Detailed information for compound 1405271

Basic information

Technical information
  • TDR Targets ID: 1405271
  • Name: 1-[4-[2-methoxy-4-[(E)-prop-1-enyl]phenoxy]bu tyl]-4-methylpiperidine
  • MW: 317.466 | Formula: C20H31NO2
  • H donors: 0 H acceptors: 0 LogP: 4.91 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C=C/c1ccc(c(c1)OC)OCCCCN1CCC(CC1)C
  • InChi: 1S/C20H31NO2/c1-4-7-18-8-9-19(20(16-18)22-3)23-15-6-5-12-21-13-10-17(2)11-14-21/h4,7-9,16-17H,5-6,10-15H2,1-3H3/b7-4+
  • InChiKey: XNBNJFWYXXSJGT-QPJJXVBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(2-methoxy-4-prop-1-enylphenoxy)butyl]-4-methylpiperidine
  • 1-[4-[2-methoxy-4-[(E)-prop-1-enyl]phenoxy]butyl]-4-methyl-piperidine
  • 1-[4-(2-methoxy-4-prop-1-enyl-phenoxy)butyl]-4-methyl-piperidine
  • MLS001006707
  • SMR000349660
  • T0516-1000

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cruzipain precursor, putative 0.0146 0.3754 0.4548
Echinococcus multilocularis muscleblind protein 0.0136 0.3468 0.3452
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.4478 0.8064
Loa Loa (eye worm) hypothetical protein 0.0033 0.0615 0.0721
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0237 0.0214
Plasmodium falciparum serine repeat antigen 3 0.0034 0.0647 0.1671
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0647 0.0787
Brugia malayi cathepsin L-like precursor 0.0101 0.2494 0.3033
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.7608 0.7602
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0072 0.0129
Brugia malayi RNA binding protein 0.0041 0.084 0.1022
Schistosoma mansoni hypothetical protein 0.003 0.0546 0.0524
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0237 0.0214
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0546 0.0524
Leishmania major cathepsin L-like protease 0.0146 0.3754 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0237 0.0214
Schistosoma mansoni jumonji domain containing protein 0.0092 0.2243 0.2225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0615 0.0721
Brugia malayi cathepsin B-like cysteine proteinase 0.0308 0.8224 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Loa Loa (eye worm) hypothetical protein 0.0136 0.3468 0.42
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0029 0.0502 0.0479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.3754 0.3566
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0546 0.0524
Plasmodium vivax vivapain-1 0.0079 0.1906 0.5047
Giardia lamblia Cathepsin L precursor 0.0034 0.0647 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.1906 0.5047
Plasmodium vivax unspecified product 0.0079 0.1906 0.5047
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0024 0.0000071748
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.0615 0.0748
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0308 0.8224 0.822
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0308 0.8224 0.822
Schistosoma mansoni cpg binding protein 0.0028 0.0473 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0119 0.299 0.2707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.1906 0.1646
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0647 0.0787
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0034 0.0647 0.1671
Trypanosoma brucei PAB1-binding protein , putative 0.0016 0.0159 0.0363
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0034 0.0647 0.1671
Echinococcus granulosus cathepsin L 0.0079 0.1906 0.1887
Giardia lamblia Cathepsin B precursor 0.0034 0.0647 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0683 0.0661
Brugia malayi jmjC domain containing protein 0.0115 0.2899 0.3525
Echinococcus granulosus cpg binding protein 0.0028 0.0473 0.045
Schistosoma mansoni cathepsin B (C01 family) 0.0034 0.0647 0.0625
Leishmania major cathepsin L-like protease 0.0146 0.3754 1
Schistosoma mansoni immunophilin 0.0029 0.0502 0.0479
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0032 0.0585 0.0684
Brugia malayi Cathepsin L-like precursor 0.0146 0.3754 0.4564
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0024 0.0000071748
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0034 0.0647 0.076
Giardia lamblia Cathepsin L-like protease 0.0034 0.0647 0.007
Loa Loa (eye worm) hypothetical protein 0.0034 0.0647 0.076
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.0615 0.0721
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0034 0.0647 0.1671
Echinococcus multilocularis cathepsin L cysteine protease 0.0146 0.3754 0.3739
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.3754 0.4548
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0683 0.1768
Brugia malayi hypothetical protein 0.0026 0.0416 0.0506
Schistosoma mansoni hypothetical protein 0.003 0.0546 0.0524
Plasmodium vivax unspecified product 0.0046 0.0969 0.2534
