Detailed information for compound 1409238

Basic information

Technical information
  • TDR Targets ID: 1409238
  • Name: 3-(2,4-dichlorophenyl)-1-[(1-ethyl-2-methylbe nzimidazole-5-carbonyl)amino]thiourea
  • MW: 422.331 | Formula: C18H17Cl2N5OS
  • H donors: 2 H acceptors: 2 LogP: 4.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(C)nc2c1ccc(c2)C(=O)NN=C(Nc1ccc(cc1Cl)Cl)S
  • InChi: 1S/C18H17Cl2N5OS/c1-3-25-10(2)21-15-8-11(4-7-16(15)25)17(26)23-24-18(27)22-14-6-5-12(19)9-13(14)20/h4-9H,3H2,1-2H3,(H,23,26)(H2,22,24,27)
  • InChiKey: BDNOMYXKJHTAPK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(2,4-dichlorophenyl)-1-[(1-ethyl-2-methyl-benzimidazole-5-carbonyl)amino]thiourea
  • 3-(2,4-dichlorophenyl)-1-[[(1-ethyl-2-methyl-5-benzimidazolyl)-oxomethyl]amino]thiourea
  • 3-(2,4-dichlorophenyl)-1-[(1-ethyl-2-methyl-benzimidazol-5-yl)carbonylamino]thiourea
  • T0504-6564
  • MLS000402363
  • SMR000262212

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans hypothetical protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chromobox protein 0.0014 0.0054 0.004
Brugia malayi Papain family cysteine protease containing protein 0.0575 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1109 0.298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0709 0.0696
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.0242
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0193 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1826 0.1781
Plasmodium vivax endoplasmin, putative 0.0039 0.0505 0.0454
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1109 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0575 1 1
Entamoeba histolytica cysteine protease, putative 0.0114 0.1826 0.1781
Loa Loa (eye worm) hypothetical protein 0.0047 0.0646 0.0646
Brugia malayi Cathepsin L-like precursor 0.0575 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0242 0.0242
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.2504 0.2504
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0187 0.3124 0.3124
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0646 0.0595
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0193 0.014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 1 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.1826 0.1781
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0242 0.0229
Giardia lamblia Cathepsin B precursor 0.0114 0.1826 0.2564
Echinococcus multilocularis cysteine protease 0.0575 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0505 0.0415
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0242 0.0242
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0242 0.0229
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Echinococcus granulosus cathepsin b 0.0417 0.7193 0.7193
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0242 0.0229
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.2504 0.2504
Schistosoma mansoni hypothetical protein 0.0205 0.3436 0.3427
Plasmodium falciparum serine repeat antigen 9 0.0114 0.1826 0.1781
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0054
Trypanosoma cruzi cruzipain precursor, putative 0.0187 0.3124 0.3058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0054 0.004
Trypanosoma brucei cysteine peptidase C (CPC) 0.0207 0.3486 0.3423
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1826 0.1814
Brugia malayi hypothetical protein 0.0013 0.0038 0.0025
Plasmodium falciparum serine repeat antigen 4 0.0114 0.1826 0.1781
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.2865 1
Echinococcus granulosus heat shock protein 90 0.0031 0.0364 0.0364
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0709 0.0659
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0038
Trypanosoma brucei heat shock protein, putative 0.0039 0.0505 0.0415
Schistosoma mansoni heat shock protein 0.0039 0.0505 0.0492
Trypanosoma cruzi cysteine proteinase, putative 0.0301 0.514 0.5093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1826 0.1781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Schistosoma mansoni endoplasmin 0.0039 0.0505 0.0492
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0114 0.1826 0.1781
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0095 0.0095
Schistosoma mansoni cathepsin C 0.0114 0.1826 0.1814
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Giardia lamblia Cathepsin L precursor 0.0114 0.1826 0.2564
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0114 0.1826 0.1781
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0242 0.0229
Giardia lamblia Cathepsin B precursor 0.0114 0.1826 0.2564
Entamoeba histolytica cysteine protease, putative 0.0575 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Schistosoma mansoni heat shock protein 0.0016 0.0095 0.0081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Echinococcus multilocularis chromobox protein 1 0.0084 0.1301 0.1301
Loa Loa (eye worm) hypothetical protein 0.0114 0.1826 0.1826
Echinococcus granulosus heat shock protein 90 0.0039 0.0505 0.0505
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0095 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0242 0.0229
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0054 0.0054
Schistosoma mansoni cpg binding protein 0.0037 0.046 0.0446
Echinococcus multilocularis cathepsin L cysteine protease 0.0575 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0242 0.0242
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0242 0.0242
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1109 0.1024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 1 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.6065 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0193 0.014
