Detailed information for compound 1395245

Basic information

Technical information
  • TDR Targets ID: 1395245
  • Name: 7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiaz epine
  • MW: 267.283 | Formula: C15H13N3O2
  • H donors: 1 H acceptors: 2 LogP: 2.85 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc2c(c1)C(=NCCN2)c1ccccc1
  • InChi: 1S/C15H13N3O2/c19-18(20)12-6-7-14-13(10-12)15(17-9-8-16-14)11-4-2-1-3-5-11/h1-7,10,16H,8-9H2
  • InChiKey: AOQMKLMZECLOEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • A3509/0148677
  • ZINC04623770

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0059 0.0058
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0059 0.0058
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0059 0.0058
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0059 0.0058
Schistosoma mansoni cpg binding protein 0.0034 0.0131 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0001
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0059 0.0059
Brugia malayi Pre-SET motif family protein 0.0037 0.0146 0.0146
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0106 0.0541 0.2226
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0106 0.0541 0.2226
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Onchocerca volvulus 0.0348 0.1922 1
Trypanosoma cruzi major cysteine proteinase, putative 0.016 0.0846 0.0368
Schistosoma mansoni hypothetical protein 0.0051 0.0229 0.0228
Entamoeba histolytica cysteine proteinase, putative 0.025 0.1362 0.6995
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.0448
Onchocerca volvulus Cathepsin L homolog 0.0348 0.1922 1
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0059 0.0058
Giardia lamblia Cathepsin B precursor 0.0619 0.3467 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0229 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Loa Loa (eye worm) hypothetical protein 0.0015 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0229 0.0228
Loa Loa (eye worm) hypothetical protein 0.0111 0.0569 0.0568
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0059 0.0058
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0569 0.0569
Schistosoma mansoni hypothetical protein 0.046 0.2559 0.2558
Brugia malayi cathepsin F-like cysteine proteinase 0.0098 0.0496 0.0496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0059 0.0059
Echinococcus multilocularis expressed protein 0.042 0.233 0.2329
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0348 0.1922 0.1922
Trypanosoma cruzi major cysteine proteinase, putative 0.0106 0.0541 0.0048
Brugia malayi Pre-SET motif family protein 0.0252 0.1373 0.1373
Echinococcus granulosus cathepsin L 0.0106 0.0541 0.0541
Brugia malayi PXA domain containing protein 0.0022 0.0059 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Schistosoma mansoni inositol transporter 0.0043 0.0182 0.0181
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0229 0.0229
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0059 0.0058
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1765 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0059 0.0058
Onchocerca volvulus 0.0348 0.1922 1
Onchocerca volvulus 0.0032 0.012 0.0329
Toxoplasma gondii cathepsin CPC1 0.0106 0.0541 0.1191
Leishmania major cathepsin L-like protease 0.0402 0.2227 0.6054
Brugia malayi cathepsin Z-like cysteine proteinase 0.0106 0.0541 0.0541
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0059 0.0058
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0106 0.0541 0.2226
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0106 0.0541 0.2226
Echinococcus granulosus cathepsin l1 0.0348 0.1922 0.1922
Brugia malayi cathepsin F-like cysteine proteinase 0.0106 0.0541 0.0541
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0106 0.0541 0.2226
Plasmodium vivax vivapain-2 0.0348 0.1922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0106 0.0541 0.2588
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0106 0.0541 0.054
Loa Loa (eye worm) hypothetical protein 0.0098 0.0496 0.0495
Echinococcus granulosus cathepsin l1 0.025 0.1362 0.1362
Loa Loa (eye worm) hypothetical protein 0.025 0.1362 0.1362
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0348 0.1922 0.1922
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0059 0.0059
Loa Loa (eye worm) cysteine protease 0.0348 0.1922 0.1922
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0204 0.1101 0.0637
Giardia lamblia Cathepsin B precursor 0.0619 0.3467 1
Loa Loa (eye worm) hypothetical protein 0.0162 0.0862 0.0861
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0134 0.0133
Schistosoma mansoni cpg binding protein 0.0034 0.0131 0.013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Echinococcus multilocularis cysteine protease 0.0348 0.1922 0.1922
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0229 0.0228
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0619 0.3467 0.3126
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0348 0.1922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Trypanosoma cruzi cysteine protease, putative 0.0204 0.1101 0.0637
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0059 0.0058
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0059 0.0058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Entamoeba histolytica hypothetical protein 0.0106 0.0541 0.2588
Loa Loa (eye worm) hypothetical protein 0.0391 0.2165 0.2165
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0059 0.0058
