Detailed information for compound 1407698

Basic information

Technical information
  • TDR Targets ID: 1407698
  • Name: methyl 4-[[5-[(4-bromophenyl)methylsulfinylme thyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanylmet hyl]benzoate
  • MW: 556.494 | Formula: C25H22BrN3O3S2
  • H donors: 1 H acceptors: 4 LogP: 5.47 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)c1ccc(cc1)CSc1nnc(n1c1ccccc1)C[S+](Cc1ccc(cc1)Br)[O-]
  • InChi: 1S/C25H22BrN3O3S2/c1-32-24(30)20-11-7-18(8-12-20)15-33-25-28-27-23(29(25)22-5-3-2-4-6-22)17-34(31)16-19-9-13-21(26)14-10-19/h2-14H,15-17H2,1H3
  • InChiKey: ITYJLYGMDMVANZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[[5-[(4-bromophenyl)methylsulfinylmethyl]-4-phenyl-1,2,4-triazol-3-yl]thio]methyl]benzoic acid methyl ester
  • 4-[[[5-[(4-bromobenzyl)sulfinylmethyl]-4-phenyl-1,2,4-triazol-3-yl]thio]methyl]benzoic acid methyl ester
  • MLS000325614
  • SMR000169939
  • methyl 4-{[(5-{[(4-bromobenzyl)sulfinyl]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}benzenecarboxylate
  • 7H-535S

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0667 0.9453 0.9452
Echinococcus multilocularis lamin dm0 0.0033 0.022 0.0197
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0667 0.9453 0.9452
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0453 0.6341 1
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0453 0.6341 0.5
Loa Loa (eye worm) hypothetical protein 0.0667 0.9453 1
Brugia malayi Nuclear hormone receptor-like 1 0.0352 0.4874 0.5156
Brugia malayi orphan nuclear receptor NR2E1 0.0314 0.4325 0.4575
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0314 0.4325 0.4312
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0667 0.9453 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.004 0.0043
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) Gln-2 protein 0.0453 0.6341 0.6708
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0667 0.9453 0.9452
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0667 0.9453 0.9452
Toxoplasma gondii glutamine synthetase, type I, putative 0.0453 0.6341 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0623 0.0659
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0667 0.9453 1
Loa Loa (eye worm) cysteine protease 0.002 0.004 0.0043
Schistosoma mansoni hypothetical protein 0.0041 0.0345 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0667 0.9453 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0667 0.9453 0.9452
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0667 0.9453 1
Brugia malayi conserved hypotetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0043
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0667 0.9453 0.9452
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1845 0.1952
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0314 0.4325 0.4312
Loa Loa (eye worm) hypothetical protein 0.0667 0.9453 1
Schistosoma mansoni hypothetical protein 0.0058 0.0594 0.0572
Onchocerca volvulus 0.0033 0.022 0.0191
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3904 0.389
Schistosoma mansoni nuclear hormone receptor 0.0667 0.9453 0.9452
Schistosoma mansoni glutamine synthetase bacteria 0.0178 0.2334 0.2316
Plasmodium falciparum glutamine synthetase, putative 0.0453 0.6341 1
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Brugia malayi ecdysone receptor 0.0314 0.4325 0.4575
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.0178 0.2334 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0667 0.9453 0.9452
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.004 0.0017
Brugia malayi photoreceptor-specific nuclear receptor 0.0667 0.9453 1
Brugia malayi MH2 domain containing protein 0.0144 0.1845 0.1952
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) hypothetical protein 0.0352 0.4874 0.5156
Mycobacterium ulcerans glutamine synthetase 0.0453 0.6341 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0868 0.0831
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0667 0.9453 0.9452
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0667 0.9453 0.9452
Entamoeba histolytica glutamine synthetase, putative 0.0178 0.2334 1
Leishmania major cathepsin L-like protease 0.0077 0.0868 0.0831
Loa Loa (eye worm) hypothetical protein 0.0667 0.9453 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.004 0.0017
Brugia malayi nuclear hormone receptor family member odr-7 0.0314 0.4325 0.4575
Schistosoma mansoni nuclear receptor nhr-48 0.0314 0.4325 0.4312
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.022 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0667 0.9453 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0314 0.4325 0.4312
Loa Loa (eye worm) hypothetical protein 0.0667 0.9453 1
Schistosoma mansoni lamin 0.0033 0.022 0.0197
Schistosoma mansoni retinoic acid receptor RXR 0.0667 0.9453 0.9452
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.004 0.0043
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0033 0.022 0.0233
Brugia malayi steroid hormone receptor 0.0667 0.9453 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0594 0.0628
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0352 0.4874 0.4862
