Detailed information for compound 1396789

Basic information

Technical information
  • TDR Targets ID: 1396789
  • Name: ethyl 2-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phe noxy]acetate
  • MW: 324.331 | Formula: C18H16N2O4
  • H donors: 0 H acceptors: 3 LogP: 3.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)COc1ccc(cc1)c1nnc(o1)c1ccccc1
  • InChi: 1S/C18H16N2O4/c1-2-22-16(21)12-23-15-10-8-14(9-11-15)18-20-19-17(24-18)13-6-4-3-5-7-13/h3-11H,2,12H2,1H3
  • InChiKey: BZAQOWWLZDSWSH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy]acetic acid ethyl ester
  • ethyl 2-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy]ethanoate
  • SMR000002388
  • [4-(5-Phenyl-[1,3,4]oxadiazol-2-yl)-phenoxy]-acetic acid ethyl ester
  • Oprea1_231626
  • MLS000031798

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0074 0.043 0.043
Echinococcus multilocularis cathepsin L 0.0169 0.1091 0.1091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0439 0.2973 0.2973
Schistosoma mansoni cathepsin F (C01 family) 0.0207 0.1356 0.1356
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0573 0.1545
Loa Loa (eye worm) hypothetical protein 0.0107 0.066 0.066
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0151 0.0151
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0573 0.2807
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0081 0.0482 0.0482
Brugia malayi GH02984p 0.0373 0.2514 0.2514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Plasmodium vivax vivapain-2 0.0288 0.1922 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.041 0.041
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0573 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.1091 0.3041
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0058
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0058 0.0058
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0322 0.0806
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0508 0.3455 1
Entamoeba histolytica cysteine proteinase 2 0.0169 0.1091 0.5541
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.041 0.041
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Entamoeba histolytica cysteine proteinase, putative 0.0288 0.1922 1
Schistosoma mansoni cpg binding protein 0.0031 0.013 0.013
Echinococcus granulosus sodium:myo inositol cotransporter 0.0041 0.0202 0.0202
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0081 0.0482 0.0482
Brugia malayi Cathepsin L-like precursor 0.0288 0.1922 0.1922
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0424 0.0424
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0058 0.0058
Entamoeba histolytica cysteine protease, putative 0.0087 0.0524 0.25
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0422 0.0422
Loa Loa (eye worm) hypothetical protein 0.0029 0.0115 0.0115
Echinococcus granulosus cpg binding protein 0.0033 0.0142 0.0142
Onchocerca volvulus 0.0288 0.1922 1
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0058 0.0058
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0073 0.0424 0.0424
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0169 0.1091 0.1049
Brugia malayi cathepsin Z-like cysteine proteinase 0.0087 0.0524 0.0524
Echinococcus multilocularis cathepsin L cysteine protease 0.0288 0.1922 0.1922
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0058 0.0058
Brugia malayi cathepsin F-like cysteine proteinase 0.0081 0.0482 0.0482
Brugia malayi hypothetical protein 0.0162 0.1045 0.1045
Brugia malayi jmjC domain containing protein 0.0073 0.0422 0.0422
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0115 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0169 0.1091 0.3041
Echinococcus granulosus intermediate filament protein 0.0029 0.0117 0.0117
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0058 0.0058
Brugia malayi Cathepsin L-like precursor 0.0207 0.1356 0.1356
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1419 0.4005
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0573 0.0573
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0288 0.1922 1
Toxoplasma gondii cathepsin CPL 0.0288 0.1922 0.5503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Onchocerca volvulus 0.0029 0.0117 0.0606
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0012
Echinococcus granulosus cathepsin l1 0.0207 0.1356 0.1356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0034 0.0151 0.0151
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0115 0.0991
Schistosoma mansoni hypothetical protein 0.0034 0.0151 0.0151
Entamoeba histolytica cysteine proteinase, putative 0.0169 0.1091 0.5541
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0087 0.0524 0.2545
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0087 0.0524 0.2545
Loa Loa (eye worm) hypothetical protein 0.0087 0.0524 0.0524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0524 0.1372
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0115 0.0198
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5726 0.5726
Entamoeba histolytica cysteine protease, putative 0.0288 0.1922 1
Plasmodium falciparum serine repeat antigen 2 0.0087 0.0524 0.2545
Plasmodium vivax unspecified product 0.0081 0.0482 0.2318
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2089 0.598
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0087 0.0524 0.25
Echinococcus granulosus high affinity choline transporter 1 0.0373 0.2514 0.2514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Schistosoma mansoni jumonji domain containing protein 0.0071 0.041 0.041
