Detailed information for compound 1402695

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 432.265 | Formula: C20H18BrNO5
  • H donors: 1 H acceptors: 3 LogP: 3.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C1N(C)C(=O)C(=C1C(=O)c1ccc(cc1)Br)O
  • InChi: 1S/C20H18BrNO5/c1-22-17(12-6-9-14(26-2)15(10-12)27-3)16(19(24)20(22)25)18(23)11-4-7-13(21)8-5-11/h4-10,17,24H,1-3H3
  • InChiKey: NFGURHNVNRTTJJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) oxidoreductase 0.0031 0.0297 0.0894
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0136 0.1596
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0297 0.0507
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0297 0.1239
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0136 0.0216
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0058 0.0676 0.0585
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0311 0.0937
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0297 0.3594
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0058 0.0676 0.0585
Brugia malayi Matrixin family protein 0.0043 0.0469 0.1955
Echinococcus multilocularis GPCR, family 2 0.0017 0.0097 0.0152
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0287
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.06 0.2506
Loa Loa (eye worm) hypothetical protein 0.018 0.2396 0.7256
Giardia lamblia Aldose reductase 0.0031 0.0297 1
Schistosoma mansoni hypothetical protein 0.0061 0.0721 0.0631
Entamoeba histolytica aldose reductase, putative 0.0031 0.0297 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0497 0.8076
Trypanosoma brucei unspecified product 0.0019 0.0136 0.1596
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0058 0.0676 0.0585
Echinococcus multilocularis geminin 0.0178 0.2369 0.3796
Loa Loa (eye worm) hypothetical protein 0.018 0.2396 0.7256
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0367 0.1533
Plasmodium vivax aspartyl protease, putative 0.0058 0.0676 0.0344
Loa Loa (eye worm) matrix metalloproteinase 0.0043 0.0469 0.1415
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0058 0.0676 0.1262
Loa Loa (eye worm) hypothetical protein 0.0053 0.06 0.1814
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0297 0.0507
Mycobacterium ulcerans hydrolase 0.0053 0.06 0.0535
Toxoplasma gondii aspartyl protease ASP1 0.0245 0.3301 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0136 0.0216
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0297 0.2926
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0297 0.3594
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0136 0.1596
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0637 0.8806 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0676 0.2044
Loa Loa (eye worm) oxidoreductase 0.0031 0.0297 0.0894
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0583 1
Leishmania major prostaglandin f synthase, putative 0.0031 0.0297 0.3594
Echinococcus multilocularis muscleblind protein 1 0.018 0.2396 0.384
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0297 0.0473
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0053 0.06 0.2506
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Onchocerca volvulus Matrilysin homolog 0.0043 0.0469 0.1889
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Plasmodium vivax aspartyl protease, putative 0.0058 0.0676 0.0344
Schistosoma mansoni cpg binding protein 0.0034 0.0336 0.0242
Plasmodium falciparum plasmepsin II 0.0245 0.3301 1
Toxoplasma gondii aspartyl protease 0.0058 0.0676 0.1262
Schistosoma mansoni hypothetical protein 0.0454 0.6237 0.62
Loa Loa (eye worm) hypothetical protein 0.0045 0.0497 0.15
Onchocerca volvulus 0.0032 0.0311 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596
Echinococcus multilocularis aldo keto reductase 0.0031 0.0297 0.0473
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0097 0.0152
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0058 0.0676 0.2044
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0297 0.3594
Brugia malayi Matrixin family protein 0.0043 0.0469 0.1955
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0136 0.0216
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Schistosoma mansoni aldo-keto reductase 0.0031 0.0297 0.0202
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0297 0.0473
Echinococcus multilocularis cpg binding protein 0.0034 0.0336 0.0537
Plasmodium vivax aspartyl protease, putative 0.0058 0.0676 0.0344
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0309 0.3857
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0136 0.0216
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0297 0.0473
Echinococcus multilocularis muscleblind protein 0.018 0.2396 0.384
