Detailed information for compound 1402812

Basic information

Technical information
  • TDR Targets ID: 1402812
  • Name: 3,4-dihydro-1H-isoquinolin-2-yl-[5-(4-fluorop henyl)-2-methyl-1,1-dioxo-1,2,6-thiadiazin-3- yl]methanone
  • MW: 399.439 | Formula: C20H18FN3O3S
  • H donors: 0 H acceptors: 3 LogP: 2.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1=NS(=O)(=O)N(C(=C1)C(=O)N1CCc2c(C1)cccc2)C
  • InChi: 1S/C20H18FN3O3S/c1-23-19(20(25)24-11-10-14-4-2-3-5-16(14)13-24)12-18(22-28(23,26)27)15-6-8-17(21)9-7-15/h2-9,12H,10-11,13H2,1H3
  • InChiKey: RDEOAPUYPFRZQE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3,4-dihydro-1H-isoquinolin-2-yl-[5-(4-fluorophenyl)-1,1-diketo-2-methyl-1,2,6-thiadiazin-3-yl]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0088 0.0479 0.0479
Mycobacterium tuberculosis Conserved protein 0.0061 0.0312 0.128
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0508 0.2134
Giardia lamblia Cathepsin L precursor 0.014 0.0794 0.2143
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Giardia lamblia Cathepsin L-like protease 0.014 0.0794 0.2143
Trypanosoma cruzi PAB1-binding protein , putative 0.0063 0.0323 0.0305
Echinococcus granulosus cathepsin l1 0.0386 0.229 0.229
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0164 0.0637
Mycobacterium tuberculosis Probable hydrolase 0.0061 0.0312 0.128
Brugia malayi beta-lactamase family protein 0.0061 0.0312 0.0312
Leishmania major cathepsin L-like protease 0.0554 0.3311 0.9087
Brugia malayi Pre-SET motif family protein 0.0233 0.1357 0.1357
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0061 0.0312 0.128
Giardia lamblia Cathepsin B precursor 0.014 0.0794 0.2143
Giardia lamblia Cathepsin B precursor 0.0608 0.3641 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0013 0.0013
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0061 0.0312 0.0312
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0018 0.5
Giardia lamblia Cathepsin L-like protease 0.014 0.0794 0.2143
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0406 0.0406
Giardia lamblia Hypothetical protein 0.014 0.0794 0.2143
Loa Loa (eye worm) glutathione reductase 0.0037 0.0164 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.0312 0.0811
Plasmodium vivax ataxin-2 like protein, putative 0.0063 0.0323 0.0925
Entamoeba histolytica cysteine proteinase, putative 0.0308 0.1814 0.4054
Toxoplasma gondii preprocathepsin c precursor, putative 0.014 0.0794 0.2143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Plasmodium vivax unspecified product 0.014 0.0794 0.2358
Plasmodium falciparum serine repeat antigen 5 0.014 0.0794 0.2358
Brugia malayi latrophilin 2 splice variant baaae 0.013 0.0731 0.0731
Toxoplasma gondii cathepsin CPC2 0.014 0.0794 0.2143
Giardia lamblia Cathepsin L precursor 0.014 0.0794 0.2143
Entamoeba histolytica cysteine protease, putative 0.0554 0.3311 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0494 0.2945 0.2945
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0168 0.096 0.096
Brugia malayi Cathepsin L-like precursor 0.0554 0.3311 0.3311
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0147 0.0147
Brugia malayi glutathione reductase 0.0037 0.0164 0.0164
Schistosoma mansoni hypothetical protein 0.006 0.0306 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Entamoeba histolytica cysteine proteinase, putative 0.0554 0.3311 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0063 0.0323 0.0925
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0554 0.3311 0.9087
Onchocerca volvulus 0.0265 0.1552 0.444
Giardia lamblia Cathepsin L precursor 0.014 0.0794 0.2143
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0508 0.2134
Loa Loa (eye worm) hypothetical protein 0.014 0.0794 0.0794
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0088 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0168 0.096 0.096
Giardia lamblia Cysteine protease 0.014 0.0794 0.2143
Giardia lamblia Cathepsin B precursor 0.014 0.0794 0.2143
Leishmania major trypanothione reductase 0.0037 0.0164 0.0403
Giardia lamblia Cathepsin B precursor 0.0608 0.3641 1
Brugia malayi cathepsin L precursor 0.014 0.0794 0.0794
Plasmodium vivax serine-repeat antigen (SERA) 0.014 0.0794 0.2358
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0164 0.0444
Onchocerca volvulus 0.0554 0.3311 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0347 0.091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0554 0.3311 0.3311
Giardia lamblia Cathepsin L precursor 0.014 0.0794 0.2143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.0794 0.0794
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0147 0.0147
Onchocerca volvulus 0.0386 0.229 0.6775
Onchocerca volvulus 0.0554 0.3311 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Loa Loa (eye worm) hypothetical protein 0.0386 0.229 0.229