Schistosoma mansoni high-affinity choline transporter 0.0373 0.2514 0.2514
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0117 0.0117
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0087 0.0524 0.2545
Plasmodium falciparum serine repeat antigen 5 0.0087 0.0524 0.2545
Toxoplasma gondii cathepsin CPC1 0.0087 0.0524 0.1401
Brugia malayi cathepsin Z-like cysteine proteinase 0.0087 0.0524 0.0524
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0347 0.0347
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0369 0.0944
Echinococcus multilocularis cysteine protease 0.0288 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0074 0.043 0.043
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0041 0.0202 0.0202
Echinococcus multilocularis cathepsin L 0.0087 0.0524 0.0524
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0058 0.0058
Echinococcus granulosus lamin dm0 0.0029 0.0117 0.0117
Echinococcus multilocularis cathepsin L cysteine protease 0.0288 0.1922 0.1922
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.0524 0.0524
Entamoeba histolytica cysteine protease, putative 0.0087 0.0524 0.25
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0087 0.0524 0.2545
Echinococcus multilocularis GPCR, family 2 0.0034 0.0151 0.0151
Trypanosoma cruzi cysteine proteinase, putative 0.0169 0.1091 0.1049
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0115 0.1565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.1342 0.6979
Brugia malayi cathepsin L precursor 0.0087 0.0524 0.0524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Plasmodium vivax unspecified product 0.0169 0.1091 0.5568
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0059 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.1356 0.382
Plasmodium falciparum serine repeat antigen 6 0.0087 0.0524 0.2545
Loa Loa (eye worm) hypothetical protein 0.0081 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.0113
Loa Loa (eye worm) ctsf protein 0.0288 0.1922 0.1922
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Loa Loa (eye worm) hypothetical protein 0.0162 0.1045 0.1045
Echinococcus multilocularis tumor protein p63 0.0408 0.276 0.276
Loa Loa (eye worm) hypothetical protein 0.0087 0.0524 0.0524
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2089 0.598
Brugia malayi jmjC domain containing protein 0.0019 0.0047 0.0047
Echinococcus granulosus phd:f box containing protein 0.0019 0.0047 0.0047
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0047 0.0047
Plasmodium falciparum serine repeat antigen 4 0.0087 0.0524 0.2545
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0012 0.0012
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.043 0.043
Leishmania major cathepsin L-like protease 0.0339 0.2277 0.6545
Plasmodium falciparum serine repeat antigen 1 0.0087 0.0524 0.2545
Brugia malayi hypothetical protein 0.0021 0.0058 0.0058
Brugia malayi Probable ClpP-like protease 0.0094 0.0573 0.0573
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0347 0.7759
Trypanosoma cruzi cysteine peptidase, putative 0.0288 0.1922 0.1884
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0047 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0047 0.0047
Schistosoma mansoni cathepsin s 0.0081 0.0482 0.0482
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1342 0.3779
Echinococcus granulosus dnaJ subfamily B 0.0439 0.2973 0.2973
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0115 0.0198
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.043 0.7194
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0288 0.1922 0.1922
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0047 0.0047
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.037 0.037
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0117 0.0117
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0087 0.0524 0.2545
Echinococcus granulosus cysteine protease 0.0169 0.1091 0.1091
Onchocerca volvulus 0.0288 0.1922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0087 0.0524 0.1372
Loa Loa (eye worm) hypothetical protein 0.0094 0.0573 0.0573
Leishmania major cathepsin L-like protease 0.0288 0.1922 0.5503
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0058 0.0058
Brugia malayi jmjC domain containing protein 0.0019 0.0047 0.0047
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0115 0.0991
Brugia malayi Papain family cysteine protease containing protein 0.0169 0.1091 0.1091
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0087 0.0524 0.1372
Schistosoma mansoni inositol transporter 0.0041 0.0202 0.0202
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.0524 0.0524
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0087 0.0524 0.0524
Brugia malayi cathepsin F-like cysteine proteinase 0.0087 0.0524 0.0524
Schistosoma mansoni cathepsin B (C01 family) 0.0087 0.0524 0.0524
Brugia malayi Papain family cysteine protease containing protein 0.0288 0.1922 0.1922
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0087 0.0524 0.0524
Schistosoma mansoni cathepsin S (C01 family) 0.0087 0.0524 0.0524
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0087 0.0524 0.0524
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0087 0.0524 0.2545
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0288 0.1922 0.5488
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0058 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Brugia malayi jmjC domain containing protein 0.0071 0.041 0.041
