Detailed information for compound 1402784

Basic information

Technical information
  • TDR Targets ID: 1402784
  • Name: N-(2-adamantyl)-2-pyrrolidin-1-ylacetamide hy drochloride
  • MW: 298.851 | Formula: C16H27ClN2O
  • H donors: 1 H acceptors: 1 LogP: 3.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1C2CC3CC1CC(C2)C3)CN1CCCC1.Cl
  • InChi: 1S/C16H26N2O.ClH/c19-15(10-18-3-1-2-4-18)17-16-13-6-11-5-12(8-13)9-14(16)7-11;/h11-14,16H,1-10H2,(H,17,19);1H
  • InChiKey: CEGCQEGZOZTBDO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-adamantyl)-2-pyrrolidin-1-yl-acetamide hydrochloride
  • N-(2-adamantyl)-2-1-pyrrolidinylacetamide hydrochloride
  • N-(2-adamantyl)-2-pyrrolidin-1-yl-ethanamide hydrochloride
  • MLS000594141
  • N-2-adamantyl-2-(1-pyrrolidinyl)acetamide hydrochloride
  • SMR000143260

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0588 0.1893 0.1893
Brugia malayi Doublecortin family protein 0.0019 0.0011 0.001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.019 0.019
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0225 0.2494
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0074 0.0175
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0588 0.1893 0.1893
Schistosoma mansoni kinase 0.0051 0.0116 0.0116
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0049
Echinococcus granulosus voltage dependent calcium channel 0.0186 0.0564 0.0563
Plasmodium vivax vivapain-3 0.0588 0.1893 0.5461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0078 0.0077
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0011 0.001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0049 0.0048
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.001
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0186 0.0564 0.0563
Loa Loa (eye worm) beta-lactamase 0.0043 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0063 0.0155 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Onchocerca volvulus Huntingtin homolog 0.0063 0.0155 0.0418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0588 0.1893 0.5166
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0032 0.0054 0.0147
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0827 0.2205
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0201
Echinococcus multilocularis cathepsin L cysteine protease 0.1061 0.3456 0.3455
Loa Loa (eye worm) inositol-1 0.0038 0.0074 0.0073
Loa Loa (eye worm) voltage-dependent calcium channel 0.0026 0.0035 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0272 0.0272
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.001
Echinococcus granulosus peregrin 0.0031 0.005 0.0049
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.019 0.019
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0255 0.0254
Trypanosoma cruzi cysteine peptidase, putative 0.0322 0.1014 0.1014
Plasmodium falciparum serine repeat antigen 6 0.0266 0.0827 0.2367
Giardia lamblia Hypothetical protein 0.0266 0.0827 0.2205
Brugia malayi PHD-finger family protein 0.0026 0.0033 0.0032
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0024 0.0023
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0032 0.0054 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0272 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1061 0.3456 0.943
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0026
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0588 0.1893 0.1893
Onchocerca volvulus 0.0043 0.0092 0.0233
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0173 0.0173
Onchocerca volvulus 0.1061 0.3456 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0042 0.0041
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0266 0.0827 0.2367
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0272 0.0271
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0661 0.1772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0053 0.0122
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0032 0.0054 0.0054
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0025 0.0025
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0266 0.0827 0.2367
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0054 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.0564 0.0563
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0049 0.0049
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0625 0.1781
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.0054 0.0483
Brugia malayi Papain family cysteine protease containing protein 0.0588 0.1893 0.1892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0266 0.0827 0.2367
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0092 0.0211
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0049 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0201
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Plasmodium vivax vivapain-2 0.1061 0.3456 1
Leishmania major cytochrome p450-like protein 0.0043 0.0089 0.0242
Echinococcus multilocularis geminin 0.0205 0.0625 0.0624
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0186 0.0564 0.0564
Brugia malayi Cathepsin L-like precursor 0.0738 0.239 0.2389
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Mycobacterium tuberculosis Probable reductase 0.0084 0.0225 0.2494
Brugia malayi Bromodomain containing protein 0.0077 0.0203 0.0203
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0186 0.0564 0.0563
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0061 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0054 0.0107
Echinococcus multilocularis General substrate transporter 0.0089 0.0241 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0092 0.0211
Schistosoma mansoni cathepsin S (C01 family) 0.0266 0.0827 0.0827
Schistosoma mansoni protein kinase 0.0032 0.0053 0.0053