Trypanosoma cruzi cruzipain precursor, putative 0.0168 0.096 0.0944
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.014 0.0794 0.2358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0794 0.2143
Mycobacterium tuberculosis Possible penicillin-binding protein 0.039 0.2313 1
Trichomonas vaginalis set domain proteins, putative 0.0265 0.1552 0.4234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Plasmodium vivax vivapain-3 0.0308 0.1814 0.5456
Trypanosoma brucei PAB1-binding protein , putative 0.0063 0.0323 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0794 0.2143
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.0312 0.0811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.0479 0.0479
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0028 0.0112 0.0112
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0167 0.0167
Giardia lamblia Cathepsin L precursor 0.014 0.0794 0.2143
Trypanosoma cruzi cysteine proteinase, putative 0.0308 0.1814 0.18
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Loa Loa (eye worm) fibroinase 0.0554 0.3311 0.3311
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0451 0.1886
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0554 0.3311 1
Loa Loa (eye worm) hypothetical protein 0.019 0.1098 0.1098
Echinococcus multilocularis geminin 0.0489 0.2912 0.2912
Mycobacterium tuberculosis Probable esterase LipL 0.0061 0.0312 0.128
Brugia malayi Cathepsin L-like precursor 0.0386 0.229 0.229
Echinococcus granulosus cysteine protease 0.0308 0.1814 0.1814
Toxoplasma gondii cathepsin CPC1 0.014 0.0794 0.2143
Schistosoma mansoni hypothetical protein 0.013 0.0731 0.0731
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0554 0.3311 0.9087
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0147 0.0147
Onchocerca volvulus Cathepsin F homolog 0.0554 0.3311 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0088 0.0479 0.0479
Leishmania major cathepsin L-like protease 0.0554 0.3311 0.9087
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0147 0.0147
Onchocerca volvulus 0.0554 0.3311 1
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.0312 0.0811
Entamoeba histolytica cysteine proteinase 2 0.0308 0.1814 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0554 0.3311 0.3311
Leishmania major cathepsin L-like protease 0.0554 0.3311 0.9087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.1814 0.4958
Plasmodium falciparum serine repeat antigen 2 0.014 0.0794 0.2358
Echinococcus granulosus geminin 0.0489 0.2912 0.2912
Trichomonas vaginalis esterase, putative 0.0061 0.0312 0.0811
Echinococcus multilocularis cpg binding protein 0.0037 0.0163 0.0163
Loa Loa (eye worm) RNA binding protein 0.0076 0.0406 0.0406
Loa Loa (eye worm) cysteine protease 0.0554 0.3311 0.3311
Echinococcus multilocularis GPCR, family 2 0.006 0.0306 0.0306
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0554 0.3311 1
Entamoeba histolytica cysteine proteinase, putative 0.0308 0.1814 0.4054
Giardia lamblia Cysteine protease 0.014 0.0794 0.2143
Brugia malayi Cathepsin L-like precursor 0.0554 0.3311 0.3311
Plasmodium falciparum serine repeat antigen 7 0.014 0.0794 0.2358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.1814 0.4958
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0406 0.0406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0554 0.3311 0.9087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.006 0.0306 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0386 0.229 0.6272
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0061 0.0312 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0406 0.0406
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0451 0.1886
Schistosoma mansoni hypothetical protein 0.006 0.0306 0.0306
Schistosoma mansoni cathepsin C 0.014 0.0794 0.0794
Plasmodium vivax vivapain-1 0.0308 0.1814 0.5456
Leishmania major hypothetical protein, conserved 0.0063 0.0323 0.0841
Onchocerca volvulus 0.0061 0.0312 0.0519
Giardia lamblia Cathepsin B precursor 0.0608 0.3641 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0794 0.2143
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0018 0.5
Leishmania major cathepsin L-like protease 0.0554 0.3311 0.9087
Loa Loa (eye worm) hypothetical protein 0.014 0.0794 0.0794
Echinococcus multilocularis cathepsin L cysteine protease 0.0554 0.3311 0.3311
Brugia malayi hypothetical protein 0.0063 0.0323 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Schistosoma mansoni hypothetical protein 0.006 0.0306 0.0306
Leishmania major cysteine peptidase A (CPA) 0.0554 0.3311 0.9087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0386 0.229 0.2277
Echinococcus multilocularis cathepsin L 0.0308 0.1814 0.1814
Onchocerca volvulus Cathepsin L homolog 0.014 0.0794 0.2045
