Detailed information for compound 1395244

Basic information

Technical information
  • TDR Targets ID: 1395244
  • Name: 3,5-di(morpholin-4-yl)-1,2,6-thiadiazin-4-one
  • MW: 284.335 | Formula: C11H16N4O3S
  • H donors: 0 H acceptors: 1 LogP: -0.69 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1c(nsnc1N1CCOCC1)N1CCOCC1
  • InChi: 1S/C11H16N4O3S/c16-9-10(14-1-5-17-6-2-14)12-19-13-11(9)15-3-7-18-8-4-15/h1-8H2
  • InChiKey: VUJNLQGKJMRDJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,5-dimorpholino-1,2,6-thiadiazin-4-one
  • 5915-79-7
  • MLS000109192
  • SMR000105138
  • 3,5-Di-morpholin-4-yl-[1,2,6]thiadiazin-4-one
  • BAS 01690938
  • Oprea1_843224
  • ZINC00446058

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.036 0.3268 0.3137
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.006 0.0254 0.1532
Giardia lamblia Cathepsin B precursor 0.036 0.3268 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1046 0.1034
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0193 0.1586 0.1575
Echinococcus granulosus cathepsin l1 0.0139 0.1046 0.1046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.1586 0.4419
Brugia malayi Cathepsin L-like precursor 0.0139 0.1046 0.1034
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0114 0.0794 0.0615
Schistosoma mansoni cathepsin C 0.006 0.0254 0.0241
Plasmodium vivax vivapain-2 0.0193 0.1586 1
Leishmania major cathepsin L-like protease 0.0193 0.1586 0.3127
Brugia malayi Cathepsin L-like precursor 0.0193 0.1586 0.1575
Loa Loa (eye worm) hypothetical protein 0.006 0.0254 0.0241
Echinococcus granulosus cathepsin l1 0.0193 0.1586 0.1586
Onchocerca volvulus 0.0193 0.1586 0.6268
Brugia malayi Cathepsin L-like cysteine proteinase 0.0139 0.1046 0.1034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0116 0.0821 0.2481
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0821 0.1879
Entamoeba histolytica cysteine proteinase 1, putative 0.0114 0.0794 0.1837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Echinococcus multilocularis mitogen activated protein kinase 3 0.0116 0.0821 0.0809
Schistosoma mansoni cathepsin s 0.0054 0.0191 0.0178
Onchocerca volvulus Cathepsin F homolog 0.0193 0.1586 0.6268
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0193 0.1586 0.1575
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3194 0.9753
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.1586 0.1422
Plasmodium vivax vivapain-2 0.0193 0.1586 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.006 0.0254 0.1532
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1382 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0116 0.0821 0.0642
Leishmania major cathepsin L-like protease 0.0193 0.1586 0.3127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.1586 0.4419
Toxoplasma gondii cathepsin CPL 0.0193 0.1586 0.4832
Echinococcus granulosus mitogen activated protein kinase 0.0116 0.0821 0.0821
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0254 0.0241
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1031 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3194 0.9753
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Leishmania major cathepsin L-like protease 0.0193 0.1586 0.3127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.1586 0.4419
Plasmodium vivax vivapain-1 0.0114 0.0794 0.4965
Leishmania major cysteine peptidase A (CPA) 0.0193 0.1586 0.3127
Loa Loa (eye worm) ctsf protein 0.0193 0.1586 0.1575
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.036 0.3268 1
Onchocerca volvulus 0.0193 0.1586 0.6268
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3194 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.0114 0.0794 0.0794
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.0794 0.1837
Trypanosoma cruzi cysteine proteinase, putative 0.0114 0.0794 0.0615
Loa Loa (eye worm) cathepsin B 0.036 0.3268 0.3259
Onchocerca volvulus Cathepsin L homolog 0.006 0.0254 0.096
Entamoeba histolytica cysteine proteinase, putative 0.0139 0.1046 0.2694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0794 0.0615
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.0794 0.0782
Trypanosoma cruzi cysteine proteinase, putative 0.0114 0.0794 0.0615
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.006 0.0254 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0193 0.1586 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.006 0.0254 0.0241
Onchocerca volvulus 0.0193 0.1586 0.6268
Entamoeba histolytica cysteine proteinase 2 0.0114 0.0794 0.1837
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.1586 0.1422
Echinococcus multilocularis cathepsin L cysteine protease 0.0193 0.1586 0.1575
Toxoplasma gondii cathepsin B 0.036 0.3268 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0114 0.0794 0.0782
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.006 0.0254 0.0241
Loa Loa (eye worm) hypothetical protein 0.0139 0.1046 0.1034
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0116 0.0821 0.0642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Brugia malayi cathepsin F-like cysteine proteinase 0.006 0.0254 0.0241
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1382 0.5
Echinococcus granulosus cathepsin l cysteine peptidase 0.0193 0.1586 0.1586
Echinococcus granulosus cathepsin L 0.0114 0.0794 0.0794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.1586 0.4419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Schistosoma mansoni cathepsin F (C01 family) 0.0193 0.1586 0.1575