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.0054 0.0483
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0867 1
Brugia malayi hypothetical protein 0.0063 0.0155 0.0154
Trichomonas vaginalis esterase, putative 0.0043 0.0092 0.0211
Brugia malayi nuclear receptor NHR-88 0.0031 0.0049 0.0048
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0024 0.0023
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0186 0.0564 0.0563
Loa Loa (eye worm) glutaminase 0.0434 0.1382 0.1382
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0032 0.0054 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.0054 0.0483
Toxoplasma gondii cathepsin B 0.1124 0.3664 1
Brugia malayi Papain family cysteine protease containing protein 0.0588 0.1893 0.1892
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0053 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0266 0.0827 0.2225
Loa Loa (eye worm) transcription factor SMAD2 0.0066 0.0166 0.0165
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0151 0.015
Loa Loa (eye worm) hypothetical protein 0.1061 0.3456 0.3455
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Onchocerca volvulus 0.1061 0.3456 1
Brugia malayi Cathepsin L-like precursor 0.0322 0.1014 0.1013
Brugia malayi cathepsin L-like precursor 0.0738 0.239 0.2389
Plasmodium falciparum protein kinase 6 0.0438 0.1396 0.402
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.007 0.0069
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.007 0.0668
Giardia lamblia Kinase, PLK 0.0098 0.0272 0.068
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0046 0.0045
Brugia malayi Bromodomain containing protein 0.0031 0.005 0.0049
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0042 0.0087
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Onchocerca volvulus 0.0043 0.0092 0.0233
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0006 0.0005
Brugia malayi cathepsin F-like cysteine proteinase 0.0266 0.0827 0.0826
Leishmania major cytochrome p450-like protein 0.0032 0.0054 0.0147
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Echinococcus granulosus RUN 0.0019 0.0011 0.001
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Mycobacterium tuberculosis Conserved protein 0.0043 0.0092 0.0927
Plasmodium vivax glutathione reductase, putative 0.0037 0.007 0.0169
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0065
Onchocerca volvulus Huntingtin homolog 0.0063 0.0155 0.0418
Brugia malayi follicle stimulating hormone receptor 0.0225 0.0693 0.0692
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Brugia malayi glutaminase DH11.1 0.0434 0.1382 0.1382
Onchocerca volvulus 0.1061 0.3456 1
Trypanosoma brucei cytochrome P450, putative 0.0043 0.0089 0.0242
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0049 0.0049
Plasmodium vivax serine-repeat antigen (SERA) 0.0266 0.0827 0.2367
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0049 0.0049
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0049 0.0048
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0006
Echinococcus granulosus zinc finger protein 0.002 0.0015 0.0014
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Loa Loa (eye worm) hypothetical protein 0.0186 0.0564 0.0563
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0049 0.0049
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0053 0.0106
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0173 0.0173
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0067 0.0183
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0053 0.0146
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0049 0.0048
Echinococcus granulosus voltage dependent calcium channel 0.0026 0.0035 0.0034
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0266 0.0827 0.0827
Brugia malayi cytochrome P450 0.0032 0.0054 0.0053
Giardia lamblia Cathepsin B precursor 0.1124 0.3664 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.019 0.019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0827 0.2225
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0049 0.0048
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Brugia malayi cathepsin L precursor 0.0266 0.0827 0.0826
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0049 0.0049
Schistosoma mansoni glucose transport protein 0.0103 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0109 0.0108
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Loa Loa (eye worm) calcium channel 0.0186 0.0564 0.0563
Brugia malayi hypothetical protein 0.0019 0.0011 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0049 0.0109
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0054 0.0107
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0266 0.0827 0.2367
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0074 0.0162
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0204 0.0204
Echinococcus multilocularis cathepsin L cysteine protease 0.1061 0.3456 0.3455
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0266 0.0827 0.0826
Onchocerca volvulus Cathepsin L homolog 0.0266 0.0827 0.2367
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Echinococcus granulosus cathepsin L cysteine proteinase 0.1061 0.3456 0.3455
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0032 0.0054 0.0219
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0089 0.0088
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.0289 0.0764
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.05 0.1418
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0032 0.0054 0.0219
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Brugia malayi cathepsin Z-like cysteine proteinase 0.0266 0.0827 0.0826
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0266 0.0827 0.2225
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0054 0.0107