Plasmodium falciparum plasmepsin VI 0.0245 0.3301 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0311 0.1297
Echinococcus granulosus aldo keto reductase 0.0031 0.0297 0.0473
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Brugia malayi aspartic protease BmAsp-2, identical 0.0058 0.0676 0.2822
Plasmodium vivax aspartyl proteinase, putative 0.0058 0.0676 0.0344
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0297 0.4617
Loa Loa (eye worm) hypothetical protein 0.0051 0.0583 0.1761
Loa Loa (eye worm) hypothetical protein 0.0036 0.0367 0.1108
Brugia malayi hypothetical protein 0.0058 0.0676 0.2822
Loa Loa (eye worm) hypothetical protein 0.0043 0.0469 0.1415
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0583 1
Leishmania major aldo-keto reductase-like protein 0.0031 0.0297 0.3594
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0309 0.0039
Entamoeba histolytica aldose reductase, putative 0.0031 0.0297 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0245 0.3301 0.3236
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0297 0.1239
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0297 0.1239
Onchocerca volvulus 0.0043 0.0469 0.1889
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0097 0.0403
Brugia malayi Eukaryotic aspartyl protease family protein 0.0058 0.0676 0.2822
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0058 0.0676 0.0585
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0297 0.0185
Plasmodium falciparum plasmepsin VIII, putative 0.0058 0.0676 0.0344
Plasmodium vivax plasmepsin IV, putative 0.0245 0.3301 1
Echinococcus multilocularis aldehyde reductase 0.0022 0.0171 0.0272
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Schistosoma mansoni hypothetical protein 0.0036 0.0367 0.0273
Echinococcus granulosus aldo keto reductase 0.0031 0.0297 0.0473
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0097 0.0152
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0058 0.0676 0.0585
Brugia malayi Muscleblind-like protein 0.018 0.2396 1
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0245 0.3301 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0097 0.0152
Schistosoma mansoni DNA polymerase eta 0.0045 0.0497 0.0404
Echinococcus multilocularis aldo keto reductase 0.0031 0.0297 0.0473
Echinococcus granulosus cpg binding protein 0.0034 0.0336 0.0537
Plasmodium falciparum plasmepsin IV 0.0245 0.3301 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0469 0.1415
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0297 0.0507
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0136 0.1596
Onchocerca volvulus Matrix metalloproteinase homolog 0.0096 0.1206 1
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0497 0.8383
Plasmodium falciparum plasmepsin V 0.0058 0.0676 0.0344
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0245 0.3301 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0058 0.0676 0.0585
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0058 0.0676 0.0585
Loa Loa (eye worm) aspartyl protease 6 0.0058 0.0676 0.2044
Entamoeba histolytica aldose reductase, putative 0.0031 0.0297 1
Loa Loa (eye worm) matrixin family protein 0.0096 0.1206 0.3648
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0186 0.0295
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0813 0.0723
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.06 0.1814
Loa Loa (eye worm) hypothetical protein 0.0043 0.0469 0.1415
Echinococcus granulosus dna polymerase eta 0.0045 0.0497 0.0794
Onchocerca volvulus 0.0058 0.0676 0.4174
Leishmania major hypothetical protein, conserved 0.0051 0.0583 1
Schistosoma mansoni hypothetical protein 0.0178 0.2369 0.2295
Plasmodium falciparum plasmepsin VII 0.0058 0.0676 0.0344
Schistosoma mansoni cpg binding protein 0.0032 0.0311 0.0216
Mycobacterium ulcerans oxidoreductase 0.0031 0.0297 0.0185
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0245 0.3301 1
Echinococcus multilocularis aldo keto reductase 0.0031 0.0297 0.0473
Brugia malayi Pepsin A precursor 0.0058 0.0676 0.2822
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0297 0.0473
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0136 0.0408
Plasmodium falciparum plasmepsin III 0.0058 0.0676 0.0344
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0297 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596
Leishmania major DNA polymerase eta, putative 0.0032 0.0309 0.3857
Echinococcus multilocularis dnaJ subfamily B 0.0454 0.6237 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0058 0.0676 0.2822
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0297 0.3594
Brugia malayi hypothetical protein 0.0058 0.0676 0.2822
Brugia malayi Matrixin family protein 0.0043 0.0469 0.1955
Echinococcus multilocularis dna polymerase eta 0.0045 0.0497 0.0794
