Detailed information for compound 1375687

Basic information

Technical information
  • TDR Targets ID: 1375687
  • Name: 5-[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfo nylpyrimidin-2-amine
  • MW: 347.435 | Formula: C16H21N5O2S
  • H donors: 1 H acceptors: 4 LogP: 1.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)N1CCN(CC1)S(=O)(=O)c1cnc(nc1)N)C
  • InChi: 1S/C16H21N5O2S/c1-12-3-4-13(2)15(9-12)20-5-7-21(8-6-20)24(22,23)14-10-18-16(17)19-11-14/h3-4,9-11H,5-8H2,1-2H3,(H2,17,18,19)
  • InChiKey: AQYMIVUMNGFIBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[4-(2,5-dimethylphenyl)-1-piperazinyl]sulfonyl]-2-pyrimidinamine
  • [5-[4-(2,5-dimethylphenyl)piperazin-1-yl]sulfonylpyrimidin-2-yl]amine
  • G830-0871
  • NCGC00134796-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cruzipain precursor, putative 0.0055 0.095 0.095
Loa Loa (eye worm) calpain family protein 1 0.0084 0.2026 0.2026
Onchocerca volvulus 0.0055 0.095 0.4962
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0098 0.103
Plasmodium vivax aspartyl proteinase, putative 0.0051 0.0785 0.8065
Echinococcus granulosus calpain 0.0043 0.0486 0.0392
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1741 0.1741
Leishmania major cathepsin L-like protease 0.0055 0.095 0.3442
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0486 0.1763
Loa Loa (eye worm) hypothetical protein 0.0055 0.095 0.095
Giardia lamblia Cathepsin B precursor 0.0104 0.2759 0.5
Leishmania major cathepsin L-like protease 0.0055 0.095 0.3442
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Brugia malayi calpain 7 0.0043 0.0486 0.0486
Giardia lamblia Cathepsin B precursor 0.0104 0.2759 0.5
Loa Loa (eye worm) hypothetical protein 0.0296 1 1
Loa Loa (eye worm) fibroinase 0.0055 0.095 0.095
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0486 0.0486
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0486 0.1763
Leishmania major cathepsin L-like protease 0.0055 0.095 0.3442
Loa Loa (eye worm) ctsf protein 0.0055 0.095 0.095
Echinococcus multilocularis cathepsin b 0.0296 1 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0104 0.2759 1
Plasmodium vivax vivapain-2 0.0055 0.095 1
Schistosoma mansoni calpain-7 (C02 family) 0.0043 0.0486 0.0392
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0051 0.0785 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Brugia malayi Cathepsin L-like precursor 0.004 0.0369 0.0369
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0486 0.1763
Brugia malayi Cathepsin L-like precursor 0.0055 0.095 0.095
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1741 0.166
Echinococcus multilocularis calpain A 0.0119 0.3351 0.3286
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0119 0.3351 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0486 0.0486
Entamoeba histolytica cysteine proteinase 2 0.0033 0.0098 0.103
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0486 0.0486
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.095 0.086
Brugia malayi cathepsin L-like precursor 0.004 0.0369 0.0369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.095 0.3201
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.095 0.086
Loa Loa (eye worm) cysteine protease 0.0055 0.095 0.095
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0369 0.3884
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0486 0.1763
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Echinococcus granulosus calpain A 0.0043 0.0486 0.0392
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0104 0.2759 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.004 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.004 0.0369 0.0369
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0098 0.0098
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0098 0.0098
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0119 0.3351 0.3286
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0369 0.1018
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0055 0.095 1
Brugia malayi calpain family protein 1 0.0114 0.3157 0.3157
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0098 0.0098
Loa Loa (eye worm) cathepsin B 0.0104 0.2759 0.2759
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0119 0.3351 0.3286
Echinococcus granulosus calpain A 0.0119 0.3351 0.3286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0098 0.0355
Schistosoma mansoni calpain (C02 family) 0.0043 0.0486 0.0392
Onchocerca volvulus 0.0055 0.095 0.4962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Echinococcus granulosus cathepsin l1 0.004 0.0369 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1741 0.166