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Loa Loa (eye worm) hypothetical protein 0.0098 0.0496 0.0495
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1765 1 1
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) fibroinase 0.0348 0.1922 0.1922
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0106 0.0541 0.2226
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0059 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0029 0.0028
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Entamoeba histolytica cysteine proteinase 1, putative 0.0204 0.1101 0.5593
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0059 0.0058
Onchocerca volvulus 0.0348 0.1922 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0106 0.0541 0.0541
Brugia malayi intermediate filament protein 0.003 0.0109 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0016
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0106 0.0541 0.1415
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Brugia malayi ecdysteroid receptor 0.0022 0.0059 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0348 0.1922 0.1501
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0229 0.0229
Brugia malayi PXA domain containing protein 0.0022 0.0059 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0059 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0059 0.0059
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0059 0.0058
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0326 0.0325
Brugia malayi Cathepsin L-like precursor 0.025 0.1362 0.1362
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0059 0.0058
Brugia malayi nuclear receptor NHR-88 0.0022 0.0059 0.0059
Entamoeba histolytica cysteine protease, putative 0.0348 0.1922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0541 0.1415
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0059 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0541 0.1415
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Schistosoma mansoni hypothetical protein 0.0051 0.0229 0.0228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0143 0.0142
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0043 0.0182 0.0181
Echinococcus multilocularis muscleblind protein 0.018 0.0965 0.0964
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Schistosoma mansoni cathepsin F (C01 family) 0.025 0.1362 0.1362
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0105
Schistosoma mansoni cathepsin C 0.0106 0.0541 0.054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0146 0.0145
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0043 0.0182 0.0181
Echinococcus granulosus cpg binding protein 0.0034 0.0131 0.013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0229 0.0228
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0348 0.1922 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0059 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0348 0.1922 0.1922
Brugia malayi steroid hormone receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0059 0.0059
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0043 0.0182 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0059 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0058
Plasmodium vivax vivapain-1 0.0204 0.1101 0.5378
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1765 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.0448
Schistosoma mansoni inositol transporter 0.0043 0.0182 0.0181
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0204 0.1101 0.11
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0293 0.0442
Echinococcus granulosus dnaJ subfamily B 0.046 0.2559 0.2559
Echinococcus granulosus geminin 0.0171 0.0908 0.0908
Echinococcus multilocularis lamin 0.003 0.0109 0.0108
Echinococcus multilocularis cathepsin L cysteine protease 0.0348 0.1922 0.1922
Echinococcus granulosus solute carrier family 5 0.0043 0.0182 0.0181
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.018 0.0965 0.0964
Schistosoma mansoni hypothetical protein 0.0051 0.0229 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0059 0.0058
Plasmodium vivax vivapain-3 0.0204 0.1101 0.5378
Echinococcus multilocularis muscleblind protein 1 0.018 0.0965 0.0964
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.0862 0.0861
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0619 0.3467 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0059 0.0058
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0059 0.0058
Echinococcus granulosus lamin 0.003 0.0109 0.0108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0106 0.0541 0.1415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Entamoeba histolytica cysteine proteinase 2 0.0204 0.1101 0.5593
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0059 0.0058
Echinococcus multilocularis musashi 0.003 0.0109 0.0108
Trypanosoma cruzi cruzipain precursor, putative 0.0402 0.2227 0.1821
Onchocerca volvulus 0.0287 0.1571 0.8115
Brugia malayi cathepsin L-like precursor 0.025 0.1362 0.1362
Brugia malayi Sodium:solute symporter family protein 0.0043 0.0182 0.0182
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0204 0.1101 0.11
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.1613 0.8341
Schistosoma mansoni coup transcription factor 0.0022 0.0059 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0059 0.0058
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0204 0.1101 0.11
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0059 0.0058
Schistosoma mansoni hypothetical protein 0.0171 0.0908 0.0908
Plasmodium vivax vivapain-2 0.0348 0.1922 1