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0087 0.0524 0.2545
Loa Loa (eye worm) cathepsin B 0.0508 0.3455 0.3455
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0288 0.1922 0.5488
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0081 0.0482 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0058 0.0058
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0041 0.0202 0.0453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0524 0.1372
Mycobacterium ulcerans hypothetical protein 0.0029 0.0115 0.0991
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0087 0.0524 0.2545
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0087 0.0524 0.2545
Loa Loa (eye worm) hypothetical protein 0.0373 0.2514 0.2514
Entamoeba histolytica cysteine protease, putative 0.0087 0.0524 0.25
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0064
Echinococcus granulosus cathepsin l cysteine peptidase 0.0288 0.1922 0.1922
Echinococcus multilocularis high affinity choline transporter 1 0.0373 0.2514 0.2514
Loa Loa (eye worm) hypothetical protein 0.0207 0.1356 0.1356
Plasmodium vivax serine-repeat antigen (SERA) 0.0087 0.0524 0.2545
Onchocerca volvulus 0.0029 0.0115 0.0596
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5726 0.5726
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0087 0.0524 0.0524
Onchocerca volvulus 0.0288 0.1922 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0087 0.0524 0.0524
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0087 0.0524 0.25
Plasmodium falciparum cysteine proteinase falcipain 3 0.0288 0.1922 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0047 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0047 0.0047
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0064 0.0218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0524 0.1372
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0087 0.0524 0.2545
Echinococcus multilocularis musashi 0.0029 0.0117 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2089 0.598
Entamoeba histolytica hypothetical protein 0.0087 0.0524 0.25
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0115 0.0115
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0058 0.0058
Echinococcus multilocularis solute carrier family 5 0.0041 0.0202 0.0202
Echinococcus granulosus solute carrier family 5 0.0041 0.0202 0.0202
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0074 0.043 1
Leishmania major cathepsin L-like protease 0.0288 0.1922 0.5503
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0288 0.1922 0.5488
Trypanosoma cruzi cysteine proteinase, putative 0.0169 0.1091 0.1049
Echinococcus multilocularis cysteine protease 0.0288 0.1922 0.1922
Echinococcus granulosus expressed protein 0.04 0.2705 0.2705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0047 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0058 0.0058
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0058 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1342 0.3779
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1342 0.3779
Plasmodium falciparum cysteine proteinase falcipain 1 0.0169 0.1091 0.5568
Entamoeba histolytica cysteine proteinase, putative 0.0288 0.1922 1
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0288 0.1922 0.5488
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0573 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0508 0.3455 0.3455
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.066 0.066
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0331 0.0331
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.043 0.7194
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0422 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0087 0.0524 0.1372
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1342 0.3779
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.2089 0.2089
Schistosoma mansoni cathepsin C 0.0087 0.0524 0.0524
Schistosoma mansoni sodium/solute symporter 0.0041 0.0202 0.0202
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0369 0.0369
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1342 0.3779
Schistosoma mansoni hypothetical protein 0.0034 0.0151 0.0151
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0047 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.0081 0.0482 0.0437
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0058 0.0058
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0115 0.0991
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0115 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0087 0.0524 0.1372
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0524 0.1372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0142 0.0505
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0047 0.0047
Entamoeba histolytica cysteine proteinase, putative 0.0207 0.1356 0.696
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0064
Onchocerca volvulus Cathepsin L homolog 0.0087 0.0524 0.2728
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0058 0.0058
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0087 0.0524 0.0524
Leishmania major cysteine peptidase A (CPA) 0.0288 0.1922 0.5503
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0142 0.0505
Echinococcus multilocularis cpg binding protein 0.0033 0.0142 0.0142
Schistosoma mansoni intermediate filament proteins 0.0029 0.0117 0.0117
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0058 0.0058