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0237 0.0184
Trypanosoma cruzi major cysteine proteinase, putative 0.0114 0.1826 0.1747
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0575 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0242 0.0229
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0242 0.0229
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0364 0.0271
Echinococcus granulosus cathepsin L 0.0114 0.1826 0.1826
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0417 0.7193 0.7189
Brugia malayi nuclear receptor NHR-88 0.0024 0.0242 0.0229
Schistosoma mansoni endoplasmin 0.0039 0.0505 0.0492
Plasmodium vivax vivapain-3 0.0301 0.514 0.5113
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0207 0.3486 0.3423
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Brugia malayi cathepsin L precursor 0.0114 0.1826 0.1814
Loa Loa (eye worm) hypothetical protein 0.0114 0.1826 0.1826
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0364 0.0271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Leishmania major cathepsin L-like protease 0.0575 1 1
Schistosoma mansoni coup transcription factor 0.0024 0.0242 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.1826 0.1781
Schistosoma mansoni cathepsin F (C01 family) 0.0388 0.6686 0.6681
Onchocerca volvulus 0.0015 0.0067 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0114 0.1826 0.1814
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0038
Plasmodium falciparum cysteine proteinase falcipain 1 0.0301 0.514 0.5113
Onchocerca volvulus Cathepsin L homolog 0.0575 1 1
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0505 0.0454
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0014 0.0014
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0014 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0301 0.514 0.5113
Toxoplasma gondii cathepsin CPL 0.0575 1 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0301 0.514 0.5093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 1 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0505 0.0415
Loa Loa (eye worm) ctsf protein 0.0575 1 1
Giardia lamblia Cathepsin L-like protease 0.0114 0.1826 0.2564
Echinococcus multilocularis cathepsin b 0.0417 0.7193 0.7193
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0242 0.0242
Echinococcus multilocularis heat shock protein 90 0.0031 0.0364 0.0364
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0089 0.0089
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0242 0.0242
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Brugia malayi Cathepsin L-like precursor 0.0575 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0114 0.1826 0.1781
Giardia lamblia Hypothetical protein 0.0114 0.1826 0.2564
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0187 0.3124 0.3114
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.022 0.0127
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Entamoeba histolytica cysteine protease, putative 0.0114 0.1826 0.1781
Onchocerca volvulus 0.0114 0.1826 0.1814
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0402 0.035
Echinococcus granulosus cathepsin L cysteine protease 0.0301 0.514 0.514
Brugia malayi Cathepsin L-like precursor 0.0575 1 1
Giardia lamblia Cathepsin L precursor 0.0114 0.1826 0.2564
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0575 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0242 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0242 0.0229
Onchocerca volvulus Cathepsin L homolog 0.0575 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.3436 0.3427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1826 0.1781
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1826 0.1814
Brugia malayi CHD4 protein 0.0016 0.0089 0.0075
Plasmodium vivax serine-repeat antigen (SERA) 0.0114 0.1826 0.1781
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1301 0.1254
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0114 0.1826 0.1781
Loa Loa (eye worm) cysteine protease 0.0575 1 1
Echinococcus multilocularis cathepsin b 0.0417 0.7193 0.7193
Echinococcus multilocularis cysteine protease 0.0575 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0575 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0301 0.514 0.5133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0242 0.0242
Onchocerca volvulus 0.0575 1 1
Brugia malayi Cathepsin L-like precursor 0.0187 0.3124 0.3114
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0014 0.0014
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0505 0.0415
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0505 0.0454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0193 0.014
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0709 0.0659
Echinococcus multilocularis cathepsin L 0.0301 0.514 0.514
Leishmania major cathepsin L-like protease 0.0575 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1826 0.1781
Echinococcus granulosus geminin 0.0205 0.3436 0.3436
Giardia lamblia Cysteine protease 0.0114 0.1826 0.2564
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.0242
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0505 0.0505
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0242 0.0229
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0242 0.0229
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0575 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0242 0.0229
Trypanosoma cruzi cysteine peptidase, putative 0.0301 0.514 0.5093
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0505 0.0415
Loa Loa (eye worm) fibroinase 0.0575 1 1
Plasmodium vivax vivapain-2 0.0575 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0038
