Detailed information for compound 1405623

Basic information

Technical information
  • TDR Targets ID: 1405623
  • Name: N-[2-(4-methoxyphenyl)ethyl]-2-nitro-4-pyrrol idin-1-ylsulfonylaniline
  • MW: 405.468 | Formula: C19H23N3O5S
  • H donors: 1 H acceptors: 4 LogP: 3.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCNc1ccc(cc1[N+](=O)[O-])S(=O)(=O)N1CCCC1
  • InChi: 1S/C19H23N3O5S/c1-27-16-6-4-15(5-7-16)10-11-20-18-9-8-17(14-19(18)22(23)24)28(25,26)21-12-2-3-13-21/h4-9,14,20H,2-3,10-13H2,1H3
  • InChiKey: OSZAJYODVQGSCR-UHFFFAOYSA-N  


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Synonyms

  • N-[2-(4-methoxyphenyl)ethyl]-2-nitro-4-pyrrolidin-1-ylsulfonyl-aniline
  • N-[2-(4-methoxyphenyl)ethyl]-2-nitro-4-1-pyrrolidinylsulfonylaniline
  • 2-(4-methoxyphenyl)ethyl-(2-nitro-4-pyrrolidin-1-ylsulfonyl-phenyl)amine
  • T5277845
  • ZINC05885983
  • MLS000393895
  • SMR000247317