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0081 0.0482 0.0482
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0058
Onchocerca volvulus 0.0087 0.0524 0.2728
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0288 0.1922 0.1922
Brugia malayi Cathepsin L-like precursor 0.0288 0.1922 0.1922
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0151 0.0151
Plasmodium vivax unspecified product 0.0087 0.0524 0.2545
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.066 0.066
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0034 0.0151 0.0151
Echinococcus granulosus cathepsin L 0.0169 0.1091 0.1091
Loa Loa (eye worm) fibroinase 0.0288 0.1922 0.1922
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0058 0.0058
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0041 0.0202 0.0202
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0573 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0059 0.0059
Leishmania major cathepsin L-like protease 0.0288 0.1922 0.5503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Schistosoma mansoni cpg binding protein 0.0033 0.0142 0.0142
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0508 0.3455 0.3424
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0058 0.0058
Entamoeba histolytica cysteine proteinase 1, putative 0.0169 0.1091 0.5541
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0058 0.0058
Brugia malayi PXA domain containing protein 0.0021 0.0058 0.0058
Onchocerca volvulus Cathepsin L homolog 0.0288 0.1922 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0058 0.0058
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0047 0.0047
Leishmania major cathepsin L-like protease 0.0339 0.2277 0.6545
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0524 0.1372
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0064
Toxoplasma gondii hypothetical protein 0.0033 0.0142 0.0278
Entamoeba histolytica cysteine proteinase, putative 0.0169 0.1091 0.5541
Brugia malayi cathepsin L-like cysteine proteinase 0.0087 0.0524 0.0524
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0074 0.043 0.1125
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.1419 0.4005
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2089 0.598
Trypanosoma cruzi cruzipain precursor, putative 0.0339 0.2277 0.2241
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2089 0.598
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0524 0.1372
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0422 0.0422
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0087 0.0524 0.2545
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.043 0.043
Onchocerca volvulus 0.0018 0.0039 0.0201
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0087 0.0524 0.0524
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0151 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.1091 0.3064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0288 0.1922 0.5488
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0115 0.1565
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0058 0.0058
Onchocerca volvulus 0.0288 0.1922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0087 0.0524 0.1372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0169 0.1091 0.3064
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0347 0.0347
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1342 0.3779
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Echinococcus granulosus cathepsin L 0.0087 0.0524 0.0524
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Loa Loa (eye worm) hypothetical protein 0.006 0.0331 0.0331
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0041 0.0202 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0207 0.1356 0.382
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0058 0.0058
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.2973 0.2973
Echinococcus granulosus tumor protein p63 0.0408 0.276 0.276
Onchocerca volvulus 0.0162 0.1045 0.5434
Loa Loa (eye worm) hypothetical protein 0.0288 0.1922 0.1922
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0029 0.0115 0.0115
Plasmodium falciparum serine repeat antigen 3 0.0087 0.0524 0.2545
Trypanosoma cruzi cysteine protease, putative 0.0169 0.1091 0.1049
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0087 0.0524 0.2545
Plasmodium vivax vivapain-1 0.0169 0.1091 0.5568
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Schistosoma mansoni cpg binding protein 0.0033 0.0142 0.0142
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0115 0.0302
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0115 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0087 0.0524 0.0524
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0288 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0087 0.0524 0.0524
Brugia malayi hypothetical protein 0.0021 0.0058 0.0058
Schistosoma mansoni cathepsin F (C01 family) 0.0288 0.1922 0.1922
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0064 0.0091
Echinococcus multilocularis lamin 0.0029 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0524 0.1372
Loa Loa (eye worm) hypothetical protein 0.0087 0.0524 0.0524
Entamoeba histolytica cysteine proteinase, putative 0.0169 0.1091 0.5541
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0058 0.0058
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0151 0.0151
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0058 0.0058
