Detailed information for compound 1404269

Basic information

Technical information
  • TDR Targets ID: 1404269
  • Name: (4-pyrazol-1-ylphenyl)-(1-pyridin-2-yl-1,3,4, 9-tetrahydropyrido[3,4-b]indol-2-yl)methanone
  • MW: 419.478 | Formula: C26H21N5O
  • H donors: 1 H acceptors: 3 LogP: 3.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCc2c(C1c1ccccn1)[nH]c1c2cccc1)c1ccc(cc1)n1cccn1
  • InChi: 1S/C26H21N5O/c32-26(18-9-11-19(12-10-18)31-16-5-15-28-31)30-17-13-21-20-6-1-2-7-22(20)29-24(21)25(30)23-8-3-4-14-27-23/h1-12,14-16,25,29H,13,17H2
  • InChiKey: BAUGDGUVSQCDLL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-pyrazol-1-ylphenyl)-[1-(2-pyridyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]methanone
  • [4-(1-pyrazolyl)phenyl]-[1-(2-pyridyl)-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]methanone
  • (4-pyrazol-1-ylphenyl)-[1-(2-pyridyl)-1,3,4,9-tetrahydro-$b-carbolin-2-yl]methanone
  • 2-[4-(1H-pyrazol-1-yl)benzoyl]-1-pyridin-2-yl-2,3,4,9-tetrahydro-1H-beta-carboline
  • MLS000732269
  • SMR000316414

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, putative 0.0335 0.3517 0.3495
Onchocerca volvulus Cathepsin L homolog 0.0083 0.0787 0.2237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0787 0.2092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Plasmodium falciparum cysteine proteinase falcipain 1 0.0186 0.1894 0.5385
Plasmodium falciparum serine repeat antigen 7 0.0083 0.0787 0.2239
Onchocerca volvulus 0.0114 0.1117 0.3174
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0061 0.0075
Schistosoma mansoni ap endonuclease 0.0018 0.0084 0.0084
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0084 0.023
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0186 0.1894 0.1867
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0061 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.3517 0.9668
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Toxoplasma gondii preprocathepsin c precursor, putative 0.0083 0.0787 0.2165
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0164 0.0361
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0186 0.1894 0.1894
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0084 0.0138
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0083 0.0787 0.0787
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0102 0.0991 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Leishmania major cathepsin L-like protease 0.0335 0.3517 0.9668
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0335 0.3517 0.9668
Schistosoma mansoni hypothetical protein 0.0205 0.2101 0.2101
Echinococcus multilocularis cathepsin L 0.0083 0.0787 0.0787
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2015 0.2015
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Toxoplasma gondii hypothetical protein 0.0011 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.3517 0.9668
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.000000000052461 0.00000000014425
Entamoeba histolytica cysteine proteinase 2 0.0186 0.1894 0.534
Brugia malayi cathepsin F-like cysteine proteinase 0.0102 0.0991 0.0991
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0358 0.0929
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Loa Loa (eye worm) hypothetical protein 0.0083 0.0787 0.0787
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0083 0.0787 0.2239
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0061 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.0713
Onchocerca volvulus 0.0335 0.3517 1
Entamoeba histolytica cysteine protease, putative 0.0083 0.0787 0.2163
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Giardia lamblia Cathepsin B precursor 0.0083 0.0787 0.2165
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0358 0.0325
Trypanosoma brucei glucosidase, putative 0.0044 0.0358 0.0898
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0358 0.0983
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.3517 0.9668
Leishmania major cathepsin L-like protease 0.0335 0.3517 0.9668
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0083 0.0787 0.2073
Brugia malayi Cathepsin L-like precursor 0.0335 0.3517 0.3517
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0358 0.0929
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0787 0.2092
Entamoeba histolytica cysteine protease, putative 0.0335 0.3517 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2015 0.2015
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0358 0.0898
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Plasmodium falciparum serine repeat antigen 6 0.0083 0.0787 0.2239
Brugia malayi TAR-binding protein 0.0076 0.0713 0.0713
Entamoeba histolytica cysteine proteinase, putative 0.0233 0.2411 0.6823
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0084 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0358 0.0898
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0001 0.0001
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.3517 0.9668
Onchocerca volvulus 0.0335 0.3517 1
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.1894 0.1894
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0358 0.0898
Schistosoma mansoni cathepsin B (C01 family) 0.0083 0.0787 0.0787