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0647 0.1671
Leishmania major cathepsin L-like protease 0.0146 0.3754 1
Toxoplasma gondii cathepsin CPC2 0.0034 0.0647 0.1671
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0647 0.1671
Schistosoma mansoni hypothetical protein 0.012 0.3037 0.3021
Schistosoma mansoni cathepsin S (C01 family) 0.0034 0.0647 0.0625
Echinococcus granulosus tar DNA binding protein 0.0041 0.084 0.0818
Brugia malayi RNA recognition motif domain containing protein 0.0041 0.084 0.1022
Loa Loa (eye worm) hypothetical protein 0.003 0.0546 0.0637
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9472 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0585 0.1504
Toxoplasma gondii cathepsin CPC1 0.0034 0.0647 0.1671
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0237 0.0572
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0615 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0041 0.084 0.0818
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0647 0.076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0207 0.0184
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0615 0.1586
Onchocerca volvulus 0.0033 0.0615 0.0552
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0615 0.0721
Onchocerca volvulus 0.0146 0.3754 1
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.1906 0.1646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0647 0.007
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0079 0.1906 0.1887
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0615 0.0035
Schistosoma mansoni cpg binding protein 0.0026 0.0432 0.0409
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.0969 0.1153
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.1906 0.1646
Onchocerca volvulus 0.0146 0.3754 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0032 0.0585 0.0562
Plasmodium falciparum phd finger protein, putative 0.0035 0.0683 0.1768
Loa Loa (eye worm) TAR-binding protein 0.0041 0.084 0.0995
Entamoeba histolytica cysteine protease, putative 0.0146 0.3754 0.3686
Plasmodium falciparum serine repeat antigen 5 0.0034 0.0647 0.1671
Onchocerca volvulus 0.0146 0.3754 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0079 0.1906 0.5047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Schistosoma mansoni hypothetical protein 0.0058 0.1321 0.13
Plasmodium falciparum serine repeat antigen 7 0.0034 0.0647 0.1671
Loa Loa (eye worm) cathepsin B 0.0119 0.299 0.3618
Plasmodium vivax unspecified product 0.0034 0.0647 0.1671
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0146 0.3754 0.3566
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0079 0.1906 0.1887
Onchocerca volvulus 0.0146 0.3754 1
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0647 0.0787
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0013 0.0062 0.0038
Echinococcus granulosus cathepsin L cysteine proteinase 0.0146 0.3754 0.3739
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0033 0.0623 0.06
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0072 0.0129
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0034 0.0647 0.1671
Onchocerca volvulus 0.0146 0.3754 1
Echinococcus multilocularis cysteine protease 0.0146 0.3754 0.3739
Loa Loa (eye worm) hypothetical protein 0.0034 0.0647 0.076
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.3754 0.4548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Schistosoma mansoni tar DNA-binding protein 0.0041 0.084 0.0818
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0237 0.026
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.4478 1
Onchocerca volvulus 0.0146 0.3754 1
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0615 0.0721
Loa Loa (eye worm) hypothetical protein 0.0101 0.2494 0.3012
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0585 0.0684
Entamoeba histolytica cysteine proteinase, putative 0.0146 0.3754 0.3686
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0146 0.3754 0.3739
Giardia lamblia Cysteine protease 0.0034 0.0647 0.007
Echinococcus granulosus cysteine protease 0.0079 0.1906 0.1887
Schistosoma mansoni cathepsin s 0.0046 0.0969 0.0947
Echinococcus granulosus muscleblind protein 0.0136 0.3468 0.3452
Entamoeba histolytica cysteine protease, putative 0.0034 0.0647 0.0255
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0683 0.0804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0647 0.007
Schistosoma mansoni survival motor neuron protein 0.0058 0.1321 0.13
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0033 0.0615 0.0079
Schistosoma mansoni hypothetical protein 0.0035 0.0683 0.0661
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0929 0.1104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9472 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0012 0.0028 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0647 0.007