Plasmodium vivax calpain, putative 0.0043 0.0486 0.456
Brugia malayi TAR-binding protein 0.0076 0.1741 0.1741
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0296 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.095 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1741 0.166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.095 0.3201
Brugia malayi calpain family protein 1 0.0114 0.3157 0.3157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1741 0.166
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0486 0.0486
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.095 1
Onchocerca volvulus 0.0055 0.095 0.4962
Loa Loa (eye worm) hypothetical protein 0.0051 0.0785 0.0785
Trypanosoma brucei calpain-like protein, putative 0.0043 0.0486 0.1763
Loa Loa (eye worm) hypothetical protein 0.004 0.0369 0.0369
Plasmodium falciparum cysteine proteinase falcipain 3 0.0055 0.095 1
Brugia malayi Cathepsin L-like precursor 0.0055 0.095 0.095
Echinococcus multilocularis calpain 0.0043 0.0486 0.0392
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0486 0.1763
Echinococcus multilocularis cysteine protease 0.0055 0.095 0.086
Echinococcus multilocularis calpain family protein 1, d 0.0084 0.2026 0.1947
Loa Loa (eye worm) hypothetical protein 0.0071 0.1539 0.1539
Echinococcus multilocularis cysteine protease 0.0055 0.095 0.086
Schistosoma mansoni cathepsin D (A01 family) 0.015 0.4519 0.4464
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Brugia malayi Cathepsin L-like precursor 0.0055 0.095 0.095
Entamoeba histolytica cysteine protease, putative 0.0055 0.095 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.004 0.0369 0.0369
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0098 0.0098
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1741 0.1741
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.095 0.3201
Echinococcus granulosus cathepsin b 0.0296 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0369 0.1018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0055 0.095 0.3201
Giardia lamblia Cathepsin B precursor 0.0104 0.2759 0.5
Plasmodium vivax plasmepsin IV, putative 0.0051 0.0785 0.8065
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0296 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0369 0.0369
Onchocerca volvulus Cathepsin L homolog 0.0055 0.095 0.4962
Plasmodium falciparum plasmepsin I 0.0051 0.0785 0.8065
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Plasmodium falciparum plasmepsin VI 0.0051 0.0785 0.8065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0296 1 1
Brugia malayi Cathepsin L-like precursor 0.004 0.0369 0.0369
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0486 0.0486
Echinococcus multilocularis cathepsin L cysteine protease 0.0055 0.095 0.086
Echinococcus multilocularis hypothetical protein 0.0043 0.0486 0.0392
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0119 0.3351 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.095 0.095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0098 0.0355
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0098 0.103
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.095 0.086
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0296 1 1
Plasmodium vivax vivapain-2 0.0055 0.095 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0098 0.103
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0055 0.095 0.086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.095 0.095
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Trypanosoma brucei cysteine peptidase C (CPC) 0.0104 0.2759 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.095 0.3201
Loa Loa (eye worm) calpain family protein 1 0.0114 0.3157 0.3157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0051 0.0785 0.0694
Trypanosoma brucei antigen, putative 0.0043 0.0486 0.1763
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.095 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Loa Loa (eye worm) hypothetical protein 0.0101 0.2671 0.2671
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0114 0.3157 0.3089
Loa Loa (eye worm) calpain 0.0043 0.0486 0.0486
Entamoeba histolytica cysteine proteinase, putative 0.0055 0.095 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1741 0.1741
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1741 0.166
Entamoeba histolytica cysteine proteinase 1, putative 0.0033 0.0098 0.103
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0486 0.0486
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0043 0.0486 0.0486
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0104 0.2759 0.2688
Onchocerca volvulus Cathepsin L homolog 0.0055 0.095 0.4962