Trypanosoma brucei cysteine peptidase C (CPC) 0.0346 0.3637 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.3517 0.3517
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0084 0.0138
Giardia lamblia Cathepsin L precursor 0.0083 0.0787 0.2165
Giardia lamblia Cathepsin L precursor 0.0083 0.0787 0.2165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0358 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1894 0.5163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.3517 0.9668
Plasmodium falciparum cysteine proteinase falcipain 3 0.0335 0.3517 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0346 0.3637 0.3615
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0001 0.0001
Echinococcus multilocularis geminin 0.0205 0.2101 0.2101
Brugia malayi RNA binding protein 0.0076 0.0713 0.0713
Loa Loa (eye worm) ctsf protein 0.0335 0.3517 0.3517
Giardia lamblia Cathepsin B precursor 0.0083 0.0787 0.2165
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0061 0.0075
Giardia lamblia Cathepsin L precursor 0.0083 0.0787 0.2165
Giardia lamblia Cathepsin L precursor 0.0083 0.0787 0.2165
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0061 0.0075
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0186 0.1894 0.1894
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0787 0.2092
Plasmodium vivax vivapain-2 0.0335 0.3517 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0991 0.0991
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0335 0.3517 1
Brugia malayi Papain family cysteine protease containing protein 0.0186 0.1894 0.1894
Brugia malayi hypothetical protein 0.0011 0.0001 0.0001
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0083 0.0787 0.2165
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0358 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Schistosoma mansoni alpha glucosidase 0.0044 0.0358 0.0358
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0083 0.0787 0.0787
Onchocerca volvulus 0.0233 0.2411 0.6853
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0787 0.0787
Brugia malayi Cathepsin L-like precursor 0.0233 0.2411 0.2411
Schistosoma mansoni cathepsin s 0.0102 0.0991 0.0991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Schistosoma mansoni cathepsin F (C01 family) 0.0335 0.3517 0.3517
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0083 0.0787 0.2073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Echinococcus multilocularis cathepsin L cysteine protease 0.0335 0.3517 0.3517
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0186 0.1894 0.1867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0233 0.2411 0.6597
Loa Loa (eye worm) hypothetical protein 0.0083 0.0787 0.0787
Giardia lamblia Cathepsin L-like protease 0.0083 0.0787 0.2165
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0061 0.0075
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Loa Loa (eye worm) RecQ helicase 0.0026 0.0164 0.0164
Echinococcus multilocularis cathepsin L 0.0186 0.1894 0.1894
Leishmania major cathepsin L-like protease 0.0335 0.3517 0.9668
Loa Loa (eye worm) RNA binding protein 0.0076 0.0713 0.0713
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0083 0.0787 0.2239
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2015 0.2015
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.0713
Echinococcus multilocularis cathepsin L cysteine protease 0.0335 0.3517 0.3517
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0335 0.3517 0.3517
Schistosoma mansoni alpha-glucosidase 0.0169 0.1719 0.1719
Schistosoma mansoni cathepsin F (C01 family) 0.0233 0.2411 0.2411
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0084 0.0238
Plasmodium falciparum serine repeat antigen 3 0.0083 0.0787 0.2239
Echinococcus granulosus cathepsin l cysteine peptidase 0.0335 0.3517 0.3517
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0233 0.2411 0.2385
Schistosoma mansoni cathepsin S (C01 family) 0.0083 0.0787 0.0787
Entamoeba histolytica cysteine proteinase, putative 0.0186 0.1894 0.534
Echinococcus multilocularis cysteine protease 0.0335 0.3517 0.3517
Echinococcus granulosus tar DNA binding protein 0.0076 0.0713 0.0713
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0335 0.3517 0.3517
Trypanosoma cruzi cysteine peptidase, putative 0.0335 0.3517 0.3495
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.3517 1
Loa Loa (eye worm) cysteine protease 0.0335 0.3517 0.3517
Trypanosoma cruzi cruzipain precursor, putative 0.0335 0.3517 0.3495
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0061 0.0075
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Trypanosoma cruzi cysteine proteinase, putative 0.0186 0.1894 0.1867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0233 0.2411 0.6597
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0061 0.0075
Plasmodium falciparum serine repeat antigen 5 0.0083 0.0787 0.2239
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0083 0.0787 0.2239
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2015 0.2015
Loa Loa (eye worm) hypothetical protein 0.0083 0.0787 0.0787
Plasmodium falciparum serine repeat antigen 2 0.0083 0.0787 0.2239
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0084 0.0084
Onchocerca volvulus 0.0335 0.3517 1
Brugia malayi N-terminal motif family protein 0.0218 0.2246 0.2246