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0242 0.0229
Entamoeba histolytica cysteine proteinase, putative 0.0575 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0242 0.0242
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.2865 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0505 0.0415
Trypanosoma cruzi cysteine peptidase, putative 0.0187 0.3124 0.3058
Brugia malayi Papain family cysteine protease containing protein 0.0301 0.514 0.5133
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0095 0.0041
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0505 0.0454
Schistosoma mansoni cathepsin F (C01 family) 0.0575 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 1 1
Echinococcus granulosus heat shock protein 0.0039 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.0242
Brugia malayi Heterochromatin protein 1 0.0084 0.1301 0.1289
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0301 0.514 0.5133
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0114 0.1826 0.1781
Trypanosoma cruzi cruzipain precursor, putative 0.0575 1 1
Toxoplasma gondii heat shock protein 75, putative 0.0016 0.0095 0.0041
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0114 0.1826 0.2564
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0054
Loa Loa (eye worm) endoplasmin 0.0039 0.0505 0.0505
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0014 0.0014
Brugia malayi Cathepsin L-like precursor 0.0575 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0417 0.7193 0.7189
Loa Loa (eye worm) hypothetical protein 0.0114 0.1826 0.1826
Loa Loa (eye worm) hypothetical protein 0.0575 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0388 0.6686 0.6668
Giardia lamblia Cathepsin L precursor 0.0114 0.1826 0.2564
Brugia malayi hypothetical protein 0.0013 0.0038 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0242 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Echinococcus granulosus dnaJ subfamily B 0.0494 0.8564 0.8564
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Onchocerca volvulus 0.0575 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0242 0.0242
Brugia malayi Cathepsin L-like precursor 0.0388 0.6686 0.6681
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0114 0.1826 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0388 0.6686 0.6668
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.0242
Plasmodium falciparum serine repeat antigen 2 0.0114 0.1826 0.1781
Brugia malayi nuclear receptor RXR 0.0013 0.0038 0.0025
Giardia lamblia Cathepsin L precursor 0.0114 0.1826 0.2564
Onchocerca volvulus 0.0575 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1114 0.1101
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0014 0.0014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0388 0.6686 0.6654
Echinococcus multilocularis geminin 0.0205 0.3436 0.3436
Leishmania major cathepsin L-like protease 0.0575 1 1
Schistosoma mansoni heat shock protein 0.0039 0.0505 0.0492
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0114 0.1826 0.1781
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1109 0.298
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Trypanosoma cruzi cysteine protease, putative 0.0301 0.514 0.5093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0388 0.6686 0.6668
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0054 0.0054
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0114 0.1826 0.1814
Schistosoma mansoni chromobox protein 0.0014 0.0054 0.004
Onchocerca volvulus 0.0575 1 1
Plasmodium vivax heat shock protein, putative 0.0016 0.0095 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0129 0.0075
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0364 0.5
Echinococcus granulosus Chromobox protein 3 0.0014 0.0054 0.0054
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0364 0.0271
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0505 0.0454
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0364 0.0312
Loa Loa (eye worm) hypothetical protein 0.0388 0.6686 0.6686
Loa Loa (eye worm) hypothetical protein 0.0187 0.3124 0.3124
Toxoplasma gondii cathepsin CPC2 0.0114 0.1826 0.1781
Trypanosoma cruzi cysteine proteinase, putative 0.0301 0.514 0.5093
Schistosoma mansoni cpg binding protein 0.0037 0.046 0.0446
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0242 0.0242
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0014 0.0014
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0207 0.3486 0.3423
Plasmodium falciparum serine repeat antigen 6 0.0114 0.1826 0.1781
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.0242
Onchocerca volvulus 0.0024 0.0242 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1826 0.1781
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1109 0.1097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0054 0.004
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Echinococcus multilocularis heat shock protein 90 0.0039 0.0505 0.0505
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.6065 1
Echinococcus multilocularis heat shock protein 0.0039 0.0505 0.0505
Giardia lamblia Cathepsin L precursor 0.0114 0.1826 0.2564
Plasmodium falciparum serine repeat antigen 3 0.0114 0.1826 0.1781
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0242 0.0242
Plasmodium falciparum endoplasmin, putative 0.0024 0.0237 0.0184
Trypanosoma brucei heat shock protein, putative 0.0039 0.0505 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0301 0.514 0.5113
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0242 0.0229
Echinococcus granulosus endoplasmin 0.0031 0.0364 0.0364
