Detailed information for compound 1405696

Basic information

Technical information
  • TDR Targets ID: 1405696
  • Name: N'-(4-chlorophenyl)-5-methyl-3-isoxazolecarbo hydrazide
  • MW: 251.669 | Formula: C11H10ClN3O2
  • H donors: 2 H acceptors: 2 LogP: 2.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NNC(=O)c1noc(c1)C
  • InChi: 1S/C11H10ClN3O2/c1-7-6-10(15-17-7)11(16)14-13-9-4-2-8(12)3-5-9/h2-6,13H,1H3,(H,14,16)
  • InChiKey: HEUYRRNRMBUJQQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MLS000834818
  • SMR000458436
  • ZINC00152299

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cathepsin B 0.1084 0.3656 0.3656
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0256 0.0815 0.217
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0256 0.0815 0.0815
Entamoeba histolytica cysteine protease, putative 0.0256 0.0815 0.217
Entamoeba histolytica cysteine protease, putative 0.0256 0.0815 0.217
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0568 0.1884 0.1884
Onchocerca volvulus Cathepsin L homolog 0.0256 0.0815 0.2258
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0076 0.0076
Echinococcus granulosus intermediate filament protein 0.0033 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Plasmodium falciparum cysteine proteinase falcipain 1 0.0568 0.1884 0.5458
Brugia malayi cathepsin L-like cysteine proteinase 0.0256 0.0815 0.0815
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0124 0.0124
Onchocerca volvulus Cathepsin F homolog 0.1024 0.3452 1
Onchocerca volvulus 0.0114 0.0325 0.0819
Brugia malayi Cathepsin L-like precursor 0.1024 0.3452 0.3452
Plasmodium vivax serine-repeat antigen (SERA) 0.0256 0.0815 0.2362
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0256 0.0815 0.2362
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0084 0.0084
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0084 0.0231
Leishmania major cathepsin L-like protease 0.1024 0.3452 0.9443
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Loa Loa (eye worm) fibroinase 0.1024 0.3452 0.3452
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0713 0.2383 0.6437
Loa Loa (eye worm) hypothetical protein 0.1024 0.3452 0.3452
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 0.0815 0.2046
Brugia malayi cathepsin Z-like cysteine proteinase 0.0256 0.0815 0.0815
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0256 0.0815 0.0815
Brugia malayi cathepsin F-like cysteine proteinase 0.0256 0.0815 0.0815
Onchocerca volvulus 0.1024 0.3452 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.061 0.061
Plasmodium falciparum serine repeat antigen 1 0.0256 0.0815 0.2362
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1084 0.3656 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0256 0.0815 0.2362
Trypanosoma cruzi cysteine peptidase, putative 0.0311 0.1004 0.1004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Schistosoma mansoni intermediate filament proteins 0.0033 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0256 0.0815 0.2046
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 0.0815 0.2046
Trypanosoma cruzi cysteine protease, putative 0.0568 0.1884 0.1884
Schistosoma mansoni cathepsin F (C01 family) 0.1024 0.3452 0.3452
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1024 0.3452 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.061 0.061
Leishmania major cathepsin L-like protease 0.1024 0.3452 0.9443
Entamoeba histolytica cysteine protease, putative 0.0256 0.0815 0.217
Loa Loa (eye worm) hypothetical protein 0.0713 0.2383 0.2383
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0256 0.0815 0.0815
Leishmania major cathepsin L-like protease 0.1024 0.3452 0.9443
Brugia malayi Cathepsin L-like precursor 0.0311 0.1004 0.1004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0256 0.0815 0.0815
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0046 0.0046
Echinococcus granulosus cysteine protease 0.0568 0.1884 0.1884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Echinococcus multilocularis cysteine protease 0.1024 0.3452 0.3452
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0311 0.1004 0.1004
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0256 0.0815 0.2046
Loa Loa (eye worm) hypothetical protein 0.0713 0.2383 0.2383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0256 0.0815 0.2362
Trypanosoma cruzi cysteine peptidase, putative 0.0568 0.1884 0.1884
Schistosoma mansoni alpha glucosidase 0.0044 0.0084 0.0084
Echinococcus granulosus cathepsin l1 0.1024 0.3452 0.3452
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Echinococcus granulosus cathepsin L 0.0256 0.0815 0.0815
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0713 0.2383 0.2383
Onchocerca volvulus Cathepsin L homolog 0.1024 0.3452 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Onchocerca volvulus 0.1024 0.3452 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Loa Loa (eye worm) hypothetical protein 0.0256 0.0815 0.0815