Toxoplasma gondii ABC1 family protein 0.0061 0.0312 0.0811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.0479 0.0479
Brugia malayi Cathepsin L-like precursor 0.0554 0.3311 0.3311
Brugia malayi beta-lactamase family protein 0.0061 0.0312 0.0312
Entamoeba histolytica cysteine proteinase, putative 0.0308 0.1814 0.4054
Brugia malayi Cathepsin L-like precursor 0.0554 0.3311 0.3311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0794 0.2143
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0013 0.0013
Giardia lamblia Dipeptidyl-peptidase I precursor 0.014 0.0794 0.2143
Loa Loa (eye worm) papain family cysteine protease containing protein 0.014 0.0794 0.0794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0817 0.0817
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.0312
Loa Loa (eye worm) pigment dispersing factor receptor c 0.019 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.014 0.0794 0.0794
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0406 0.0406
Onchocerca volvulus 0.0554 0.3311 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0794 0.2143
Trypanosoma cruzi cysteine peptidase, putative 0.0168 0.096 0.0944
Giardia lamblia Dipeptidyl-peptidase I precursor 0.014 0.0794 0.2143
Schistosoma mansoni cathepsin F (C01 family) 0.0554 0.3311 0.3311
Echinococcus granulosus cathepsin l cysteine peptidase 0.0554 0.3311 0.3311
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.014 0.0794 0.0794
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Mycobacterium ulcerans lipase LipD 0.0061 0.0312 1
Mycobacterium ulcerans hypothetical protein 0.0061 0.0312 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.0312 0.0312
Schistosoma mansoni cpg binding protein 0.0037 0.0163 0.0163
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0061 0.0312 0.0312
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.014 0.0794 0.2358
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0554 0.3311 0.9087
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.0312 0.0811
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.1357 0.1357
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0554 0.3311 0.9087
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0308 0.1814 0.1814
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0147 0.0358
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0312 0.0294
Entamoeba histolytica cysteine proteinase, putative 0.0308 0.1814 0.4054
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0061 0.0312 0.128
Brugia malayi Papain family cysteine protease containing protein 0.014 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.0168 0.096 0.096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Brugia malayi cathepsin L-like precursor 0.0386 0.229 0.229
Onchocerca volvulus 0.014 0.0794 0.2045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Onchocerca volvulus 0.0554 0.3311 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0554 0.3311 0.9087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0308 0.1814 0.4958
Brugia malayi MH2 domain containing protein 0.0144 0.0817 0.0817
Schistosoma mansoni cpg binding protein 0.0037 0.0163 0.0163
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0135 0.0135
Echinococcus granulosus cathepsin L cysteine protease 0.0308 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.006 0.0306 0.0306
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.014 0.0794 0.2143
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0308 0.1814 0.18
Echinococcus granulosus tar DNA binding protein 0.0076 0.0406 0.0406
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0451 0.1886
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0018
Plasmodium falciparum serine repeat antigen 6 0.014 0.0794 0.2358
Trichomonas vaginalis penicillin-binding protein, putative 0.0061 0.0312 0.0811
Plasmodium falciparum serine repeat antigen 4 0.014 0.0794 0.2358
Trypanosoma cruzi cysteine protease, putative 0.0308 0.1814 0.18
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0406 0.0406
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.014 0.0794 0.2358
Echinococcus multilocularis cysteine protease 0.0554 0.3311 0.3311
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0406 0.0406
Schistosoma mansoni hypothetical protein 0.0028 0.0112 0.0112
Brugia malayi TAR-binding protein 0.0076 0.0406 0.0406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Onchocerca volvulus Cathepsin L homolog 0.0554 0.3311 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.014 0.0794 0.2358
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Trypanosoma brucei cysteine peptidase C (CPC) 0.0608 0.3641 1
Echinococcus multilocularis cathepsin L 0.014 0.0794 0.0794
Schistosoma mansoni cathepsin F (C01 family) 0.0554 0.3311 0.3311