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0034 0.0647 0.1671
Loa Loa (eye worm) hypothetical protein 0.0033 0.0615 0.0721
Brugia malayi jmjC domain containing protein 0.0011 0.0024 0.0029
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0032 0.0585 0.0562
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0683 0.0661
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Plasmodium vivax vivapain-3 0.0079 0.1906 0.5047
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0119 0.299 0.2974
Entamoeba histolytica cysteine proteinase 1, putative 0.0079 0.1906 0.1646
Giardia lamblia Cathepsin L precursor 0.0034 0.0647 0.007
Loa Loa (eye worm) RNA binding protein 0.0041 0.084 0.0995
Mycobacterium ulcerans beta-lactamase 0.0033 0.0615 0.0079
Trypanosoma cruzi cysteine peptidase, putative 0.0079 0.1906 0.2296
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0647 0.0625
Schistosoma mansoni cathepsin C 0.0034 0.0647 0.0625
Giardia lamblia Hypothetical protein 0.0034 0.0647 0.007
Schistosoma mansoni tar DNA-binding protein 0.0041 0.084 0.0818
Loa Loa (eye worm) hypothetical protein 0.0308 0.8224 1
Giardia lamblia Cysteine protease 0.0034 0.0647 0.007
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0237 0.0214
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0032 0.0585 0.0684
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Echinococcus multilocularis GPCR, family 2 0.003 0.0546 0.0524
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.3754 0.3566
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0647 0.0255
Echinococcus granulosus cathepsin l1 0.0146 0.3754 0.3739
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.9472 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.0237 0.0288
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0647 0.0647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2494 0.2149
Leishmania major hypothetical protein, conserved 0.0016 0.0159 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0034 0.0647 0.007
Onchocerca volvulus 0.0033 0.0615 0.0552
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0615 0.0593
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0647 0.0625
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.4478 1
Echinococcus granulosus peregrin 0.0035 0.0683 0.0661
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0647 0.1671
Trypanosoma cruzi cysteine proteinase, putative 0.0079 0.1906 0.2296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9472 1
Leishmania major hypothetical protein, conserved 0.0033 0.0615 0.1586
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0546 0.0524
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Plasmodium falciparum serine repeat antigen 1 0.0034 0.0647 0.1671
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9472 1
Toxoplasma gondii LsmAD domain-containing protein 0.0016 0.0159 0.0363
Brugia malayi cathepsin L-like cysteine proteinase 0.0034 0.0647 0.0787
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0237 0.0572
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0119 0.299 0.3618
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.9472 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.3754 0.3566
Giardia lamblia Cathepsin B precursor 0.0034 0.0647 0.007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0969 0.1153
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0079 0.1906 0.1887
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0159 0.0165
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0683 0.0661
Echinococcus multilocularis tar DNA binding protein 0.0041 0.084 0.0818
Brugia malayi beta-lactamase family protein 0.0033 0.0615 0.0748
Trypanosoma brucei cysteine peptidase C (CPC) 0.0119 0.299 0.7954
Brugia malayi Cathepsin L-like precursor 0.0146 0.3754 0.4564
Loa Loa (eye worm) hypothetical protein 0.0046 0.0969 0.1153
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.1906 0.2318
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.3754 0.3566
Mycobacterium ulcerans lipase LipD 0.0033 0.0615 0.0079
Giardia lamblia Cathepsin B precursor 0.0119 0.299 0.2707
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0096 0.2354 0.2862
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.3754 0.3566
Brugia malayi Cathepsin L-like precursor 0.0146 0.3754 0.4564
Loa Loa (eye worm) hypothetical protein 0.0033 0.0615 0.0721
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.9472 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1379 0.1652
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0237 0.026
Plasmodium falciparum cysteine proteinase falcipain 3 0.0146 0.3754 1
