TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 506.573 | Formula: C26H26N4O5S
H donors: 2 H acceptors: 4 LogP: 3.1 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc2ccnc(c2cc1CN1CC[C@@H](C1=O)NS(=O)(=O)c1ccc2c(c1)cc(cc2)OC)N
InChi: 1S/C26H26N4O5S/c1-34-20-5-3-16-4-6-21(12-18(16)11-20)36(32,33)29-23-8-10-30(26(23)31)15-19-13-22-17(14-24(19)35-2)7-9-28-25(22)27/h3-7,9,11-14,23,29H,8,10,15H2,1-2H3,(H2,27,28)/t23-/m0/s1
InChiKey: RTZPSFNQGNYELJ-QHCPKHFHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Coagulation factor X	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Huntingtin homolog	0.0131	0.3108	0.8077
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0044	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.0026
Brugia malayi	photoreceptor-specific nuclear receptor	0.0007	0.0044	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0096
Leishmania major	4-coumarate:coa ligase-like protein	0.0009	0.0074	0.162
Schistosoma mansoni	ferritin	0.0009	0.0072	0.0093
Toxoplasma gondii	hypothetical protein	0.0018	0.0319	0.0319
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0402	0.2406
Onchocerca volvulus		0.0041	0.0887	0.2281
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3845	0.4983
Onchocerca volvulus	Huntingtin homolog	0.0131	0.3108	0.8077
Echinococcus multilocularis	expressed protein	0.0009	0.0072	0.0093
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0457	1
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0457	0.2807
Entamoeba histolytica	hypothetical protein	0.0037	0.0788	0.4833
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.0026
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0402	0.2469
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0009	0.0074	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0027	0.0164
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0071	0.163	1
Brugia malayi	Delta serrate ligand family protein	0.0006	0.0014	0.0035
Schistosoma mansoni	ferritin	0.0009	0.0072	0.0093
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0409	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0261	0.0338
Echinococcus multilocularis	tyrosine protein kinase shark	0.0066	0.1494	0.1937
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.025	0.6053	0.6434
Schistosoma mansoni	notch	0.0006	0.0014	0.0018
Schistosoma mansoni	notch	0.0006	0.0014	0.0018
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0007	0.0044	0.0114
Brugia malayi	Fibulin-1 precursor	0.0016	0.0261	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0044	0.0057
Brugia malayi	Muscle positioning protein 4	0.0006	0.0014	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0007	0.0044	0.0114
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0409	1	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0009	0.0074	0.0054
Echinococcus multilocularis	Tolloid protein 1	0.0016	0.0261	0.0338
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0071	0.163	0.4239
Echinococcus granulosus	ferritin	0.0009	0.0072	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.0026
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	0.0007	0.0027	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0071	0.163	0.2112
Echinococcus granulosus	notch	0.0006	0.0014	0.0018
Brugia malayi	RNA, U transporter 1	0.0084	0.1953	0.508
Schistosoma mansoni	nuclear hormone receptor	0.0007	0.0044	0.0057
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3108	0.4028
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0007	0.0044	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Brugia malayi	Calcium binding EGF domain containing protein	0.0006	0.0014	0.0035
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0402	0.6744
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0007	0.0044	0.0057
Echinococcus multilocularis	ecdysone induced protein 78C	0.0007	0.0044	0.0057
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0007	0.0044	0.0057
Echinococcus granulosus	neurogenic locus protein delta	0.0006	0.0014	0.0018
Echinococcus multilocularis	neural cadherin	0.0006	0.0014	0.0018
Schistosoma mansoni	hypothetical protein	0.0181	0.4352	0.5641
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0597	0.0597
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0007	0.0044	0.0057
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0402	0.1046
Brugia malayi	AMP-binding enzyme family protein	0.0009	0.0074	0.0193
Schistosoma mansoni	slit	0.0006	0.0014	0.0018
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0597	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0788	0.1021
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0007	0.0044	0.0114
Schistosoma mansoni	hypothetical protein	0.0006	0.0014	0.0018
Entamoeba histolytica	hypothetical protein	0.0037	0.0788	0.4833
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0044	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0261	0.0338
Brugia malayi	Cadherin domain containing protein	0.0006	0.0014	0.0035
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0788	0.1021