Onchocerca volvulus Cathepsin L homolog 0.0554 0.3311 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0817 0.0817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.014 0.0794 0.2143
Echinococcus granulosus cathepsin L cysteine proteinase 0.0554 0.3311 0.3311
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.014 0.0794 0.2143
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0308 0.1814 0.1814
Echinococcus multilocularis cysteine protease 0.0554 0.3311 0.3311
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.014 0.0794 0.2358
Entamoeba histolytica cysteine proteinase 1, putative 0.0308 0.1814 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0308 0.1814 0.1814
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0554 0.3311 1
Trypanosoma cruzi cysteine peptidase, putative 0.0554 0.3311 0.3299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2945 0.2945
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Brugia malayi RNA binding protein 0.0076 0.0406 0.0406
Loa Loa (eye worm) hypothetical protein 0.0386 0.229 0.229
Giardia lamblia Cysteine protease 0.014 0.0794 0.2143
Plasmodium vivax unspecified product 0.0308 0.1814 0.5456
Mycobacterium tuberculosis Probable lipase LipD 0.0061 0.0312 0.128
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0164 0.0164
Echinococcus multilocularis beta LACTamase domain containing family member 0.0061 0.0312 0.0312
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.014 0.0794 0.2358
Brugia malayi cathepsin F-like cysteine proteinase 0.014 0.0794 0.0794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Brugia malayi hypothetical protein 0.0041 0.0187 0.0187
Plasmodium vivax glutathione reductase, putative 0.0037 0.0164 0.0444
Plasmodium falciparum cysteine proteinase falcipain 1 0.0308 0.1814 0.5456
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0028 0.0112 0.0112
Giardia lamblia Dipeptidyl-peptidase I precursor 0.014 0.0794 0.2143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Brugia malayi Cathepsin L-like precursor 0.0554 0.3311 0.3311
Plasmodium falciparum serine repeat antigen 3 0.014 0.0794 0.2358
Trypanosoma cruzi cysteine proteinase, putative 0.0308 0.1814 0.18
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.0312
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0554 0.3311 0.9087
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2945 0.2945
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0554 0.3311 0.9087
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.014 0.0794 0.2143
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0554 0.3311 0.3311
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0018 0.0018
Plasmodium vivax serine-repeat antigen (SERA), putative 0.014 0.0794 0.2358
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.0794 0.0794
Entamoeba histolytica cysteine proteinase, putative 0.0386 0.229 0.5946
Giardia lamblia Cathepsin B precursor 0.014 0.0794 0.2143
Toxoplasma gondii cathepsin B 0.0608 0.3641 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0147 0.0394
Leishmania major cathepsin L-like protease 0.0554 0.3311 0.9087
Schistosoma mansoni cpg binding protein 0.0035 0.0151 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.0479 0.0479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0147 0.0147
Onchocerca volvulus 0.0554 0.3311 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.0312
Schistosoma mansoni cathepsin B (C01 family) 0.014 0.0794 0.0794
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0312 0.0892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0386 0.229 0.6272
Toxoplasma gondii thioredoxin reductase 0.0037 0.0164 0.0403
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0168 0.096 0.096
Giardia lamblia Cathepsin B precursor 0.014 0.0794 0.2143
Schistosoma mansoni cathepsin s 0.0168 0.096 0.096
Schistosoma mansoni hypothetical protein 0.0489 0.2912 0.2912
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Onchocerca volvulus 0.0554 0.3311 1
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0164 0.0146
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.006 0.0306 0.0306
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0508 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0451 0.7093
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0151 0.0151
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.014 0.0794 0.2358
Schistosoma mansoni cathepsin F (C01 family) 0.0386 0.229 0.229
Loa Loa (eye worm) beta-lactamase 0.0061 0.0312 0.0312
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.006 0.0306 0.0306
Brugia malayi Papain family cysteine protease containing protein 0.014 0.0794 0.0794
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0088 0.0479 0.0479
Plasmodium falciparum serine repeat antigen 8 0.014 0.0794 0.2358