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.005 0.0072
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0074 0.0145
Loa Loa (eye worm) glutathione reductase 0.0037 0.007 0.0069
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0032 0.0054 0.0219
Plasmodium vivax unspecified product 0.0266 0.0827 0.2367
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0078 0.0078
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0053 0.0119
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0067 0.0067
Giardia lamblia Cathepsin L-like protease 0.0266 0.0827 0.2205
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Toxoplasma gondii preprocathepsin c precursor, putative 0.0266 0.0827 0.2236
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.0054 0.0483
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0588 0.1893 0.5146
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0827 0.2205
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0049 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Brugia malayi Cathepsin L-like cysteine proteinase 0.0738 0.239 0.2389
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0053 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0131 0.013
Giardia lamblia Cathepsin B precursor 0.1124 0.3664 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Schistosoma mansoni voltage-gated cation channel 0.0186 0.0564 0.0564
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.0089 0.0477
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.007 0.0069
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0042 0.0041
Schistosoma mansoni hypothetical protein 0.0035 0.0062 0.0062
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0827 0.2205
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0024 0.0024
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0018 0.0017
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0225 0.2494
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0074 0.0366
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0827 0.2225
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1061 0.3456 0.3455
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0049 0.0048
Echinococcus multilocularis sodium channel protein 0.0048 0.0107 0.0106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0024 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.019 0.019
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0092 0.0927
Schistosoma mansoni glucose transport protein 0.0103 0.0289 0.0289
Entamoeba histolytica cysteine proteinase 1, putative 0.0588 0.1893 0.5445
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0025 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Mycobacterium ulcerans beta-lactamase 0.0043 0.0092 0.0498
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0053 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.0054 0.0483
Echinococcus granulosus geminin 0.0205 0.0625 0.0624
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0054 0.0107
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0092 0.0927
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Leishmania major trypanothione reductase 0.0037 0.007 0.019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0049 0.0048
Brugia malayi nuclear hormone receptor 0.0031 0.0049 0.0048
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0049 0.0048
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0067 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.001
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Echinococcus multilocularis cathepsin L 0.0266 0.0827 0.0826
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0131 0.013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0092 0.0498
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0032 0.0054 0.0219
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.0054 0.0483
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0024
Trypanosoma cruzi cruzipain precursor, putative 0.0322 0.1014 0.1014
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.005 0.005
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0032 0.0054 0.0219
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0225 0.2494
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0173 0.0172
Onchocerca volvulus 0.006 0.0146 0.039
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0024 0.0024
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0049 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.0054 0.0483
Schistosoma mansoni hypothetical protein 0.0103 0.0289 0.0289
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.0054 0.0483
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.0054 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.005 0.0049
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.005 0.0049
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0024 0.0023
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0049 0.0109
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.019 0.2083
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0067 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0139 0.0409 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0049 0.0048
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0054 0.0054
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0092 0.0927
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0588 0.1893 0.1893
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0078 0.0078
Giardia lamblia Cathepsin L-like protease 0.0266 0.0827 0.2205
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0053 0.0122
Plasmodium falciparum cysteine proteinase falcipain 3 0.1061 0.3456 1
Plasmodium vivax unspecified product 0.0322 0.1014 0.291
Brugia malayi cathepsin Z-like cysteine proteinase 0.0266 0.0827 0.0826
