Detailed information for compound 1395372

Basic information

Technical information
  • TDR Targets ID: 1395372
  • Name: [2-[[2-(cyanomethylsulfanyl)phenyl]amino]-2-o xoethyl] 2-(1H-indol-3-yl)acetate
  • MW: 379.432 | Formula: C20H17N3O3S
  • H donors: 2 H acceptors: 3 LogP: 3.04 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCSc1ccccc1NC(=O)COC(=O)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C20H17N3O3S/c21-9-10-27-18-8-4-3-7-17(18)23-19(24)13-26-20(25)11-14-12-22-16-6-2-1-5-15(14)16/h1-8,12,22H,10-11,13H2,(H,23,24)
  • InChiKey: NJYHCYCXLNVTNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[[2-(cyanomethylsulfanyl)phenyl]amino]-2-oxo-ethyl] 2-(1H-indol-3-yl)acetate
  • 2-(1H-indol-3-yl)acetic acid [2-[[2-(cyanomethylthio)phenyl]amino]-2-oxoethyl] ester
  • 2-(1H-indol-3-yl)acetic acid [2-[[2-(cyanomethylthio)phenyl]amino]-2-keto-ethyl] ester
  • [2-[[2-(cyanomethylsulfanyl)phenyl]amino]-2-oxo-ethyl] 2-(1H-indol-3-yl)ethanoate
  • ZINC06384143
  • T5348192

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi fibroinase precursor 0.0076 0.0599 0.0584
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0027 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0189 0.1581 0.433
Echinococcus granulosus high affinity choline transporter 1 0.0369 0.315 0.315
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0496 0.0897
Echinococcus granulosus cathepsin L 0.0153 0.1269 0.1269
Onchocerca volvulus 0.0043 0.0313 0.1282
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0027 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0111 0.0111
Onchocerca volvulus 0.0029 0.0183 0.0701
Loa Loa (eye worm) hypothetical protein 0.0076 0.0599 0.0583
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0027 0.0027
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0266 0.2251 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0111 0.0111
Entamoeba histolytica cysteine proteinase 2 0.0153 0.1269 0.5408
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0077 0.0604 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0027 0.0027
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0027 0.0027
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0111 0.0111
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.3718 0.3718
Giardia lamblia Cathepsin B precursor 0.041 0.3506 1
Brugia malayi Cathepsin L-like precursor 0.0266 0.2251 0.224
Trypanosoma cruzi cysteine proteinase, putative 0.0153 0.1269 0.0987
Schistosoma mansoni coup transcription factor 0.0011 0.0027 0.0027
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0076 0.0599 0.1476
Plasmodium vivax vivapain-2 0.0266 0.2251 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0226 0.021
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0027 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0226 0.0226
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0856 0.0842
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0076 0.0599 0.0599
Echinococcus granulosus cathepsin l1 0.0266 0.2251 0.2251
Brugia malayi cathepsin F-like cysteine proteinase 0.0077 0.0604 0.059
Leishmania major cathepsin L-like protease 0.0412 0.3518 1
Trypanosoma cruzi cysteine peptidase, putative 0.0412 0.3518 0.3309
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0027 0.0011
Echinococcus granulosus cathepsin l1 0.0189 0.1581 0.1581
Schistosoma mansoni hypothetical protein 0.0034 0.0226 0.0226
Brugia malayi CXXC zinc finger family protein 0.0031 0.02 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0496 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0599 0.0584
Brugia malayi beta-lactamase family protein 0.0043 0.0313 0.0298
Brugia malayi beta-lactamase 0.0043 0.0313 0.0298
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0335 0.2848 0.2618
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0266 0.2251 0.2251
Brugia malayi cathepsin F-like cysteine proteinase 0.0076 0.0599 0.0584
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.2251 0.6303
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0856 0.0842
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0068 0.0053
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.2251 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0496 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0599 0.0599
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0266 0.2251 0.2251
Schistosoma mansoni hypothetical protein 0.0034 0.0226 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0189 0.1581 0.433
Brugia malayi Sodium:solute symporter family protein 0.0041 0.0289 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0599 0.1436
Onchocerca volvulus 0.0266 0.2251 1
Brugia malayi intermediate filament protein 0.0029 0.0183 0.0169
Schistosoma mansoni hypothetical protein 0.0034 0.0226 0.0226
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0027 0.0027
Brugia malayi nuclear hormone receptor 0.0011 0.0027 0.0012
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0027 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1156 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0027 0.0012