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0114 0.1826 0.1781
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.8564 0.8564
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0114 0.1826 0.1781
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0242 0.0229
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.1826 0.1814
Onchocerca volvulus Cathepsin F homolog 0.0575 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0114 0.1826 0.2564
Toxoplasma gondii cathepsin CPC1 0.0114 0.1826 0.1781
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0114 0.1826 0.1781
Schistosoma mansoni cathepsin F (C01 family) 0.0575 1 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0114 0.1826 0.1781
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0038 0.0025
Entamoeba histolytica cysteine protease, putative 0.0114 0.1826 0.1781
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1826 0.1781
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0054 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0114 0.1826 0.1781
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0054
Onchocerca volvulus 0.0014 0.0054 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0575 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0114 0.1826 0.1781
Entamoeba histolytica cysteine proteinase 2 0.0301 0.514 0.5113
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0575 1 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0114 0.1826 0.1781
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0014 0.0014
Loa Loa (eye worm) helicase 0.0014 0.0054 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0193 0.014
Giardia lamblia Cysteine protease 0.0114 0.1826 0.2564
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0242 0.0229
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0505 0.0415
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0417 0.7193 0.7166
Trypanosoma cruzi major cysteine proteinase, putative 0.0114 0.1826 0.1747
Plasmodium vivax vivapain-2 0.0575 1 1
Echinococcus granulosus chromobox protein 2 0.0014 0.0054 0.0054
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0114 0.1826 0.1781
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0114 0.1826 0.1781
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0242 0.0242
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1109 0.298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 1 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0038 0.0038
Plasmodium vivax unspecified product 0.0114 0.1826 0.1781
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.0242
Echinococcus granulosus cathepsin b 0.0417 0.7193 0.7193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Brugia malayi fibroinase precursor 0.0114 0.1826 0.1814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.1826 0.1814
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0095 0.0041
Brugia malayi Hsp90 protein 0.0016 0.0095 0.0081
Loa Loa (eye worm) hypothetical protein 0.0388 0.6686 0.6686
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0646 0.0595
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0364 0.0312
Echinococcus multilocularis cathepsin L cysteine protease 0.0575 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1826 0.1814
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Brugia malayi SET domain containing protein 0.0015 0.0067 0.0053
Giardia lamblia Cysteine protease 0.0114 0.1826 0.2564
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0114 0.1826 0.1781
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0242 0.0242
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0014 0.0014
Entamoeba histolytica cysteine protease, putative 0.0114 0.1826 0.1781
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0129 0.0075
Brugia malayi hypothetical protein 0.0014 0.0054 0.004
Giardia lamblia Cathepsin B precursor 0.0114 0.1826 0.2564
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0505 0.0415
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0193 0.014
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0242 0.0242
Brugia malayi nuclear hormone receptor 0.0024 0.0242 0.0229
Loa Loa (eye worm) cathepsin B 0.0207 0.3486 0.3486
Brugia malayi heat shock protein 90 0.0039 0.0505 0.0492
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Plasmodium falciparum serine repeat antigen 1 0.0114 0.1826 0.1781
Giardia lamblia Cathepsin B precursor 0.0207 0.3486 0.5476
Entamoeba histolytica cysteine protease, putative 0.0114 0.1826 0.1781
Plasmodium falciparum cysteine proteinase falcipain 3 0.0575 1 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.6686 0.6686
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0054
Echinococcus multilocularis cathepsin L 0.0114 0.1826 0.1826
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0089 0.0075
Echinococcus multilocularis endoplasmin 0.0031 0.0364 0.0364
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0974 0.0925
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0038 0.0025
Brugia malayi cathepsin Z-like cysteine proteinase 0.0114 0.1826 0.1814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.0242
Giardia lamblia Hypothetical protein 0.0114 0.1826 0.2564
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0207 0.3486 0.345
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0505 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0242 0.0229
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0089 0.0089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1826 0.1814
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0301 0.514 0.5133
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Schistosoma mansoni cpg binding protein 0.0035 0.0424 0.0411
