0.4857
Echinococcus multilocularis cathepsin L 0.0035 0.0152 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.1309 0.1527
Plasmodium falciparum serine repeat antigen 2 0.0035 0.0152 0.1163
Toxoplasma gondii cathepsin CPC1 0.0035 0.0152 0.0476
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0035 0.0152 0.052
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0066 0.0698 0.0698
Plasmodium vivax importin-beta 2, putative 0.0035 0.0152 0.0515
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0209 0.3198 1
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Echinococcus granulosus cathepsin L cysteine protease 0.0066 0.0698 0.0594
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.007 0.0764 0.0764
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Leishmania major cathepsin L-like protease 0.0101 0.1309 0.4094
Echinococcus granulosus calpain A 0.0087 0.1063 0.0963
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0035 0.0152 0.052
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0054 0.0493 0.1542
Onchocerca volvulus Cathepsin L homolog 0.0101 0.1309 0.1416
Plasmodium falciparum serine repeat antigen 7 0.0035 0.0152 0.1163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0152 0.0178
Echinococcus granulosus snurportin 1 0.0372 0.6039 0.5995
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Schistosoma mansoni calpain-7 (C02 family) 0.0087 0.1063 0.1063
Plasmodium vivax serine-repeat antigen (SERA) 0.0035 0.0152 0.052
Brugia malayi calpain 5 0.0061 0.0606 0.0606
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0087 0.1063 0.3323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.1309 0.8974
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0035 0.0152 0.052
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.1309 0.1309
Toxoplasma gondii cathepsin CPL 0.0101 0.1309 0.4094
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0087 0.1063 0.1063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.023 0.0121
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.011 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0035 0.0152 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0698 0.2182
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Giardia lamblia Cysteine protease 0.0035 0.0152 0.0136
Trypanosoma cruzi major cysteine proteinase, putative 0.0035 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.1309 0.1527
Echinococcus granulosus calpain A 0.0241 0.3754 0.3684
Loa Loa (eye worm) hypothetical protein 0.0101 0.1309 0.1309
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0087 0.1063 0.1063
Loa Loa (eye worm) hypothetical protein 0.007 0.0764 0.0764
Plasmodium falciparum cysteine proteinase falcipain 3 0.0101 0.1309 1
Plasmodium falciparum plasmepsin IV 0.0054 0.0493 0.3767
Onchocerca volvulus Cathepsin L homolog 0.0101 0.1309 0.1416
Echinococcus granulosus calpain 7 C02 family 0.0087 0.1063 0.0963
Brugia malayi Cathepsin L-like precursor 0.0101 0.1309 0.1309
Loa Loa (eye worm) hypothetical protein 0.0144 0.2052 0.2052
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0101 0.1309 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0152 0.0042
Onchocerca volvulus 0.0065 0.0682 0.0675
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0152
Echinococcus granulosus cathepsin l1 0.0101 0.1309 0.1212
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0035 0.0152 0.0178
Echinococcus multilocularis protein dispatched 1 0.0054 0.0481 0.0375
Schistosoma mansoni calpain (C02 family) 0.0087 0.1063 0.1063
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0231 0.3572 0.3572
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0101 0.1309 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0152 0.0178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.1309 0.1527
Brugia malayi Cathepsin L-like precursor 0.0101 0.1309 0.1309
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0152 0.0178
Plasmodium vivax vivapain-2 0.0101 0.1309 1
Entamoeba histolytica hypothetical protein 0.004 0.0243 0.1667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0152 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Brugia malayi Bromodomain containing protein 0.0032 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0045 0.0336 0.0336
Schistosoma mansoni cathepsin D (A01 family) 0.016 0.2344 0.2344
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.1309 0.8974
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0682 0.0577
Leishmania major cathepsin L-like protease 0.0101 0.1309 0.4094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0152 0.0152
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0087 0.1063 0.1063
Echinococcus multilocularis cysteine protease 0.0101 0.1309 0.1212
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0682 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0698 0.0814
Echinococcus multilocularis cathepsin L cysteine protease 0.0101 0.1309 0.1212
Brugia malayi CHE-14 protein 0.0047 0.0365 0.0365
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0333 0.0225
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0054 0.0493 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0365 0.0426
Echinococcus multilocularis cathepsin L cysteine protease 0.0101 0.1309 0.1212