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0061 0.1968
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0068 0.0068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0204 0.0203
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0192 0.0192
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0661 0.1772
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0048 0.0107 0.0106
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0054 0.0146
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0092 0.0927
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0272 0.0271
Echinococcus granulosus cathepsin L cysteine protease 0.0588 0.1893 0.1892
Brugia malayi ecdysteroid receptor 0.0031 0.0049 0.0048
Schistosoma mansoni cathepsin s 0.0322 0.1014 0.1014
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0256 1
Plasmodium falciparum serine repeat antigen 9 0.0266 0.0827 0.2367
Echinococcus granulosus cathepsin l cysteine peptidase 0.1061 0.3456 0.3455
Echinococcus granulosus cathepsin L 0.0266 0.0827 0.0826
Plasmodium vivax SET domain protein, putative 0.006 0.0146 0.039
Brugia malayi cathepsin L-like cysteine proteinase 0.0266 0.0827 0.0826
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Plasmodium vivax vivapain-1 0.0588 0.1893 0.5461
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0049 0.0048
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0067 0.0067
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0024 0.0039
Schistosoma mansoni hypothetical protein 0.0205 0.0625 0.0625
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.0564 0.0563
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0266 0.0827 0.2367
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0327 0.0327
Schistosoma mansoni hypothetical protein 0.0028 0.0042 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Trypanosoma brucei trypanothione reductase 0.0037 0.007 0.019
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0034
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0008 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0272 0.0272
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Loa Loa (eye worm) hypothetical protein 0.0322 0.1014 0.1013
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0266 0.0827 0.2367
Echinococcus granulosus cathepsin l1 0.0738 0.239 0.2389
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.0054 0.0483
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0049 0.0048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0115 0.0114
Toxoplasma gondii ABC1 family protein 0.0043 0.0092 0.0224
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.005 0.0097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Entamoeba histolytica cysteine proteinase, putative 0.0738 0.239 0.6894
Trypanosoma cruzi major cysteine proteinase, putative 0.0266 0.0827 0.0827
Brugia malayi beta-lactamase family protein 0.0043 0.0092 0.0091
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0142 0.0141
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0006 0.0005
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0067 0.0157
Plasmodium vivax CDK-related protein kinase 6, putative 0.0438 0.1396 0.402
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0049 0.0048
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Brugia malayi Cytochrome P450 family protein 0.0043 0.0089 0.0088
Loa Loa (eye worm) hypothetical protein 0.0051 0.0115 0.0114
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0256 0.2856
Loa Loa (eye worm) hypothetical protein 0.0073 0.0189 0.0188
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0092 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Loa Loa (eye worm) hypothetical protein 0.0738 0.239 0.2389
Onchocerca volvulus Alhambra homolog 0.0028 0.0042 0.0088
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0256 0.2856
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.007 0.0069
Schistosoma mansoni bromodomain containing protein 0.0065 0.0163 0.0163
Plasmodium falciparum serine repeat antigen 4 0.0266 0.0827 0.2367
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0053 0.0119
Giardia lamblia Encystation-specific protease 0.0266 0.0827 0.2205
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.0054 0.0483
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.0054 0.0483
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0204 0.0203
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0049 0.0048
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.0054 0.0483
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1124 0.3664 0.3664
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0173 0.0172
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1061 0.3456 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0053 0.0085
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0054 0.0146
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0089 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0049 0.0048
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0151 0.015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0827 0.2225
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0074 0.0073
Plasmodium falciparum thioredoxin reductase 0.0037 0.007 0.0169
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0054 0.0146
Mycobacterium ulcerans hypothetical protein 0.0043 0.0092 0.0498
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0092 0.0091
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0041
Plasmodium vivax vivapain-2 0.1061 0.3456 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0588 0.1893 0.5146
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0074 0.0162
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.0054 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0049 0.0048
