TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 480.515 | Formula: C19H20N4O7S2
H donors: 3 H acceptors: 6 LogP: 0.73 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(OC(C(=O)Nc1ccc(cc1)S(=O)(=O)N)C)CCNC1=NS(=O)(=O)c2c1cccc2
InChi: 1S/C19H20N4O7S2/c1-12(19(25)22-13-6-8-14(9-7-13)31(20,26)27)30-17(24)10-11-21-18-15-4-2-3-5-16(15)32(28,29)23-18/h2-9,12H,10-11H2,1H3,(H,21,23)(H,22,25)(H2,20,26,27)
InChiKey: ZMEZXRLQFATOPE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Cysteine protease	0.0198	0.079	0.2172
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0198	0.079	0.079
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0437	0.1847	0.1847
Onchocerca volvulus		0.0788	0.3398	1
Loa Loa (eye worm)	ctsf protein	0.0788	0.3398	0.3398
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0788	0.3398	0.3398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0198	0.079	0.2172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0437	0.1847	0.5077
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0198	0.079	0.079
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Giardia lamblia	Cysteine protease	0.0198	0.079	0.2172
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0843	0.3639	0.3639
Toxoplasma gondii	cathepsin CPL	0.0788	0.3398	0.9338
Echinococcus granulosus	cathepsin L	0.0437	0.1847	0.1847
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Trypanosoma cruzi	major cysteine proteinase, putative	0.0198	0.079	0.079
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0198	0.079	0.2326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0198	0.079	0.2172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Giardia lamblia	Cathepsin L-like protease	0.0198	0.079	0.2172
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0198	0.079	0.2326
Plasmodium vivax	unspecified product	0.0239	0.0972	0.2862
Brugia malayi	Cathepsin L-like precursor	0.0549	0.2341	0.2341
Giardia lamblia	Cathepsin B precursor	0.0198	0.079	0.2172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0437	0.1847	0.5077
Leishmania major	cathepsin L-like protease	0.0788	0.3398	0.9338
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0437	0.1847	0.1847
Schistosoma mansoni	cathepsin F (C01 family)	0.0549	0.2341	0.2341
Giardia lamblia	Hypothetical protein	0.0198	0.079	0.2172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0198	0.079	0.2172
Brugia malayi	Papain family cysteine protease containing protein	0.0198	0.079	0.079
Trypanosoma cruzi	major cysteine proteinase, putative	0.0198	0.079	0.079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0549	0.2341	0.6433
Echinococcus granulosus	cysteine protease	0.0437	0.1847	0.1847
Brugia malayi	Cathepsin L-like precursor	0.0788	0.3398	0.3398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0549	0.2341	0.6433
Plasmodium vivax	unspecified product	0.0198	0.079	0.2326
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0843	0.3639	1
Leishmania major	cathepsin L-like protease	0.0788	0.3398	0.9338
Echinococcus multilocularis	cathepsin L cysteine protease	0.0788	0.3398	0.3398
Loa Loa (eye worm)	hypothetical protein	0.0549	0.2341	0.2341
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0198	0.079	0.2172
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0198	0.079	0.079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0198	0.079	0.2326
Entamoeba histolytica	cysteine proteinase, putative	0.0437	0.1847	0.5437
Onchocerca volvulus		0.0788	0.3398	1
Toxoplasma gondii	cathepsin CPC2	0.0198	0.079	0.2172
Plasmodium vivax	vivapain-2	0.0788	0.3398	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0239	0.0972	0.0972
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0788	0.3398	0.9338
Giardia lamblia	Cathepsin B precursor	0.0198	0.079	0.2172
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Loa Loa (eye worm)	hypothetical protein	0.0239	0.0972	0.0972
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Entamoeba histolytica	cysteine protease, putative	0.0198	0.079	0.2326
Plasmodium vivax	vivapain-2	0.0788	0.3398	1
Entamoeba histolytica	cysteine proteinase, putative	0.0549	0.2341	0.6889
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0437	0.1847	0.5437
Giardia lamblia	Cathepsin L precursor	0.0198	0.079	0.2172
Giardia lamblia	Cysteine protease	0.0198	0.079	0.2172
Brugia malayi	Cathepsin L-like precursor	0.0239	0.0972	0.0972
Leishmania major	cathepsin L-like protease	0.0788	0.3398	0.9338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0198	0.079	0.2172
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0198	0.079	0.2172
