Detailed information for compound 1394795
Basic information
Technical information
- TDR Targets ID: 1394795
- Name: N-cyclohexyl-N-[2-[4-(4-methoxyphenyl)piperaz in-1-yl]-2-oxoethyl]methanesulfonamide
- MW: 409.543 | Formula: C20H31N3O4S
-
H donors: 0
H acceptors: 3
LogP: 2.41
Rotable bonds: 7
Rule of 5 violations (Lipinski): 1 - SMILES: COc1ccc(cc1)N1CCN(CC1)C(=O)CN(S(=O)(=O)C)C1CCCCC1
- InChi: 1S/C20H31N3O4S/c1-27-19-10-8-17(9-11-19)21-12-14-22(15-13-21)20(24)16-23(28(2,25)26)18-6-4-3-5-7-18/h8-11,18H,3-7,12-16H2,1-2H3
- InChiKey: JGDUOPHPWDELFF-UHFFFAOYSA-N
Network
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Synonyms
- N-cyclohexyl-N-[2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-oxo-ethyl]methanesulfonamide
- N-cyclohexyl-N-[2-[4-(4-methoxyphenyl)-1-piperazinyl]-2-oxoethyl]methanesulfonamide
- N-cyclohexyl-N-[2-keto-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl]methanesulfonamide
- ZINC00687757
- MLS000715506
- SMR000275485
- BAS 07784676
- AN-698/42374897
- STK135195
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0053 | 0.2341 | 0.2341 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0097 | 1 | 1 |
| Leishmania major | pteridine reductase 1 | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0097 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0097 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Echinococcus granulosus | WW domain containing oxidoreductase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Brugia malayi | Retinol dehydrogenase 12 | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | epidermal retinal dehydrogenase 2 | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0097 | 1 | 1 |
| Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | hydroxyacyl dehydrogenase, putative | 0.0097 | 1 | 1 |
| Plasmodium vivax | steroid dehydrogenase, putative | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase | 0.0097 | 1 | 1 |
| Plasmodium falciparum | steroid dehydrogenase, putative | 0.0097 | 1 | 1 |
| Entamoeba histolytica | oxidoreductase, short chain dehydrogenase/reductase family | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Trichomonas vaginalis | steroid dehydrogenase, putative | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | oxidoreductase | 0.0097 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | carveol-like dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 2 | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 13 | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short chain alcohol dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Plasmodium falciparum | heat shock protein 90 | 0.0066 | 0.4654 | 0.451 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0097 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0066 | 0.4654 | 0.302 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0097 | 1 | 1 |
| Plasmodium vivax | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0097 | 1 | 1 |
| Echinococcus granulosus | epidermal retinal dehydrogenase 2 | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/decarboxylase protein | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Trypanosoma brucei | oxidoreductase-like protein | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 3, putative | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Plasmodium falciparum | oxidoreductase, short-chain dehydrogenase family, putative | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0097 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0097 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | quinonoid dihydropteridine reductase, putative | 0.0097 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Leishmania major | short chain dehydrogenase-like protein | 0.0097 | 1 | 1 |
| Giardia lamblia | Reductase, putative | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | transient receptor potential cation channel | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0097 | 1 | 1 |
| Onchocerca volvulus | Sepiapterin reductase homolog | 0.0097 | 1 | 0.5 |
| Trypanosoma cruzi | Heat shock protein 83, putative | 0.0066 | 0.4654 | 0.4654 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Decaprenylphosphoryl-D-2-keto erythro pentose reductase | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | conserved hypothetical protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | dehydrogenase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 2 | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Entamoeba histolytica | hypothetical protein | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Echinococcus granulosus | Dehydrogenase:reductase SDR family | 0.0097 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 9 | 0.0097 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Leishmania major | dehydrogenase-like protein | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | heat shock protein | 0.0066 | 0.4654 | 0.302 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0053 | 0.2341 | 0.2134 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0097 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable shortchain dehydrogenase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | oxidoreductase short chain dehydrogenase/reductase family | 0.0097 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0097 | 1 | 1 |
| Entamoeba histolytica | 3-ketodihydrosphingosine reductase protein, putative | 0.0097 | 1 | 1 |
| Echinococcus granulosus | heat shock protein 90 | 0.0066 | 0.4654 | 0.302 |
| Loa Loa (eye worm) | dehydrogenase | 0.0097 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | retinal dehydrogenase | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Possible ketoacyl reductase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Possible iron-regulated short-chain dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Toxoplasma gondii | 3-ketoacyl-CoA reductase, putative | 0.0097 | 1 | 1 |