Schistosoma mansoni hypothetical protein 0.0489 0.2912 0.2912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0308 0.1814 0.4958
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Brugia malayi cathepsin Z-like cysteine proteinase 0.014 0.0794 0.0794
Loa Loa (eye worm) latrophilin receptor protein 2 0.006 0.0306 0.0306
Brugia malayi cathepsin F-like cysteine proteinase 0.0168 0.096 0.096
Leishmania major cathepsin L-like protease 0.0554 0.3311 0.9087
Loa Loa (eye worm) hypothetical protein 0.014 0.0794 0.0794
Loa Loa (eye worm) ctsf protein 0.0554 0.3311 0.3311
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.014 0.0794 0.2143
Treponema pallidum NADH oxidase 0.0013 0.0018 0.5
Plasmodium falciparum thioredoxin reductase 0.0037 0.0164 0.0444
Echinococcus granulosus cpg binding protein 0.0037 0.0163 0.0163
Plasmodium falciparum glutathione reductase 0.0037 0.0164 0.0444
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0088 0.0479 0.0479
Plasmodium falciparum ataxin-2 like protein, putative 0.0063 0.0323 0.0925
Toxoplasma gondii cathepsin CPL 0.0554 0.3311 0.9087
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.0312
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0018 0.0018
Loa Loa (eye worm) papain family cysteine protease containing protein 0.014 0.0794 0.0794
Leishmania major hypothetical protein, conserved 0.0061 0.0312 0.0811
Trypanosoma cruzi cysteine peptidase, putative 0.0308 0.1814 0.18
Loa Loa (eye worm) hypothetical protein 0.0386 0.229 0.229
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.014 0.0794 0.0794
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0608 0.3641 0.363
Onchocerca volvulus 0.0061 0.0312 0.0519
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0061 0.0312 0.128
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0794 0.2143
Brugia malayi cathepsin L-like cysteine proteinase 0.014 0.0794 0.0794
Onchocerca volvulus 0.0035 0.0151 0.0012
Brugia malayi Papain family cysteine protease containing protein 0.0554 0.3311 0.3311
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0554 0.3311 0.9087
Mycobacterium tuberculosis Probable reductase 0.0084 0.0451 0.1886
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0395 0.0395
Mycobacterium tuberculosis Probable lipase LipE 0.0061 0.0312 0.128
Loa Loa (eye worm) hypothetical protein 0.014 0.0794 0.0794
Trypanosoma cruzi cysteine peptidase, putative 0.0554 0.3311 0.3299
Giardia lamblia Cathepsin L precursor 0.014 0.0794 0.2143
Brugia malayi cathepsin Z-like cysteine proteinase 0.014 0.0794 0.0794
Echinococcus granulosus cathepsin L 0.0308 0.1814 0.1814
Mycobacterium ulcerans beta-lactamase 0.0061 0.0312 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.019 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.0168 0.096 0.096
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.014 0.0794 0.2143
Schistosoma mansoni hypothetical protein 0.006 0.0306 0.0306
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0147 0.0147
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0012 0.0012
Brugia malayi Papain family cysteine protease containing protein 0.014 0.0794 0.0794
Trichomonas vaginalis D-aminoacylase, putative 0.0061 0.0312 0.0811
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.014 0.0794 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0794 0.2143
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.4737 0.4737
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0554 0.3311 0.3311
Brugia malayi Cathepsin L-like cysteine proteinase 0.0386 0.229 0.229
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.014 0.0794 0.2358
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.0794 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0794 0.2143
Plasmodium falciparum cysteine proteinase falcipain 3 0.0554 0.3311 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.019 0.1098 0.1098
Plasmodium vivax serine-repeat antigen (SERA) 0.014 0.0794 0.2358
Brugia malayi Pre-SET motif family protein 0.0034 0.0147 0.0147
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0018 0.5
Brugia malayi Thioredoxin reductase 0.0037 0.0164 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0312 0.0294
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0088 0.0479 0.0479
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0406 0.0406
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.006 0.0306 0.0306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0554 0.3311 0.9087
Loa Loa (eye worm) hypothetical protein 0.014 0.0794 0.0794
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.0794 0.0794
Plasmodium vivax unspecified product 0.0168 0.096 0.2862
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0406 0.0406
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.014 0.0794 0.2143
Loa Loa (eye worm) hypothetical protein 0.0554 0.3311 0.3311