Echinococcus multilocularis	snurportin 1	0.0317	0.7715	1
Echinococcus multilocularis	protein jagged 1	0.0006	0.0014	0.0018
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0007	0.0027	0.0035
Trypanosoma brucei	glutaminyl cyclase, putative	0.0007	0.0027	0.0448
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0007	0.0044	0.0057
Echinococcus multilocularis	fibrillin 1	0.0016	0.0261	0.0338
Mycobacterium ulcerans	acyl-CoA synthetase	0.0009	0.0074	0.0054
Echinococcus granulosus	glutaminyl peptide cyclotransferase	0.0007	0.0027	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0044	0.0057
Brugia malayi	AMP-binding enzyme family protein	0.0009	0.0074	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0071	0.163	1
Echinococcus granulosus	expressed protein	0.0009	0.0072	0.0093
Schistosoma mansoni	apoferritin-2	0.0009	0.0072	0.0093
Echinococcus granulosus	importin subunit beta 1	0.003	0.0597	0.0773
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0009	0.0074	0.0054
Schistosoma mansoni	RAR-like nuclear receptor	0.0007	0.0044	0.0057
Schistosoma mansoni	egf-like domain protein	0.0016	0.0261	0.0338
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0402	0.8721
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0007	0.0044	0.0114
Echinococcus granulosus	neurogenic locus notch protein 4	0.0006	0.0014	0.0018
Mycobacterium ulcerans	bacterioferritin BfrB	0.0009	0.0072	0.0052
Brugia malayi	Calcium binding EGF domain containing protein	0.0006	0.0014	0.0035
Plasmodium vivax	importin-beta 2, putative	0.003	0.0597	0.3661
Brugia malayi	EGF-like domain containing protein	0.0006	0.0014	0.0035
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0018	0.0319	0.5355
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0006	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0044	0.0057
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0009	0.0074	0.0054
Mycobacterium ulcerans	acyl-CoA synthetase	0.0009	0.0074	0.0054
Echinococcus granulosus	tyrosine protein kinase shark	0.0066	0.1494	0.1937
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.01	0.2351	0.3047
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0261	0.0338
Trypanosoma brucei	hypothetical protein, conserved	0.0018	0.0319	0.5355
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0044	0.0057
Echinococcus granulosus	geminin	0.0181	0.4352	0.5641
Echinococcus granulosus	delta-like protein 1	0.0006	0.0014	0.0018
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0071	0.163	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0044	0.0057
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0016	0.0261	0.0338
Schistosoma mansoni	septate junction protein	0.0006	0.0014	0.0018
Mycobacterium ulcerans	hypothetical protein	0.0007	0.0027	0.0007
Echinococcus granulosus	fibropellin Ia	0.0006	0.0014	0.0018
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0007	0.0044	0.0057
Brugia malayi	leucyl aminopeptidase	0.0007	0.0027	0.007
Schistosoma mansoni	nicalin (M28 family)	0.0007	0.0027	0.0035
Entamoeba histolytica	hypothetical protein	0.0037	0.0788	0.4833
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0007	0.0044	0.0114
Trichomonas vaginalis	Clan MH, family M28, aminopeptidase S-like metallopeptidase	0.0007	0.0027	0.0164
Onchocerca volvulus	Arrow homolog	0.0016	0.0261	0.0646
Loa Loa (eye worm)	Notch2	0.0006	0.0014	0.0018
Brugia malayi	EGF-like domain containing protein	0.0006	0.0014	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0161	0.3845	0.4983
Onchocerca volvulus	Fxna peptidase homolog	0.0007	0.0027	0.0034
Schistosoma mansoni	thyroid hormone receptor	0.0007	0.0044	0.0057
Brugia malayi	steroid hormone receptor	0.0007	0.0044	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0009	0.0074	0.0165
Mycobacterium ulcerans	hypothetical protein	0.0009	0.0074	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0027	0.0164
Schistosoma mansoni	glutaminyl cyclase (M28 family)	0.0007	0.0027	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0007	0.0044	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0035
Echinococcus granulosus	neural cadherin	0.0006	0.0014	0.0018
Schistosoma mansoni	hypothetical protein	0.0006	0.0014	0.0018
Echinococcus multilocularis	ferritin	0.0009	0.0072	0.0093
Brugia malayi	Cadherin domain containing protein	0.0006	0.0014	0.0035
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0009	0.0074	0.0455
Entamoeba histolytica	Ran family GTPase	0.0022	0.0402	0.2469
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Loa Loa (eye worm)	runx1	0.002	0.0361	0.0467
Loa Loa (eye worm)	notch protein	0.0006	0.0014	0.0018
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0018	0.0319	0.0414
Brugia malayi	Nuclear hormone receptor-like 1	0.0007	0.0044	0.0114
Trichomonas vaginalis	ferritin, putative	0.0009	0.0072	0.0442
Echinococcus multilocularis	neurogenic locus protein delta	0.0006	0.0014	0.0018
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0009	0.0074	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0044	0.0057
Echinococcus granulosus	protein jagged 2	0.0006	0.0014	0.0018