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0152 0.0152
Plasmodium falciparum serine repeat antigen 6 0.0035 0.0152 0.1163
Echinococcus granulosus cathepsin L cysteine proteinase 0.0101 0.1309 0.1212
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0101 0.1309 0.1309
Schistosoma mansoni cathepsin B (C01 family) 0.0035 0.0152 0.0152
Echinococcus granulosus cysteine protease 0.0066 0.0698 0.0594
Plasmodium vivax unspecified product 0.0066 0.0698 0.4991
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0035 0.0152 0.0152
Echinococcus multilocularis cathepsin b 0.0598 1 1
Entamoeba histolytica cysteine proteinase 2 0.0066 0.0698 0.4784
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.0089 0.0089
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.011 0.011
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0035 0.0152 0.0136
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0087 0.1063 0.1063
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.1309 0.1527
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0037 0.0043
Echinococcus granulosus cathepsin L 0.0066 0.0698 0.0594
Onchocerca volvulus 0.0101 0.1309 0.1416
Brugia malayi Importin beta-1 subunit 0.0035 0.0152 0.0152
Plasmodium falciparum importin beta, putative 0.0035 0.0152 0.1158
Giardia lamblia Hypothetical protein 0.0035 0.0152 0.0136
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0152 0.0049
Entamoeba histolytica hypothetical protein 0.004 0.0243 0.1667
Trypanosoma cruzi cruzipain precursor, putative 0.0101 0.1309 0.1309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0066 0.0698 0.0814
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0243 0.0134
Plasmodium falciparum serine repeat antigen 1 0.0035 0.0152 0.1163
Giardia lamblia Cathepsin L-like protease 0.0035 0.0152 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0598 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0035 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0056 0.0516 0.0516
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0682 0.0682
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0066 0.0698 0.0698
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0698 0.0698
Echinococcus multilocularis calpain 5 0.0087 0.1063 0.0963
Schistosoma mansoni jumonji domain containing protein 0.0084 0.1019 0.1019
Entamoeba histolytica hypothetical protein 0.004 0.0243 0.1667
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0243 0.0243
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0087 0.1063 0.1063
Entamoeba histolytica cysteine proteinase, putative 0.0066 0.0698 0.4784
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.2281 0.2195
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0152 0.0152
Loa Loa (eye worm) calpain family protein 1 0.017 0.2509 0.2509
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0241 0.3754 0.3684
Schistosoma mansoni cathepsin S (C01 family) 0.0035 0.0152 0.0152
Giardia lamblia Cathepsin L-like protease 0.0035 0.0152 0.0136
Brugia malayi calpain family protein 1 0.0231 0.3572 0.3572
Entamoeba histolytica cysteine protease, putative 0.0035 0.0152 0.1044
Echinococcus multilocularis hypothetical protein 0.0087 0.1063 0.0963
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0035 0.0152 0.0178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0682 0.0577
Brugia malayi calpain 7 0.0087 0.1063 0.1063
Echinococcus multilocularis calpain family protein 1, d 0.017 0.2509 0.2425
Leishmania major cysteine peptidase A (CPA) 0.0101 0.1309 0.4094
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0035 0.0152 0.1163
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0035 0.0152 0.1163
Toxoplasma gondii preprocathepsin c precursor, putative 0.0035 0.0152 0.0476
Trypanosoma brucei calpain-like protein, putative 0.0087 0.1063 0.3323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0204 0.3115 0.3115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Brugia malayi jmjC domain containing protein 0.0106 0.1401 0.1401
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0054 0.0493 0.0493
Giardia lamblia Cathepsin L precursor 0.0035 0.0152 0.0136
Entamoeba histolytica cysteine protease, putative 0.0035 0.0152 0.1044
Giardia lamblia Cathepsin L precursor 0.0035 0.0152 0.0136
Brugia malayi cathepsin F-like cysteine proteinase 0.0035 0.0152 0.0152
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0035 0.0152 0.052
Schistosoma mansoni hypothetical protein 0.0372 0.6039 0.6039
Echinococcus multilocularis snurportin 1 0.0372 0.6039 0.5995
Trypanosoma cruzi cysteine proteinase, putative 0.0066 0.0698 0.0698
Schistosoma mansoni hypothetical protein 0.0045 0.0336 0.0336
Brugia malayi Cathepsin L-like precursor 0.0101 0.1309 0.1309
Trypanosoma brucei calpain-like protein, putative 0.0087 0.1063 0.3323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0101 0.1309 0.1527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0764 0.089
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0152 0.0152
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.1488 0.1488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.1309 0.1527
Entamoeba histolytica protein kinase, putative 0.0061 0.0606 0.4154
Plasmodium vivax hypothetical protein, conserved 0.0032 0.011 0.0178