Brugia malayi Cathepsin L-like cysteine proteinase 0.0713 0.2383 0.2383
Loa Loa (eye worm) hypothetical protein 0.0311 0.1004 0.1004
Echinococcus granulosus cathepsin l1 0.0713 0.2383 0.2383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0124 0.0124
Leishmania major cathepsin L-like protease 0.1024 0.3452 0.9443
Trypanosoma cruzi cysteine peptidase, putative 0.1024 0.3452 0.3452
Loa Loa (eye worm) cysteine protease 0.1024 0.3452 0.3452
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0568 0.1884 0.1884
Entamoeba histolytica cysteine proteinase 2 0.0568 0.1884 0.5344
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0124 0.0124
Echinococcus multilocularis lamin 0.0033 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0713 0.2383 0.2383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1024 0.3452 0.943
Plasmodium falciparum cysteine proteinase falcipain 3 0.1024 0.3452 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0256 0.0815 0.2362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1024 0.3452 0.943
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Trichomonas vaginalis conserved hypothetical protein 0.0256 0.0815 0.2046
Brugia malayi cathepsin F-like cysteine proteinase 0.0311 0.1004 0.1004
Plasmodium falciparum serine repeat antigen 5 0.0256 0.0815 0.2362
Brugia malayi Cathepsin L-like precursor 0.1024 0.3452 0.3452
Trypanosoma brucei cysteine peptidase C (CPC) 0.1084 0.3656 1
Loa Loa (eye worm) hypothetical protein 0.0311 0.1004 0.1004
Brugia malayi Papain family cysteine protease containing protein 0.0568 0.1884 0.1884
Echinococcus granulosus cathepsin L cysteine proteinase 0.1024 0.3452 0.3452
Trypanosoma cruzi cruzipain precursor, putative 0.1024 0.3452 0.3452
Plasmodium vivax vivapain-2 0.1024 0.3452 1
Echinococcus granulosus lamin dm0 0.0033 0.0046 0.0046
Brugia malayi Cathepsin L-like precursor 0.1024 0.3452 0.3452
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0256 0.0815 0.2362
Brugia malayi cathepsin L precursor 0.0256 0.0815 0.0815
Onchocerca volvulus 0.1024 0.3452 1
Brugia malayi Cathepsin L-like precursor 0.1024 0.3452 0.3452
Plasmodium falciparum serine repeat antigen 8 0.0256 0.0815 0.2362
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0256 0.0815 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 0.0815 0.2046
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0256 0.0815 0.2362
Plasmodium vivax vivapain-3 0.0568 0.1884 0.5458
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0256 0.0815 0.0815
Plasmodium vivax vivapain-2 0.1024 0.3452 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 0.0815 0.2046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 0.0815 0.2046
Brugia malayi Cathepsin L-like precursor 0.1024 0.3452 0.3452
Trypanosoma cruzi cysteine proteinase, putative 0.0568 0.1884 0.1884
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0256 0.0815 0.0815
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1024 0.3452 0.3452
Loa Loa (eye worm) hypothetical protein 0.0256 0.0815 0.0815
Entamoeba histolytica cysteine proteinase, putative 0.0568 0.1884 0.5344
Entamoeba histolytica cysteine protease, putative 0.1024 0.3452 1
Plasmodium falciparum serine repeat antigen 9 0.0256 0.0815 0.2362
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0256 0.0815 0.2046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0568 0.1884 0.5154
Entamoeba histolytica cysteine proteinase, putative 0.1024 0.3452 1
Trichomonas vaginalis conserved hypothetical protein 0.0256 0.0815 0.2046
Loa Loa (eye worm) hypothetical protein 0.006 0.0141 0.0141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1024 0.3452 0.943
Plasmodium vivax unspecified product 0.0568 0.1884 0.5458
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0568 0.1884 0.504
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0256 0.0815 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Loa Loa (eye worm) hypothetical protein 0.0256 0.0815 0.0815
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1024 0.3452 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1024 0.3452 0.943
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0256 0.0815 0.2362
Entamoeba histolytica cysteine proteinase 1, putative 0.0568 0.1884 0.5344
Schistosoma mansoni hypothetical protein 0.0205 0.0637 0.0637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1024 0.3452 0.943
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0032 0.0044 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0124 0.0124
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1024 0.3452 0.3452
Trypanosoma cruzi cysteine proteinase, putative 0.0568 0.1884 0.1884
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0141 0.0141
Leishmania major cathepsin L-like protease 0.1024 0.3452 0.9443