Echinococcus granulosus lamin dm0 0.0029 0.0183 0.0183
Brugia malayi cathepsin L precursor 0.0076 0.0599 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0599 0.1436
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0077 0.0604 0.0589
Echinococcus multilocularis cathepsin L 0.0153 0.1269 0.1269
Entamoeba histolytica hypothetical protein 0.0076 0.0599 0.2278
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0027 0.0027
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0111 0.0111
Echinococcus granulosus axis inhibition protein axin 0.002 0.0111 0.0111
Onchocerca volvulus Cathepsin F homolog 0.0266 0.2251 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Echinococcus granulosus axis inhibition protein axin 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Loa Loa (eye worm) hypothetical protein 0.0266 0.2251 0.2239
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.1269 0.5408
Echinococcus granulosus sodium:glucose cotransporter 2 0.0041 0.0289 0.0289
Entamoeba histolytica cysteine proteinase, putative 0.0189 0.1581 0.6869
Entamoeba histolytica cysteine protease, putative 0.0076 0.0599 0.2278
Onchocerca volvulus 0.0029 0.0183 0.0701
Schistosoma mansoni axis inhibition protein axin 0.002 0.0111 0.0111
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Loa Loa (eye worm) beta-lactamase 0.0043 0.0313 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.2251 0.6303
Loa Loa (eye worm) hypothetical protein 0.0041 0.0289 0.0273
Schistosoma mansoni cathepsin B (C01 family) 0.0076 0.0599 0.0599
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0111 0.0111
Schistosoma mansoni cathepsin S (C01 family) 0.0076 0.0599 0.0599
Brugia malayi Cathepsin L-like precursor 0.0266 0.2251 0.224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0266 0.2251 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0153 0.1269 0.1269
Toxoplasma gondii cathepsin CPL 0.0266 0.2251 0.6099
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0068 0.0052
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0111 0.0096
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.1269 0.1255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Onchocerca volvulus 0.0266 0.2251 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0496 0.0571
Onchocerca volvulus 0.0266 0.2251 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0226 0.0226
Plasmodium falciparum cysteine proteinase falcipain 3 0.0266 0.2251 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0076 0.0599 0.1476
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.0369 0.315 0.3138
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0313 0.0593
Loa Loa (eye worm) fibroinase 0.0266 0.2251 0.2239
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1156 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0266 0.2251 0.2251
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0599 0.1436
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0111 0.0095
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0076 0.0599 0.0584
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0027 0.0012
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0041 0.0289 0.0289
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0313 0.0313
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0599 0.1436
Onchocerca volvulus 0.0189 0.1581 0.6987
Plasmodium vivax unspecified product 0.0153 0.1269 0.4931
Entamoeba histolytica cysteine protease, putative 0.0076 0.0599 0.2278
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0076 0.0599 0.1476
Brugia malayi cathepsin L-like cysteine proteinase 0.0076 0.0599 0.0584
Schistosoma mansoni lamin 0.0029 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0076 0.0599 0.0583
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0095
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0076 0.0599 0.1476
Echinococcus multilocularis lamin dm0 0.0029 0.0183 0.0183
Schistosoma mansoni cpg binding protein 0.0032 0.0215 0.0215
Echinococcus granulosus GPCR family 2 0.0034 0.0226 0.0226
Schistosoma mansoni cathepsin F (C01 family) 0.0266 0.2251 0.2251
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0604 0.0301
Loa Loa (eye worm) hypothetical protein 0.0106 0.0856 0.0842
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0076 0.0599 0.1476
Echinococcus multilocularis cathepsin L 0.0076 0.0599 0.0599
Loa Loa (eye worm) hypothetical protein 0.0189 0.1581 0.1568
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0153 0.1269 0.1269
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0498 0.0498
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0111 0.0096
Leishmania major cathepsin L-like protease 0.0412 0.3518 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0027 0.0027
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0183 0.0168
Entamoeba histolytica cysteine protease, putative 0.0076 0.0599 0.2278
Leishmania major cathepsin L-like protease 0.0266 0.2251 0.6047