Leishmania major cathepsin L-like protease 0.0193 0.1586 0.3127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.1046 0.2627
Schistosoma mansoni cathepsin S (C01 family) 0.006 0.0254 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0193 0.1586 1
Brugia malayi Cathepsin L-like precursor 0.0193 0.1586 0.1575
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.1586 0.4419
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3194 0.9753
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.1586 0.1422
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0821 0.1879
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0821 0.1879
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1382 0.5
Brugia malayi cathepsin L precursor 0.006 0.0254 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Plasmodium vivax serine-repeat antigen (SERA) 0.006 0.0254 0.1532
Onchocerca volvulus 0.0193 0.1586 0.6268
Plasmodium vivax serine-repeat antigen (SERA) 0.006 0.0254 0.1532
Echinococcus multilocularis cathepsin b 0.1031 1 1
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.006 0.0254 0.1532
Plasmodium vivax unspecified product 0.006 0.0254 0.1532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Echinococcus granulosus mitogen activated protein kinase 3 0.0116 0.0821 0.0821
Entamoeba histolytica cysteine proteinase, putative 0.0193 0.1586 0.4531
Schistosoma mansoni cathepsin B (C01 family) 0.006 0.0254 0.0241
Trypanosoma cruzi cysteine peptidase, putative 0.0193 0.1586 0.1422
Brugia malayi fibroinase precursor 0.006 0.0254 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Echinococcus multilocularis cathepsin L 0.0114 0.0794 0.0782
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3194 0.9753
Echinococcus multilocularis cysteine protease 0.0193 0.1586 0.1575
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3194 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0114 0.0794 0.0782
Toxoplasma gondii cathepsin CPC2 0.006 0.0254 0.074
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0193 0.1586 0.1575
Trypanosoma cruzi cysteine protease, putative 0.0114 0.0794 0.0615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.0794 0.1791
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.006 0.0254 0.1532
Brugia malayi Papain family cysteine protease containing protein 0.006 0.0254 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1031 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0254 0.0241
Brugia malayi cathepsin L-like precursor 0.0139 0.1046 0.1034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3194 0.9753
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.1586 0.4419
Brugia malayi cahepsin L-like non-peptiedase homolog 0.006 0.0254 0.0241
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3194 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0191 0.0178
Brugia malayi Cathepsin L-like precursor 0.0193 0.1586 0.1575
Brugia malayi Papain family cysteine protease containing protein 0.006 0.0254 0.0241
Loa Loa (eye worm) cysteine protease 0.0193 0.1586 0.1575
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3194 0.9753
Leishmania major cathepsin L-like protease 0.0193 0.1586 0.3127
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1031 1 1
Loa Loa (eye worm) fibroinase 0.0193 0.1586 0.1575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Trypanosoma brucei cysteine peptidase C (CPC) 0.036 0.3268 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.006 0.0254 0.0241
Brugia malayi Pre-SET motif family protein 0.0251 0.2174 0.2164
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0193 0.1586 0.1575
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.0821 0.0809
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0193 0.1586 0.4419
Loa Loa (eye worm) hypothetical protein 0.1031 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.006 0.0254 0.0241
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3194 0.9753
Loa Loa (eye worm) hypothetical protein 0.0054 0.0191 0.0178
Loa Loa (eye worm) hypothetical protein 0.0054 0.0191 0.0178
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.006 0.0254 0.1532
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1031 1 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.006 0.0254 0.1532
Echinococcus multilocularis cathepsin L cysteine protease 0.0193 0.1586 0.1575
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.006 0.0254 0.1532
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.0794 0.0782
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0114 0.0794 0.0782
Loa Loa (eye worm) hypothetical protein 0.006 0.0254 0.0241
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 0.0191 0.0178
Brugia malayi Cathepsin L-like precursor 0.0193 0.1586 0.1575
Onchocerca volvulus 0.006 0.0254 0.096
Echinococcus granulosus cathepsin b 0.1031 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Plasmodium vivax unspecified product 0.0054 0.0191 0.1133
Brugia malayi Cathepsin L-like precursor 0.0054 0.0191 0.0178
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.0794 0.1837
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0054 0.0191 0.0178
Leishmania major cathepsin L-like protease 0.0193 0.1586 0.3127
Brugia malayi cathepsin L-like cysteine proteinase 0.006 0.0254 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.1586 0.4419
Entamoeba histolytica cysteine proteinase, putative 0.0193 0.1586 0.4531
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Loa Loa (eye worm) hypothetical protein 0.006 0.0254 0.0241