Onchocerca volvulus 0.0322 0.1772 0.9194
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0059 0.0058
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Onchocerca volvulus 0.0043 0.0182 0.066
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0106 0.0541 0.2226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Brugia malayi Cathepsin L-like precursor 0.025 0.1362 0.1362
Echinococcus multilocularis GPCR, family 2 0.0051 0.0229 0.0228
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0059 0.0058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0229 0.0228
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0059 0.0058
Onchocerca volvulus 0.0106 0.0541 0.2588
Brugia malayi CXXC zinc finger family protein 0.0032 0.012 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0098 0.0496 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0098 0.0496 0.0496
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0098 0.0496 0.0495
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0106 0.0541 0.2226
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0043 0.0182 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0146 0.0145
Loa Loa (eye worm) hypothetical protein 0.025 0.1362 0.1362
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus granulosus sodium:glucose cotransporter 2 0.0043 0.0182 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Echinococcus multilocularis dnaJ subfamily B 0.046 0.2559 0.2559
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0059 0.0058
Echinococcus granulosus expressed protein 0.042 0.233 0.2329
Trypanosoma cruzi cysteine proteinase, putative 0.0204 0.1101 0.0637
Brugia malayi Papain family cysteine protease containing protein 0.0348 0.1922 0.1922
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1765 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0059 0.0058
Plasmodium vivax unspecified product 0.0106 0.0541 0.2226
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0106 0.0541 0.0541
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0326 0.0325
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Brugia malayi GH02984p 0.0391 0.2165 0.2165
Toxoplasma gondii preprocathepsin c precursor, putative 0.0106 0.0541 0.1191
Echinococcus granulosus high affinity choline transporter 1 0.0391 0.2165 0.2165
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0016
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.1613 0.3664
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0059 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0204 0.1101 0.0637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0326 0.0542
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0059 0.0058
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0619 0.3467 0.3466
Brugia malayi Papain family cysteine protease containing protein 0.0204 0.1101 0.1101
Echinococcus granulosus cathepsin l cysteine peptidase 0.0348 0.1922 0.1922
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0059 0.0058
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Schistosoma mansoni cathepsin s 0.0098 0.0496 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.1362 0.3825
Onchocerca volvulus 0.0348 0.1922 1
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Schistosoma mansoni lamin 0.003 0.0109 0.0108
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Toxoplasma gondii cathepsin CPC2 0.0106 0.0541 0.1191
Onchocerca volvulus 0.003 0.0109 0.0269
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0106 0.0541 0.054
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0755 1
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Onchocerca volvulus Cathepsin L homolog 0.0106 0.0541 0.2588
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0304 0.1667 0.1232
Echinococcus granulosus sodium:glucose cotransporter 0.0043 0.0182 0.0181
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0334 0.0333
Brugia malayi hypothetical protein 0.0022 0.0059 0.0059
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0059 0.0058
Schistosoma mansoni cathepsin B (C01 family) 0.0106 0.0541 0.054
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0059 0.0058
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Echinococcus multilocularis cathepsin b 0.1765 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0106 0.0541 0.054
Trypanosoma cruzi cysteine proteinase, putative 0.0204 0.1101 0.0637
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.0862 0.0862
Schistosoma mansoni cathepsin S (C01 family) 0.0106 0.0541 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0204 0.1101 0.3058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0146 0.0145
Schistosoma mansoni cpg binding protein 0.0032 0.012 0.0119
Brugia malayi hypothetical protein 0.0036 0.0143 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0541 0.1415
Schistosoma mansoni hypothetical protein 0.0171 0.0908 0.0908
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0059 0.0058
Onchocerca volvulus 0.0348 0.1922 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0106 0.0541 0.1415
Trypanosoma brucei cysteine peptidase C (CPC) 0.0619 0.3467 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0058
Echinococcus granulosus cathepsin L 0.0204 0.1101 0.1101
Plasmodium vivax serine-repeat antigen (SERA) 0.0106 0.0541 0.2226
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Leishmania major cathepsin L-like protease 0.0402 0.2227 0.6054
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0043 0.0182 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1728 0.9789 0.9789