Echinococcus granulosus bloom syndrome protein 0.0026 0.0164 0.0164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0083 0.0787 0.2092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0084 0.005
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0061 0.0075
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0001 0.0001
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0083 0.0787 0.0787
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0346 0.3637 0.3637
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0061 0.0075
Trypanosoma cruzi cysteine protease, putative 0.0186 0.1894 0.1867
Schistosoma mansoni ap endonuclease 0.0018 0.0084 0.0084
Onchocerca volvulus 0.0083 0.0787 0.2237
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0787 0.0787
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0358 0.0358
Onchocerca volvulus 0.0335 0.3517 1
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0164 0.0361
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0084 0.5
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Plasmodium vivax unspecified product 0.0083 0.0787 0.2073
Onchocerca volvulus 0.0335 0.3517 1
Plasmodium falciparum serine repeat antigen 4 0.0083 0.0787 0.2239
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0787 0.0787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0787 0.2092
Giardia lamblia Hypothetical protein 0.0083 0.0787 0.2165
Plasmodium falciparum serine repeat antigen 1 0.0083 0.0787 0.2239
Loa Loa (eye worm) hypothetical protein 0.0233 0.2411 0.2411
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0001 0.0001
Trypanosoma cruzi cruzipain precursor, putative 0.0102 0.0991 0.0961
Loa Loa (eye worm) fibroinase 0.0335 0.3517 0.3517
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0358 0.0898
Echinococcus granulosus cathepsin l1 0.0335 0.3517 0.3517
Brugia malayi Cathepsin L-like precursor 0.0335 0.3517 0.3517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0186 0.1894 0.5163
Giardia lamblia Cathepsin L precursor 0.0083 0.0787 0.2165
Entamoeba histolytica cysteine proteinase, putative 0.0335 0.3517 1
Giardia lamblia Cysteine protease 0.0083 0.0787 0.2165
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0713 0.0713
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0083 0.0787 0.2165
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0102 0.0991 0.0991
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0083 0.0787 0.2092
Loa Loa (eye worm) hypothetical protein 0.0083 0.0787 0.0787
Schistosoma mansoni dep domain containing protein 0.0011 0.0001 0.0001
Onchocerca volvulus 0.0335 0.3517 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8909 0.8909
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0787 0.0787
Plasmodium vivax serine-repeat antigen (SERA) 0.0083 0.0787 0.2073
Entamoeba histolytica cysteine protease, putative 0.0083 0.0787 0.2163
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Brugia malayi Cathepsin L-like precursor 0.0335 0.3517 0.3517
Schistosoma mansoni cathepsin F (C01 family) 0.0335 0.3517 0.3517
Giardia lamblia Encystation-specific protease 0.0083 0.0787 0.2165
Trypanosoma cruzi cysteine peptidase, putative 0.0335 0.3517 0.3495
Plasmodium falciparum serine repeat antigen 9 0.0083 0.0787 0.2239
Entamoeba histolytica cysteine protease, putative 0.0083 0.0787 0.2163
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0001 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0084 0.5
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0083 0.0787 0.2073
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0335 0.3517 1
Giardia lamblia Cysteine protease 0.0083 0.0787 0.2165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Plasmodium vivax vivapain-2 0.0335 0.3517 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0084 0.0143
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.0713
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Toxoplasma gondii cathepsin B 0.0346 0.3637 1
Entamoeba histolytica cysteine protease, putative 0.0083 0.0787 0.2163
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0358 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Giardia lamblia Cathepsin B precursor 0.0346 0.3637 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.013 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0787 0.2092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.3517 0.9668
Entamoeba histolytica cysteine protease, putative 0.0083 0.0787 0.2163
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0358 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0335 0.3517 0.9668
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni dishevelled 0.0011 0.0001 0.0001
Giardia lamblia Cysteine protease 0.0083 0.0787 0.2165
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0083 0.0787 0.2163
Plasmodium vivax vivapain-3 0.0186 0.1894 0.5287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Entamoeba histolytica cysteine protease, putative 0.0083 0.0787 0.2163
Toxoplasma gondii cathepsin CPC2 0.0083 0.0787 0.2165
Giardia lamblia Cathepsin B precursor 0.0346 0.3637 1
Giardia lamblia Cathepsin B precursor 0.0083 0.0787 0.2165
Schistosoma mansoni dishevelled 0.0011 0.0001 0.0001