Brugia malayi cathepsin F-like cysteine proteinase 0.0054 0.0191 0.0178
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.0794 0.1837
Giardia lamblia Cathepsin B precursor 0.036 0.3268 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0139 0.1046 0.2627
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.0821 0.1879
Plasmodium falciparum cysteine proteinase falcipain 1 0.0114 0.0794 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0193 0.1586 0.1575
Trypanosoma cruzi major cysteine proteinase, putative 0.006 0.0254 0.0064
Loa Loa (eye worm) hypothetical protein 0.006 0.0254 0.0241
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3194 0.9753
Toxoplasma gondii preprocathepsin c precursor, putative 0.006 0.0254 0.074
Toxoplasma gondii cathepsin CPC1 0.006 0.0254 0.074
Brugia malayi Cathepsin L-like precursor 0.0193 0.1586 0.1575
Onchocerca volvulus 0.0193 0.1586 0.6268
Brugia malayi cathepsin Z-like cysteine proteinase 0.006 0.0254 0.0241
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.0794 0.1791
Echinococcus granulosus cysteine protease 0.0114 0.0794 0.0794
Onchocerca volvulus 0.0139 0.1046 0.4117
Brugia malayi Cathepsin L-like precursor 0.0193 0.1586 0.1575
Trypanosoma cruzi cruzipain precursor, putative 0.0193 0.1586 0.1422
Leishmania major cathepsin L-like protease 0.0193 0.1586 0.3127
Echinococcus granulosus cathepsin L 0.006 0.0254 0.0254
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.006 0.0254 0.0241
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0139 0.1046 0.0871
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Brugia malayi MAP kinase sur-1 0.0116 0.0821 0.0809
Plasmodium vivax unspecified product 0.0114 0.0794 0.4965
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0193 0.1586 1
Entamoeba histolytica cysteine protease, putative 0.0193 0.1586 0.4531
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0254 0.0241
Trypanosoma cruzi major cysteine proteinase, putative 0.006 0.0254 0.0064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2174 0.2164
Giardia lamblia Kinase, CMGC MAPK 0.0116 0.0821 0.1879
Onchocerca volvulus 0.0193 0.1586 0.6268
Loa Loa (eye worm) hypothetical protein 0.006 0.0254 0.0241
Echinococcus multilocularis mitogen activated protein kinase 0.0116 0.0821 0.0809
Echinococcus multilocularis cathepsin b 0.1031 1 1
Echinococcus multilocularis cysteine protease 0.0193 0.1586 0.1575
Trypanosoma brucei protein kinase, putative 0.0116 0.0821 0.0107
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0254 0.0241
Loa Loa (eye worm) papain family cysteine protease containing protein 0.006 0.0254 0.0241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3194 0.9753
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Loa Loa (eye worm) hypothetical protein 0.0139 0.1046 0.1034
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1031 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.036 0.3268 1
Echinococcus multilocularis cathepsin L 0.006 0.0254 0.0241
Plasmodium falciparum cysteine proteinase falcipain 3 0.0193 0.1586 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Entamoeba histolytica cysteine proteinase, putative 0.0114 0.0794 0.1837
Entamoeba histolytica cysteine protease, putative 0.0114 0.0794 0.1837
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0116 0.0821 0.0642
Echinococcus granulosus cathepsin L cysteine proteinase 0.0193 0.1586 0.1586
Plasmodium vivax serine-repeat antigen (SERA), putative 0.006 0.0254 0.1532
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0116 0.0821 0.0809
Giardia lamblia Cathepsin B precursor 0.036 0.3268 1
Onchocerca volvulus 0.0193 0.1586 0.6268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.1586 0.4419
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0116 0.0821 0.0107
Brugia malayi Cathepsin L-like precursor 0.0139 0.1046 0.1034
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2523 0.7525
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Plasmodium vivax serine-repeat antigen (SERA), putative 0.006 0.0254 0.1532
Onchocerca volvulus Cathepsin L homolog 0.0193 0.1586 0.6268
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.006 0.0254 0.0241
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0254 0.0241
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0193 0.1586 0.4419
Plasmodium vivax vivapain-3 0.0114 0.0794 0.4965
Brugia malayi Papain family cysteine protease containing protein 0.006 0.0254 0.0241
Loa Loa (eye worm) hypothetical protein 0.0193 0.1586 0.1575
Schistosoma mansoni cathepsin F (C01 family) 0.0139 0.1046 0.1034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0193 0.1586 0.4419
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0116 0.0821 0.0642
Onchocerca volvulus 0.0286 0.2523 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.036 0.3268 0.3259
Loa Loa (eye worm) hypothetical protein 0.006 0.0254 0.0241
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0193 0.1586 0.3201
Schistosoma mansoni cathepsin F (C01 family) 0.0193 0.1586 0.1575
Onchocerca volvulus Cathepsin L homolog 0.0193 0.1586 0.6268
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.006 0.0254 0.1532
Leishmania major cathepsin L-like protease 0.0193 0.1586 0.3127
Echinococcus granulosus cathepsin b 0.1031 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.7741 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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