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0091 0.0162
Schistosoma mansoni importin beta-1 0.0035 0.017 0.0324
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0183 0.0348
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0174 0.0321
Entamoeba histolytica hypothetical protein 0.0043 0.026 1
Brugia malayi PHD-finger family protein 0.003 0.0121 0.0214
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0102 0.021
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0074 0.2525
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0174 0.0313
Brugia malayi hypothetical protein 0.0043 0.026 0.0473
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0174 0.0332
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0074 0.328
Brugia malayi jmjC domain containing protein 0.0115 0.1008 0.1866
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0044 0.5
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0227 1
Leishmania major cytochrome p450-like protein 0.0027 0.0088 0.389
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0102 0.4475
Schistosoma mansoni hypothetical protein 0.0043 0.026 0.0495
Loa Loa (eye worm) hypothetical protein 0.0535 0.5375 1
Echinococcus granulosus peregrin 0.0038 0.0204 0.0378
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0044 0.1038
Plasmodium vivax pyruvate kinase, putative 0.004 0.0227 1
Brugia malayi hypothetical protein 0.0535 0.5375 1
Echinococcus granulosus pyruvate kinase 0.004 0.0227 0.0422
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0397 0.0392
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0174 0.0168
Schistosoma mansoni ceramide glucosyltransferase 0.0523 0.5249 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.029 0.0529
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0022 0.0042
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1008 0.1003
Schistosoma mansoni pyruvate kinase 0.004 0.0227 0.0432
Brugia malayi jmjC domain containing protein 0.0045 0.0275 0.0502
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0011
Loa Loa (eye worm) pyruvate kinase 0.004 0.0227 0.0412
Schistosoma mansoni pyruvate kinase 0.0021 0.0023 0.0044
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0044 0.1942
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0434 0.0798
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0183 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0397 0.0757
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0174 0.7411
Brugia malayi Bromodomain containing protein 0.0091 0.075 0.1387
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0761 0.145
Entamoeba histolytica hypothetical protein 0.0028 0.0102 0.2664
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2785 1
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0227 0.0102
Trypanosoma brucei pyruvate kinase 1 0.004 0.0227 1
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0318 0.0595
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0022 0.0031
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.026 0.0495
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.01 0.2596
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0044 0.1942
Plasmodium falciparum importin beta, putative 0.0035 0.017 0.7214
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0183 0.0348
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0275 0.0514
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0174 0.7411
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.017 0.7495
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.026 0.0254
Schistosoma mansoni hypothetical protein 0.0025 0.0067 0.0128
Giardia lamblia PHD finger protein 15 0.0035 0.0174 0.0672
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0088 0.389
Schistosoma mansoni pyruvate kinase 0.004 0.0227 0.0432
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1008 0.1911
Echinococcus multilocularis ceramide glucosyltransferase 0.0523 0.5249 0.5246
Echinococcus multilocularis snurportin 1 0.0372 0.3677 0.3673
Schistosoma mansoni lozenge 0.0067 0.0506 0.0964
Echinococcus multilocularis pyruvate kinase 0.0021 0.0023 0.0017
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0044 0.0071
Plasmodium vivax SET domain protein, putative 0.0036 0.0183 0.784
Loa Loa (eye worm) hypothetical protein 0.0057 0.0397 0.0729
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0259 0.0254
Entamoeba histolytica hypothetical protein 0.0043 0.026 1
Brugia malayi Cytochrome P450 family protein 0.0027 0.0088 0.0153
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0044 0.5
Echinococcus multilocularis zinc finger protein 0.0024 0.0054 0.0048
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.003 0.0044
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0523 0.5249 0.9758
Schistosoma mansoni hypothetical protein 0.0035 0.0174 0.0332
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0074 0.0128
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0074 0.328
Echinococcus multilocularis pyruvate kinase 0.004 0.0227 0.0221
Echinococcus multilocularis peregrin 0.0038 0.0204 0.0198
Giardia lamblia Pyruvate kinase 0.004 0.0227 0.0906
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0227 0.0412
Plasmodium vivax importin-beta 2, putative 0.0035 0.017 0.7214
Brugia malayi PHD-finger family protein 0.0035 0.0174 0.0313
Loa Loa (eye worm) ceramide glucosyltransferase 0.0523 0.5249 0.9765
Schistosoma mansoni zinc finger protein 0.0024 0.0054 0.0102
Echinococcus granulosus importin subunit beta 1 0.0035 0.017 0.0313
Brugia malayi Bromodomain containing protein 0.0038 0.0204 0.0369
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0067 0.0114
Echinococcus multilocularis pyruvate kinase 0.0032 0.0139 0.0133
Brugia malayi RNA, U transporter 1 0.0099 0.0838 0.155
Onchocerca volvulus 0.0286 0.2785 0.502
Echinococcus granulosus pyruvate kinase 0.0021 0.0023 0.0032
Leishmania major GTP-binding protein, putative 0.0026 0.0074 0.328
Loa Loa (eye worm) hypothetical protein 0.0041 0.0236 0.0429
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0074 0.0131
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0169 0.0311
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0318 0.0312
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.017 0.7214
Echinococcus multilocularis pyruvate kinase 0.0021 0.0023 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0236 0.0429
Echinococcus multilocularis pyruvate kinase 0.004 0.0227 0.0221
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0044 0.0094
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0044 0.0038