Mycobacterium tuberculosis Probable lipase LipD 0.0033 0.0615 0.0719
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0028 0.0011
Brugia malayi Latrophilin receptor protein 2 0.003 0.0546 0.0664
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0615 0.0035
Mycobacterium tuberculosis Conserved protein 0.0033 0.0615 0.0719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Entamoeba histolytica cysteine protease, putative 0.0034 0.0647 0.0255
Giardia lamblia Cathepsin B precursor 0.0119 0.299 0.2707
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0615 0.0593
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0034 0.0647 0.1671
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0034 0.0647 0.007
Mycobacterium tuberculosis Probable esterase LipL 0.0033 0.0615 0.0719
Echinococcus multilocularis muscleblind protein 1 0.0136 0.3468 0.3452
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0026 0.0416 0.0393
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0647 0.007
Loa Loa (eye worm) ctsf protein 0.0146 0.3754 0.4548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0647 0.007
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0033 0.0623 0.0228
Leishmania major cathepsin L-like protease 0.0146 0.3754 1
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0032 0.0585 0.1504
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0237 0.0572
Echinococcus granulosus cathepsin l cysteine peptidase 0.0146 0.3754 0.3739
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0647 0.0625
Giardia lamblia Cathepsin B precursor 0.0034 0.0647 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9472 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0146 0.3754 0.4548
Plasmodium vivax ataxin-2 like protein, putative 0.0016 0.0159 0.0363
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.1517 0.1845
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0432 0.0498
Echinococcus granulosus cathepsin l1 0.0101 0.2494 0.2476
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0209 0.5497 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.3754 0.3566
Schistosoma mansoni hypothetical protein 0.003 0.0546 0.0524
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0237 0.0572
Mycobacterium tuberculosis Probable hydrolase 0.0033 0.0615 0.0719
Onchocerca volvulus 0.0058 0.1321 0.2675
Brugia malayi cathepsin F-like cysteine proteinase 0.0046 0.0969 0.1178
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0237 0.0288
Loa Loa (eye worm) hypothetical protein 0.0033 0.0615 0.0721
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0146 0.3754 0.3739
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0615 0.0035
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0034 0.0647 0.1671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0647 0.007
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0647 0.0787
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0647 0.1671
Loa Loa (eye worm) cysteine protease 0.0146 0.3754 0.4548
Onchocerca volvulus 0.0033 0.0615 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0146 0.3754 0.3566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0237 0.026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9472 1
Entamoeba histolytica cysteine protease, putative 0.0034 0.0647 0.0255
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0096 0.2354 0.2841
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0647 0.0625
Echinococcus multilocularis fk506 binding protein 0.0032 0.0585 0.0562
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0237 0.0572
Echinococcus multilocularis cathepsin L 0.0079 0.1906 0.1887
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0034 0.0647 0.0625
Brugia malayi Papain family cysteine protease containing protein 0.0146 0.3754 0.4564
Trypanosoma cruzi cysteine proteinase, putative 0.0079 0.1906 0.2296
Brugia malayi hypothetical protein 0.0286 0.7608 0.925
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0647 0.007
Plasmodium falciparum cysteine proteinase falcipain 1 0.0079 0.1906 0.5047
Entamoeba histolytica hypothetical protein 0.0034 0.0647 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0237 0.0214
Entamoeba histolytica cysteine proteinase 2 0.0079 0.1906 0.1646
Brugia malayi Papain family cysteine protease containing protein 0.0079 0.1906 0.2318
Echinococcus granulosus cathepsin b 0.0308 0.8224 0.822
Echinococcus multilocularis geminin 0.012 0.3037 0.3021
Loa Loa (eye worm) hypothetical protein 0.0065 0.1517 0.1821
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0647 0.007
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0046 0.0969 0.1178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0647 0.007
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0615 0.1586
