Detailed information for compound 1403797

Basic information

Technical information
  • TDR Targets ID: 1403797
  • Name: N-(4-methoxyphenyl)-2-[4-methyl-5-[2-oxo-2-(1 ,3-thiazol-2-ylamino)ethyl]sulfanyl-1,2,4-tri azol-3-yl]acetamide
  • MW: 418.493 | Formula: C17H18N6O3S2
  • H donors: 2 H acceptors: 5 LogP: 1.32 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)Cc1nnc(n1C)SCC(=O)Nc1nccs1
  • InChi: 1S/C17H18N6O3S2/c1-23-13(9-14(24)19-11-3-5-12(26-2)6-4-11)21-22-17(23)28-10-15(25)20-16-18-7-8-27-16/h3-8H,9-10H2,1-2H3,(H,19,24)(H,18,20,25)
  • InChiKey: OBIZWOXFEXIDBJ-UHFFFAOYSA-N  


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Synonyms

  • N-(4-methoxyphenyl)-2-[4-methyl-5-[2-oxo-2-(thiazol-2-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]acetamide
  • N-(4-methoxyphenyl)-2-[4-methyl-5-[[2-oxo-2-(2-thiazolylamino)ethyl]thio]-1,2,4-triazol-3-yl]acetamide
  • 2-[5-[[2-keto-2-(thiazol-2-ylamino)ethyl]thio]-4-methyl-1,2,4-triazol-3-yl]-N-(4-methoxyphenyl)acetamide
  • N-(4-methoxyphenyl)-2-[4-methyl-5-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]ethanamide
  • ASN 13395312
  • STK221537

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cysteine protease 0.0232 0.0765 0.2058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Giardia lamblia Cathepsin L precursor 0.0232 0.0765 0.2058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0232 0.0765 0.0742
Leishmania major cathepsin L-like protease 0.0922 0.3358 0.9273
Toxoplasma gondii cathepsin CPL 0.0922 0.3358 0.9268
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0512 0.1816 0.1796
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0992 0.3621 0.3605
Brugia malayi jmjC domain containing protein 0.0043 0.0053 0.0053
Brugia malayi cathepsin L-like cysteine proteinase 0.0232 0.0765 0.0765
Brugia malayi Papain family cysteine protease containing protein 0.0512 0.1816 0.1816
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0512 0.1816 0.1138
Loa Loa (eye worm) ctsf protein 0.0922 0.3358 0.3358
Brugia malayi cathepsin Z-like cysteine proteinase 0.0232 0.0765 0.0765
Echinococcus granulosus cathepsin L cysteine proteinase 0.0922 0.3358 0.3341
Brugia malayi cathepsin L precursor 0.0232 0.0765 0.0765
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0232 0.0765 0.0742
Onchocerca volvulus 0.0922 0.3358 1
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Onchocerca volvulus 0.0642 0.2307 0.6869
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0922 0.3358 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0512 0.1816 0.5408
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0232 0.0765 0.222
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0232 0.0765 0.0742
Loa Loa (eye worm) hypothetical protein 0.0642 0.2307 0.2307
Entamoeba histolytica cysteine protease, putative 0.0232 0.0765 0.2278
Loa Loa (eye worm) hypothetical protein 0.006 0.0119 0.0119
Brugia malayi Cathepsin L-like precursor 0.0642 0.2307 0.2307
Plasmodium falciparum cysteine proteinase falcipain 3 0.0922 0.3358 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0512 0.1816 0.5374
Echinococcus granulosus cathepsin l1 0.0642 0.2307 0.2287
Brugia malayi cathepsin F-like cysteine proteinase 0.028 0.0944 0.0944
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0025 0.0025
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0232 0.0765 0.2058
Giardia lamblia Cathepsin L precursor 0.0232 0.0765 0.2058
Loa Loa (eye worm) hypothetical protein 0.028 0.0944 0.0944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Brugia malayi PHD-finger family protein 0.0035 0.0025 0.0025
Trypanosoma cruzi cysteine peptidase, putative 0.028 0.0944 0.0194
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0922 0.3358 0.9078
Plasmodium vivax vivapain-2 0.0922 0.3358 1
Brugia malayi Papain family cysteine protease containing protein 0.0512 0.1816 0.1816
Brugia malayi cathepsin F-like cysteine proteinase 0.0232 0.0765 0.0765
Onchocerca volvulus 0.0922 0.3358 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0053 0.0028
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Brugia malayi Cathepsin L-like precursor 0.0642 0.2307 0.2307
Echinococcus multilocularis cathepsin L cysteine protease 0.0922 0.3358 0.3341
Toxoplasma gondii cathepsin CPC1 0.0232 0.0765 0.2058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0237 0.0213
Trypanosoma brucei cysteine peptidase C (CPC) 0.0992 0.3621 1
Trypanosoma cruzi cysteine peptidase, putative 0.0922 0.3358 0.2808
Giardia lamblia Cathepsin B precursor 0.0232 0.0765 0.2058