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0256 0.0815 0.2046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 0.0815 0.2046
Leishmania major cathepsin L-like protease 0.1024 0.3452 0.9443
Leishmania major cysteine peptidase A (CPA) 0.1024 0.3452 0.9443
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.061 0.061
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0568 0.1884 0.1884
Brugia malayi Papain family cysteine protease containing protein 0.0256 0.0815 0.0815
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Giardia lamblia Cathepsin B precursor 0.1084 0.3656 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0568 0.1884 0.5154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1024 0.3452 0.943
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0256 0.0815 0.0815
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0568 0.1884 0.1884
Toxoplasma gondii cathepsin CPC2 0.0256 0.0815 0.223
Entamoeba histolytica cysteine proteinase, putative 0.0713 0.2383 0.6826
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1024 0.3452 0.943
Entamoeba histolytica cysteine protease, putative 0.0256 0.0815 0.217
Plasmodium falciparum serine repeat antigen 2 0.0256 0.0815 0.2362
Leishmania major cathepsin L-like protease 0.1024 0.3452 0.9443
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1024 0.3452 0.3452
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Plasmodium vivax unspecified product 0.0311 0.1004 0.2907
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0256 0.0815 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0311 0.1004 0.1004
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0141 0.0141
Echinococcus multilocularis cysteine protease 0.1024 0.3452 0.3452
Schistosoma mansoni cathepsin s 0.0311 0.1004 0.1004
Brugia malayi Papain family cysteine protease containing protein 0.0256 0.0815 0.0815
Schistosoma mansoni lamin 0.0033 0.0046 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.1024 0.3452 0.3452
Toxoplasma gondii cathepsin B 0.1084 0.3656 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.061 0.061
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0256 0.0815 0.0815
Toxoplasma gondii cathepsin CPL 0.1024 0.3452 0.9443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Onchocerca volvulus 0.0713 0.2383 0.6861
Echinococcus granulosus cathepsin L 0.0568 0.1884 0.1884
Brugia malayi MH2 domain containing protein 0.0144 0.043 0.043
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0256 0.0815 0.2362
Brugia malayi Cathepsin L-like precursor 0.0713 0.2383 0.2383
Loa Loa (eye worm) hypothetical protein 0.0256 0.0815 0.0815
Loa Loa (eye worm) hypothetical protein 0.0256 0.0815 0.0815
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0084 0.0231
Trypanosoma cruzi cysteine peptidase, putative 0.1024 0.3452 0.3452
Brugia malayi Cathepsin L-like precursor 0.0713 0.2383 0.2383
Entamoeba histolytica hypothetical protein 0.0256 0.0815 0.217
Echinococcus multilocularis lamin dm0 0.0033 0.0046 0.0046
Schistosoma mansoni cathepsin B (C01 family) 0.0256 0.0815 0.0815
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0141 0.0141
Entamoeba histolytica cysteine proteinase, putative 0.0568 0.1884 0.5344
Loa Loa (eye worm) hypothetical protein 0.0311 0.1004 0.1004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0713 0.2383 0.6437
Entamoeba histolytica cysteine proteinase, putative 0.0568 0.1884 0.5344
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0076
Onchocerca volvulus 0.1024 0.3452 1
Brugia malayi cathepsin L-like precursor 0.0713 0.2383 0.2383
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.061 0.061
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1024 0.3452 0.943
Brugia malayi intermediate filament protein 0.0033 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Loa Loa (eye worm) hypothetical protein 0.0256 0.0815 0.0815
Entamoeba histolytica cysteine protease, putative 0.0256 0.0815 0.217
Echinococcus multilocularis cathepsin L cysteine protease 0.1024 0.3452 0.3452
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0256 0.0815 0.217
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1024 0.3452 0.943
Trypanosoma cruzi major cysteine proteinase, putative 0.0256 0.0815 0.0815
Schistosoma mansoni cathepsin S (C01 family) 0.0256 0.0815 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0256 0.0815 0.2046
Brugia malayi Papain family cysteine protease containing protein 0.1024 0.3452 0.3452
Schistosoma mansoni cathepsin F (C01 family) 0.1024 0.3452 0.3452
Echinococcus multilocularis cathepsin L 0.0568 0.1884 0.1884
Entamoeba histolytica cysteine proteinase, putative 0.0568 0.1884 0.5344
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0256 0.0815 0.0815
Giardia lamblia Cathepsin B precursor 0.1084 0.3656 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.043 0.043
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0256 0.0815 0.0815