Trichomonas vaginalis esterase, putative 0.0033 0.0615 0.0035
Brugia malayi cathepsin L precursor 0.0034 0.0647 0.0787
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.0615 0.0593
Schistosoma mansoni immunophilin 0.0033 0.0623 0.06
Plasmodium vivax vivapain-2 0.0146 0.3754 1
Toxoplasma gondii cathepsin B 0.0119 0.299 0.7954
Brugia malayi Cathepsin L-like precursor 0.0146 0.3754 0.4564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0079 0.1906 0.2296
Brugia malayi Muscleblind-like protein 0.0136 0.3468 0.4216
Loa Loa (eye worm) hypothetical protein 0.0101 0.2494 0.3012
Plasmodium falciparum serine repeat antigen 4 0.0034 0.0647 0.1671
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.1906 0.1487
Loa Loa (eye worm) hypothetical protein 0.0136 0.3468 0.42
Loa Loa (eye worm) beta-lactamase 0.0033 0.0615 0.0721
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0029 0.0502 0.0479
Echinococcus granulosus geminin 0.012 0.3037 0.3021
Brugia malayi Cathepsin L-like cysteine proteinase 0.0101 0.2494 0.3033
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0033 0.0615 0.0719
Giardia lamblia Cysteine protease 0.0034 0.0647 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Onchocerca volvulus 0.0101 0.2494 0.6208
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0585 0.0684
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0034 0.0647 0.0787
Brugia malayi CXXC zinc finger family protein 0.0026 0.0432 0.0525
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0032 0.0585 0.0711
Onchocerca volvulus 0.0034 0.0647 0.0647
Loa Loa (eye worm) fibroinase 0.0146 0.3754 0.4548
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0033 0.0623 0.06
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0647 0.007
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0888 0.0866
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0647 0.007
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0034 0.0647 0.1671
Loa Loa (eye worm) hypothetical protein 0.0027 0.0464 0.0537
Schistosoma mansoni tar DNA-binding protein 0.0041 0.084 0.0818
Giardia lamblia Cathepsin L precursor 0.0034 0.0647 0.007
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0034 0.0647 0.0625
Plasmodium falciparum serine repeat antigen 2 0.0034 0.0647 0.1671
Schistosoma mansoni cathepsin F (C01 family) 0.0101 0.2494 0.2476
Loa Loa (eye worm) hypothetical protein 0.0016 0.0159 0.0165
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0146 0.3754 1
Brugia malayi Cathepsin L-like precursor 0.0046 0.0969 0.1178
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0034 0.0647 0.007
Giardia lamblia Cathepsin B precursor 0.0034 0.0647 0.007
Loa Loa (eye worm) hypothetical protein 0.0034 0.0647 0.076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0079 0.1906 0.1487
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.0615 0.0593
Loa Loa (eye worm) hypothetical protein 0.0286 0.7608 0.9248
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0034 0.0647 0.1671
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.3754 0.3566
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0308 0.8224 0.822
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0034 0.0647 0.007
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0969 0.1153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9472 1
Mycobacterium tuberculosis Conserved protein 0.0033 0.0615 0.0719
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0683 0.1768
Plasmodium falciparum serine repeat antigen 8 0.0034 0.0647 0.1671
Echinococcus granulosus jumonji domain containing protein 0.0049 0.1065 0.1043
Brugia malayi PHD-finger family protein 0.0013 0.0069 0.0084
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0647 0.076
Brugia malayi jmjC domain containing protein 0.0011 0.0024 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.3754 0.4548
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0308 0.8224 0.822
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Schistosoma mansoni hypothetical protein 0.012 0.3037 0.3021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0237 0.0214
Loa Loa (eye worm) hypothetical protein 0.0096 0.2354 0.2841
Brugia malayi Cathepsin L-like precursor 0.0146 0.3754 0.4564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0647 0.007
Leishmania major peptidylprolyl isomerase-like protein 0.0032 0.0585 0.1504
Brugia malayi jmjC domain containing protein 0.0044 0.0929 0.113
Echinococcus multilocularis cathepsin L cysteine protease 0.0146 0.3754 0.3739
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0032 0.0585 0.0711
Loa Loa (eye worm) FKBP5 protein 0.0032 0.0585 0.0684
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0034 0.0647 0.007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2899 0.2882