Toxoplasma gondii cathepsin CPC2 0.0232 0.0765 0.2058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Giardia lamblia Cathepsin B precursor 0.0992 0.3621 1
Giardia lamblia Cathepsin B precursor 0.0232 0.0765 0.2058
Plasmodium vivax unspecified product 0.0512 0.1816 0.5374
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0166 0.0166
Echinococcus granulosus cathepsin L cysteine protease 0.0512 0.1816 0.1796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0232 0.0765 0.222
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0232 0.0765 0.222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Plasmodium vivax unspecified product 0.028 0.0944 0.2757
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Brugia malayi Cathepsin L-like precursor 0.0922 0.3358 0.3358
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0232 0.0765 0.222
Giardia lamblia Cathepsin L precursor 0.0232 0.0765 0.2058
Plasmodium vivax vivapain-2 0.0922 0.3358 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0642 0.2307 0.5398
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Giardia lamblia Cathepsin B precursor 0.0232 0.0765 0.2058
Entamoeba histolytica cysteine proteinase 2 0.0512 0.1816 0.5408
Onchocerca volvulus Cathepsin F homolog 0.0922 0.3358 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0922 0.3358 0.9078
Entamoeba histolytica cysteine protease, putative 0.0232 0.0765 0.2278
Schistosoma mansoni cathepsin F (C01 family) 0.0922 0.3358 0.3341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0053 0.0028
Loa Loa (eye worm) fibroinase 0.0922 0.3358 0.3358
Loa Loa (eye worm) papain family cysteine protease containing protein 0.028 0.0944 0.0944
Giardia lamblia Cathepsin B precursor 0.0232 0.0765 0.2058
Loa Loa (eye worm) hypothetical protein 0.0922 0.3358 0.3358
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0232 0.0765 0.0742
Toxoplasma gondii cathepsin B 0.0992 0.3621 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.0765 0.0765
Plasmodium falciparum serine repeat antigen 6 0.0232 0.0765 0.222
Giardia lamblia Cathepsin B precursor 0.0992 0.3621 1
Giardia lamblia Cysteine protease 0.0232 0.0765 0.2058
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0053 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0922 0.3358 0.9078
Echinococcus granulosus cathepsin l1 0.0922 0.3358 0.3341
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0922 0.3358 0.9078
Echinococcus granulosus cathepsin L 0.0232 0.0765 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Entamoeba histolytica cysteine protease, putative 0.0232 0.0765 0.2278
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0326 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Onchocerca volvulus 0.0922 0.3358 1
Brugia malayi cathepsin L-like precursor 0.0642 0.2307 0.2307
Giardia lamblia Cathepsin B precursor 0.0992 0.3621 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Plasmodium falciparum serine repeat antigen 1 0.0232 0.0765 0.222
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0232 0.0765 0.0765
Giardia lamblia Cathepsin L-like protease 0.0232 0.0765 0.2058
Giardia lamblia Cysteine protease 0.0232 0.0765 0.2058
Leishmania major cathepsin L-like protease 0.0922 0.3358 0.9273
Leishmania major cysteine peptidase A (CPA) 0.0922 0.3358 0.9273
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0232 0.0765 0.222
Entamoeba histolytica cysteine proteinase, putative 0.0512 0.1816 0.5408
Echinococcus granulosus cathepsin L 0.0512 0.1816 0.1796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0922 0.3358 0.9078
Giardia lamblia Cysteine protease 0.0232 0.0765 0.2058
Entamoeba histolytica cysteine proteinase, putative 0.0922 0.3358 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.0765 0.0765
Giardia lamblia Cathepsin L precursor 0.0232 0.0765 0.2058
Giardia lamblia Hypothetical protein 0.0232 0.0765 0.2058
Entamoeba histolytica cysteine protease, putative 0.0232 0.0765 0.2278
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0232 0.0765 0.222
Giardia lamblia Cathepsin L precursor 0.0232 0.0765 0.2058
Entamoeba histolytica cysteine proteinase, putative 0.0512 0.1816 0.5408
Schistosoma mansoni cathepsin B (C01 family) 0.0232 0.0765 0.0742
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0053 0.0028
Brugia malayi jmjC domain containing protein 0.0115 0.0326 0.0326
Brugia malayi fibroinase precursor 0.0232 0.0765 0.0765
Plasmodium falciparum serine repeat antigen 7 0.0232 0.0765 0.222
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0232 0.0765 0.0742
Plasmodium vivax serine-repeat antigen (SERA) 0.0232 0.0765 0.222
