Detailed information for compound 1403575

Basic information

Technical information
  • TDR Targets ID: 1403575
  • Name: 5-[(4-methoxyphenyl)amino]-2-[2-(2-methoxyphe nyl)ethenyl]-1,3-oxazole-4-carbonitrile
  • MW: 347.367 | Formula: C20H17N3O3
  • H donors: 1 H acceptors: 2 LogP: 5.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Nc1oc(nc1C#N)/C=C/c1ccccc1OC
  • InChi: 1S/C20H17N3O3/c1-24-16-10-8-15(9-11-16)22-20-17(13-21)23-19(26-20)12-7-14-5-3-4-6-18(14)25-2/h3-12,22H,1-2H3/b12-7+
  • InChiKey: STYBDEZEAHYSNF-KPKJPENVSA-N  


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Synonyms

  • 5-[(4-methoxyphenyl)amino]-2-[(E)-2-(2-methoxyphenyl)ethenyl]-1,3-oxazole-4-carbonitrile
  • 5-[(4-methoxyphenyl)amino]-2-[(E)-2-(2-methoxyphenyl)vinyl]oxazole-4-carbonitrile
  • 5-[(4-methoxyphenyl)amino]-2-[2-(2-methoxyphenyl)vinyl]oxazole-4-carbonitrile
  • 5-[(4-methoxyphenyl)amino]-2-[(E)-2-(2-methoxyphenyl)vinyl]-4-oxazolecarbonitrile
  • 5-[(4-methoxyphenyl)amino]-2-[2-(2-methoxyphenyl)vinyl]-4-oxazolecarbonitrile
  • ZINC04839315
  • D151-0356
  • NCGC00116659-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0731 0.2362 0.2362
Entamoeba histolytica cysteine protease, putative 0.0263 0.0788 0.2293
Toxoplasma gondii cathepsin CPL 0.1051 0.3435 0.9291
Entamoeba histolytica cysteine proteinase, putative 0.1051 0.3435 1
Loa Loa (eye worm) hypothetical protein 0.0319 0.0977 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Entamoeba histolytica cysteine proteinase, putative 0.0582 0.1861 0.5418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1051 0.3435 0.9291
Onchocerca volvulus 0.1051 0.3435 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1111 0.3637 1
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0582 0.1861 0.1165
Leishmania major cathepsin L-like protease 0.1051 0.3435 0.9445
Entamoeba histolytica cysteine proteinase 2 0.0582 0.1861 0.5418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Trypanosoma cruzi cysteine peptidase, putative 0.1051 0.3435 0.2874
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1051 0.3435 0.9291
Onchocerca volvulus 0.1051 0.3435 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1051 0.3435 0.9291
Entamoeba histolytica cysteine proteinase, putative 0.0731 0.2362 0.6876
Entamoeba histolytica cysteine proteinase 1, putative 0.0582 0.1861 0.5418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Onchocerca volvulus 0.0731 0.2362 0.6876
Entamoeba histolytica cysteine protease, putative 0.0263 0.0788 0.2293
Entamoeba histolytica cysteine protease, putative 0.0263 0.0788 0.2293
Brugia malayi Cathepsin L-like precursor 0.1051 0.3435 0.3435
Onchocerca volvulus Cathepsin L homolog 0.1051 0.3435 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0582 0.1861 0.4054
Echinococcus multilocularis cathepsin L 0.0582 0.1861 0.1165
Loa Loa (eye worm) hypothetical protein 0.0731 0.2362 0.2362
Trypanosoma cruzi cruzipain precursor, putative 0.0319 0.0977 0.0205
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1051 0.3435 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0319 0.0977 0.0977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Brugia malayi Cathepsin L-like cysteine proteinase 0.0731 0.2362 0.2362
Trypanosoma cruzi cysteine protease, putative 0.0582 0.1861 0.1165
Plasmodium vivax vivapain-2 0.1051 0.3435 1
Echinococcus granulosus cathepsin L cysteine protease 0.0582 0.1861 0.1165
Echinococcus multilocularis cysteine protease 0.1051 0.3435 0.2874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Brugia malayi cathepsin L-like cysteine proteinase 0.0263 0.0788 0.0788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0731 0.2362 0.5525
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0319 0.0977 0.0977
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Entamoeba histolytica cysteine protease, putative 0.0263 0.0788 0.2293
Loa Loa (eye worm) hypothetical protein 0.0731 0.2362 0.2362
Brugia malayi Cathepsin L-like precursor 0.0731 0.2362 0.2362
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0263 0.0788 0.0788
Echinococcus multilocularis cysteine protease 0.1051 0.3435 0.2874
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0263 0.0788 0.0788
Echinococcus granulosus cathepsin L cysteine proteinase 0.1051 0.3435 0.2874
Schistosoma mansoni cathepsin F (C01 family) 0.0731 0.2362 0.1709