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0146 0.0145
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Onchocerca volvulus 0.0037 0.0146 0.0466
Echinococcus granulosus cysteine protease 0.0204 0.1101 0.1101
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.002 0.0019
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1765 1 1
Brugia malayi cathepsin L precursor 0.0106 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Echinococcus granulosus sodium:myo inositol cotransporter 0.0043 0.0182 0.0181
Trypanosoma cruzi cysteine peptidase, putative 0.0402 0.2227 0.1821
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0106 0.0541 0.2226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0146 0.0145
Echinococcus granulosus cathepsin b 0.1765 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0059 0.0058
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0059 0.0058
Echinococcus multilocularis geminin 0.0171 0.0908 0.0908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0106 0.0541 0.054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.018 0.0965 0.0964
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Echinococcus multilocularis cathepsin b 0.1765 1 1
Echinococcus multilocularis cathepsin L 0.0106 0.0541 0.0541
Entamoeba histolytica cysteine protease, putative 0.0106 0.0541 0.2588
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0059 0.0059
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1373 0.1373
Trypanosoma cruzi cysteine peptidase, putative 0.0402 0.2227 0.1821
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.1613 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0204 0.1101 0.1101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Echinococcus granulosus lamin dm0 0.003 0.0109 0.0108
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0059 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0059 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0059 0.0058
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0619 0.3467 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0755 1
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0059 0.0059
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1571 0.4438
Plasmodium falciparum cysteine proteinase falcipain 1 0.0204 0.1101 0.4054
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0059 0.0058
Onchocerca volvulus 0.0348 0.1922 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0059 0.0058
Echinococcus granulosus intermediate filament protein 0.003 0.0109 0.0108
Plasmodium vivax serine-repeat antigen (SERA) 0.0106 0.0541 0.2226
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0348 0.1922 0.1922
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0326 0.0325
Loa Loa (eye worm) intermediate filament protein 0.003 0.0109 0.0108
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Brugia malayi Cathepsin L-like precursor 0.0098 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0322 0.1772 0.1772
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0059 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0059 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0059 0.0059
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0755 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.1765 1 1
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0059 0.0058
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0059 0.0059
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.0862 0.0862
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.025 0.1362 0.3825
Brugia malayi hypothetical protein 0.0022 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0051 0.0229 0.0228
Brugia malayi Cathepsin L-like cysteine proteinase 0.025 0.1362 0.1362
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0106 0.0541 0.0541
Schistosoma mansoni high-affinity choline transporter 0.0391 0.2165 0.2164
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.1613 0.8341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0059 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0402 0.2227 0.476
Brugia malayi nuclear receptor RXR 0.0011 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0106 0.0541 0.1415
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0059 0.0059
Echinococcus granulosus cathepsin L cysteine protease 0.0204 0.1101 0.1101
Leishmania major cathepsin L-like protease 0.0402 0.2227 0.6054
Giardia lamblia Cathepsin B precursor 0.0619 0.3467 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0059 0.0059
Brugia malayi hypothetical protein 0.0322 0.1772 0.1772
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0059 0.0059
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0348 0.1922 0.5468
Brugia malayi Muscleblind-like protein 0.018 0.0965 0.0965
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1101 0.5593
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0059 0.0058
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus granulosus muscleblind protein 0.018 0.0965 0.0964
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0059 0.0058
Onchocerca volvulus 0.003 0.0109 0.0269
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.0448
Echinococcus multilocularis cpg binding protein 0.0034 0.0131 0.013
Toxoplasma gondii cathepsin B 0.0619 0.3467 1
Loa Loa (eye worm) cathepsin B 0.0619 0.3467 0.3466
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0059 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Echinococcus multilocularis cathepsin L 0.0204 0.1101 0.1101