Echinococcus multilocularis ecdysone induced protein 78C 0.0667 0.9453 0.9452
Loa Loa (eye worm) fibroinase 0.002 0.004 0.0043
Echinococcus granulosus nuclear receptor nhr 48 0.0314 0.4325 0.4312
Schistosoma mansoni zinc finger protein 0.0314 0.4325 0.4312
Loa Loa (eye worm) hypothetical protein 0.0041 0.0345 0.0365
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0043
Brugia malayi nuclear receptor RXR 0.0314 0.4325 0.4575
Brugia malayi Nuclear hormone receptor-like 1 0.0352 0.4874 0.5156
Loa Loa (eye worm) hypothetical protein 0.0286 0.3904 0.413
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0314 0.4325 0.4575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0667 0.9453 0.9452
Brugia malayi Steroid receptor seven-up type 2 0.0667 0.9453 1
Echinococcus granulosus intermediate filament protein 0.0033 0.022 0.0197
Echinococcus granulosus lamin dm0 0.0033 0.022 0.0197
Echinococcus multilocularis musashi 0.0033 0.022 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0667 0.9453 1
Brugia malayi hypothetical protein 0.0352 0.4874 0.5156
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0667 0.9453 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0623 0.0659
Brugia malayi nuclear receptor RXR 0.0352 0.4874 0.5156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0314 0.4325 0.4312
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0868 0.0831
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0023 0.0025
Brugia malayi hypothetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) hypothetical protein 0.0667 0.9453 1
Entamoeba histolytica glutamine synthetase, putative 0.0178 0.2334 1
Schistosoma mansoni lamin 0.0033 0.022 0.0197
Echinococcus granulosus Nuclear hormone receptor HR96 0.0314 0.4325 0.4312
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Onchocerca volvulus Protein ultraspiracle homolog 0.0667 0.9453 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1845 0.1952
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0667 0.9453 0.9452
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0667 0.9453 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0314 0.4325 0.4312
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0667 0.9453 1
Echinococcus granulosus ecdysone induced protein 78C 0.0667 0.9453 0.9452
Brugia malayi tailless protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) hypothetical protein 0.0352 0.4874 0.5156
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0667 0.9453 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.004 0.0017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0667 0.9453 0.9452
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0352 0.4874 0.4862
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.004 0.0017
Brugia malayi nuclear receptor NHR-67 0.0314 0.4325 0.4575
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0868 0.0831
Schistosoma mansoni thyroid hormone receptor 0.0667 0.9453 0.9452
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0043
Echinococcus multilocularis FTZ F1 alpha 0.0667 0.9453 0.9452
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Brugia malayi hypothetical protein 0.0286 0.3904 0.413
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0043
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0667 0.9453 1
Brugia malayi Nuclear hormone receptor E75 0.0314 0.4325 0.4575
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.022 0.0233
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0023 0.0025
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.004 0.0017
Loa Loa (eye worm) nuclear receptor NHR-67 0.0314 0.4325 0.4575
Echinococcus granulosus cathepsin l1 0.002 0.004 0.0017
Brugia malayi nuclear receptor NHR-88 0.0667 0.9453 1
Schistosoma mansoni nuclear receptor 0.0314 0.4325 0.4312
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0043
Onchocerca volvulus 0.0033 0.022 0.0191
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0314 0.4325 0.4312
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) hypothetical protein 0.0667 0.9453 1
Brugia malayi Nuclear hormone receptor E75 0.0314 0.4325 0.4575
Echinococcus granulosus Nuclear hormone receptor HR96 0.0314 0.4325 0.4312
Schistosoma mansoni thyroid hormone receptor 0.0667 0.9453 0.9452
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0667 0.9453 0.9452
Loa Loa (eye worm) hypothetical protein 0.0667 0.9453 1
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0667 0.9453 1
Schistosoma mansoni nuclear hormone receptor 0.0314 0.4325 0.4312
Echinococcus multilocularis cysteine protease 0.002 0.004 0.0017
Onchocerca volvulus Glutamine synthetase homolog 0.0453 0.6341 0.6694
Loa Loa (eye worm) hypothetical protein 0.0667 0.9453 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.022 0.0197
Plasmodium vivax glutamine synthetase, putative 0.0453 0.6341 1
Loa Loa (eye worm) hypothetical protein 0.0352 0.4874 0.5156
Schistosoma mansoni steroid hormone receptor ad4bp 0.0667 0.9453 0.9452
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0043
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0352 0.4874 0.5156