Plasmodium falciparum serine repeat antigen 6 0.0034 0.0647 0.1671
Brugia malayi Cathepsin L-like precursor 0.0101 0.2494 0.3033
Echinococcus multilocularis peregrin 0.0035 0.0683 0.0661
Entamoeba histolytica cysteine protease, putative 0.0034 0.0647 0.0255
Brugia malayi hypothetical protein 0.0016 0.0159 0.0194
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0546 0.0524
Leishmania major fk506-binding protein 1-like protein 0.0032 0.0585 0.1504
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Brugia malayi beta-lactamase 0.0033 0.0615 0.0748
Onchocerca volvulus Alhambra homolog 0.0035 0.0683 0.0756
Echinococcus granulosus cathepsin L cysteine protease 0.0079 0.1906 0.1887
Brugia malayi Bromodomain containing protein 0.0035 0.0683 0.0831
Onchocerca volvulus Cathepsin L homolog 0.0146 0.3754 1
Leishmania major cathepsin L-like protease 0.0146 0.3754 1
Schistosoma mansoni hypothetical protein 0.0065 0.1517 0.1497
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0065 0.0041
Mycobacterium tuberculosis Conserved protein 0.0033 0.0615 0.0719
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0647 0.0625
Giardia lamblia Cathepsin L precursor 0.0034 0.0647 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0647 0.076
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2899 0.2882
Brugia malayi jmjC domain containing protein 0.0011 0.0024 0.0029
Brugia malayi jmjC domain containing protein 0.0011 0.0024 0.0029
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0034 0.0647 0.1671
Leishmania major cathepsin L-like protease 0.0146 0.3754 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0033 0.0615 0.0719
Echinococcus multilocularis cathepsin b 0.0308 0.8224 0.822
Brugia malayi cathepsin F-like cysteine proteinase 0.0034 0.0647 0.0787
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.3754 0.3566
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0546 0.0664
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1321 0.1606
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0055 0.1242 0.1221
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0159 0.0363
Loa Loa (eye worm) hypothetical protein 0.0046 0.0969 0.1153
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.7608 0.7602
Toxoplasma gondii cathepsin CPL 0.0146 0.3754 1
Brugia malayi fibroinase precursor 0.0034 0.0647 0.0787
Giardia lamblia Cathepsin B precursor 0.0119 0.299 0.2707
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0308 0.8224 1
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0647 0.0787
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0159 0.0165
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0929 0.0908
Schistosoma mansoni transcription factor LCR-F1 0.0026 0.0416 0.0393
Onchocerca volvulus Cathepsin F homolog 0.0146 0.3754 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0647 0.007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0683 0.0804
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0146 0.3754 0.3566
Trypanosoma cruzi major cysteine proteinase, putative 0.0034 0.0647 0.076
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0033 0.0623 0.0228
Giardia lamblia Cathepsin B precursor 0.0034 0.0647 0.007
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0237 0.0214
Schistosoma mansoni cathepsin F (C01 family) 0.0146 0.3754 0.3739
Entamoeba histolytica cysteine protease, putative 0.0034 0.0647 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0647 0.007
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0146 0.3754 0.4548
Echinococcus granulosus GPCR family 2 0.003 0.0546 0.0524
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9472 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0034 0.0647 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0929 0.0908
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0647 0.007
Giardia lamblia Cysteine protease 0.0034 0.0647 0.007
Plasmodium vivax vivapain-2 0.0146 0.3754 1
Giardia lamblia Encystation-specific protease 0.0034 0.0647 0.007
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0683 0.1768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0647 0.007
Toxoplasma gondii histone lysine methyltransferase SET1 0.0049 0.1078 0.2827
Echinococcus multilocularis cathepsin b 0.0308 0.8224 0.822
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.172 0.2069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.2494 0.2149
Brugia malayi Cathepsin L-like precursor 0.0101 0.2494 0.3033
Leishmania major cysteine peptidase A (CPA) 0.0146 0.3754 1
Entamoeba histolytica cysteine proteinase, putative 0.0146 0.3754 0.3686
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0237 0.0572
Schistosoma mansoni hypothetical protein 0.0012 0.0028 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.3754 1