Brugia malayi ecdysteroid receptor 0.0011 0.0027 0.0012
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0076 0.0599 0.0583
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0027 0.0027
Echinococcus multilocularis cathepsin b 0.1156 1 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0076 0.0599 0.1476
Loa Loa (eye worm) hypothetical protein 0.0034 0.0226 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0041 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0011
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0076 0.0599 0.1476
Plasmodium vivax unspecified product 0.0077 0.0604 0.1503
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0226 0.0211
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1156 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0027 0.0012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0027 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0861 0.7436 0.7436
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0226 0.0211
Brugia malayi Cathepsin L-like precursor 0.0266 0.2251 0.224
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.041 0.3506 1
Echinococcus granulosus sodium:glucose cotransporter 0.0041 0.0289 0.0289
Brugia malayi hypothetical protein 0.002 0.0111 0.0096
Brugia malayi hypothetical protein 0.002 0.0111 0.0096
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0076 0.0599 0.1476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0027 0.0011
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0011
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.041 0.3506 0.3297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.0599 0.1436
Plasmodium falciparum cysteine proteinase falcipain 1 0.0153 0.1269 0.4054
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0111 0.0111
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0076 0.0599 0.0599
Toxoplasma gondii preprocathepsin c precursor, putative 0.0076 0.0599 0.0964
Brugia malayi Cathepsin L-like cysteine proteinase 0.0189 0.1581 0.1569
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1156 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0604 0.0301
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.0599 0.1436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0599 0.0584
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0027 0.0012
Echinococcus multilocularis cathepsin L cysteine protease 0.0266 0.2251 0.2251
Schistosoma mansoni hypothetical protein 0.0434 0.3718 0.3718
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0076 0.0599 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0027 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0095
Plasmodium vivax vivapain-2 0.0266 0.2251 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0095
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.1269 0.5408
Toxoplasma gondii cathepsin B 0.041 0.3506 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0179 0.0163
Loa Loa (eye worm) hypothetical protein 0.0189 0.1581 0.1568
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.2251 0.6303
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0027 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0415 0.0415
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0111 0.0111
Trypanosoma cruzi major cysteine proteinase, putative 0.0222 0.1866 0.1603
Brugia malayi cathepsin Z-like cysteine proteinase 0.0076 0.0599 0.0584
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0111 0.0111
Trichomonas vaginalis esterase, putative 0.0043 0.0313 0.0593
Echinococcus multilocularis cysteine protease 0.0266 0.2251 0.2251
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0565 0.055
Echinococcus multilocularis cathepsin L cysteine protease 0.0266 0.2251 0.2251
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0111 0.0111
Schistosoma mansoni intermediate filament proteins 0.0029 0.0183 0.0183
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0111 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0153 0.1269 0.2982
Brugia malayi hypothetical protein 0.0161 0.1332 0.1319
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0076 0.0599 0.0583
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0027 0.0027
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.1269 0.5408
Leishmania major cathepsin L-like protease 0.0266 0.2251 0.6047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0027 0.0011
Echinococcus granulosus cathepsin b 0.1156 1 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0183 0.0168
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0076 0.0599 0.2278
Brugia malayi PXA domain containing protein 0.002 0.0111 0.0096
Onchocerca volvulus 0.0266 0.2251 1
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0027 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.041 0.3506 0.3506
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0041 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0027 0.0027
Onchocerca volvulus 0.0041 0.0289 0.1174
Entamoeba histolytica cysteine proteinase 1, putative 0.0153 0.1269 0.5408
