Detailed information for compound 1405906

Basic information

Technical information
  • TDR Targets ID: 1405906
  • Name: N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-4-(2,5 -dioxopyrrolidin-1-yl)benzamide
  • MW: 379.432 | Formula: C20H17N3O3S
  • H donors: 1 H acceptors: 4 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCC(=O)N1c1ccc(cc1)C(=O)Nc1nc2c(s1)c(C)ccc2C
  • InChi: 1S/C20H17N3O3S/c1-11-3-4-12(2)18-17(11)21-20(27-18)22-19(26)13-5-7-14(8-6-13)23-15(24)9-10-16(23)25/h3-8H,9-10H2,1-2H3,(H,21,22,26)
  • InChiKey: MESADALDHZDWFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-4-(2,5-dioxo-1-pyrrolidinyl)benzamide
  • N-(4,7-dimethyl-1,3-benzothiazol-2-yl)-4-succinimido-benzamide
  • MLS000696928
  • SMR000237361
  • ZINC04292212

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Loa Loa (eye worm) ctsf protein 0.0956 0.3393 0.3393
Brugia malayi GCC2 and GCC3 family protein 0.0121 0.029 0.029
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0239 0.0728 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0239 0.0728 0.2025
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0239 0.0728 0.2025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Onchocerca volvulus Cathepsin L homolog 0.0239 0.0728 0.2146
Entamoeba histolytica cysteine proteinase 1, putative 0.053 0.1809 0.4054
Trypanosoma cruzi cysteine protease, putative 0.053 0.1809 0.1809
Echinococcus multilocularis c4b binding protein beta chain 0.0104 0.0225 0.0225
Echinococcus granulosus cathepsin L 0.053 0.1809 0.1809
Plasmodium falciparum serine repeat antigen 4 0.0239 0.0728 0.1588
Plasmodium falciparum serine repeat antigen 5 0.0239 0.0728 0.1588
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0239 0.0728 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0239 0.0728 0.0728
Trypanosoma cruzi major cysteine proteinase, putative 0.0239 0.0728 0.0728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0239 0.0728 0.2025
Echinococcus multilocularis cathepsin L 0.053 0.1809 0.1809
Onchocerca volvulus 0.0239 0.0728 0.2146
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0239 0.0728 0.2025
Plasmodium falciparum serine repeat antigen 7 0.0239 0.0728 0.1588
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Entamoeba histolytica cysteine proteinase, putative 0.053 0.1809 0.4054
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0239 0.0728 0.2146
Trypanosoma cruzi cysteine peptidase, putative 0.1013 0.3604 0.3604
Leishmania major cysteine peptidase A (CPA) 0.0956 0.3393 0.9414
Loa Loa (eye worm) hypothetical protein 0.0116 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0121 0.029 0.029
Echinococcus multilocularis muscleblind protein 1 0.018 0.0509 0.0509
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0239 0.0728 0.0728
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Echinococcus multilocularis cathepsin L 0.0239 0.0728 0.0728
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Leishmania major cathepsin L-like protease 0.1013 0.3604 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Entamoeba histolytica cysteine proteinase, putative 0.0956 0.3393 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Toxoplasma gondii rhoptry neck protein RON1 0.0104 0.0225 0.0626
Entamoeba histolytica cysteine proteinase, putative 0.0956 0.3393 1
Plasmodium vivax unspecified product 0.0291 0.0919 0.2708
Brugia malayi Sushi domain 0.0104 0.0225 0.0225
Onchocerca volvulus 0.0104 0.0225 0.0663
Leishmania major cathepsin L-like protease 0.1013 0.3604 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0239 0.0728 0.2146
Schistosoma mansoni cathepsin F (C01 family) 0.0956 0.3393 0.3393
Brugia malayi Muscleblind-like protein 0.018 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.018 0.0509 0.0509
Brugia malayi jmjC domain containing protein 0.0071 0.0102 0.0102
Schistosoma mansoni c4b-binding protein beta chain 0.0104 0.0225 0.0225
Plasmodium falciparum serine repeat antigen 3 0.0239 0.0728 0.1588
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0239 0.0728 0.1588
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.053 0.1809 0.1809
Plasmodium vivax apical sushi protein, putative 0.0104 0.0225 0.0663
Trypanosoma brucei cysteine peptidase C (CPC) 0.1011 0.3596 0.9977