Schistosoma mansoni cathepsin C 0.0256 0.0815 0.0815
Echinococcus granulosus geminin 0.0205 0.0637 0.0637
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.043 0.043
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Plasmodium falciparum serine repeat antigen 4 0.0256 0.0815 0.2362
Toxoplasma gondii cathepsin CPC1 0.0256 0.0815 0.223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 0.0815 0.2046
Schistosoma mansoni lamin 0.0033 0.0046 0.0046
Echinococcus granulosus cathepsin L cysteine protease 0.0568 0.1884 0.1884
Leishmania major cathepsin L-like protease 0.1024 0.3452 0.9443
Brugia malayi Papain family cysteine protease containing protein 0.0256 0.0815 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1084 0.3656 1
Schistosoma mansoni hypothetical protein 0.0205 0.0637 0.0637
Onchocerca volvulus 0.1024 0.3452 1
Plasmodium falciparum serine repeat antigen 6 0.0256 0.0815 0.2362
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0256 0.0815 0.2362
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0256 0.0815 0.2046
Plasmodium falciparum serine repeat antigen 3 0.0256 0.0815 0.2362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0124 0.0124
Echinococcus multilocularis cathepsin L 0.0256 0.0815 0.0815
Loa Loa (eye worm) hypothetical protein 0.0033 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0568 0.1884 0.504
Entamoeba histolytica cysteine protease, putative 0.0568 0.1884 0.5344
Brugia malayi Papain family cysteine protease containing protein 0.0568 0.1884 0.1884
Onchocerca volvulus 0.1024 0.3452 1
Onchocerca volvulus 0.1024 0.3452 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0256 0.0815 0.223
Onchocerca volvulus 0.0256 0.0815 0.2258
Brugia malayi fibroinase precursor 0.0256 0.0815 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0256 0.0815 0.2046
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0256 0.0815 0.2362
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0256 0.0815 0.2362
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0256 0.0815 0.2362
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0256 0.0815 0.2362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1024 0.3452 0.943
Entamoeba histolytica cysteine protease, putative 0.0256 0.0815 0.217
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0256 0.0815 0.0815
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0084 0.0084
Loa Loa (eye worm) ctsf protein 0.1024 0.3452 0.3452
Plasmodium vivax vivapain-1 0.0568 0.1884 0.5458
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0084 0.0084
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1024 0.3452 0.3452
Onchocerca volvulus Cathepsin L homolog 0.1024 0.3452 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1024 0.3452 0.9443
Echinococcus multilocularis musashi 0.0033 0.0046 0.0046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1084 0.3656 0.3656
Schistosoma mansoni cathepsin F (C01 family) 0.0713 0.2383 0.2383
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0084 0.0084
Entamoeba histolytica cysteine proteinase, putative 0.1024 0.3452 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0084 0.0084
Echinococcus granulosus cathepsin l cysteine peptidase 0.1024 0.3452 0.3452
Trypanosoma cruzi cysteine peptidase, putative 0.1024 0.3452 0.3452
Plasmodium falciparum serine repeat antigen 7 0.0256 0.0815 0.2362
Echinococcus multilocularis geminin 0.0205 0.0637 0.0637
Echinococcus multilocularis cathepsin L cysteine protease 0.1024 0.3452 0.3452
Trypanosoma cruzi cruzipain precursor, putative 0.0311 0.1004 0.1004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0124 0.0124
Trypanosoma brucei glucosidase, putative 0.0044 0.0084 0.0231
Schistosoma mansoni alpha-glucosidase 0.0169 0.0516 0.0516
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1024 0.3452 0.943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Trypanosoma cruzi major cysteine proteinase, putative 0.0256 0.0815 0.0815
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0124 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1024 0.3452 0.943
Schistosoma mansoni alpha-glucosidase 0.0169 0.0516 0.0516
Brugia malayi cathepsin Z-like cysteine proteinase 0.0256 0.0815 0.0815
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1084 0.3656 0.3656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0256 0.0815 0.2046
Plasmodium vivax serine-repeat antigen (SERA) 0.0256 0.0815 0.2362
Giardia lamblia Cathepsin B precursor 0.1084 0.3656 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0256 0.0815 0.0815
Brugia malayi Cathepsin L-like precursor 0.1024 0.3452 0.3452
Echinococcus granulosus lamin 0.0033 0.0046 0.0046
Plasmodium vivax unspecified product 0.0256 0.0815 0.2362

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0562 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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