Leishmania major	cathepsin L-like protease	0.0788	0.3398	0.9338
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0198	0.079	0.079
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0437	0.1847	0.1847
Brugia malayi	Cathepsin L-like precursor	0.0788	0.3398	0.3398
Giardia lamblia	Cathepsin L precursor	0.0198	0.079	0.2172
Echinococcus granulosus	cathepsin L cysteine protease	0.0437	0.1847	0.1847
Giardia lamblia	Cathepsin B precursor	0.0843	0.3639	1
Entamoeba histolytica	cysteine proteinase, putative	0.0437	0.1847	0.5437
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0198	0.079	0.079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Entamoeba histolytica	cysteine protease, putative	0.0198	0.079	0.2326
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0843	0.3639	0.3639
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0198	0.079	0.2172
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0198	0.079	0.079
Loa Loa (eye worm)	hypothetical protein	0.0198	0.079	0.079
Toxoplasma gondii	cathepsin B	0.0843	0.3639	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0198	0.079	0.2172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0198	0.079	0.2172
Entamoeba histolytica	cysteine protease, putative	0.0788	0.3398	1
Entamoeba histolytica	cysteine protease, putative	0.0198	0.079	0.2326
Loa Loa (eye worm)	fibroinase	0.0788	0.3398	0.3398
Trypanosoma cruzi	cruzipain precursor, putative	0.0239	0.0972	0.0972
Brugia malayi	MH2 domain containing protein	0.0122	0.0452	0.0452
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0198	0.079	0.079
Schistosoma mansoni	cathepsin F (C01 family)	0.0788	0.3398	0.3398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Onchocerca volvulus	Cathepsin F homolog	0.0788	0.3398	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0788	0.3398	0.9338
Entamoeba histolytica	cysteine protease, putative	0.0198	0.079	0.2326
Giardia lamblia	Cathepsin B precursor	0.0843	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0549	0.2341	0.2341
Trypanosoma cruzi	cysteine peptidase, putative	0.0788	0.3398	0.3398
Onchocerca volvulus		0.0788	0.3398	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Trypanosoma cruzi	cysteine peptidase, putative	0.0788	0.3398	0.3398
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0198	0.079	0.2326
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0198	0.079	0.2326
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0198	0.079	0.2326
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0788	0.3398	0.9338
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0437	0.1847	0.1847
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0788	0.3398	0.9338
Echinococcus granulosus	cathepsin l1	0.0788	0.3398	0.3398
Brugia malayi	cathepsin L precursor	0.0198	0.079	0.079
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0198	0.079	0.2172
Brugia malayi	cathepsin F-like cysteine proteinase	0.0198	0.079	0.079
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0198	0.079	0.079
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0198	0.079	0.2326
Entamoeba histolytica	cysteine proteinase, putative	0.0788	0.3398	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0788	0.3398	0.9338
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Giardia lamblia	Cathepsin L precursor	0.0198	0.079	0.2172
Entamoeba histolytica	cysteine proteinase, putative	0.0437	0.1847	0.5437
Plasmodium vivax	vivapain-1	0.0437	0.1847	0.5437
Plasmodium falciparum	serine repeat antigen 2	0.0198	0.079	0.2326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0198	0.079	0.079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0198	0.079	0.2172
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0198	0.079	0.079
Echinococcus multilocularis	cathepsin L	0.0198	0.079	0.079
Leishmania major	cathepsin L-like protease	0.0788	0.3398	0.9338
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0843	0.3639	1
Schistosoma mansoni	cathepsin C	0.0198	0.079	0.079
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0198	0.079	0.2326
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0198	0.079	0.2326
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.079	0.2172
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0788	0.3398	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0198	0.079	0.2172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0198	0.079	0.2172
Plasmodium falciparum	serine repeat antigen 4	0.0198	0.079	0.2326
Schistosoma mansoni	cathepsin S (C01 family)	0.0198	0.079	0.079
Entamoeba histolytica	hypothetical protein	0.0198	0.079	0.2326