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0358 0.0898
Brugia malayi Cathepsin L-like precursor 0.0335 0.3517 0.3517
Brugia malayi Papain family cysteine protease containing protein 0.0083 0.0787 0.0787
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0083 0.0787 0.0787
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0084 0.0084
Echinococcus granulosus cathepsin L 0.0083 0.0787 0.0787
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0787 0.0787
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0787 0.2092
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0105 0.0105
Giardia lamblia Cathepsin L-like protease 0.0083 0.0787 0.2165
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0346 0.3637 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0083 0.0787 0.2092
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2015 0.2015
Brugia malayi cathepsin L-like cysteine proteinase 0.0083 0.0787 0.0787
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0084 0.0138
Plasmodium vivax vivapain-1 0.0186 0.1894 0.5287
Giardia lamblia Cysteine protease 0.0083 0.0787 0.2165
Loa Loa (eye worm) hypothetical protein 0.0102 0.0991 0.0991
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0001 0.0001
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0061 0.0027
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0083 0.0787 0.2073
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0083 0.0787 0.0787
Loa Loa (eye worm) hypothetical protein 0.0233 0.2411 0.2411
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8909 0.8909
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0787 0.2092
Onchocerca volvulus 0.0335 0.3517 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0083 0.0787 0.2073
Toxoplasma gondii cathepsin CPC1 0.0083 0.0787 0.2165
Schistosoma mansoni alpha-glucosidase 0.0169 0.1719 0.1719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0787 0.2092
Schistosoma mansoni cathepsin C 0.0083 0.0787 0.0787
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0164 0.0164
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0358 0.0898
Trypanosoma cruzi major cysteine proteinase, putative 0.0083 0.0787 0.0756
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0001 0.0001
Onchocerca volvulus Cathepsin L homolog 0.0335 0.3517 1
Leishmania major cathepsin L-like protease 0.0335 0.3517 0.9668
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0083 0.0787 0.0787
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0358 0.0898
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0083 0.0787 0.2073
Loa Loa (eye worm) hypothetical protein 0.0102 0.0991 0.0991
Plasmodium vivax unspecified product 0.0102 0.0991 0.2666
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Entamoeba histolytica cysteine proteinase 1, putative 0.0186 0.1894 0.534
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1147 0.1147
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.0713
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0787 0.0787
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0084 0.0138
Brugia malayi Cathepsin L-like precursor 0.0233 0.2411 0.2411
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0083 0.0787 0.2092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0787 0.2092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0787 0.2092
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0358 0.0325
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0335 0.3517 0.3517
Brugia malayi cathepsin Z-like cysteine proteinase 0.0083 0.0787 0.0787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0787 0.2092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0107 0.0107
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0084 0.0084
Toxoplasma gondii exonuclease III APE 0.0018 0.0084 0.023
Giardia lamblia Cathepsin L precursor 0.0083 0.0787 0.2165
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0061 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0061 0.0027
Loa Loa (eye worm) hypothetical protein 0.0233 0.2411 0.2411
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0117 0.1147 0.1147
Brugia malayi Cathepsin L-like cysteine proteinase 0.0233 0.2411 0.2411
Loa Loa (eye worm) hypothetical protein 0.0083 0.0787 0.0787
Brugia malayi Cathepsin L-like precursor 0.0102 0.0991 0.0991
Entamoeba histolytica cysteine proteinase, putative 0.0186 0.1894 0.534
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0713 0.0713
Trypanosoma cruzi major cysteine proteinase, putative 0.0083 0.0787 0.0756
Echinococcus granulosus geminin 0.0205 0.2101 0.2101
Trypanosoma cruzi cysteine peptidase, putative 0.0335 0.3517 0.3495
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0061 0.0061
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0001 0.0001
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0083 0.0787 0.2073
Brugia malayi cathepsin L-like precursor 0.0233 0.2411 0.2411
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0083 0.0787 0.2092
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0083 0.0787 0.0787
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0713 0.0713
Echinococcus granulosus cathepsin L cysteine protease 0.0186 0.1894 0.1894
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0083 0.0787 0.2163