Echinococcus multilocularis cpg binding protein 0.0032 0.0215 0.0215
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1156 1 1
Brugia malayi Cathepsin L-like precursor 0.0077 0.0604 0.059
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0034
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0111 0.0111
Echinococcus granulosus sodium:myo inositol cotransporter 0.0041 0.0289 0.0289
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0111 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0027 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0076 0.0599 0.1436
Giardia lamblia Cathepsin B precursor 0.041 0.3506 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0297
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0313 0.0313
Onchocerca volvulus 0.0266 0.2251 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.02 0.0184
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0111 0.0095
Trypanosoma cruzi cruzipain precursor, putative 0.0412 0.3518 0.3309
Onchocerca volvulus Cathepsin L homolog 0.0076 0.0599 0.2569
Loa Loa (eye worm) hypothetical protein 0.0189 0.1581 0.1568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0599 0.1436
Brugia malayi steroid hormone receptor 0.0011 0.0027 0.0012
Schistosoma mansoni cathepsin s 0.0077 0.0604 0.0604
Mycobacterium leprae Probable lipase LipE 0.0043 0.0313 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.0599 0.0583
Loa Loa (eye worm) cysteine protease 0.0266 0.2251 0.2239
Schistosoma mansoni inositol transporter 0.0041 0.0289 0.0289
Brugia malayi Cathepsin L-like precursor 0.0266 0.2251 0.224
Echinococcus granulosus cathepsin L 0.0076 0.0599 0.0599
Loa Loa (eye worm) hypothetical protein 0.0029 0.0183 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0297
Echinococcus granulosus lamin 0.0029 0.0183 0.0183
Onchocerca volvulus 0.0161 0.1332 0.5866
Giardia lamblia Cathepsin B precursor 0.041 0.3506 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0111 0.0096
Loa Loa (eye worm) cathepsin B 0.041 0.3506 0.3496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.1269 0.3409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0599 0.1436
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0415 0.0415
Echinococcus multilocularis lamin 0.0029 0.0183 0.0183
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0111 0.0111
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0111 0.0111
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0313 0.0593
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0027 0.0012
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Echinococcus granulosus cathepsin l cysteine peptidase 0.0266 0.2251 0.2251
Schistosoma mansoni hypothetical protein 0.0072 0.0565 0.0565
Onchocerca volvulus 0.0043 0.0313 0.1282
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0027 0.0027
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0054 0.0054
Brugia malayi Cathepsin L-like precursor 0.0266 0.2251 0.224
Leishmania major cathepsin L-like protease 0.0266 0.2251 0.6047
Loa Loa (eye worm) hypothetical protein 0.0076 0.0599 0.0583
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0111 0.0111
Brugia malayi Cathepsin L-like precursor 0.0189 0.1581 0.1569
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0027 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0189 0.1581 0.1581
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0111 0.0096
Loa Loa (eye worm) hypothetical protein 0.0077 0.0604 0.0589
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0313 0.0593
Trypanosoma cruzi cysteine proteinase, putative 0.0153 0.1269 0.0987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0027 0.0011
Schistosoma mansoni sodium/solute symporter 0.0041 0.0289 0.0289
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0226 0.0226
Echinococcus granulosus cysteine protease 0.0153 0.1269 0.1269
Trypanosoma cruzi major cysteine proteinase, putative 0.0076 0.0599 0.0295
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0496 0.0496
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0415 0.04
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0076 0.0599 0.0583
Brugia malayi beta-lactamase family protein 0.0043 0.0313 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0415 0.0415
Entamoeba histolytica cysteine protease, putative 0.0076 0.0599 0.2278
Schistosoma mansoni regulator of G protein signaling 0.002 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.2251 0.6303
Echinococcus multilocularis musashi 0.0029 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0599 0.1436
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0313 0.0313
Schistosoma mansoni high-affinity choline transporter 0.0369 0.315 0.315
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0599 0.1436
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0297
Entamoeba histolytica cysteine protease, putative 0.0076 0.0599 0.2278
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0111 0.0111
Echinococcus multilocularis cathepsin b 0.1156 1 1