Onchocerca volvulus 0.0037 0.0465 0.0452
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0054 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0114 0.1826 0.1781
Brugia malayi chromobox protein homolog 3 0.0047 0.0646 0.0633
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0505 0.0248
Loa Loa (eye worm) hypothetical protein 0.0114 0.1826 0.1826
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1301 0.1254
Schistosoma mansoni thyroid hormone receptor 0.0176 0.2937 0.2927
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Entamoeba histolytica cysteine protease, putative 0.0114 0.1826 0.1781
Onchocerca volvulus 0.0388 0.6686 0.6681
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0114 0.1826 0.1781
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0016 0.0095 0.0081
Toxoplasma gondii cathepsin B 0.0207 0.3486 0.345
Plasmodium falciparum serine repeat antigen 7 0.0114 0.1826 0.1781
Brugia malayi Cathepsin L-like cysteine proteinase 0.0388 0.6686 0.6681
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0242 0.0229
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0505 0.0454
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0038 0.0025
Brugia malayi cathepsin L-like precursor 0.0388 0.6686 0.6681
Toxoplasma gondii preprocathepsin c precursor, putative 0.0114 0.1826 0.1781
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0016 0.0095 0.0041
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0242 0.0229
Plasmodium falciparum heat shock protein 90 0.0039 0.0505 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0402 0.035
Entamoeba histolytica cysteine proteinase, putative 0.0301 0.514 0.5113
Toxoplasma gondii Hsp90 domain-containing protein 0.0016 0.0095 0.0041
Brugia malayi Papain family cysteine protease containing protein 0.0301 0.514 0.5133
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0014 0.0014
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0242 0.0242
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0114 0.1826 0.1781
Entamoeba histolytica hypothetical protein 0.0114 0.1826 0.1781
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0242 0.0229
Loa Loa (eye worm) hypothetical protein 0.0037 0.0465 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.1826 0.1781
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0575 1 1
Giardia lamblia Cathepsin L precursor 0.0114 0.1826 0.2564
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0242 0.0229
Plasmodium vivax heat shock protein 90, putative 0.0016 0.0095 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0114 0.1826 0.1826
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0054 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0242 0.0242
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0114 0.1826 0.1814
Brugia malayi Cathepsin L-like precursor 0.0575 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0193 0.014
Onchocerca volvulus 0.0575 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0114 0.1826 0.1814
Trypanosoma cruzi cysteine peptidase, putative 0.0575 1 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0364 0.0312
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0114 0.1826 0.1781
Trypanosoma cruzi cysteine peptidase, putative 0.0575 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1826 0.1781
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0054
Entamoeba histolytica cysteine proteinase, putative 0.0301 0.514 0.5113
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Loa Loa (eye worm) hypothetical protein 0.0417 0.7193 0.7193
Brugia malayi cathepsin F-like cysteine proteinase 0.0187 0.3124 0.3114
Onchocerca volvulus 0.0575 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0242 0.0229
Echinococcus granulosus cathepsin l cysteine peptidase 0.0575 1 1
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0095 0.0095
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0417 0.7193 0.7189
Leishmania major cysteine peptidase A (CPA) 0.0575 1 1
Echinococcus granulosus cysteine protease 0.0301 0.514 0.514
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0242 0.0242
Onchocerca volvulus 0.0014 0.0054 0.004
Brugia malayi ecdysteroid receptor 0.0024 0.0242 0.0229
Trypanosoma brucei heat shock protein, putative 0.0039 0.0505 0.0415
Trypanosoma brucei heat shock protein, putative 0.0039 0.0505 0.0415
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0014 0.0014
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0054 0.004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0242 0.0229
Brugia malayi cathepsin B-like cysteine proteinase 0.0417 0.7193 0.7189
Schistosoma mansoni chromobox protein 0.0084 0.1301 0.1289
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Echinococcus multilocularis Chromo domain 0.0014 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0152 0.2504 0.2494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Echinococcus granulosus chromobox protein 1 0.0084 0.1301 0.1301
Plasmodium vivax unspecified product 0.0301 0.514 0.5113
Plasmodium vivax unspecified product 0.0187 0.3124 0.3086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0242 0.0242
Brugia malayi Endoplasmin precursor 0.0039 0.0505 0.0492
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0054 0.004
Plasmodium vivax vivapain-1 0.0301 0.514 0.5113
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0424 0.0424
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0114 0.1826 0.1826
Echinococcus granulosus Chromo domain 0.0014 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Echinococcus multilocularis chromobox protein 2 0.0014 0.0054 0.0054
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Brugia malayi Papain family cysteine protease containing protein 0.0114 0.1826 0.1814
