Detailed information for compound 1394793
Basic information
Technical information
- TDR Targets ID: 1394793
- Name: 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetami de
- MW: 197.257 | Formula: C8H11N3OS
-
H donors: 1
H acceptors: 3
LogP: 0.79
Rotable bonds: 3
Rule of 5 violations (Lipinski): 1 - SMILES: NC(=O)CSc1nc(C)cc(n1)C
- InChi: 1S/C8H11N3OS/c1-5-3-6(2)11-8(10-5)13-4-7(9)12/h3H,4H2,1-2H3,(H2,9,12)
- InChiKey: CYWIRZGTWFPTMH-UHFFFAOYSA-N
Network
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Synonyms
- 2-[(4,6-dimethyl-2-pyrimidinyl)thio]acetamide
- 2-[(4,6-dimethylpyrimidin-2-yl)thio]acetamide
- 2-(4,6-dimethylpyrimidin-2-yl)sulfanylethanamide
- MLS000693131
- SMR000284759
- ZINC00370350
- STOCK2S-90040
- 2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetamide
- BAS 03014660
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Echinococcus granulosus | WW domain containing oxidoreductase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0079 | 0.3726 | 0.3726 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Leishmania major | pteridine reductase 1 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Plasmodium vivax | steroid dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | hydroxyacyl dehydrogenase, putative | 0.0113 | 1 | 1 |
| Entamoeba histolytica | oxidoreductase, short chain dehydrogenase/reductase family | 0.0113 | 1 | 1 |
| Plasmodium falciparum | steroid dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Echinococcus multilocularis | epidermal retinal dehydrogenase 2 | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Brugia malayi | Retinol dehydrogenase 12 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | steroid dehydrogenase, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | carveol-like dehydrogenase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Mycobacterium tuberculosis | Probable short chain alcohol dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0113 | 1 | 1 |
| Plasmodium falciparum | heat shock protein 90 | 0.0099 | 0.7408 | 0.7295 |
| Echinococcus granulosus | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0099 | 0.7408 | 0.5869 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 2 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 13 | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/decarboxylase protein | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma brucei | oxidoreductase-like protein | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Plasmodium vivax | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Echinococcus granulosus | epidermal retinal dehydrogenase 2 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | quinonoid dihydropteridine reductase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase-like protein | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Giardia lamblia | Reductase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 3, putative | 0.0113 | 1 | 1 |
| Plasmodium falciparum | oxidoreductase, short-chain dehydrogenase family, putative | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0113 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 2 | 0.0113 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | Dehydrogenase:reductase SDR family | 0.0113 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 9 | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Echinococcus multilocularis | transient receptor potential cation channel | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | Heat shock protein 83, putative | 0.0099 | 0.7408 | 0.7408 |
| Onchocerca volvulus | Sepiapterin reductase homolog | 0.0113 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Decaprenylphosphoryl-D-2-keto erythro pentose reductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | conserved hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | oxidoreductase short chain dehydrogenase/reductase family | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Echinococcus multilocularis | heat shock protein | 0.0099 | 0.7408 | 0.5869 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Leishmania major | dehydrogenase-like protein | 0.0113 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0113 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.3726 | 0.3452 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable shortchain dehydrogenase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | 3-ketoacyl-CoA reductase, putative | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible iron-regulated short-chain dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible ketoacyl reductase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Giardia lamblia | Hypothetical protein | 0.0113 | 1 | 1 |
| Trypanosoma brucei | 3-ketoacyl-CoA reductase, putative | 0.0113 | 1 | 1 |
| Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0113 | 1 | 1 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | heat shock protein | 0.0099 | 0.7408 | 0.5869 |
| Brugia malayi | Dehydrogenases, short chain protein 30 | 0.0113 | 1 | 1 |
| Brugia malayi | D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | Dehydrogenase:reductase SDR family | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Entamoeba histolytica | 3-ketodihydrosphingosine reductase protein, putative | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | dehydrogenase | 0.0113 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Echinococcus granulosus | heat shock protein 90 | 0.0099 | 0.7408 | 0.5869 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | retinal dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0099 | 0.7408 | 0.7408 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0113 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 1 homolog | 0.0113 | 1 | 0.5 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Mycobacterium ulcerans | oxidoreductase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.3726 | 0.3452 |
| Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 2 | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain membrane-associated dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Treponema pallidum | heat shock protein 90 | 0.0079 | 0.3726 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0113 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0113 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Echinococcus granulosus | 3 ketodihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0079 | 0.3726 | 0.3452 |
| Leishmania major | oxidoreductase-like protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenases/reductase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | estradiol 17 beta-dehydrogenase, putative | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0099 | 0.7408 | 0.7408 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type oxidoreductase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Echinococcus multilocularis | heat shock protein 90 | 0.0099 | 0.7408 | 0.5869 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible fatty acyl-CoA reductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible short-chain dehydrogenase EphD | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Mycobacterium leprae | PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Brugia malayi | Hypothetical oxidoreductase F56D1.5 | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Trypanosoma cruzi | heat shock protein 90, putative | 0.0099 | 0.7408 | 0.7408 |
| Mycobacterium leprae | ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 | 0.0113 | 1 | 1 |
| Toxoplasma gondii | carbonyl reductase 1, putative | 0.0113 | 1 | 1 |
| Echinococcus granulosus | oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Giardia lamblia | Short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Leishmania major | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | 3 ketodihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.0113 | 1 | 1 |
| Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0113 | 1 | 1 |
| Schistosoma mansoni | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type oxidoreductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0099 | 0.7408 | 0.7295 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Trypanosoma brucei | beta-D-hydroxybutyrate dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0113 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0099 | 0.7408 | 0.7408 |
| Echinococcus multilocularis | estradiol 17 beta dehydrogenase 12 | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0113 | 1 | 1 |
| Onchocerca volvulus | 0.0113 | 1 | 0.5 | |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium leprae | Probable oxidoreductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Trypanosoma brucei | 3-keto-dihydrosphingosine reductase | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0113 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0113 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 90, putative | 0.0079 | 0.3726 | 0.3726 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0113 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0099 | 0.7408 | 0.5869 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0113 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0113 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0113 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0113 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0113 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0113 | 1 | 1 |
| Schistosoma mansoni | short-chain dehydrogenase/reductase | 0.0113 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Inhibition (binding) | < 10 % | Inhibition of GST-tagged human SIRT1 (133 to 747 amino acids) using ZMAL as substrate at 200 uM after 4 hrs by fluorescence-based microplate reader method | ChEMBL. | 26696402 |
| Inhibition (binding) | < 10 % | Inhibition of N-terminal his6-tagged human SIRT2 (25 to 389 amino acids) using ZMAL as substrate at 50 uM after 4 hrs by fluorescence-based microplate reader method | ChEMBL. | 26696402 |
| Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1526762
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.