Schistosoma mansoni hypothetical protein 0.0372 0.3677 0.7005
Echinococcus granulosus pyruvate kinase 0.0021 0.0023 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0397 0.0746
Echinococcus multilocularis importin subunit beta 1 0.0035 0.017 0.0164
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0275 0.0502
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0074 0.0128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0183 0.784
Chlamydia trachomatis pyruvate kinase 0.004 0.0227 0.5
Plasmodium falciparum pyruvate kinase 0.004 0.0227 1
Loa Loa (eye worm) runx1 0.0067 0.0506 0.0931
Entamoeba histolytica Ran family GTPase 0.0026 0.0074 0.1406
Schistosoma mansoni ran 0.0026 0.0074 0.0142
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0275 0.0524
Brugia malayi Ceramide glucosyltransferase 0.0523 0.5249 0.9765
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0074 0.2525
Plasmodium falciparum phd finger protein, putative 0.0035 0.0174 0.7411
Loa Loa (eye worm) hypothetical protein 0.0035 0.017 0.0306
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0074 0.0069
Giardia lamblia Ceramide glucosyltransferase 0.0237 0.2274 1
Loa Loa (eye worm) pyruvate kinase 0.004 0.0227 0.0412
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0074 0.328
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0091 0.0085
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0227 0.5
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0227 0.0667
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0558 0.0552
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0102 0.021
Schistosoma mansoni ran 0.0026 0.0074 0.0142
Echinococcus granulosus snurportin 1 0.0372 0.3677 0.7001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0044 0.1942
Echinococcus granulosus pyruvate kinase 0.0021 0.0023 0.0032
Loa Loa (eye worm) hypothetical protein 0.0052 0.0344 0.0629
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0088 0.389
Schistosoma mansoni hypothetical protein 0.0041 0.0236 0.045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0044 0.1038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0003
Leishmania major importin beta-1 subunit, putative 0.0028 0.0102 0.4475
Schistosoma mansoni ceramide glucosyltransferase 0.0523 0.5249 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.026 0.0484
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0174 0.7411
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3677 0.6837
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0227 1
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0227 0.0412
Schistosoma mansoni ap endonuclease 0.0023 0.0044 0.0084
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0259 0.0483
Entamoeba histolytica hypothetical protein 0.0043 0.026 1
Echinococcus granulosus pyruvate kinase 0.004 0.0227 0.0422
Loa Loa (eye worm) hypothetical protein 0.006 0.0434 0.0798
Echinococcus multilocularis pyruvate kinase 0.0021 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.006 0.0436 0.0801
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.0313
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0564 0.104
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0227 1
Loa Loa (eye worm) pyruvate kinase 0.004 0.0227 0.0412
Brugia malayi Bromodomain containing protein 0.0046 0.0289 0.0527
Leishmania major pyruvate kinase 0.004 0.0227 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0183 0.033
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0102 0.021
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0022 0.0042
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0227 0.0102
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0088 0.0153
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0434 0.0798
Echinococcus granulosus zinc finger protein 0.0024 0.0054 0.0091
Loa Loa (eye worm) hypothetical protein 0.0535 0.5375 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0088 0.2416
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0011
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0434 0.0798
Leishmania major pyruvate kinase 0.004 0.0227 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.01 0.0175
Schistosoma mansoni bromodomain containing protein 0.0076 0.0603 0.1149
Mycobacterium ulcerans pyruvate kinase 0.004 0.0227 1
Echinococcus multilocularis Protein lozenge 0.0067 0.0506 0.05
Trichomonas vaginalis ran, putative 0.0026 0.0074 0.0111
Onchocerca volvulus 0.0535 0.5375 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0091 0.0173
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0275 0.0524
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2424 0.4503
Echinococcus granulosus ceramide glucosyltransferase 0.0523 0.5249 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0074 0.0229
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0227 0.0102
Schistosoma mansoni ap endonuclease 0.0023 0.0044 0.0084
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0074 0.2525
Onchocerca volvulus 0.0036 0.0183 0.0017
Loa Loa (eye worm) hypothetical protein 0.0049 0.032 0.0584
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.017 0.7495
Brugia malayi Cytochrome P450 family protein 0.0027 0.0088 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0397 0.0757
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0088 0.0153
Brugia malayi Importin beta-1 subunit 0.0035 0.017 0.0306
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0227 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.01 0.0175
Entamoeba histolytica hypothetical protein 0.0043 0.026 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0022 0.0016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0044 0.0073
Loa Loa (eye worm) hypothetical protein 0.0085 0.0697 0.1286
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0044 0.0071
Brugia malayi Pre-SET motif family protein 0.0251 0.2424 0.4503
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0227 0.0412
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0044 0.1942
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0251 0.0245
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0227 0.0667
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0558 0.1053
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0011
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0088 0.0153
Toxoplasma gondii exonuclease III APE 0.0023 0.0044 0.1038
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0088 0.389
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0011

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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