Echinococcus granulosus cathepsin L cysteine proteinase 0.0956 0.3393 0.3393
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0239 0.0728 0.1588
Toxoplasma gondii cathepsin B 0.1011 0.3596 1
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0239 0.0728 0.0728
Onchocerca volvulus Cathepsin L homolog 0.0956 0.3393 1
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0104 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Giardia lamblia Cathepsin B precursor 0.1011 0.3596 1
Echinococcus multilocularis cysteine protease 0.0956 0.3393 0.3393
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0722 0.2524 0.2524
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Echinococcus granulosus cathepsin l cysteine peptidase 0.0956 0.3393 0.3393
Loa Loa (eye worm) hypothetical protein 0.0291 0.0919 0.0919
Plasmodium falciparum serine repeat antigen 8 0.0239 0.0728 0.1588
Toxoplasma gondii cathepsin CPL 0.0956 0.3393 0.9436
Entamoeba histolytica cysteine proteinase, putative 0.053 0.1809 0.4054
Loa Loa (eye worm) hypothetical protein 0.0291 0.0919 0.0919
Onchocerca volvulus 0.0104 0.0225 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Plasmodium vivax vivapain-2 0.0956 0.3393 1
Trypanosoma cruzi cysteine peptidase, putative 0.1013 0.3604 0.3604
Brugia malayi cathepsin Z-like cysteine proteinase 0.0239 0.0728 0.0728
Onchocerca volvulus 0.0104 0.0225 0.0663
Entamoeba histolytica cysteine proteinase, putative 0.0666 0.2313 0.5946
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0956 0.3393 0.3393
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Onchocerca volvulus 0.0104 0.0225 0.0663
Plasmodium falciparum serine repeat antigen 2 0.0239 0.0728 0.1588
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0102 0.0102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Entamoeba histolytica cysteine proteinase, putative 0.053 0.1809 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Trypanosoma cruzi cruzipain precursor, putative 0.1013 0.3604 0.3604
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0239 0.0728 0.2146
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0956 0.3393 0.3393
Schistosoma mansoni cathepsin F (C01 family) 0.0956 0.3393 0.3393
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Plasmodium vivax vivapain-3 0.053 0.1809 0.533
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.053 0.1809 0.1809
Brugia malayi fibroinase precursor 0.0239 0.0728 0.0728
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1011 0.3596 0.3596
Onchocerca volvulus 0.0956 0.3393 1
Echinococcus multilocularis cysteine protease 0.0956 0.3393 0.3393
Trypanosoma cruzi major cysteine proteinase, putative 0.0296 0.0939 0.0939
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.2313 0.6432
Entamoeba histolytica cysteine proteinase, putative 0.053 0.1809 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.018 0.0509 0.0509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Onchocerca volvulus 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0956 0.3393 0.9436
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0239 0.0728 0.0728
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Brugia malayi Papain family cysteine protease containing protein 0.053 0.1809 0.1809
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0239 0.0728 0.2146
Echinococcus granulosus cysteine protease 0.053 0.1809 0.1809
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Leishmania major cathepsin L-like protease 0.1013 0.3604 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.053 0.1809 0.503
Brugia malayi cathepsin L-like cysteine proteinase 0.0239 0.0728 0.0728
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.0728 0.2025
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1011 0.3596 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0239 0.0728 0.0728
Entamoeba histolytica cysteine protease, putative 0.0956 0.3393 1
Echinococcus granulosus C type lectin domian containing protein 0.0104 0.0225 0.0225
Echinococcus multilocularis cathepsin L cysteine protease 0.0956 0.3393 0.3393
Loa Loa (eye worm) hypothetical protein 0.0666 0.2313 0.2313
Loa Loa (eye worm) hypothetical protein 0.0666 0.2313 0.2313
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Plasmodium vivax serine-repeat antigen (SERA) 0.0239 0.0728 0.2146