Schistosoma mansoni cathepsin F (C01 family) 0.0055 0.095 0.086
Onchocerca volvulus 0.0055 0.095 0.4962
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0055 0.095 0.095
Echinococcus granulosus cathepsin b 0.0296 1 1
Echinococcus multilocularis cathepsin b 0.0296 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0098 0.0098
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0098 0.0098
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Schistosoma mansoni Mername-AA248 (C02 family) 0.0043 0.0486 0.0392
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0055 0.095 1
Schistosoma mansoni calpain C (C02 family) 0.0043 0.0486 0.0392
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0043 0.0486 0.1763
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Schistosoma mansoni cathepsin D (A01 family) 0.015 0.4519 0.4464
Brugia malayi RNA binding protein 0.0076 0.1741 0.1741
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0055 0.095 0.095
Echinococcus granulosus tar DNA binding protein 0.0076 0.1741 0.166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Echinococcus granulosus calpain 7 C02 family 0.0043 0.0486 0.0392
Toxoplasma gondii cathepsin CPL 0.0055 0.095 0.0835
Brugia malayi Cathepsin L-like precursor 0.0055 0.095 0.095
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0486 0.0486
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Schistosoma mansoni calpain-7 (C02 family) 0.0043 0.0486 0.0392
Loa Loa (eye worm) RNA binding protein 0.0076 0.1741 0.1741
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.095 0.3201
Leishmania major cathepsin L-like protease 0.0055 0.095 0.3442
Brugia malayi Papain family cysteine protease containing protein 0.0055 0.095 0.095
Echinococcus granulosus cathepsin l1 0.0055 0.095 0.086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.095 0.3201
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0486 0.1763
Onchocerca volvulus 0.0055 0.095 0.4962
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.095 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Echinococcus multilocularis calpain 7 (C02 family) 0.0043 0.0486 0.0392
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0098 0.103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0055 0.095 0.3442
Leishmania major cathepsin L-like protease 0.0055 0.095 0.3442
Brugia malayi Cathepsin L-like precursor 0.0055 0.095 0.095
Loa Loa (eye worm) hypothetical protein 0.0114 0.3157 0.3157
Leishmania major cysteine peptidase A (CPA) 0.0055 0.095 0.3442
Echinococcus granulosus calpain 5 0.0043 0.0486 0.0392
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0486 0.1763
Leishmania major cathepsin L-like protease 0.0055 0.095 0.3442
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.095 0.3201
Onchocerca volvulus 0.0055 0.095 0.4962
Loa Loa (eye worm) hypothetical protein 0.0084 0.2026 0.2026
Onchocerca volvulus 0.0055 0.095 0.4962
Plasmodium falciparum plasmepsin II 0.0051 0.0785 0.8065
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1741 0.166
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0051 0.0785 0.2581
Leishmania major cathepsin L-like protease 0.0055 0.095 0.3442
Echinococcus granulosus cathepsin l cysteine peptidase 0.0055 0.095 0.086
Brugia malayi Cathepsin L-like precursor 0.0055 0.095 0.095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Echinococcus multilocularis calpain 5 0.0043 0.0486 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0055 0.095 0.3201
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0043 0.0486 0.0486
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0369 0.0274
Toxoplasma gondii cathepsin B 0.0104 0.2759 1
Leishmania major cathepsin L-like protease 0.0055 0.095 0.3442
Onchocerca volvulus Cathepsin F homolog 0.0055 0.095 0.4962
Plasmodium falciparum plasmepsin IV 0.0051 0.0785 0.8065
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0043 0.0486 0.0486
Onchocerca volvulus 0.0071 0.1539 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0055 0.095 0.3201
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0104 0.2759 0.2759
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0051 0.0785 0.0785
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0296 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0055 0.095 0.086
Trypanosoma cruzi cysteine peptidase, putative 0.0055 0.095 0.095
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0051 0.0785 0.0694
Entamoeba histolytica cysteine protease, putative 0.0033 0.0098 0.103

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.2589 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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