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5726 0.5726
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0009
Echinococcus granulosus sodium:glucose cotransporter 2 0.0041 0.0202 0.0202
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0347 0.7759
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0288 0.1922 1
Plasmodium falciparum serine repeat antigen 9 0.0087 0.0524 0.2545
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0369 0.5984
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0058 0.0058
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0058 0.0058
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0347 0.5056
Loa Loa (eye worm) hypothetical protein 0.0207 0.1356 0.1356
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0087 0.0524 0.0524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Trypanosoma cruzi cysteine peptidase, putative 0.0169 0.1091 0.1049
Echinococcus granulosus GPCR family 2 0.0034 0.0151 0.0151
Loa Loa (eye worm) cysteine protease 0.0288 0.1922 0.1922
Trypanosoma cruzi cysteine peptidase, putative 0.0339 0.2277 0.2241
Onchocerca volvulus 0.0029 0.0117 0.0606
Echinococcus granulosus cathepsin L cysteine proteinase 0.0288 0.1922 0.1922
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0288 0.1922 0.5488
Plasmodium vivax serine-repeat antigen (SERA) 0.0087 0.0524 0.2545
Brugia malayi PXA domain containing protein 0.0021 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0087 0.0524 0.1372
Leishmania major cathepsin L-like protease 0.0288 0.1922 0.5503
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.2089 0.598
Onchocerca volvulus 0.006 0.0331 0.1724
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0288 0.1922 0.1922
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0047 0.0047
Schistosoma mansoni cathepsin F (C01 family) 0.0288 0.1922 0.1922
Brugia malayi Cathepsin L-like precursor 0.0081 0.0482 0.0482
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0047 0.0047
Schistosoma mansoni lamin 0.0029 0.0117 0.0117
Brugia malayi cathepsin L-like precursor 0.0207 0.1356 0.1356
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0369 0.5984
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0151 0.0151
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0573 1
Onchocerca volvulus Cathepsin F homolog 0.0288 0.1922 1
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Echinococcus granulosus cathepsin l1 0.0288 0.1922 0.1922
Onchocerca volvulus Cathepsin L homolog 0.0288 0.1922 1
Plasmodium vivax vivapain-3 0.0169 0.1091 0.5568
Leishmania major cathepsin L-like protease 0.0288 0.1922 0.5503
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0115 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0524 0.1372
Brugia malayi Cathepsin L-like precursor 0.0288 0.1922 0.1922
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0524 0.0524
Plasmodium vivax vivapain-2 0.0288 0.1922 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0041 0.0202 0.0202
Echinococcus granulosus sodium:glucose cotransporter 0.0041 0.0202 0.0202
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0369 0.8355
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0087 0.0524 0.1372
Schistosoma mansoni lamin 0.0029 0.0117 0.0117
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0573 0.2807
Toxoplasma gondii cathepsin CPC2 0.0087 0.0524 0.1401
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Brugia malayi Cathepsin L-like cysteine proteinase 0.0207 0.1356 0.1356
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0169 0.1091 0.1091
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0087 0.0524 0.0524
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0573 0.1545
Brugia malayi Papain family cysteine protease containing protein 0.0169 0.1091 0.1091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Onchocerca volvulus 0.0031 0.013 0.0674
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0422 0.0422
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0087 0.0524 0.2545
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Plasmodium falciparum serine repeat antigen 7 0.0087 0.0524 0.2545
Echinococcus granulosus lamin 0.0029 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0524 0.1372
Brugia malayi jmjC domain containing protein 0.0019 0.0047 0.0047
Onchocerca volvulus 0.0288 0.1922 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6743 0.6743
Toxoplasma gondii preprocathepsin c precursor, putative 0.0087 0.0524 0.1401
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0023 0.0023
Brugia malayi Sodium:solute symporter family protein 0.0041 0.0202 0.0202
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0087 0.0524 0.1372
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0573 1
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0258 0.1711 0.1672
Brugia malayi Papain family cysteine protease containing protein 0.0087 0.0524 0.0524
Giardia lamblia Cathepsin B precursor 0.0508 0.3455 1
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0047 0.0047
Trypanosoma cruzi major cysteine proteinase, putative 0.0138 0.0879 0.0836
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0369 0.0369
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0087 0.0524 0.0524
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0012 0.0012
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0369 0.0369
Plasmodium falciparum serine repeat antigen 8 0.0087 0.0524 0.2545
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.041 0.041