Echinococcus granulosus cathepsin b 0.0308 0.8224 0.822
Echinococcus multilocularis cysteine protease 0.0146 0.3754 0.3739
Loa Loa (eye worm) hypothetical protein 0.0101 0.2494 0.3012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0026 0.0416 0.0393
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0546 0.0637
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0647 0.0625
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0647 0.0625
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0237 0.0572
Leishmania major cathepsin L-like protease 0.0146 0.3754 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0034 0.0647 0.1671
Leishmania major cathepsin L-like protease 0.0146 0.3754 1
Toxoplasma gondii ABC1 family protein 0.0033 0.0615 0.1586
Giardia lamblia Cathepsin L precursor 0.0034 0.0647 0.007
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.3754 0.4548
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0929 0.0908
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0032 0.0585 0.0684
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0055
Onchocerca volvulus Cathepsin L homolog 0.0146 0.3754 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0647 0.076
Giardia lamblia Cathepsin L precursor 0.0034 0.0647 0.007
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0032 0.0585 0.1504
Schistosoma mansoni cathepsin F (C01 family) 0.0146 0.3754 0.3739
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0159 0.0363
Loa Loa (eye worm) hypothetical protein 0.0146 0.3754 0.4548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0647 0.007
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.9472 1
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0615 0.0035
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.1065 0.1043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0034 0.0647 0.1671
Giardia lamblia Cathepsin L-like protease 0.0034 0.0647 0.007
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0028 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0079 0.1906 0.1646
Trypanosoma cruzi cruzipain precursor, putative 0.0046 0.0969 0.1153
Onchocerca volvulus 0.0146 0.3754 1
Echinococcus multilocularis cpg binding protein 0.0028 0.0473 0.045
Loa Loa (eye worm) hypothetical protein 0.0033 0.0615 0.0721
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0146 0.3754 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0647 0.0255
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0028 0.0011
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0033 0.0615 0.0719
Schistosoma mansoni immunophilin 0.0033 0.0623 0.06
Schistosoma mansoni cpg binding protein 0.0028 0.0473 0.045
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0119 0.299 0.7954
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0065 0.0041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0096 0.2354 0.2862
Brugia malayi TAR-binding protein 0.0041 0.084 0.1022
Schistosoma mansoni hypothetical protein 0.003 0.0546 0.0524
Giardia lamblia PHD finger protein 15 0.0035 0.0683 0.0111
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0249 0.0302
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0041 0.084 0.0995
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0146 0.3754 0.3566
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0032 0.0585 0.1504
Schistosoma mansoni tar DNA-binding protein 0.0041 0.084 0.0818
Mycobacterium ulcerans hypothetical protein 0.0033 0.0615 0.0079
Entamoeba histolytica cysteine protease, putative 0.0079 0.1906 0.1646
Loa Loa (eye worm) hypothetical protein 0.0034 0.0647 0.076
Schistosoma mansoni hypothetical protein 0.0026 0.0416 0.0393
Brugia malayi AF-10 protein 0.0012 0.0028 0.0034
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.2494 0.2295
Mycobacterium ulcerans esterase/lipase LipP 0.0033 0.0615 0.0079
Brugia malayi beta-lactamase family protein 0.0033 0.0615 0.0748
Mycobacterium tuberculosis Probable lipase LipE 0.0033 0.0615 0.0719
Giardia lamblia Hypothetical protein 0.0034 0.0647 0.007
Trypanosoma cruzi major cysteine proteinase, putative 0.0034 0.0647 0.076
Echinococcus granulosus cathepsin L 0.0034 0.0647 0.0625
Echinococcus multilocularis cathepsin L 0.0034 0.0647 0.0625
Plasmodium falciparum serine repeat antigen 9 0.0034 0.0647 0.1671
Entamoeba histolytica cysteine protease, putative 0.0034 0.0647 0.0255
Trypanosoma cruzi cysteine protease, putative 0.0079 0.1906 0.2296
Brugia malayi Cathepsin L-like precursor 0.0146 0.3754 0.4564
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0101 0.2494 0.3012
Brugia malayi PHD-finger family protein 0.0035 0.0683 0.0831

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.005 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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