Brugia malayi	nuclear receptor NHR-88	0.0007	0.0044	0.0114
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0071	0.163	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0009	0.0074	0.162
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0006	0.0014	0.0018
Chlamydia trachomatis	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.025	0.6053	0.6045
Brugia malayi	EGF-like domain containing protein	0.0006	0.0014	0.0035
Toxoplasma gondii	hypothetical protein	0.0007	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0094	0.2185	0.2832
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0007	0.0044	0.0114
Schistosoma mansoni	ferritin light chain	0.0009	0.0072	0.0093
Schistosoma mansoni	notch	0.0006	0.0014	0.0018
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0007	0.0044	0.0057
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0402	0.0402
Onchocerca volvulus	Fxna peptidase homolog	0.0007	0.0027	0.0034
Mycobacterium tuberculosis	3-dehydroquinate synthase AroB	0.0159	0.3808	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0053	0.1171	0.7186
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0007	0.0044	0.0057
Onchocerca volvulus	Protein ultraspiracle homolog	0.0007	0.0044	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0007	0.0044	0.0057
Schistosoma mansoni	tyrosine kinase	0.0064	0.1457	0.1889
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0018	0.0319	0.0414
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0007	0.0027	0.0035
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0018	0.0319	0.196
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0016	0.0261	0.0261
Echinococcus multilocularis	fibropellin Ia	0.0006	0.0014	0.0018
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0018	0.0319	0.0414
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0071	0.163	0.2112
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0006	0.0014	0.0018
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0007	0.0044	0.0079
Echinococcus granulosus	neurogenic locus notch protein	0.0006	0.0014	0.0018
Brugia malayi	Steroid receptor seven-up type 2	0.0007	0.0044	0.0114
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0457	0.2807
Toxoplasma gondii	EGF family domain-containing protein	0.0006	0.0014	0.0014
Toxoplasma gondii	hypothetical protein	0.0053	0.1171	0.1171
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0044	0.0057
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0007	0.0044	0.0057
Echinococcus granulosus	protein jagged 1	0.0006	0.0014	0.0018
Echinococcus multilocularis	FTZ F1 alpha	0.0007	0.0044	0.0057
Schistosoma mansoni	Fxna peptidase (M28 family)	0.0007	0.0027	0.0035
Schistosoma mansoni	ferritin	0.0009	0.0072	0.0093
Brugia malayi	EGF-like domain containing protein	0.0006	0.0014	0.0035
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0071	0.163	0.2112
Schistosoma mansoni	hypothetical protein	0.0006	0.0014	0.0018
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0006	0.002	0.0023
Entamoeba histolytica	acyl-coA synthetase, putative	0.0009	0.0074	0.0455
Treponema pallidum	HPr kinase/phosphorylase	0.0383	0.9369	1
Leishmania major	GTP-binding protein, putative	0.0022	0.0402	0.8795
Giardia lamblia	Rab geranylgeranyltransferase	0.0071	0.163	1
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0066	0.1492	0.1934
Onchocerca volvulus	Bile acid receptor homolog	0.0007	0.0044	0.0079
Onchocerca volvulus	Glutaminyl cyclase homolog	0.0007	0.0027	0.0034
Schistosoma mansoni	thyroid hormone receptor	0.0007	0.0044	0.0057
Chlamydia trachomatis	dehyroquinate synthase	0.0159	0.3808	0.3795
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0402	0.2469
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0009	0.0074	0.0002
Brugia malayi	ecdysteroid receptor	0.0007	0.0044	0.0114
Schistosoma mansoni	hypothetical protein	0.0006	0.0014	0.0018
Echinococcus granulosus	laminin	0.0016	0.0261	0.0338
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0409	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0046	0.0996	0.2591
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0261	0.0338
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0016	0.0261	0.0338
Onchocerca volvulus		0.0009	0.0074	0.0158
Brugia malayi	Calcium binding EGF domain containing protein	0.0006	0.0014	0.0035
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0018	0.0319	0.0414
Echinococcus granulosus	FTZ F1 alpha	0.0007	0.0044	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0096
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0018	0.0319	0.0831
Loa Loa (eye worm)	steroid hormone receptor	0.0007	0.0044	0.0057
Brugia malayi	EGF-like domain containing protein	0.0006	0.0014	0.0035
Toxoplasma gondii	peptidase, M28 family protein	0.0007	0.0027	0.0027
Onchocerca volvulus	Tyrosine kinase homolog	0.0043	0.0922	0.2371
Schistosoma mansoni	ferritin light chain	0.0009	0.0072	0.0093
Brugia malayi	FXNA	0.0007	0.0027	0.007
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0007	0.0044	0.0057
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0007	0.0027	0.0035
