TDR Targets

Basic information

Technical information

TDR Targets ID: 1374262
Name: N-(furan-2-ylmethyl)-3-[3-(2-methylphenyl)-1, 2,4-oxadiazol-5-yl]propanamide
MW: 311.335 | Formula: C17H17N3O3
H donors: 1 H acceptors: 3 LogP: 2.31 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NCc1ccco1)CCc1onc(n1)c1ccccc1C
InChi: 1S/C17H17N3O3/c1-12-5-2-3-7-14(12)17-19-16(23-20-17)9-8-15(21)18-11-13-6-4-10-22-13/h2-7,10H,8-9,11H2,1H3,(H,18,21)
InChiKey: RGHSWQSXVKVRCM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-furylmethyl)-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]propanamide
N-(2-furylmethyl)-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]propionamide
ZINC02390645
MLS000763066
N-Furan-2-ylmethyl-3-(3-o-tolyl-[1,2,4]oxadiazol-5-yl)-propionamide
SMR000438296

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0066	0.3586	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0076	1	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0066	0.3586	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Mycobacterium ulcerans	short-chain dehydrogenase	0.0066	0.3586	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0066	0.3586	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.3586	0.5
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0066	0.3586	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0066	0.3586	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.3586	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Leishmania major	short chain dehydrogenase, putative	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0066	0.3586	0.5
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Mycobacterium ulcerans	dehydrogenase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0066	0.3586	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Leishmania major	quinonoid dihydropteridine reductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0076	1	1
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0066	0.3586	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Mycobacterium ulcerans	oxidoreductase	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Entamoeba histolytica	hypothetical protein, conserved	0.0066	0.3586	0.5
Echinococcus granulosus	tar DNA binding protein	0.0076	1	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0066	0.3586	0.5
Leishmania major	hypothetical protein, conserved	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Onchocerca volvulus		0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0066	0.3586	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Onchocerca volvulus		0.0066	0.3586	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Toxoplasma gondii	oxidoreductase, putative	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0066	0.3586	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Onchocerca volvulus		0.0066	0.3586	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0066	0.3586	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0066	0.3586	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Onchocerca volvulus		0.0066	0.3586	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0066	0.3586	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Mycobacterium ulcerans	short-chain dehydrogenase	0.0066	0.3586	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0066	0.3586	0.5
Brugia malayi	hypothetical protein	0.0066	0.3586	0.3586
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0066	0.3586	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0066	0.3586	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Onchocerca volvulus		0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.3586	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0066	0.3586	0.3586
Leishmania major	short chain dehydrogenase-like protein	0.0066	0.3586	0.5
Onchocerca volvulus		0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0066	0.3586	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0066	0.3586	0.5
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0066	0.3586	0.3586
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0066	0.3586	0.5
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0066	0.3586	0.5
Leishmania major	hypothetical protein, conserved	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0066	0.3586	0.3586
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0066	0.3586	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0066	0.3586	0.5
Onchocerca volvulus		0.0066	0.3586	0.5
Loa Loa (eye worm)	oxidoreductase	0.0066	0.3586	0.3586
Loa Loa (eye worm)	oxidoreductase	0.0066	0.3586	0.3586
Loa Loa (eye worm)	TAR-binding protein	0.0076	1	1
Leishmania major	quinonoid dihydropteridine reductase	0.0066	0.3586	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0066	0.3586	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0066	0.3586	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0066	0.3586	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0066	0.3586	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0066	0.3586	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0066	0.3586	0.5
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0066	0.3586	0.5
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0066	0.3586	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Leishmania major	oxidoreductase-like protein	0.0066	0.3586	0.5
Leishmania major	hypothetical protein, conserved	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Brugia malayi	dehydrogenases, short chain protein 2	0.0066	0.3586	0.3586
Giardia lamblia	Short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0066	0.3586	0.5
Loa Loa (eye worm)	dehydrogenase	0.0066	0.3586	0.3586
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0066	0.3586	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0066	0.3586	0.5
Brugia malayi	dehydrogenases, short chain protein 9	0.0066	0.3586	0.3586
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0066	0.3586	0.5
Plasmodium falciparum	steroid dehydrogenase, putative	0.0066	0.3586	0.5
Brugia malayi	hypothetical protein	0.0066	0.3586	0.3586
Toxoplasma gondii	carbonyl reductase 1, putative	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase	0.0066	0.3586	0.3586
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Giardia lamblia	Hypothetical protein	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Loa Loa (eye worm)	oxidoreductase	0.0066	0.3586	0.3586
Onchocerca volvulus		0.0066	0.3586	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0066	0.3586	0.3586
Mycobacterium tuberculosis	Possible oxidoreductase	0.0066	0.3586	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Leishmania major	hypothetical protein, conserved	0.0066	0.3586	0.5
Loa Loa (eye worm)	oxidoreductase	0.0066	0.3586	0.3586
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Mycobacterium ulcerans	oxidoreductase	0.0066	0.3586	0.5
Onchocerca volvulus		0.0066	0.3586	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Brugia malayi	Retinol dehydrogenase 12	0.0066	0.3586	0.3586
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Leishmania major	quinonoid dihydropteridine reductase	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0066	0.3586	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0066	0.3586	0.5
Loa Loa (eye worm)	oxidoreductase	0.0066	0.3586	0.3586
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0066	0.3586	0.5
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0066	0.3586	0.5
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0066	0.3586	0.3586
Trypanosoma brucei	oxidoreductase-like protein	0.0066	0.3586	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0066	0.3586	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.3586	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0066	0.3586	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Giardia lamblia	Reductase, putative	0.0066	0.3586	0.5
Loa Loa (eye worm)	oxidoreductase	0.0066	0.3586	0.3586
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0066	0.3586	0.5
Brugia malayi	Dehydrogenases, short chain protein 2	0.0066	0.3586	0.3586
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0066	0.3586	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.3586	0.5
Onchocerca volvulus		0.0066	0.3586	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0066	0.3586	0.5
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3586	0.3586
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Onchocerca volvulus		0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Loa Loa (eye worm)	oxidoreductase	0.0066	0.3586	0.3586
Entamoeba histolytica	hypothetical protein	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0066	0.3586	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0066	0.3586	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Loa Loa (eye worm)	RNA binding protein	0.0076	1	1
Leishmania major	pteridine reductase 1	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Onchocerca volvulus	Sepiapterin reductase homolog	0.0066	0.3586	0.5
Loa Loa (eye worm)	oxidoreductase	0.0066	0.3586	0.3586
Leishmania major	quinonoid dihydropteridine reductase	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0066	0.3586	0.5
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0066	0.3586	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0066	0.3586	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0066	0.3586	0.5
Loa Loa (eye worm)	oxidoreductase	0.0066	0.3586	0.3586
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0066	0.3586	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0066	0.3586	0.5
Onchocerca volvulus		0.0066	0.3586	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0066	0.3586	0.5
Leishmania major	hypothetical protein, conserved	0.0066	0.3586	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0066	0.3586	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0066	0.3586	0.3586
Loa Loa (eye worm)	dehydrogenase	0.0066	0.3586	0.3586
Leishmania major	short chain dehydrogenase, putative	0.0066	0.3586	0.5
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0066	0.3586	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0066	0.3586	0.5
Brugia malayi	TAR-binding protein	0.0076	1	1
Entamoeba histolytica	short chain dehydrogenase family protein	0.0066	0.3586	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0066	0.3586	0.5
Onchocerca volvulus		0.0066	0.3586	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0066	0.3586	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0066	0.3586	0.5
Leishmania major	dehydrogenase-like protein	0.0066	0.3586	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1506171

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1374262