Trypanosoma cruzi hexose transporter 0.0032 0.0054 0.0054
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0032 0.0054 0.0219
Toxoplasma gondii cathepsin CPC2 0.0266 0.0827 0.2236
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Onchocerca volvulus 0.0738 0.239 0.6905
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0032 0.0054 0.0219
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.0289 0.0288
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0092 0.025
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0078 0.0077
Plasmodium falciparum glutathione reductase 0.0037 0.007 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0131 0.0131
Trypanosoma brucei glucose transporter 2A 0.0032 0.0054 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0049 0.0048
Trichomonas vaginalis set domain proteins, putative 0.0474 0.1517 0.4117
Schistosoma mansoni cathepsin F (C01 family) 0.1061 0.3456 0.3456
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0092 0.0927
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Echinococcus multilocularis cysteine protease 0.1061 0.3456 0.3455
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Brugia malayi MH2 domain containing protein 0.0066 0.0166 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0131 0.013
Schistosoma mansoni cathepsin F (C01 family) 0.1061 0.3456 0.3456
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.001
Mycobacterium leprae putative cytochrome p450 0.0032 0.0054 0.169
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0186 0.0564 0.0564
Onchocerca volvulus Cathepsin L homolog 0.1061 0.3456 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0266 0.0827 0.2225
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Giardia lamblia Hypothetical protein 0.0266 0.0827 0.2205
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0092 0.3245
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0266 0.0827 0.0826
Schistosoma mansoni hypothetical protein 0.0205 0.0625 0.0625
Loa Loa (eye worm) sugar transporter 0.0103 0.0289 0.0288
Brugia malayi Sugar transporter family protein 0.0103 0.0289 0.0288
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0061 0.0562
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0053 0.0052
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0266 0.0827 0.2367
Schistosoma mansoni protein kinase 0.0032 0.0053 0.0053
Toxoplasma gondii transporter, cation channel family protein 0.0026 0.0035 0.007
Brugia malayi Papain family cysteine protease containing protein 0.1061 0.3456 0.3455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0111 0.0265
Echinococcus granulosus cathepsin L 0.0588 0.1893 0.1892
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0115 0.0114
Entamoeba histolytica cysteine proteinase 2 0.0588 0.1893 0.5445
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0827 0.2225
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.1326 0.1326
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0054 0.0053
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0011 0.001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0139 0.0409 0.0408
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0089 0.0089
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Brugia malayi jmjC domain containing protein 0.0093 0.0255 0.0254
Schistosoma mansoni coup transcription factor 0.0031 0.0049 0.0049
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.007 0.007
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0049 0.0109
Loa Loa (eye worm) glutaminase 2 0.0434 0.1382 0.1382
Mycobacterium ulcerans lipase LipD 0.0043 0.0092 0.0498
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1061 0.3456 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.0054 0.0483
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0131 0.013
Brugia malayi Cytochrome P450 family protein 0.0043 0.0089 0.0088
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0049
Mycobacterium leprae Probable lipase LipE 0.0043 0.0092 0.3245
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0255 0.0254
Brugia malayi cathepsin F-like cysteine proteinase 0.0322 0.1014 0.1013
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0266 0.0827 0.2367
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0049 0.0048
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0272 0.0741
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0146 0.0146
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0115 0.0114
Onchocerca volvulus 0.1061 0.3456 1
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0588 0.1893 0.5166
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.0564 0.0563
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0042 0.0041
Mycobacterium tuberculosis Conserved protein 0.0043 0.0092 0.0927
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0256 0.2856
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.005 0.0049
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0053 0.0122
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0054 0.0054
Brugia malayi Inositol-1 0.0038 0.0074 0.0073
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.005 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0131 0.0131
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.0054 0.169
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0049 0.0048
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0032 0.0054 0.0219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0049 0.0048
Leishmania major glucose transporter, lmgt3 0.0032 0.0054 0.0146
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0092 0.0927
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Loa Loa (eye worm) hypothetical protein 0.0738 0.239 0.2389