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0239 0.0728 0.0728
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Brugia malayi jmjC domain containing protein 0.0071 0.0102 0.0102
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.053 0.1809 0.1809
Plasmodium falciparum cysteine proteinase falcipain 3 0.0956 0.3393 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0666 0.2313 0.2313
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Echinococcus multilocularis muscleblind protein 0.018 0.0509 0.0509
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Onchocerca volvulus 0.0104 0.0225 0.0663
Onchocerca volvulus 0.0666 0.2313 0.6816
Brugia malayi cathepsin F-like cysteine proteinase 0.0291 0.0919 0.0919
Toxoplasma gondii cathepsin CPC2 0.0239 0.0728 0.2025
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Schistosoma mansoni cathepsin s 0.0291 0.0919 0.0919
Trypanosoma cruzi cysteine peptidase, putative 0.1013 0.3604 0.3604
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Onchocerca volvulus 0.0956 0.3393 1
Echinococcus granulosus cathepsin L cysteine protease 0.053 0.1809 0.1809
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1011 0.3596 0.9977
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0239 0.0728 0.2146
Toxoplasma gondii cathepsin CPC1 0.0239 0.0728 0.2025
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0239 0.0728 0.2146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0239 0.0728 0.2146
Trichomonas vaginalis conserved hypothetical protein 0.0239 0.0728 0.2025
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0239 0.0728 0.2025
Brugia malayi cathepsin L precursor 0.0239 0.0728 0.0728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Brugia malayi cathepsin F-like cysteine proteinase 0.0239 0.0728 0.0728
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0956 0.3393 0.3393
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Plasmodium vivax unspecified product 0.053 0.1809 0.533
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0666 0.2313 0.2313
Plasmodium vivax vivapain-2 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0956 0.3393 0.9436
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0291 0.0919 0.0919
Echinococcus granulosus cathepsin L 0.0239 0.0728 0.0728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Giardia lamblia Cathepsin B precursor 0.1011 0.3596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0239 0.0728 0.2025
Trypanosoma cruzi cysteine peptidase, putative 0.0956 0.3393 0.3393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Plasmodium vivax serine-repeat antigen (SERA) 0.0239 0.0728 0.2146
Trypanosoma cruzi cysteine proteinase, putative 0.053 0.1809 0.1809
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.053 0.1809 0.1809
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.053 0.1809 0.5018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0239 0.0728 0.2025
Trypanosoma cruzi cysteine peptidase, putative 0.053 0.1809 0.1809
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Brugia malayi pregnancy-associated plasma protein-A 0.0104 0.0225 0.0225
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Toxoplasma gondii rhoptry neck protein RON9 0.0104 0.0225 0.0626
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Onchocerca volvulus 0.0956 0.3393 1
Onchocerca volvulus 0.0104 0.0225 0.0663
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0956 0.3393 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0239 0.0728 0.1588
Echinococcus multilocularis C type lectin domian containing protein 0.0104 0.0225 0.0225
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0291 0.0919 0.0919
Brugia malayi Cathepsin L-like precursor 0.0956 0.3393 0.3393
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Onchocerca volvulus 0.0104 0.0225 0.0663
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.053 0.1809 0.503
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Brugia malayi Papain family cysteine protease containing protein 0.0956 0.3393 0.3393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0666 0.2313 0.6432
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0239 0.0728 0.2025
Giardia lamblia Cathepsin B precursor 0.1011 0.3596 1
Loa Loa (eye worm) hypothetical protein 0.0956 0.3393 0.3393