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0731 0.2362 0.1709
Onchocerca volvulus 0.1051 0.3435 1
Leishmania major cathepsin L-like protease 0.1051 0.3435 0.9445
Onchocerca volvulus 0.1051 0.3435 1
Onchocerca volvulus Cathepsin F homolog 0.1051 0.3435 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1111 0.3637 0.3093
Trypanosoma brucei cysteine peptidase C (CPC) 0.1111 0.3637 1
Brugia malayi Papain family cysteine protease containing protein 0.0263 0.0788 0.0788
Brugia malayi cathepsin L precursor 0.0263 0.0788 0.0788
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0582 0.1861 0.1165
Schistosoma mansoni cathepsin F (C01 family) 0.1051 0.3435 0.2874
Loa Loa (eye worm) hypothetical protein 0.0319 0.0977 0.0977
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2705 0.2081
Echinococcus granulosus cathepsin l cysteine peptidase 0.1051 0.3435 0.2874
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1051 0.3435 0.9291
Trypanosoma cruzi cysteine peptidase, putative 0.0582 0.1861 0.1165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Plasmodium falciparum cysteine proteinase falcipain 3 0.1051 0.3435 1
Trypanosoma cruzi cysteine peptidase, putative 0.0319 0.0977 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1051 0.3435 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Loa Loa (eye worm) hypothetical protein 0.0263 0.0788 0.0788
Loa Loa (eye worm) cysteine protease 0.1051 0.3435 0.3435
Brugia malayi Cathepsin L-like precursor 0.0319 0.0977 0.0977
Leishmania major cathepsin L-like protease 0.1051 0.3435 0.9445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0731 0.2362 0.5525
Echinococcus multilocularis cathepsin L cysteine protease 0.1051 0.3435 0.2874
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2705 0.2081
Entamoeba histolytica cysteine protease, putative 0.1051 0.3435 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0582 0.1861 0.3767
Trypanosoma cruzi cysteine peptidase, putative 0.1051 0.3435 0.2874
Loa Loa (eye worm) fibroinase 0.1051 0.3435 0.3435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Entamoeba histolytica cysteine proteinase, putative 0.0582 0.1861 0.5418
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Leishmania major cathepsin L-like protease 0.1051 0.3435 0.9445
Onchocerca volvulus 0.1051 0.3435 1
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Toxoplasma gondii cathepsin B 0.1111 0.3637 1
Trypanosoma cruzi cysteine peptidase, putative 0.1051 0.3435 0.2874
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1051 0.3435 1
Onchocerca volvulus 0.0263 0.0788 0.2293
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0263 0.0788 0.2293
Brugia malayi cathepsin Z-like cysteine proteinase 0.0263 0.0788 0.0788
Brugia malayi Cathepsin L-like precursor 0.1051 0.3435 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0582 0.1861 0.1165
Echinococcus granulosus cysteine protease 0.0582 0.1861 0.1165
Trypanosoma cruzi cysteine proteinase, putative 0.0582 0.1861 0.1165
Giardia lamblia Cathepsin B precursor 0.1111 0.3637 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Onchocerca volvulus Cathepsin L homolog 0.1051 0.3435 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.0788 0.0788
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1111 0.3637 0.3093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1051 0.3435 0.9291
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Giardia lamblia Cathepsin B precursor 0.1111 0.3637 1
Loa Loa (eye worm) ctsf protein 0.1051 0.3435 0.3435
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0319 0.0977 0.0977
Loa Loa (eye worm) hypothetical protein 0.0263 0.0788 0.0788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0582 0.1861 0.3767
Trypanosoma cruzi cysteine proteinase, putative 0.0582 0.1861 0.1165
Leishmania major cathepsin L-like protease 0.1051 0.3435 0.9445
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0263 0.0788 0.2293
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Entamoeba histolytica cysteine proteinase, putative 0.1051 0.3435 1
Brugia malayi Cathepsin L-like precursor 0.1051 0.3435 0.3435
Leishmania major cathepsin L-like protease 0.1051 0.3435 0.9445
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Plasmodium vivax unspecified product 0.0582 0.1861 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1051 0.3435 0.9291