Echinococcus granulosus cathepsin l1 0.0233 0.2411 0.2411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1894 0.5163
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1147 0.1147
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0001 0.0001
Leishmania major cathepsin L-like protease 0.0335 0.3517 0.9668
Leishmania major cysteine peptidase A (CPA) 0.0335 0.3517 0.9668
Brugia malayi cathepsin L precursor 0.0083 0.0787 0.0787
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0001 0.0001
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0083 0.0787 0.2073
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0001 0.0001
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0713 0.0713
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.3517 0.3517
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0164 0.0164
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0001 0.0001
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2246 0.6384
Loa Loa (eye worm) hypothetical protein 0.0083 0.0787 0.0787
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0084 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0186 0.1894 0.534
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0071 0.0196
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0061 0.0075
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0083 0.0787 0.2073
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0346 0.3637 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Echinococcus granulosus cysteine protease 0.0186 0.1894 0.1894
Brugia malayi cathepsin F-like cysteine proteinase 0.0083 0.0787 0.0787
Giardia lamblia Cathepsin B precursor 0.0083 0.0787 0.2165
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0713 0.0713
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0084 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0358 0.0898
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0335 0.3517 0.3517
Giardia lamblia Hypothetical protein 0.0083 0.0787 0.2165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.3517 0.9668
Echinococcus granulosus cathepsin L 0.0186 0.1894 0.1894
Loa Loa (eye worm) cathepsin B 0.0346 0.3637 0.3637
Toxoplasma gondii cathepsin CPL 0.0335 0.3517 0.9671
Giardia lamblia Cathepsin B precursor 0.0083 0.0787 0.2165
Leishmania major cathepsin L-like protease 0.0335 0.3517 0.9668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0787 0.2092
Trypanosoma cruzi cysteine peptidase, putative 0.0102 0.0991 0.0961
Leishmania major cathepsin L-like protease 0.0335 0.3517 0.9668
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Leishmania major cathepsin L-like protease 0.0335 0.3517 0.9668
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0083 0.0787 0.2073
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0083 0.0787 0.2092
Entamoeba histolytica cysteine proteinase, putative 0.0186 0.1894 0.534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.3517 0.9668
Onchocerca volvulus Cathepsin F homolog 0.0335 0.3517 1
Trypanosoma cruzi cysteine proteinase, putative 0.0186 0.1894 0.1867
Plasmodium vivax unspecified product 0.0186 0.1894 0.5287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Brugia malayi Cathepsin L-like precursor 0.0335 0.3517 0.3517
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0218 0.2246 0.2246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0083 0.0787 0.2092
Brugia malayi fibroinase precursor 0.0083 0.0787 0.0787
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0083 0.0787 0.0787
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0084 0.003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0084 0.5
Onchocerca volvulus Cathepsin L homolog 0.0335 0.3517 1
Brugia malayi DIX domain containing protein 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0186 0.1894 0.1894
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0083 0.0787 0.2165
Echinococcus granulosus cathepsin L cysteine proteinase 0.0335 0.3517 0.3517
Entamoeba histolytica cysteine protease, putative 0.0186 0.1894 0.534
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.3517 0.9668
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0186 0.1894 0.5163
Entamoeba histolytica hypothetical protein 0.0083 0.0787 0.2163
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0061 0.0061
Brugia malayi Cathepsin L-like precursor 0.0335 0.3517 0.3517
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0083 0.0787 0.2165
Giardia lamblia Cathepsin B precursor 0.0346 0.3637 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0083 0.0787 0.2073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0335 0.3517 0.9668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.3517 0.9668
Schistosoma mansoni hypothetical protein 0.0205 0.2101 0.2101
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0083 0.0787 0.0787
Plasmodium falciparum serine repeat antigen 8 0.0083 0.0787 0.2239
Echinococcus multilocularis cysteine protease 0.0335 0.3517 0.3517
Brugia malayi cathepsin Z-like cysteine proteinase 0.0083 0.0787 0.0787
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8909 0.8909

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0731 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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