Entamoeba histolytica cysteine protease, putative 0.0232 0.0765 0.2278
Leishmania major cathepsin L-like protease 0.0922 0.3358 0.9273
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0232 0.0765 0.2058
Schistosoma mansoni cathepsin S (C01 family) 0.0232 0.0765 0.0742
Echinococcus multilocularis cathepsin L 0.0232 0.0765 0.0742
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0992 0.3621 1
Leishmania major cathepsin L-like protease 0.0922 0.3358 0.9273
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Brugia malayi Cathepsin L-like cysteine proteinase 0.0642 0.2307 0.2307
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0232 0.0765 0.0742
Trypanosoma cruzi cruzipain precursor, putative 0.0922 0.3358 0.2808
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Loa Loa (eye worm) cysteine protease 0.0922 0.3358 0.3358
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0642 0.2307 0.5398
Brugia malayi Papain family cysteine protease containing protein 0.0232 0.0765 0.0765
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0512 0.1816 0.1796
Onchocerca volvulus 0.0922 0.3358 1
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Entamoeba histolytica cysteine proteinase, putative 0.0922 0.3358 1
Trypanosoma cruzi cysteine peptidase, putative 0.0922 0.3358 0.2808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0642 0.2307 0.1669
Trypanosoma cruzi cruzipain precursor, putative 0.028 0.0944 0.0194
Schistosoma mansoni cathepsin C 0.0232 0.0765 0.0742
Loa Loa (eye worm) hypothetical protein 0.0642 0.2307 0.2307
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0232 0.0765 0.2058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0922 0.3358 0.9078
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0077 0.0052
Brugia malayi Cathepsin L-like precursor 0.0922 0.3358 0.3358
Onchocerca volvulus 0.0922 0.3358 1
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0232 0.0765 0.222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0512 0.1816 0.368
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0232 0.0765 0.2058
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0922 0.3358 0.3358
Loa Loa (eye worm) hypothetical protein 0.0642 0.2307 0.2307
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0232 0.0765 0.222
Plasmodium falciparum serine repeat antigen 3 0.0232 0.0765 0.222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Onchocerca volvulus 0.0922 0.3358 1
Trypanosoma cruzi cysteine proteinase, putative 0.0512 0.1816 0.1138
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0232 0.0765 0.2278
Loa Loa (eye worm) hypothetical protein 0.028 0.0944 0.0944
Leishmania major cathepsin L-like protease 0.0922 0.3358 0.9273
Schistosoma mansoni cathepsin F (C01 family) 0.0922 0.3358 0.3341
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0232 0.0765 0.222
Entamoeba histolytica cysteine proteinase, putative 0.0642 0.2307 0.6869
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0922 0.3358 0.3341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Plasmodium falciparum serine repeat antigen 2 0.0232 0.0765 0.222
Onchocerca volvulus 0.0922 0.3358 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.0765 0.0765
Plasmodium vivax unspecified product 0.0232 0.0765 0.222
Loa Loa (eye worm) cathepsin B 0.0992 0.3621 0.3621
Giardia lamblia Encystation-specific protease 0.0232 0.0765 0.2058
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0077 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0232 0.0765 0.222
Entamoeba histolytica hypothetical protein 0.0232 0.0765 0.2278
Giardia lamblia Hypothetical protein 0.0232 0.0765 0.2058
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0232 0.0765 0.0742
Leishmania major cathepsin L-like protease 0.0922 0.3358 0.9273
Entamoeba histolytica cysteine protease, putative 0.0232 0.0765 0.2278
Trypanosoma cruzi cysteine peptidase, putative 0.0512 0.1816 0.1138
Giardia lamblia Cathepsin L-like protease 0.0232 0.0765 0.2058
Toxoplasma gondii preprocathepsin c precursor, putative 0.0232 0.0765 0.2058
Loa Loa (eye worm) hypothetical protein 0.0232 0.0765 0.0765
Brugia malayi Papain family cysteine protease containing protein 0.0232 0.0765 0.0765
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0992 0.3621 0.3093
Echinococcus granulosus cysteine protease 0.0512 0.1816 0.1796
Leishmania major cathepsin L-like protease 0.0922 0.3358 0.9273
Plasmodium falciparum serine repeat antigen 8 0.0232 0.0765 0.222
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0232 0.0765 0.2278