| Trypanosoma brucei | 3-ketoacyl-CoA reductase, putative | 0.0097 | 1 | 1 |
| Giardia lamblia | Hypothetical protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0097 | 1 | 1 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0097 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | Dehydrogenase:reductase SDR family | 0.0097 | 1 | 1 |
| Echinococcus granulosus | heat shock protein | 0.0066 | 0.4654 | 0.302 |
| Brugia malayi | Dehydrogenases, short chain protein 30 | 0.0097 | 1 | 1 |
| Brugia malayi | D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0053 | 0.2341 | 0.2134 |
| Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0097 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 2 | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0066 | 0.4654 | 0.4654 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0097 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 1 homolog | 0.0097 | 1 | 0.5 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Loa Loa (eye worm) | oxidoreductase | 0.0097 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0097 | 1 | 1 |
| Echinococcus granulosus | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0097 | 1 | 1 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenases/reductase, putative | 0.0097 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | estradiol 17 beta-dehydrogenase, putative | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0066 | 0.4654 | 0.4654 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain membrane-associated dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Treponema pallidum | heat shock protein 90 | 0.0053 | 0.2341 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0097 | 1 | 1 |
| Echinococcus granulosus | 3 ketodihydrosphingosine reductase | 0.0097 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0097 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0053 | 0.2341 | 0.2134 |
| Loa Loa (eye worm) | oxidoreductase | 0.0097 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Leishmania major | oxidoreductase-like protein | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | heat shock protein 90 | 0.0066 | 0.4654 | 0.302 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Possible fatty acyl-CoA reductase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Mycobacterium tuberculosis | Probable short-chain type oxidoreductase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Brugia malayi | Hypothetical oxidoreductase F56D1.5 | 0.0097 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Mycobacterium leprae | ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 90, putative | 0.0066 | 0.4654 | 0.4654 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Mycobacterium tuberculosis | Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 | 0.0097 | 1 | 1 |
| Echinococcus granulosus | oxidoreductase | 0.0097 | 1 | 1 |
| Toxoplasma gondii | carbonyl reductase 1, putative | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Possible short-chain dehydrogenase EphD | 0.0097 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium leprae | PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | 3-keto-dihydrosphingosine reductase | 0.0097 | 1 | 1 |
| Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type oxidoreductase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0097 | 1 | 1 |
| Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Giardia lamblia | Short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Leishmania major | 3-keto-dihydrosphingosine reductase | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase | 0.0097 | 1 | 1 |
| Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | 3 ketodihydrosphingosine reductase | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | estradiol 17 beta dehydrogenase 12 | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 85, putative | 0.0066 | 0.4654 | 0.4654 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0097 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Onchocerca volvulus | 0.0097 | 1 | 0.5 | |
| Mycobacterium leprae | Probable oxidoreductase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Trypanosoma brucei | 3-keto-dihydrosphingosine reductase | 0.0097 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | heat shock protein, putative | 0.0066 | 0.4654 | 0.451 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Trypanosoma brucei | beta-D-hydroxybutyrate dehydrogenase | 0.0097 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0097 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0097 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Leishmania major | heat shock protein 83-1 | 0.0066 | 0.4654 | 0.302 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0097 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0097 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0097 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0097 | 1 | 1 |
| Schistosoma mansoni | short-chain dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0097 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0097 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0097 | 1 | 1 |
| Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0097 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0097 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0097 | 1 | 1 |
| Trypanosoma cruzi | heat shock protein 90, putative | 0.0053 | 0.2341 | 0.2341 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
| Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1526765
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.