Trypanosoma brucei trypanothione reductase 0.0037 0.0164 0.0403
Mycobacterium ulcerans esterase/lipase LipP 0.0061 0.0312 1
Brugia malayi Cathepsin L-like precursor 0.0386 0.229 0.229
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Brugia malayi Cathepsin L-like precursor 0.0168 0.096 0.096
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0451 0.1886
Entamoeba histolytica cysteine protease, putative 0.0308 0.1814 0.4054
Plasmodium falciparum serine repeat antigen 9 0.014 0.0794 0.2358
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0794 0.2143
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.014 0.0794 0.2143
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.014 0.0794 0.0794
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.014 0.0794 0.2358
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0406 0.0406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Giardia lamblia Encystation-specific protease 0.014 0.0794 0.2143
Mycobacterium tuberculosis Conserved protein 0.0061 0.0312 0.128
Onchocerca volvulus 0.0061 0.0312 0.0519
Brugia malayi beta-lactamase 0.0061 0.0312 0.0312
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0308 0.1814 0.1814
Echinococcus granulosus cathepsin L 0.014 0.0794 0.0794
Echinococcus multilocularis cathepsin L cysteine protease 0.0554 0.3311 0.3311
Brugia malayi Cathepsin L-like precursor 0.0554 0.3311 0.3311
Giardia lamblia Hypothetical protein 0.014 0.0794 0.2143
Echinococcus granulosus cathepsin l1 0.0554 0.3311 0.3311
Loa Loa (eye worm) hypothetical protein 0.013 0.0731 0.0731
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0147 0.0147
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0167 0.0167
Trypanosoma cruzi major cysteine proteinase, putative 0.014 0.0794 0.0778
Trypanosoma cruzi cysteine peptidase, putative 0.0554 0.3311 0.3299
Mycobacterium tuberculosis Conserved protein 0.0061 0.0312 0.128
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.014 0.0794 0.2358
Trypanosoma cruzi cysteine peptidase, putative 0.0554 0.3311 0.3299
Echinococcus granulosus beta LACTamase domain containing family member 0.0061 0.0312 0.0312
Giardia lamblia Cysteine protease 0.014 0.0794 0.2143
Plasmodium vivax vivapain-2 0.0554 0.3311 1
Leishmania major cathepsin L-like protease 0.0554 0.3311 0.9087
Loa Loa (eye worm) cathepsin B 0.0608 0.3641 0.3641
Leishmania major cathepsin L-like protease 0.0554 0.3311 0.9087
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0451 0.1886
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0063 0.0323 0.0323
Plasmodium vivax vivapain-2 0.0554 0.3311 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.0794 0.0794
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.014 0.0794 0.2143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0554 0.3311 0.9087
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0608 0.3641 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.0312
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Toxoplasma gondii LsmAD domain-containing protein 0.0063 0.0323 0.0841
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0554 0.3311 0.9087
Plasmodium falciparum serine repeat antigen 1 0.014 0.0794 0.2358
Brugia malayi Latrophilin receptor protein 2 0.006 0.0306 0.0306
Echinococcus granulosus GPCR family 2 0.006 0.0306 0.0306
Brugia malayi cahepsin L-like non-peptiedase homolog 0.014 0.0794 0.0794
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.014 0.0794 0.2358
Schistosoma mansoni cathepsin S (C01 family) 0.014 0.0794 0.0794
Trypanosoma cruzi major cysteine proteinase, putative 0.014 0.0794 0.0778
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0554 0.3311 0.9087
Brugia malayi Papain family cysteine protease containing protein 0.0308 0.1814 0.1814
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.006 0.0306 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.014 0.0794 0.2143
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0608 0.3641 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.014 0.0794 0.0794
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0061 0.0312 0.0312
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0508 0.2134
Trypanosoma cruzi PAB1-binding protein , putative 0.0063 0.0323 0.0305
Trypanosoma cruzi cruzipain precursor, putative 0.0554 0.3311 0.3299
Brugia malayi fibroinase precursor 0.014 0.0794 0.0794
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.014 0.0794 0.2358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.014 0.0794 0.2143
Loa Loa (eye worm) hypothetical protein 0.0061 0.0312 0.0312
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0608 0.3641 0.3641
Giardia lamblia Cathepsin B precursor 0.014 0.0794 0.2143

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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