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0106 0.0541 0.1415
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1101 0.5593
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0059 0.0058
Onchocerca volvulus 0.025 0.1362 0.6995
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0143 0.0142
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0059 0.0058
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0146 0.0145
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0059 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0348 0.1922 1
Plasmodium vivax unspecified product 0.0204 0.1101 0.5378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0348 0.1922 0.5468
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0059 0.0058
Echinococcus multilocularis solute carrier family 5 0.0043 0.0182 0.0181
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Toxoplasma gondii cathepsin CPL 0.0348 0.1922 0.535
Brugia malayi cathepsin Z-like cysteine proteinase 0.0106 0.0541 0.0541
Echinococcus granulosus GPCR family 2 0.0051 0.0229 0.0228
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0106 0.0541 0.2226
Brugia malayi Papain family cysteine protease containing protein 0.0106 0.0541 0.0541
Schistosoma mansoni lamin 0.003 0.0109 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0541 0.1415
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0059 0.0058
Echinococcus granulosus cathepsin b 0.1765 1 1
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0059 0.0058
Schistosoma mansoni intermediate filament proteins 0.003 0.0109 0.0108
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1101 0.5593
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0059 0.0059
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0043 0.0182 0.0181
Loa Loa (eye worm) ctsf protein 0.0348 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0143 0.0142
Echinococcus multilocularis lamin dm0 0.003 0.0109 0.0108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Schistosoma mansoni hypothetical protein 0.0036 0.0143 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0106 0.0541 0.1415
Leishmania major cysteine peptidase A (CPA) 0.0348 0.1922 0.5084
Brugia malayi fibroinase precursor 0.0106 0.0541 0.0541
Schistosoma mansoni cathepsin F (C01 family) 0.0348 0.1922 0.1922
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0058
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0059 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0059 0.0059
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0059 0.0059
Echinococcus multilocularis cysteine protease 0.0348 0.1922 0.1922
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0059 0.0058
Brugia malayi nuclear hormone receptor 0.0022 0.0059 0.0059
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0106 0.0541 0.0541
Entamoeba histolytica cysteine proteinase, putative 0.0204 0.1101 0.5593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0204 0.1101 0.3058
Plasmodium vivax unspecified product 0.0098 0.0496 0.1972
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Onchocerca volvulus Cathepsin L homolog 0.0348 0.1922 1
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0348 0.1922 0.5468
Plasmodium falciparum cysteine proteinase falcipain 3 0.0348 0.1922 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0106 0.0541 0.1415
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0348 0.1922 0.1922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0106 0.0541 0.1415
Schistosoma mansoni sodium/solute symporter 0.0043 0.0182 0.0181
Schistosoma mansoni hypothetical protein 0.0051 0.0229 0.0228
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.0348 0.1922 0.1922
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0059 0.0059
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0111 0.0569 0.0568
Loa Loa (eye worm) hypothetical protein 0.003 0.0109 0.0108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.1613 0.4561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0146 0.0145
Echinococcus granulosus cathepsin L cysteine proteinase 0.0348 0.1922 0.1922
Entamoeba histolytica cysteine protease, putative 0.0204 0.1101 0.5593
Onchocerca volvulus Cathepsin F homolog 0.0348 0.1922 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0326 0.0325
Onchocerca volvulus 0.0348 0.1922 1
Echinococcus multilocularis high affinity choline transporter 1 0.0391 0.2165 0.2165
Brugia malayi Cathepsin L-like precursor 0.0348 0.1922 0.1922
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0059 0.0058
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0106 0.0541 0.2588
Entamoeba histolytica hypothetical protein 0.0036 0.0143 0.0448
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0348 0.1922 0.5468
Leishmania major cathepsin L-like protease 0.0348 0.1922 0.5084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0106 0.0541 0.054
Trypanosoma cruzi cysteine peptidase, putative 0.0402 0.2227 0.1821
Echinococcus multilocularis cathepsin L cysteine protease 0.0348 0.1922 0.1922
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0109 0.0108
Loa Loa (eye worm) hypothetical protein 0.025 0.1362 0.1362
Entamoeba histolytica cysteine proteinase, putative 0.0348 0.1922 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0059 0.0058

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0066 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.1413 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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