Toxoplasma gondii cathepsin CPC1 0.0076 0.0599 0.0964
Brugia malayi Papain family cysteine protease containing protein 0.0076 0.0599 0.0584
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0153 0.1269 0.2982
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0111 0.0096
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.041 0.3506 0.9963
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0041 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0077 0.0604 0.0589
Trypanosoma cruzi cysteine peptidase, putative 0.0412 0.3518 0.3309
Onchocerca volvulus 0.0043 0.0313 0.1282
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0076 0.0599 0.1436
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0153 0.1269 0.1269
Entamoeba histolytica cysteine proteinase, putative 0.0266 0.2251 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0027 0.0027
Brugia malayi cathepsin L-like precursor 0.0189 0.1581 0.1569
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0016
Brugia malayi GH02984p 0.0369 0.315 0.3139
Toxoplasma gondii cathepsin CPC2 0.0076 0.0599 0.0964
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.1269 0.5408
Schistosoma mansoni lamin 0.0029 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.1269 0.3409
Onchocerca volvulus Cathepsin L homolog 0.0266 0.2251 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0095
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0027 0.0027
Onchocerca volvulus 0.0266 0.2251 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0266 0.2251 0.6303
Entamoeba histolytica cysteine protease, putative 0.0076 0.0599 0.2278
Brugia malayi Cathepsin L-like precursor 0.0266 0.2251 0.224
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0076 0.0599 0.1476
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0266 0.2251 0.6303
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0599 0.0599
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0111 0.0111
Schistosoma mansoni inositol transporter 0.0041 0.0289 0.0289
Schistosoma mansoni cpg binding protein 0.0031 0.02 0.02
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0599 0.0599
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.1269 0.1255
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0111 0.0111
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0111 0.0095
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0027 0.0012
Brugia malayi nuclear receptor NHR-88 0.0011 0.0027 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0076 0.0599 0.1436
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0076 0.0599 0.1436
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0313 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0599 0.1436
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0027 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.2251 0.6303
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0313 0.0313
Leishmania major cathepsin L-like protease 0.0412 0.3518 1
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0111 0.0111
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0226 0.0226
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0266 0.2251 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0297
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0111 0.0111
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0437 0.0462
Onchocerca volvulus 0.0031 0.02 0.0774
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0027 0.0027
Brugia malayi cathepsin Z-like cysteine proteinase 0.0076 0.0599 0.0584
Onchocerca volvulus 0.0266 0.2251 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.041 0.3506 0.9963
Loa Loa (eye worm) ctsf protein 0.0266 0.2251 0.2239
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0027 0.0027
Echinococcus granulosus cathepsin b 0.1156 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0297
Echinococcus granulosus expressed protein 0.0396 0.3387 0.3387
Echinococcus multilocularis solute carrier family 5 0.0041 0.0289 0.0289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0027 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0161 0.1332 0.1318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0415 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.2251 0.6303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0076 0.0599 0.1436
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0027 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0412 0.3518 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0415 0.0401
Toxoplasma gondii ABC1 family protein 0.0043 0.0313 0.0075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0599 0.0599
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0076 0.0599 0.1436
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0599 0.1436
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.2251 0.224
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0496 0.0496
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0496 0.0496
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0496 1