Plasmodium falciparum	serine repeat antigen 8	0.0198	0.079	0.2326
Giardia lamblia	Cathepsin B precursor	0.0198	0.079	0.2172
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Brugia malayi	fibroinase precursor	0.0198	0.079	0.079
Loa Loa (eye worm)	hypothetical protein	0.0198	0.079	0.079
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0239	0.0972	0.0972
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0452	0.0452
Echinococcus granulosus	cathepsin l1	0.0549	0.2341	0.2341
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Entamoeba histolytica	cysteine proteinase 2	0.0437	0.1847	0.5437
Brugia malayi	Cathepsin L-like precursor	0.0788	0.3398	0.3398
Entamoeba histolytica	cysteine proteinase, putative	0.0788	0.3398	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0198	0.079	0.2172
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0549	0.2341	0.2341
Onchocerca volvulus		0.0788	0.3398	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0788	0.3398	0.3398
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0788	0.3398	0.3398
Plasmodium falciparum	serine repeat antigen 7	0.0198	0.079	0.2326
Leishmania major	cathepsin L-like protease	0.0788	0.3398	0.9338
Brugia malayi	cathepsin L-like precursor	0.0549	0.2341	0.2341
Toxoplasma gondii	cathepsin CPC1	0.0198	0.079	0.2172
Brugia malayi	Cathepsin L-like precursor	0.0788	0.3398	0.3398
Loa Loa (eye worm)	hypothetical protein	0.0239	0.0972	0.0972
Onchocerca volvulus		0.0788	0.3398	1
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Loa Loa (eye worm)	hypothetical protein	0.0239	0.0972	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0198	0.079	0.079
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0549	0.2341	0.2341
Loa Loa (eye worm)	hypothetical protein	0.0788	0.3398	0.3398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Trypanosoma cruzi	cysteine proteinase, putative	0.0437	0.1847	0.1847
Schistosoma mansoni	cathepsin B (C01 family)	0.0198	0.079	0.079
Onchocerca volvulus		0.0788	0.3398	1
Leishmania major	cathepsin L-like protease	0.0788	0.3398	0.9338
Plasmodium falciparum	serine repeat antigen 1	0.0198	0.079	0.2326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0437	0.1847	0.5077
Entamoeba histolytica	cysteine protease, putative	0.0198	0.079	0.2326
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0198	0.079	0.2326
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0788	0.3398	0.9338
Giardia lamblia	Cathepsin L-like protease	0.0198	0.079	0.2172
Onchocerca volvulus		0.0549	0.2341	0.5946
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0198	0.079	0.079
Plasmodium falciparum	serine repeat antigen 5	0.0198	0.079	0.2326
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0198	0.079	0.2172
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0198	0.079	0.2172
Giardia lamblia	Cathepsin L precursor	0.0198	0.079	0.2172
Loa Loa (eye worm)	cathepsin B	0.0843	0.3639	0.3639
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Onchocerca volvulus		0.0788	0.3398	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0198	0.079	0.2326
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0239	0.0972	0.0972
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0198	0.079	0.079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0788	0.3398	0.3398
Loa Loa (eye worm)	hypothetical protein	0.0549	0.2341	0.2341
Schistosoma mansoni	cathepsin F (C01 family)	0.0788	0.3398	0.3398
Plasmodium falciparum	serine repeat antigen 6	0.0198	0.079	0.2326
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.0452	0.0452
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0788	0.3398	1
Giardia lamblia	Cathepsin B precursor	0.0198	0.079	0.2172
Brugia malayi	cathepsin L-like cysteine proteinase	0.0198	0.079	0.079
Brugia malayi	Cathepsin L-like precursor	0.0788	0.3398	0.3398
Giardia lamblia	Encystation-specific protease	0.0198	0.079	0.2172
Leishmania major	cysteine peptidase A (CPA)	0.0788	0.3398	0.9338
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Plasmodium falciparum	serine repeat antigen 9	0.0198	0.079	0.2326
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0843	0.3639	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0198	0.079	0.2326
Brugia malayi	Papain family cysteine protease containing protein	0.0198	0.079	0.079
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0198	0.079	0.2326
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0198	0.079	0.2326
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Echinococcus granulosus	cathepsin L	0.0198	0.079	0.079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0437	0.1847	0.5077