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0046 0.0045
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0092 0.0927
Brugia malayi Thioredoxin reductase 0.0037 0.007 0.0069
Plasmodium falciparum serine repeat antigen 3 0.0266 0.0827 0.2367
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0049 0.0049
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Onchocerca volvulus Cathepsin F homolog 0.1061 0.3456 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0049 0.0048
Entamoeba histolytica cysteine proteinase, putative 0.1061 0.3456 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0049 0.0049
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0032 0.0054 0.0219
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0032 0.0054 0.0219
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0024 0.0037
Schistosoma mansoni glucose transport protein 0.0103 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0049 0.0048
Echinococcus multilocularis peregrin 0.0031 0.005 0.0049
Leishmania major protein kinase, putative 0.0032 0.0053 0.0146
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0738 0.239 0.239
Schistosoma mansoni hypothetical protein 0.0032 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0166 0.0165
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Trypanosoma cruzi cysteine protease, putative 0.0588 0.1893 0.1893
Toxoplasma gondii cathepsin CPL 0.1061 0.3456 0.9431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Onchocerca volvulus 0.1061 0.3456 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0053 0.0122
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0979 0.0979
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0067 0.0183
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0068 0.0068
Brugia malayi Cam kinase protein 1 0.0032 0.0053 0.0052
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.0564 0.0563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0266 0.0827 0.2367
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0266 0.0827 0.2367
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0067 0.0169 0.0462
Loa Loa (eye worm) hypothetical protein 0.0738 0.239 0.2389
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0092 0.0092
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.019 0.0494
Brugia malayi Bromodomain containing protein 0.0039 0.0078 0.0078
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0054 0.0054
Loa Loa (eye worm) ctsf protein 0.1061 0.3456 0.3455
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0092
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0071 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Echinococcus granulosus cathepsin l1 0.1061 0.3456 0.3455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0738 0.239 0.6509
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0062 0.0061
Brugia malayi Pre-SET motif family protein 0.0417 0.1326 0.1326
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.05 0.1418
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0272 0.0721
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0266 0.0827 0.2367
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.019 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0738 0.239 0.6509
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0049 0.0048
Schistosoma mansoni inositol monophosphatase 0.0038 0.0074 0.0074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.019 0.1225
Echinococcus granulosus General substrate transporter 0.0089 0.0241 0.024
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0032 0.0054 0.0219
Brugia malayi PHD-finger family protein 0.0028 0.0042 0.0041
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0979 0.0979
Schistosoma mansoni cathepsin C 0.0266 0.0827 0.0827
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0032 0.0054 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0049 0.0048
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0044 0.0093 0.0092
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0032 0.0054 0.0219
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0053 0.0119
Loa Loa (eye worm) hypothetical protein 0.0077 0.0204 0.0203
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0032 0.0054 0.0219
Schistosoma mansoni glutaminase 0.0434 0.1382 0.1382
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Plasmodium falciparum protein kinase 7 0.0292 0.0912 0.2616
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0322 0.1014 0.1013
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1124 0.3664 0.3664
Brugia malayi Pre-SET motif family protein 0.006 0.0146 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0146 0.0146
Trypanosoma brucei polo-like protein kinase 0.0098 0.0272 0.0741
Plasmodium falciparum serine repeat antigen 1 0.0266 0.0827 0.2367
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Onchocerca volvulus 0.0266 0.0827 0.2367
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0289 0.0752
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.05 0.1341
Plasmodium falciparum serine repeat antigen 5 0.0266 0.0827 0.2367
Echinococcus granulosus cysteine protease 0.0588 0.1893 0.1892
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0272 0.0271
Plasmodium vivax hexose transporter 0.0103 0.0289 0.0806
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0078
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0092 0.0498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0009
Loa Loa (eye worm) CYP4Cod1 0.0043 0.0089 0.0088
Entamoeba histolytica cysteine protease, putative 0.1061 0.3456 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0042 0.0087
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Brugia malayi glutathione reductase 0.0037 0.007 0.0069
