Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0066 | 0.2527 | 1 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0066 | 0.2527 | 1 |
Brugia malayi | protein ZK524.3 | 0.0025 | 0.0308 | 0.0457 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6732 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1924 | 0.1667 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1924 | 0.1667 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1924 | 0.1667 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6732 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | methionyl-tRNA synthetase | 0.0025 | 0.0308 | 0.0457 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.0041 | 0.1157 | 0.1322 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0066 | 0.2527 | 0.229 |
Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.2527 | 0.3754 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0583 | 0.1241 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0066 | 0.2527 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0583 | 0.0429 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0066 | 0.2527 | 0.5 |
Onchocerca volvulus | 0.0041 | 0.1157 | 0.5 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0583 | 0.1241 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0066 | 0.2527 | 0.3455 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0066 | 0.2527 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1924 | 0.1667 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0025 | 0.0308 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0583 | 0.1241 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0583 | 0.1241 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1924 | 0.1667 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1924 | 0.2858 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0066 | 0.2527 | 0.5 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0066 | 0.2527 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1924 | 0.1667 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0066 | 0.2527 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0025 | 0.0308 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1924 | 0.2516 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1924 | 0.1667 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0025 | 0.0308 | 0.5 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0066 | 0.2527 | 0.229 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6732 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0583 | 0.1241 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0025 | 0.0308 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0066 | 0.2527 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0066 | 0.2527 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0066 | 0.2527 | 0.229 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0025 | 0.0308 | 0.5 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0066 | 0.2527 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0583 | 0.0866 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0066 | 0.2527 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 1.584 uM | PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 3.538 uM | PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.