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Onchocerca volvulus	Cathepsin L homolog	0.0788	0.3398	1
Giardia lamblia	Cathepsin L precursor	0.0198	0.079	0.2172
Trypanosoma cruzi	cruzipain precursor, putative	0.0788	0.3398	0.3398
Giardia lamblia	Cathepsin B precursor	0.0198	0.079	0.2172
Echinococcus multilocularis	cathepsin L	0.0437	0.1847	0.1847
Giardia lamblia	Cathepsin L precursor	0.0198	0.079	0.2172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Loa Loa (eye worm)	hypothetical protein	0.0198	0.079	0.079
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0788	0.3398	0.9338
Entamoeba histolytica	cysteine proteinase 1, putative	0.0437	0.1847	0.5437
Entamoeba histolytica	cysteine proteinase, putative	0.0437	0.1847	0.5437
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0198	0.079	0.2326
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Echinococcus multilocularis	cathepsin L cysteine protease	0.0788	0.3398	0.3398
Trypanosoma cruzi	cysteine protease, putative	0.0437	0.1847	0.1847
Loa Loa (eye worm)	hypothetical protein	0.0198	0.079	0.079
Leishmania major	cathepsin L-like protease	0.0788	0.3398	0.9338
Plasmodium vivax	unspecified product	0.0437	0.1847	0.5437
Echinococcus multilocularis	cysteine protease	0.0788	0.3398	0.3398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0198	0.079	0.2172
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0198	0.079	0.2172
Giardia lamblia	Hypothetical protein	0.0198	0.079	0.2172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0788	0.3398	0.9338
Brugia malayi	Papain family cysteine protease containing protein	0.0437	0.1847	0.1847
Echinococcus multilocularis	cysteine protease	0.0788	0.3398	0.3398
Entamoeba histolytica	cysteine protease, putative	0.0198	0.079	0.2326
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0198	0.079	0.079
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0788	0.3398	1
Plasmodium falciparum	serine repeat antigen 3	0.0198	0.079	0.2326
Trypanosoma cruzi	cysteine proteinase, putative	0.0437	0.1847	0.1847
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0788	0.3398	0.9338
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0198	0.079	0.2326
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0198	0.079	0.2326
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0198	0.079	0.2172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0788	0.3398	0.9338
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0198	0.079	0.079
Brugia malayi	Papain family cysteine protease containing protein	0.0437	0.1847	0.1847
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0198	0.079	0.2172
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0198	0.079	0.079
Loa Loa (eye worm)	hypothetical protein	0.0198	0.079	0.079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Trypanosoma cruzi	cysteine peptidase, putative	0.0437	0.1847	0.1847
Brugia malayi	Papain family cysteine protease containing protein	0.0788	0.3398	0.3398
Trypanosoma cruzi	cysteine peptidase, putative	0.0788	0.3398	0.3398
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0788	0.3398	0.3398
Brugia malayi	cathepsin F-like cysteine proteinase	0.0239	0.0972	0.0972
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.079	0.2172
Brugia malayi	Cathepsin L-like precursor	0.0788	0.3398	0.3398
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0198	0.079	0.2172
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0788	0.3398	0.9338
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0198	0.079	0.2172
Giardia lamblia	Cysteine protease	0.0198	0.079	0.2172
Schistosoma mansoni	cathepsin s	0.0239	0.0972	0.0972
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0788	0.3398	0.3398
Giardia lamblia	Cathepsin B precursor	0.0843	0.3639	1
Plasmodium vivax	vivapain-3	0.0437	0.1847	0.5437
Loa Loa (eye worm)	cysteine protease	0.0788	0.3398	0.3398
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0788	0.3398	0.9338
Brugia malayi	Cathepsin L-like precursor	0.0549	0.2341	0.2341
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0788	0.3398	0.9338
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0788	0.3398	0.3398
Entamoeba histolytica	cysteine protease, putative	0.0437	0.1847	0.5437
Onchocerca volvulus	Cathepsin L homolog	0.0788	0.3398	1
Brugia malayi	Papain family cysteine protease containing protein	0.0198	0.079	0.079

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1562127

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1403306