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0922 0.3358 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0053 0.0053
Brugia malayi Cathepsin L-like precursor 0.0922 0.3358 0.3358
Loa Loa (eye worm) hypothetical protein 0.0232 0.0765 0.0765
Echinococcus multilocularis cathepsin L cysteine protease 0.0922 0.3358 0.3341
Entamoeba histolytica cysteine proteinase, putative 0.0512 0.1816 0.5408
Leishmania major cathepsin L-like protease 0.0922 0.3358 0.9273
Plasmodium falciparum serine repeat antigen 5 0.0232 0.0765 0.222
Plasmodium vivax vivapain-1 0.0512 0.1816 0.5374
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0922 0.3358 0.9078
Onchocerca volvulus Cathepsin L homolog 0.0232 0.0765 0.2278
Brugia malayi Cathepsin L-like precursor 0.028 0.0944 0.0944
Entamoeba histolytica cysteine proteinase, putative 0.0512 0.1816 0.5408
Trypanosoma cruzi cysteine protease, putative 0.0512 0.1816 0.1138
Brugia malayi Bromodomain containing protein 0.0035 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.028 0.0944 0.0944
Onchocerca volvulus Alhambra homolog 0.0035 0.0025 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0922 0.3358 0.2808
Onchocerca volvulus Cathepsin L homolog 0.0922 0.3358 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0326 0.0302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0232 0.0765 0.222
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0232 0.0765 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0922 0.3358 0.9078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0512 0.1816 0.368
Brugia malayi Cathepsin L-like precursor 0.0922 0.3358 0.3358
Plasmodium falciparum serine repeat antigen 4 0.0232 0.0765 0.222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0922 0.3358 0.9078
Loa Loa (eye worm) hypothetical protein 0.0035 0.0025 0.0025
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0232 0.0765 0.0765
Echinococcus multilocularis cysteine protease 0.0922 0.3358 0.3341
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Giardia lamblia Cathepsin L precursor 0.0232 0.0765 0.2058
Loa Loa (eye worm) hypothetical protein 0.0232 0.0765 0.0765
Echinococcus multilocularis cysteine protease 0.0922 0.3358 0.3341
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0512 0.1816 0.1796
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0922 0.3358 0.9078
Trypanosoma cruzi cysteine peptidase, putative 0.0922 0.3358 0.2808
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0232 0.0765 0.222
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0232 0.0765 0.0742
Brugia malayi Cathepsin L-like precursor 0.0922 0.3358 0.3358
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0922 0.3358 0.3341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Brugia malayi Papain family cysteine protease containing protein 0.0922 0.3358 0.3358
Echinococcus multilocularis cathepsin L 0.0512 0.1816 0.1796
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.028 0.0944 0.0944
Brugia malayi Cathepsin L-like precursor 0.0922 0.3358 0.3358
Plasmodium falciparum serine repeat antigen 9 0.0232 0.0765 0.222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0922 0.3358 0.9078
Trypanosoma cruzi cysteine proteinase, putative 0.0512 0.1816 0.1138
Plasmodium vivax serine-repeat antigen (SERA) 0.0232 0.0765 0.222
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0232 0.0765 0.222
Brugia malayi cathepsin Z-like cysteine proteinase 0.0232 0.0765 0.0765
Brugia malayi Papain family cysteine protease containing protein 0.0232 0.0765 0.0765
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0232 0.0765 0.0765
Entamoeba histolytica cysteine protease, putative 0.0512 0.1816 0.5408
Onchocerca volvulus Cathepsin L homolog 0.0922 0.3358 1
Giardia lamblia Cathepsin B precursor 0.0232 0.0765 0.2058
Entamoeba histolytica cysteine protease, putative 0.0922 0.3358 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0922 0.3358 0.8542
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0922 0.3358 0.3358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0922 0.3358 0.9078
Schistosoma mansoni cathepsin F (C01 family) 0.0642 0.2307 0.2287
Plasmodium vivax vivapain-3 0.0512 0.1816 0.5374
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0992 0.3621 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0922 0.3358 0.3341
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0232 0.0765 0.0765
Schistosoma mansoni cathepsin s 0.028 0.0944 0.0921
Onchocerca volvulus 0.0232 0.0765 0.2278

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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