Plasmodium falciparum serine repeat antigen 2 0.0266 0.0827 0.2367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.019 0.1225
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0092
Brugia malayi Cytochrome P450 family protein 0.0088 0.024 0.0239
Loa Loa (eye worm) cytochrome P450 family protein 0.0088 0.024 0.0239
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0092 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Onchocerca volvulus 0.0474 0.1517 0.4371
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0139 0.0409 0.0408
Mycobacterium tuberculosis Conserved protein 0.0043 0.0092 0.0927
Trypanosoma cruzi cruzipain precursor, putative 0.1061 0.3456 0.3456
Schistosoma mansoni inositol monophosphatase 0.0038 0.0074 0.0074
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0186 0.0564 0.0563
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Brugia malayi beta-lactamase family protein 0.0043 0.0092 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Schistosoma mansoni lipoxygenase 0.0115 0.0327 0.0327
Entamoeba histolytica hypothetical protein 0.0266 0.0827 0.2339
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1124 0.3664 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0092 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1124 0.3664 1
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0131 0.013
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0225 0.873
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0327 0.0327
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1061 0.3456 0.3455
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.0564 0.0563
Schistosoma mansoni zinc finger protein 0.002 0.0015 0.0015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0042 0.0042
Leishmania major glucose transporter, lmgt1 0.0032 0.0054 0.0146
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Loa Loa (eye worm) fibroinase 0.1061 0.3456 0.3455
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0146 0.0145
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0068 0.0067
Trypanosoma brucei glucose transporter 1E 0.0032 0.0054 0.0146
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0067 0.0169 0.0169
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0049 0.0049
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0032 0.0054 0.0219
Leishmania major cysteine peptidase A (CPA) 0.1061 0.3456 0.9433
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0266 0.0827 0.2339
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0322 0.1014 0.1013
Echinococcus multilocularis cathepsin L 0.0588 0.1893 0.1892
Toxoplasma gondii cathepsin CPC1 0.0266 0.0827 0.2236
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0024 0.047
Onchocerca volvulus 0.1061 0.3456 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0074 0.0162
Plasmodium falciparum phd finger protein, putative 0.0028 0.0042 0.0088
Toxoplasma gondii protein kinase, putative 0.0292 0.0912 0.247
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0074
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Brugia malayi hypothetical protein 0.0019 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0009
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.0054 0.0483
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0001 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.007 0.0169
Plasmodium falciparum hexose transporter 0.0103 0.0289 0.0806
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0123 0.0356 0.0356
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0173 0.0172
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Onchocerca volvulus 0.0031 0.0049 0.0109
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0266 0.0827 0.0827
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0049 0.0048
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0049 0.0049
Brugia malayi jmjC domain containing protein 0.0036 0.0068 0.0067
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0266 0.0827 0.2367
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0032 0.0054 0.0219
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0049 0.0048
Onchocerca volvulus 0.0043 0.0092 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0272 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0266 0.0827 0.2225
Plasmodium falciparum serine repeat antigen 7 0.0266 0.0827 0.2367
Echinococcus multilocularis RUN 0.0019 0.0011 0.001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0588 0.1893 0.1893
Loa Loa (eye worm) hypothetical protein 0.0322 0.1014 0.1013
Brugia malayi Cytochrome P450 family protein 0.0032 0.0054 0.0053
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0032 0.0054 0.0219
Entamoeba histolytica protein kinase, putative 0.0032 0.0053 0.0085
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0146 0.0372
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0092 0.0092
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0032 0.0054 0.0219
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.0564 0.0563
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Schistosoma mansoni protein kinase 0.0032 0.0053 0.0053
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0225 0.2494
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0053 0.0052
Trypanosoma brucei cysteine peptidase C (CPC) 0.1124 0.3664 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0049 0.0049
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0092 0.0091
Onchocerca volvulus 0.1061 0.3456 1
Echinococcus multilocularis 0.0032 0.0054 0.0053
Plasmodium vivax serine-repeat antigen (SERA) 0.0266 0.0827 0.2367
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0006 0.0006
Trypanosoma cruzi major cysteine proteinase, putative 0.0266 0.0827 0.0827
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0173 0.0472