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1011 0.3596 0.3596
Trypanosoma cruzi cruzipain precursor, putative 0.0291 0.0919 0.0919
Brugia malayi Papain family cysteine protease containing protein 0.0239 0.0728 0.0728
Loa Loa (eye worm) fibroinase 0.0956 0.3393 0.3393
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0239 0.0728 0.2025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Plasmodium falciparum serine repeat antigen 1 0.0239 0.0728 0.1588
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0239 0.0728 0.2146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0239 0.0728 0.2025
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0102 0.0102
Plasmodium falciparum cysteine proteinase falcipain 1 0.053 0.1809 0.4999
Schistosoma mansoni cathepsin B (C01 family) 0.0239 0.0728 0.0728
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0102 0.0102
Leishmania major cathepsin L-like protease 0.0956 0.3393 0.9414
Plasmodium falciparum serine repeat antigen 9 0.0239 0.0728 0.1588
Entamoeba histolytica cysteine proteinase 2 0.053 0.1809 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1013 0.3604 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0239 0.0728 0.0728
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0871 1
Plasmodium vivax unspecified product 0.0239 0.0728 0.2146
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0239 0.0728 0.0728
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0956 0.3393 0.3393
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.053 0.1809 0.1809
Onchocerca volvulus 0.0104 0.0225 0.0663
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Schistosoma mansoni cathepsin C 0.0239 0.0728 0.0728
Onchocerca volvulus 0.0956 0.3393 1
Schistosoma mansoni cathepsin S (C01 family) 0.0239 0.0728 0.0728
Onchocerca volvulus 0.0104 0.0225 0.0663
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0102 0.0102
Echinococcus multilocularis cathepsin L cysteine protease 0.0956 0.3393 0.3393
Loa Loa (eye worm) hypothetical protein 0.0239 0.0728 0.0728
Echinococcus granulosus cathepsin l1 0.0666 0.2313 0.2313
Loa Loa (eye worm) cysteine protease 0.0956 0.3393 0.3393
Echinococcus granulosus c4b binding protein beta chain 0.0104 0.0225 0.0225
Brugia malayi Cathepsin L-like precursor 0.0666 0.2313 0.2313
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.053 0.1809 0.5018
Echinococcus granulosus cathepsin l1 0.0956 0.3393 0.3393
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0102 0.0102
Onchocerca volvulus Cathepsin L homolog 0.0956 0.3393 1
Onchocerca volvulus 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Onchocerca volvulus Cathepsin F homolog 0.0956 0.3393 1
Plasmodium vivax vivapain-1 0.053 0.1809 0.533
Brugia malayi Cathepsin L-like precursor 0.0291 0.0919 0.0919
Schistosoma mansoni cathepsin F (C01 family) 0.0666 0.2313 0.2313
Brugia malayi hypothetical protein 0.0104 0.0225 0.0225
Toxoplasma gondii preprocathepsin c precursor, putative 0.0239 0.0728 0.2025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436
Brugia malayi Cathepsin L-like precursor 0.0666 0.2313 0.2313
Echinococcus granulosus muscleblind protein 0.018 0.0509 0.0509
Trypanosoma cruzi cysteine proteinase, putative 0.053 0.1809 0.1809
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Onchocerca volvulus 0.0104 0.0225 0.0663
Loa Loa (eye worm) cathepsin B 0.1011 0.3596 0.3596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0956 0.3393 0.9436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0239 0.0728 0.2025
Brugia malayi cathepsin L-like precursor 0.0666 0.2313 0.2313
Loa Loa (eye worm) hypothetical protein 0.0291 0.0919 0.0919
Plasmodium falciparum serine repeat antigen 6 0.0239 0.0728 0.1588
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0291 0.0919 0.0919
Onchocerca volvulus 0.0956 0.3393 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0239 0.0728 0.2025
Entamoeba histolytica cysteine protease, putative 0.053 0.1809 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0956 0.3393 0.9436

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.1995 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 5.6234 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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