Loa Loa (eye worm)	leucyl aminopeptidase	0.0007	0.0027	0.0035
Schistosoma mansoni	hypothetical protein	0.0006	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0016	0.0261	0.0679
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0007	0.0027	0.0035
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0009	0.0074	0.0165
Schistosoma mansoni	apoferritin-2	0.0009	0.0072	0.0093
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0007	0.0044	0.0114
Mycobacterium ulcerans	lipoprotein aminopeptidase LpqL	0.0009	0.0087	0.0067
Mycobacterium tuberculosis	Probable lipoprotein aminopeptidase LpqL	0.0009	0.0087	0.02
Loa Loa (eye worm)	hypothetical protein	0.0019	0.033	0.0428
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0016	0.0261	0.0338
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0018	0.0319	0.5355
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0071	0.163	1
Onchocerca volvulus		0.0161	0.3845	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0457	0.2807
Brugia malayi	hypothetical protein	0.0131	0.3108	0.8084
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0044	0.0057
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0402	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2411	0.3125
Echinococcus granulosus	protein jagged 1	0.0006	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0044	0.0057
Brugia malayi	nicalin	0.0007	0.0027	0.007
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0044	0.0057
Brugia malayi	notch-like transmembrane receptor	0.0006	0.0014	0.0035
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0402	0.0521
Brugia malayi	nuclear hormone receptor	0.0007	0.0044	0.0114
Echinococcus multilocularis	laminin	0.0016	0.0261	0.0338
Schistosoma mansoni	retinoic acid receptor RXR	0.0007	0.0044	0.0057
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0007	0.0044	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0071	0.163	0.2112
Loa Loa (eye worm)	hypothetical protein	0.003	0.0597	0.0773
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0007	0.0044	0.0057
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0018	0.0319	0.6796
Schistosoma mansoni	ran	0.0022	0.0402	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1553	0.2013
Onchocerca volvulus		0.0018	0.0319	0.0798
Echinococcus multilocularis	slit 2 protein	0.0006	0.0014	0.0018
Schistosoma mansoni	hypothetical protein	0.0037	0.0788	0.1021
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0007	0.0044	0.0114
Brugia malayi	GCC2 and GCC3 family protein	0.0006	0.0014	0.0035
Schistosoma mansoni	ferritin	0.0009	0.0072	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0319	0.6796
Schistosoma mansoni	hypothetical protein	0.0006	0.0014	0.0018
Schistosoma mansoni	hypothetical protein	0.0181	0.4352	0.5641
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Echinococcus multilocularis	protein jagged 1	0.0006	0.0014	0.0018
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0006	0.0014	0.0035
Leishmania major	glutaminyl cyclase, putative	0.0007	0.0027	0.0584
Brugia malayi	hypothetical protein	0.0161	0.3845	1
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0597	0.0773
Onchocerca volvulus		0.0007	0.0044	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3108	0.4028
Trichomonas vaginalis	ran, putative	0.0022	0.0402	0.2469
Leishmania major	hypothetical protein, conserved	0.0007	0.0027	0.0584
Schistosoma mansoni	notch	0.0006	0.0014	0.0018
Mycobacterium ulcerans	bacterioferritin BfrA	0.0009	0.0072	0.0052
Echinococcus granulosus	snurportin 1	0.0317	0.7715	1
Echinococcus multilocularis	notch	0.0006	0.0014	0.0018
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0007	0.0044	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Schistosoma mansoni	tyrosine kinase	0.0066	0.1494	0.1937
Mycobacterium tuberculosis	Conserved protein	0.0007	0.0027	0.004
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0007	0.0044	0.0114
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0007	0.0044	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Schistosoma mansoni	cell polarity protein	0.0006	0.0014	0.0018
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0402	0.0521
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0009	0.0074	0.0002
Echinococcus granulosus	neurogenic locus notch protein	0.0006	0.0014	0.0018
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0007	0.0044	0.0057
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0007	0.0044	0.0057
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0071	0.163	1
Schistosoma mansoni	glutaminyl-peptide cyclotransferase-related	0.0007	0.0027	0.0035
Schistosoma mansoni	3-dehydroquinate synthase	0.0159	0.3808	0.4935
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0007	0.0044	0.0057
Echinococcus multilocularis	neurogenic locus protein delta	0.0006	0.0014	0.0018
Plasmodium falciparum	acyl-CoA synthetase	0.0006	0.002	0.0124
Plasmodium falciparum	importin beta, putative	0.003	0.0597	0.3661
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0018	0.0319	0.6796