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0496 0.0644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.2251 0.6303
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0027 0.0027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0027 0.0027
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Leishmania major cathepsin L-like protease 0.0266 0.2251 0.6047
Trypanosoma cruzi cysteine peptidase, putative 0.0412 0.3518 0.3309
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.2251 0.6303
Leishmania major cathepsin L-like protease 0.0266 0.2251 0.6047
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0313 0.0593
Trypanosoma cruzi cysteine peptidase, putative 0.0266 0.2251 0.2001
Echinococcus granulosus cpg binding protein 0.0032 0.0215 0.0215
Schistosoma mansoni cpg binding protein 0.0032 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0011
Loa Loa (eye worm) hypothetical protein 0.0076 0.0599 0.0583
Echinococcus granulosus dnaJ subfamily B 0.0434 0.3718 0.3718
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0027 0.0012
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.2251 0.2239
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0856 0.0842
Echinococcus multilocularis cysteine protease 0.0266 0.2251 0.2251
Echinococcus granulosus cathepsin L cysteine protease 0.0153 0.1269 0.1269
Trypanosoma cruzi cysteine peptidase, putative 0.0153 0.1269 0.0987
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0027 0.0012
Echinococcus multilocularis expressed protein 0.0396 0.3387 0.3387
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0076 0.0599 0.1476
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0027 0.0027
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0076 0.0599 0.1476
Onchocerca volvulus Cathepsin L homolog 0.0266 0.2251 1
Onchocerca volvulus 0.0076 0.0599 0.2569
Loa Loa (eye worm) hypothetical protein 0.1156 1 1
Loa Loa (eye worm) RGS-3 protein 0.002 0.0111 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.2251 0.6303
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0313 0.0593
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0095
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0038
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0076 0.0599 0.2278
Echinococcus multilocularis high affinity choline transporter 1 0.0369 0.315 0.315
Loa Loa (eye worm) hypothetical protein 0.0072 0.0565 0.0549
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0027 0.0027
Schistosoma mansoni axis inhibition protein axin 0.002 0.0111 0.0111
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0043 0.0313 0.0297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.2251 0.6303
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0111 0.0111
Plasmodium vivax unspecified product 0.0076 0.0599 0.1476
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0011
Schistosoma mansoni cathepsin C 0.0076 0.0599 0.0599
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0027 0.0012
Entamoeba histolytica cysteine protease, putative 0.0153 0.1269 0.5408
Brugia malayi Cathepsin L-like precursor 0.0189 0.1581 0.1569
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0183 0.0169
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0496 0.0496
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0266 0.2251 0.2239
Leishmania major cysteine peptidase A (CPA) 0.0266 0.2251 0.6047
Plasmodium vivax vivapain-1 0.0153 0.1269 0.4931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0076 0.0599 0.1436
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0027 0.0027
Echinococcus multilocularis GPCR, family 2 0.0034 0.0226 0.0226
Plasmodium vivax serine-repeat antigen (SERA) 0.0076 0.0599 0.1476
Echinococcus granulosus intermediate filament protein 0.0029 0.0183 0.0183
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0076 0.0599 0.0599
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2353 1
Trypanosoma cruzi cysteine protease, putative 0.0153 0.1269 0.0987
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0313 0.0298
Schistosoma mansoni hypothetical protein 0.0034 0.0226 0.0226
Echinococcus granulosus solute carrier family 5 0.0041 0.0289 0.0289
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0077 0.0604 0.0589
Plasmodium vivax vivapain-3 0.0153 0.1269 0.4931
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0111 0.0111
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0076 0.0599 0.0599
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0076 0.0599 0.0599
Schistosoma mansoni cathepsin F (C01 family) 0.0266 0.2251 0.2251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0111 0.0095
Brugia malayi PXA domain containing protein 0.002 0.0111 0.0096
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0027 0.0027
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0313 0.0297
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0111 0.0095
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0153 0.1269 0.0987

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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