Loa Loa (eye worm) hypothetical protein 0.0263 0.0788 0.0788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Echinococcus granulosus cathepsin l1 0.1051 0.3435 0.2874
Trypanosoma cruzi cruzipain precursor, putative 0.1051 0.3435 0.2874
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2705 0.2081
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Giardia lamblia Cathepsin B precursor 0.1111 0.3637 1
Trypanosoma cruzi cysteine peptidase, putative 0.1051 0.3435 0.2874
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1051 0.3435 0.9291
Loa Loa (eye worm) hypothetical protein 0.1051 0.3435 0.3435
Loa Loa (eye worm) hypothetical protein 0.0319 0.0977 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Leishmania major cathepsin L-like protease 0.1051 0.3435 0.9445
Brugia malayi Cathepsin L-like precursor 0.1051 0.3435 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1051 0.3435 0.3435
Brugia malayi Papain family cysteine protease containing protein 0.0582 0.1861 0.1861
Leishmania major cathepsin L-like protease 0.1051 0.3435 0.9445
Brugia malayi fibroinase precursor 0.0263 0.0788 0.0788
Entamoeba histolytica cysteine proteinase, putative 0.0582 0.1861 0.5418
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1051 0.3435 0.2874
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0263 0.0788 0.0788
Loa Loa (eye worm) hypothetical protein 0.0263 0.0788 0.0788
Brugia malayi cathepsin F-like cysteine proteinase 0.0263 0.0788 0.0788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Entamoeba histolytica hypothetical protein 0.0263 0.0788 0.2293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Entamoeba histolytica cysteine protease, putative 0.0263 0.0788 0.2293
Schistosoma mansoni cathepsin F (C01 family) 0.1051 0.3435 0.2874
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0582 0.1861 0.1165
Entamoeba histolytica cysteine protease, putative 0.0582 0.1861 0.5418
Brugia malayi Papain family cysteine protease containing protein 0.0582 0.1861 0.1861
Brugia malayi Papain family cysteine protease containing protein 0.0263 0.0788 0.0788
Brugia malayi Papain family cysteine protease containing protein 0.1051 0.3435 0.3435
Brugia malayi Cathepsin L-like precursor 0.0731 0.2362 0.2362
Schistosoma mansoni cathepsin s 0.0319 0.0977 0.0205
Onchocerca volvulus 0.1051 0.3435 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1051 0.3435 0.9291
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1051 0.3435 0.9291
Plasmodium vivax vivapain-2 0.1051 0.3435 1
Echinococcus granulosus cathepsin L 0.0582 0.1861 0.1165
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0263 0.0788 0.0788
Leishmania major cysteine peptidase A (CPA) 0.1051 0.3435 0.9445
Loa Loa (eye worm) hypothetical protein 0.0263 0.0788 0.0788
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Echinococcus multilocularis cathepsin L cysteine protease 0.1051 0.3435 0.2874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Brugia malayi cathepsin Z-like cysteine proteinase 0.0263 0.0788 0.0788
Loa Loa (eye worm) cathepsin B 0.1111 0.3637 0.3637
Brugia malayi Cathepsin L-like precursor 0.1051 0.3435 0.3435
Onchocerca volvulus Cathepsin L homolog 0.0263 0.0788 0.2293
Brugia malayi Cathepsin L-like precursor 0.1051 0.3435 0.3435
Echinococcus granulosus cathepsin l1 0.0731 0.2362 0.1709
Plasmodium vivax unspecified product 0.0319 0.0977 0.0715
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1111 0.3637 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1051 0.3435 0.8863
Brugia malayi cathepsin L-like precursor 0.0731 0.2362 0.2362
Onchocerca volvulus 0.1051 0.3435 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1051 0.3435 0.9291
Brugia malayi Papain family cysteine protease containing protein 0.0263 0.0788 0.0788
Entamoeba histolytica cysteine proteinase, putative 0.0582 0.1861 0.5418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1051 0.3435 0.9291
Entamoeba histolytica cysteine protease, putative 0.0263 0.0788 0.2293
Plasmodium vivax vivapain-1 0.0582 0.1861 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1051 0.3435 0.9291
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1051 0.3435 0.2874
Plasmodium vivax vivapain-3 0.0582 0.1861 0.4054

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.3582 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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