Schistosoma mansoni	notch	0.0006	0.0014	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0007	0.0044	0.0114
Schistosoma mansoni	lozenge	0.002	0.0361	0.0467
Schistosoma mansoni	hypothetical protein	0.0006	0.0014	0.0018
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0016	0.0261	0.0261
Mycobacterium ulcerans	acyl-CoA synthetase	0.0009	0.0074	0.0054
Schistosoma mansoni	importin beta-1	0.003	0.0597	0.0773
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0402	0.8721
Giardia lamblia	Rab geranylgeranyltransferase	0.0018	0.0319	0.1893
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0018	0.0319	0.196
Echinococcus multilocularis	neurogenic locus notch protein	0.0006	0.0014	0.0018
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.025	0.6053	0.6045
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0009	0.0072	0.0159
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.025	0.6053	1
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0018	0.0319	0.196
Entamoeba histolytica	hypothetical protein	0.0037	0.0788	0.4833
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0046	0.0996	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0018	0.0319	0.0414
Echinococcus granulosus	protein jagged 2	0.0006	0.0014	0.0018
Brugia malayi	hypothetical protein	0.0037	0.0788	0.2049
Brugia malayi	AMP-binding enzyme family protein	0.0009	0.0074	0.0193
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0007	0.0044	0.0057
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0018	0.0319	0.0414
Leishmania major	4-coumarate:coa ligase-like protein	0.0009	0.0074	0.162
Loa Loa (eye worm)	hypothetical protein	0.0006	0.002	0.0026
Schistosoma mansoni	hypothetical protein	0.0317	0.7715	1
Echinococcus multilocularis	protein jagged 2	0.0006	0.0014	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Plasmodium vivax	acyl-CoA synthetase, putative	0.0006	0.002	0.0124
Onchocerca volvulus	Fxna peptidase homolog	0.0007	0.0027	0.0034
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0007	0.0044	0.0057
Brugia malayi	EGF-like domain containing protein	0.0006	0.0014	0.0035
Echinococcus granulosus	slit 2 protein	0.0006	0.0014	0.0018
Brugia malayi	EGF-like domain containing protein	0.0006	0.0014	0.0035
Echinococcus granulosus	Tolloid protein 1	0.0016	0.0261	0.0338
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0018	0.0319	0.196
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0007	0.0044	0.0057
Schistosoma mansoni	laminin gamma-3 chain	0.0006	0.0014	0.0018
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0018	0.0319	0.6983
Mycobacterium leprae	3-dehydroquinate synthase AroB	0.0159	0.3808	0.3763
Brugia malayi	Peptidase family M28 containing protein	0.0007	0.0027	0.007
Mycobacterium tuberculosis	3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS)	0.0159	0.3808	1
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0016	0.0261	0.0338
Echinococcus multilocularis	geminin	0.0181	0.4352	0.5641
Brugia malayi	Importin beta-1 subunit	0.003	0.0597	0.1552
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0027	0.0035
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0071	0.163	0.2112
Mycobacterium ulcerans	3-dehydroquinate synthase	0.0159	0.3808	0.3795
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0457	1
Schistosoma mansoni	coup transcription factor	0.0007	0.0044	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0014	0.0018
Schistosoma mansoni	ran	0.0022	0.0402	0.0521
Echinococcus multilocularis	neurogenic locus notch protein	0.0006	0.0014	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0007	0.0044	0.0114
Echinococcus multilocularis	Protein lozenge	0.002	0.0361	0.0467
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0027	0.0164
Entamoeba histolytica	hypothetical protein	0.0024	0.0457	0.2807
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0007	0.0044	0.0057
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0317	0.7715	1
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0018	0.0319	0.5355
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0007	0.0044	0.0057
Echinococcus granulosus	ecdysone induced protein 78C	0.0007	0.0044	0.0057
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0009	0.0072	0.0159
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0007	0.0044	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0096
Schistosoma mansoni	notch	0.0006	0.0014	0.0018
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0319	0.6796
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0788	0.1021
Onchocerca volvulus		0.0007	0.0027	0.0034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0007	0.0044	0.0057
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0018	0.0319	0.6796
Brugia malayi	Calcium binding EGF domain containing protein	0.0016	0.0261	0.0679

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.89 uM	In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex	ChEMBL.	10498204
Ki (binding)	= 0.89 uM	In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex	ChEMBL.	10498204

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 139926