Trypanosoma cruzi cysteine peptidase, putative 0.0339 0.2277 0.2241
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.013 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0508 0.3455 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0573 0.0573
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0047 0.0047
Trypanosoma cruzi major cysteine proteinase, putative 0.0087 0.0524 0.048
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0169 0.1091 0.1091
Brugia malayi CXXC zinc finger family protein 0.0031 0.013 0.013
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0033 0.0142 0.0593
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.2089 0.2089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0369 0.5984
Giardia lamblia Cathepsin B precursor 0.0508 0.3455 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0369 0.0944
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0058 0.0058
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0288 0.1922 0.5488
Onchocerca volvulus 0.0041 0.0202 0.1048
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0058 0.0058
Echinococcus multilocularis expressed protein 0.04 0.2705 0.2705
Entamoeba histolytica cysteine protease, putative 0.0087 0.0524 0.25
Echinococcus multilocularis lamin dm0 0.0029 0.0117 0.0117
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0115 0.0198
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0064 0.0091
Brugia malayi jmjC domain containing protein 0.0019 0.0047 0.0047
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0288 0.1922 0.5488
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0573 1
Toxoplasma gondii cathepsin B 0.0508 0.3455 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0151 0.0151
Trypanosoma cruzi cysteine peptidase, putative 0.0339 0.2277 0.2241
Echinococcus granulosus cathepsin L cysteine protease 0.0169 0.1091 0.1091
Brugia malayi Cathepsin L-like precursor 0.0288 0.1922 0.1922
Loa Loa (eye worm) hypothetical protein 0.0207 0.1356 0.1356
Entamoeba histolytica cysteine proteinase, putative 0.0169 0.1091 0.5541
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0115 0.0991
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0288 0.1922 0.5488
Loa Loa (eye worm) hypothetical protein 0.0029 0.0115 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0087 0.0524 0.1372
Loa Loa (eye worm) hypothetical protein 0.0087 0.0524 0.0524
Entamoeba histolytica cysteine protease, putative 0.0087 0.0524 0.25
Leishmania major cathepsin L-like protease 0.0339 0.2277 0.6545
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1342 0.3779
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0064
Entamoeba histolytica cysteine protease, putative 0.0087 0.0524 0.25
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0087 0.0524 0.1372
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.066 0.066
Giardia lamblia Cathepsin B precursor 0.0508 0.3455 1
Brugia malayi Cathepsin L-like precursor 0.0207 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0288 0.1922 0.5488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0573 0.0573
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0115 0.0302
Trypanosoma brucei cysteine peptidase C (CPC) 0.0508 0.3455 1
Schistosoma mansoni inositol transporter 0.0041 0.0202 0.0202
Entamoeba histolytica cysteine protease, putative 0.0169 0.1091 0.5541
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0058 0.0058
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0573 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0058
Brugia malayi Cathepsin L-like precursor 0.0288 0.1922 0.1922
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0365 0.0365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0339 0.2277 0.6545
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0058 0.0058
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0058 0.0058
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0115 0.0991
Onchocerca volvulus 0.0288 0.1922 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0288 0.1922 0.5488
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0087 0.0524 0.0524
Trypanosoma cruzi cruzipain precursor, putative 0.0081 0.0482 0.0437
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0009
Brugia malayi fibroinase precursor 0.0087 0.0524 0.0524
Loa Loa (eye worm) hypothetical protein 0.0034 0.0151 0.0151
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0058 0.0058
Onchocerca volvulus 0.0288 0.1922 1
Brugia malayi Cathepsin L-like precursor 0.0288 0.1922 0.1922
Brugia malayi intermediate filament protein 0.0029 0.0117 0.0117
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0087 0.0524 0.0524
Onchocerca volvulus 0.0207 0.1356 0.7052
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0169 0.1091 0.1091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0117
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0041 0.0202 0.0202
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0115 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0288 0.1922 0.5488

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 10 um PUBCHEM_BIOASSAY: Dose response cell-based high throughput screening assay to identify enhancers of beta-glucosidase activity. (Class of assay: confirmatory) [Related pubchem assays: 784 ] ChEMBL. No reference
Potency (binding) = 1.5849 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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