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0152
Toxoplasma gondii aspartyl protease ASP1 0.0054 0.0493 0.1542
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.1309 0.1309
Trypanosoma cruzi major cysteine proteinase, putative 0.0035 0.0152 0.0152
Schistosoma mansoni calpain-7 (C02 family) 0.0087 0.1063 0.1063
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0054 0.0493 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0152 0.0178
Echinococcus multilocularis protein patched 0.0047 0.0365 0.0258
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0035 0.0152 0.052
Loa Loa (eye worm) hypothetical protein 0.0032 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0152
Schistosoma mansoni calpain C (C02 family) 0.0087 0.1063 0.1063
Schistosoma mansoni cathepsin F (C01 family) 0.007 0.0764 0.0764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0152 0.0178
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.1309 0.1309
Giardia lamblia Cathepsin L precursor 0.0035 0.0152 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.1309 0.1309
Entamoeba histolytica hypothetical protein 0.0028 0.0037 0.0251
Echinococcus multilocularis expressed conserved protein 0.0103 0.1343 0.1246
Trypanosoma brucei antigen, putative 0.0087 0.1063 0.3323
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0035 0.0152 0.0152
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0087 0.1063 0.1063
Loa Loa (eye worm) fibroinase 0.0101 0.1309 0.1309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.1459 0.1363
Leishmania major importin beta-1 subunit, putative 0.0028 0.0037 0.0114
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0714 0.0714
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.011 0.0345
Schistosoma mansoni cathepsin s 0.0031 0.0089 0.0089
Echinococcus granulosus cathepsin l1 0.007 0.0764 0.066
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0598 1 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.3572 0.3572
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0152 0.0152
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0035 0.0152 0.052
Trypanosoma brucei calpain-like protein, putative 0.0087 0.1063 0.3323
Brugia malayi Pre-SET motif family protein 0.0065 0.0682 0.0682
Onchocerca volvulus Cathepsin F homolog 0.0101 0.1309 0.1416
Plasmodium falciparum serine repeat antigen 8 0.0035 0.0152 0.1163
Schistosoma mansoni cathepsin C 0.0035 0.0152 0.0152
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.023 0.023
Toxoplasma gondii cathepsin CPC2 0.0035 0.0152 0.0476
Giardia lamblia Cysteine protease 0.0035 0.0152 0.0136
Echinococcus multilocularis cysteine protease 0.0101 0.1309 0.1212
Giardia lamblia Cathepsin B precursor 0.0209 0.3198 1
Schistosoma mansoni importin beta-1 0.0035 0.0152 0.0152
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0365 0.0365
Brugia malayi RNA, U transporter 1 0.0099 0.1274 0.1274
Onchocerca volvulus 0.0144 0.2052 0.2294
Entamoeba histolytica cysteine protease, putative 0.0066 0.0698 0.4784
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0101 0.1309 0.1212
Toxoplasma gondii cathepsin B 0.0209 0.3198 1
Giardia lamblia Cathepsin B precursor 0.0035 0.0152 0.0136
Brugia malayi Cathepsin L-like precursor 0.0101 0.1309 0.1309
Giardia lamblia Cysteine protease 0.0035 0.0152 0.0136
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0035 0.0152 0.0152
Brugia malayi cathepsin Z-like cysteine proteinase 0.0035 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.007 0.0764 0.089
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0087 0.1063 0.3323
Entamoeba histolytica cysteine protease, putative 0.0035 0.0152 0.1044
Echinococcus multilocularis calpain 7 (C02 family) 0.0087 0.1063 0.0963
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0101 0.1309 0.1309
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0031 0.0089 0.0089
Brugia malayi Cathepsin L-like cysteine proteinase 0.007 0.0764 0.0764
Brugia malayi cathepsin L-like cysteine proteinase 0.0035 0.0152 0.0152
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.1309 0.1309
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.6039 0.6039
Brugia malayi Papain family cysteine protease containing protein 0.0066 0.0698 0.0698
Echinococcus multilocularis calpain A 0.0241 0.3754 0.3684
Brugia malayi jmjC domain containing protein 0.0039 0.023 0.023
Entamoeba histolytica cysteine proteinase, putative 0.007 0.0764 0.5234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0152 0.0178
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0087 0.1063 0.1063
Entamoeba histolytica cysteine protease, putative 0.0035 0.0152 0.1044
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0454 0.748 0.748
Giardia lamblia Cathepsin B precursor 0.0209 0.3198 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.1309 0.4094
Leishmania major cathepsin L-like protease 0.0101 0.1309 0.4094
Loa Loa (eye worm) hypothetical protein 0.0035 0.0152 0.0152
Echinococcus granulosus expressed conserved protein 0.0103 0.1343 0.1246
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0037 0.0043
Brugia malayi Cathepsin L-like precursor 0.007 0.0764 0.0764
Plasmodium vivax vivapain-2 0.0101 0.1309 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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