Onchocerca volvulus Bile acid receptor homolog 0.0667 0.9453 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0623 0.0659
Onchocerca volvulus 0.0667 0.9453 1
Brugia malayi intermediate filament protein 0.0033 0.022 0.0233
Loa Loa (eye worm) hypothetical protein 0.0352 0.4874 0.5156
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0345 0.0365
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0314 0.4325 0.4312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0667 0.9453 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0314 0.4325 0.4312
Schistosoma mansoni coup transcription factor 0.0667 0.9453 0.9452
Echinococcus multilocularis lamin 0.0033 0.022 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0667 0.9453 1
Brugia malayi nuclear receptor NHR-88 0.0314 0.4325 0.4575
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0667 0.9453 0.9452
Trichomonas vaginalis glutamine synthetase, putative 0.0178 0.2334 1
Brugia malayi Cathepsin L-like precursor 0.002 0.004 0.0043
Schistosoma mansoni hypothetical protein 0.0205 0.2726 0.2709
Brugia malayi hypothetical protein 0.0352 0.4874 0.5156
Onchocerca volvulus 0.0058 0.0594 0.0588
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0667 0.9453 0.9452
Brugia malayi Nuclear hormone receptor-like 1 0.0667 0.9453 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0667 0.9453 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0314 0.4325 0.4552
Onchocerca volvulus 0.0314 0.4325 0.4552
Echinococcus multilocularis geminin 0.0205 0.2726 0.2709
Brugia malayi hypothetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) DR-78 0.0314 0.4325 0.4575
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0667 0.9453 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.004 0.0017
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0314 0.4325 0.4312
Brugia malayi glutamine synthetase 0.0251 0.3405 0.3602
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) ctsf protein 0.002 0.004 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0667 0.9453 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0314 0.4325 0.4312
Loa Loa (eye worm) steroid hormone receptor 0.0667 0.9453 1
Schistosoma mansoni nuclear hormone receptor 0.0314 0.4325 0.4312
Echinococcus granulosus lamin 0.0033 0.022 0.0197
Schistosoma mansoni RAR-like nuclear receptor 0.0667 0.9453 0.9452
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0667 0.9453 1
Echinococcus multilocularis cysteine protease 0.002 0.004 0.0017
Brugia malayi nuclear hormone receptor 0.0314 0.4325 0.4575
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0868 0.0831
Schistosoma mansoni glutamine synthetase bacteria 0.0178 0.2334 0.2316
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0667 0.9453 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0023 0.0025
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0314 0.4325 0.4575
Leishmania major cathepsin L-like protease 0.0077 0.0868 0.0831
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0314 0.4325 0.4552
Schistosoma mansoni hypothetical protein 0.0205 0.2726 0.2709
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0352 0.4874 0.4862
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.0178 0.2334 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0352 0.4874 0.5156
Onchocerca volvulus 0.0314 0.4325 0.4552
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0453 0.6341 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0314 0.4325 0.4312
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0667 0.9453 0.9452
Brugia malayi nuclear hormone receptor family member nhr-6 0.0314 0.4325 0.4575
Schistosoma mansoni nuclear receptor 0.0314 0.4325 0.4312
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.077 0.0733
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0623 0.0659
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0628 0.059
Loa Loa (eye worm) intermediate filament protein 0.0033 0.022 0.0233
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0667 0.9453 0.9452
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0667 0.9453 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3904 0.389
Brugia malayi nuclear hormone receptor 0.0667 0.9453 1
Brugia malayi ecdysteroid receptor 0.0667 0.9453 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0667 0.9453 0.9452
Loa Loa (eye worm) hypothetical protein 0.0032 0.0211 0.0224
Echinococcus multilocularis thyroid hormone receptor alpha 0.0667 0.9453 0.9452
Loa Loa (eye worm) nuclear hormone receptor 0.0314 0.4325 0.4575
Schistosoma mansoni survival motor neuron protein 0.0058 0.0594 0.0572
Leishmania major cathepsin L-like protease 0.0077 0.0868 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0667 0.9453 1
Echinococcus granulosus geminin 0.0205 0.2726 0.2709
Loa Loa (eye worm) hypothetical protein 0.0314 0.4325 0.4575
Echinococcus granulosus FTZ F1 alpha 0.0667 0.9453 0.9452
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0667 0.9453 0.9452
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0352 0.4874 0.4862
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.004 0.0043

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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