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0139 0.0409 0.0408
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0063 0.0155 0.0154
Brugia malayi beta-lactamase 0.0043 0.0092 0.0091
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0025 0.0024
Echinococcus multilocularis cysteine protease 0.1061 0.3456 0.3455
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0024 0.5
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0074 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0204 0.0204
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0266 0.0827 0.2339
Schistosoma mansoni polycystin 1-related 0.0019 0.0011 0.0011
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0173 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0131 0.013
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0092 0.0211
Toxoplasma gondii thioredoxin reductase 0.0037 0.007 0.0164
Loa Loa (eye worm) cysteine protease 0.1061 0.3456 0.3455
Toxoplasma gondii cytochrome p450 superfamily protein 0.0032 0.0054 0.012
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Plasmodium vivax unspecified product 0.0588 0.1893 0.5461
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0092 0.0211
Loa Loa (eye worm) cathepsin B 0.1124 0.3664 0.3663
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0074 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0322 0.1014 0.1013
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0001 0.0001
Echinococcus multilocularis zinc finger protein 0.002 0.0015 0.0014
Trypanosoma cruzi cysteine proteinase, putative 0.0588 0.1893 0.1893
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0053 0.0122
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1061 0.3456 0.3455
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0173 0.0472
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Schistosoma mansoni lipoxygenase 0.008 0.0213 0.0213
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi steroid hormone receptor 0.0031 0.0049 0.0048
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0053 0.0122
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0053 0.0122
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.0693 0.0692
Loa Loa (eye worm) hypothetical protein 0.0042 0.0087 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0042 0.0088
Leishmania major glucose transporter, lmgt2 0.0032 0.0054 0.0146
Schistosoma mansoni cathepsin F (C01 family) 0.0738 0.239 0.239
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.005 0.1544
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0827 0.2225
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1061 0.3456 0.3455
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0111 0.0265
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0266 0.0827 0.2205
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0173 0.0173
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0049 0.0048
Plasmodium falciparum cysteine proteinase falcipain 1 0.0588 0.1893 0.5461
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Schistosoma mansoni cytochrome P450 0.0032 0.0054 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0054 0.0107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Trichomonas vaginalis glutaminase, putative 0.0434 0.1382 0.3748
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0272 0.0755
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0067 0.0162
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Loa Loa (eye worm) cytochrome P450 0.0032 0.0054 0.0053
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0225 0.2494
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0071 0.007
Mycobacterium ulcerans glutaminase 0.0434 0.1382 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0138 0.0138
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0092 0.0233
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.0054 0.0483
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.005 0.0076
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0173 0.0433
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Leishmania major hypothetical protein, conserved 0.0043 0.0092 0.025
Brugia malayi Cathepsin L-like precursor 0.0738 0.239 0.2389
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Schistosoma mansoni loxhd1 0.0019 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.0054 0.0483
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.0054 0.0483
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0266 0.0827 0.2367
Schistosoma mansoni cathepsin B (C01 family) 0.0266 0.0827 0.0827
Onchocerca volvulus Cathepsin L homolog 0.1061 0.3456 1
Brugia malayi fibroinase precursor 0.0266 0.0827 0.0826
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0054 0.0107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0054 0.0146
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Giardia lamblia PHD finger protein 15 0.0028 0.0042 0.0049
Giardia lamblia Cathepsin B precursor 0.1124 0.3664 1
Entamoeba histolytica cysteine proteinase, putative 0.1061 0.3456 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0266 0.0827 0.0827
Leishmania major cytochrome p450-like protein 0.0032 0.0054 0.0147
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.0054 0.0483
Trypanosoma cruzi cysteine proteinase, putative 0.0588 0.1893 0.1893
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.019 0.1225
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0049 0.0048
Plasmodium falciparum serine repeat antigen 8 0.0266 0.0827 0.2367
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0266 0.0827 0.0827
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0032 0.0054 0.0147
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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