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Schistosoma mansoni cpg binding protein 0.0034 0.0336 0.0242
Loa Loa (eye worm) hypothetical protein 0.0031 0.0297 0.0894
Loa Loa (eye worm) matrixin family protein 0.0104 0.1327 0.4015
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0245 0.3301 0.5292
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0297 0.0507
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Plasmodium falciparum plasmepsin X 0.0058 0.0676 0.0344
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0053 0.06 0.0535
Echinococcus granulosus muscleblind protein 0.018 0.2396 0.384
Echinococcus granulosus hypothetical protein 0.0031 0.0297 0.0473
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0157 0.2064 0.3307
Loa Loa (eye worm) hypothetical protein 0.0058 0.0676 0.2044
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0043 0.0469 0.0376
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0297 0.4617
Loa Loa (eye worm) oxidoreductase 0.0031 0.0297 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0186 0.0295
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0583 1
Plasmodium falciparum plasmepsin IX 0.0058 0.0676 0.0344
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0297 0.0473
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0711 0.1379
Plasmodium vivax plasmepsin V, putative 0.0058 0.0676 0.0344
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0297 0.1239
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0297 0.0473
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0245 0.3301 0.5292
Schistosoma mansoni aldo-keto reductase 0.0031 0.0297 0.0202
Brugia malayi hypothetical protein 0.0051 0.0583 0.2432
Loa Loa (eye worm) oxidoreductase 0.0031 0.0297 0.0894
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Onchocerca volvulus 0.0058 0.0676 0.4174
Loa Loa (eye worm) hypothetical protein 0.0053 0.06 0.1814
Giardia lamblia Aldose reductase 0.0031 0.0297 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.06 0.2506
Schistosoma mansoni hypothetical protein 0.0178 0.2369 0.2295
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0297 0.0473
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0297 0.0473
Loa Loa (eye worm) hypothetical protein 0.0245 0.3301 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0058 0.0676 0.0585
Echinococcus granulosus aldehyde reductase 0.0022 0.0171 0.0272
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0097 0.0287
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0157 0.2064 0.3307
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0136 0.004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0136 0.004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0058 0.0676 0.0585
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0297 0.0507
Echinococcus granulosus dnaJ subfamily B 0.0454 0.6237 1
Plasmodium vivax aspartyl proteinase, putative 0.0245 0.3301 1
Plasmodium falciparum plasmepsin I 0.0245 0.3301 1
Brugia malayi Matrixin family protein 0.0043 0.0469 0.1955
Echinococcus granulosus GPCR family 2 0.0017 0.0097 0.0152
Toxoplasma gondii aspartyl protease ASP3 0.0058 0.0676 0.1262
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0297 0.0473
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Leishmania major DNA polymerase eta, putative 0.0045 0.0497 0.8076
Echinococcus granulosus aldo keto reductase 0.0031 0.0297 0.0473
Onchocerca volvulus 0.0061 0.0721 0.4672
Echinococcus multilocularis aldo keto reductase 0.0031 0.0297 0.0473
Brugia malayi hypothetical protein 0.0033 0.0328 0.1368
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0097 0.0152
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0097 0.0403
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0297 0.0507
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0637 0.8806 1
Onchocerca volvulus Matrilysin homolog 0.0096 0.1206 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0136 0.0569
Schistosoma mansoni pol-related 0.0031 0.0297 0.0202
Mycobacterium leprae PROBABLE HYDROLASE 0.0053 0.06 1
Brugia malayi Matrixin family protein 0.0104 0.1327 0.5537
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0583 0.0952
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596
Echinococcus granulosus geminin 0.0178 0.2369 0.3796
Loa Loa (eye worm) oxidoreductase 0.0031 0.0297 0.0894
Schistosoma mansoni hypothetical protein 0.0023 0.0186 0.009
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0297 0.0473
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0497 0.2074
Brugia malayi Hemopexin family protein 0.0061 0.0721 0.3011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0136 0.1596

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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