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0242 0.0229
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0242 0.0242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0242 0.0229
Echinococcus granulosus chromobox protein 1 0.0084 0.1301 0.1301
Giardia lamblia Cathepsin L-like protease 0.0114 0.1826 0.2564
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0114 0.1826 0.1781
Giardia lamblia Cathepsin B precursor 0.0207 0.3486 0.5476
Brugia malayi CXXC zinc finger family protein 0.0035 0.0424 0.0411
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0015 0.0067 0.0053
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0364 0.0364
Trypanosoma brucei heat shock protein, putative 0.0039 0.0505 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Echinococcus granulosus cathepsin L 0.0301 0.514 0.514
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1109 0.1061
Leishmania major cathepsin L-like protease 0.0575 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0176 0.2937 0.2937
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0114 0.1826 0.1826
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.2865 1
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0505 0.0415
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0417 0.7193 0.7189
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0242 0.0229
Schistosoma mansoni cathepsin s 0.0187 0.3124 0.3114
Schistosoma mansoni thyroid hormone receptor 0.0176 0.2937 0.2927
Giardia lamblia Encystation-specific protease 0.0114 0.1826 0.2564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0301 0.514 0.5113
Leishmania major cathepsin L-like protease 0.0575 1 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0114 0.1826 0.1814
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0114 0.1826 0.2564
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0242 0.0229
Leishmania major cathepsin L-like protease 0.0575 1 1
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0505 0.0454
Echinococcus multilocularis chromobox protein 1 0.0084 0.1301 0.1301
Echinococcus multilocularis cpg binding protein 0.0037 0.046 0.046
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0014 0.0014
Brugia malayi cathepsin F-like cysteine proteinase 0.0114 0.1826 0.1814
Brugia malayi Cathepsin L-like precursor 0.0388 0.6686 0.6681
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1301 0.1301
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Onchocerca volvulus 0.0575 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0242 0.0242
Brugia malayi Protein cec-1. 0.0014 0.0054 0.004
Echinococcus granulosus cathepsin l1 0.0575 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0505 0.0415
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1109 0.1097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0301 0.514 0.5093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0242 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0187 0.3124 0.3124
Echinococcus granulosus cathepsin l1 0.0388 0.6686 0.6686
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0207 0.3486 0.3477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0242 0.0229
Brugia malayi steroid hormone receptor 0.0024 0.0242 0.0229
Schistosoma mansoni hypothetical protein 0.0494 0.8564 0.8562
Loa Loa (eye worm) DR-78 0.0012 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0114 0.1826 0.1781
Entamoeba histolytica cysteine proteinase, putative 0.0301 0.514 0.5113
Trypanosoma brucei heat shock protein, putative 0.0039 0.0505 0.0415
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0038
Entamoeba histolytica cysteine proteinase 1, putative 0.0301 0.514 0.5113
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0038
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0038 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0118 0.0065
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0114 0.1826 0.1814
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0014
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0575 1 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.3124 0.3124
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.6065 0.6044
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0242 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0301 0.514 0.5093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0575 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0242 0.0242
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0114 0.1826 0.1781
Plasmodium falciparum serine repeat antigen 5 0.0114 0.1826 0.1781
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0242 0.0242
Trypanosoma cruzi cysteine peptidase, putative 0.0575 1 1
Giardia lamblia Cathepsin B precursor 0.0207 0.3486 0.5476
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0014 0.0014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0014 0.0014
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1109 0.1109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0575 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1826 0.1826
Onchocerca volvulus Cathepsin L homolog 0.0114 0.1826 0.1814
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0575 1 1
Leishmania major cathepsin L-like protease 0.0575 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0575 1 1
Onchocerca volvulus 0.0035 0.0424 0.0411
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0114 0.1826 0.2564
Loa Loa (eye worm) hypothetical protein 0.0114 0.1826 0.1826
Plasmodium falciparum serine repeat antigen 8 0.0114 0.1826 0.1781
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0575 1 1
Schistosoma mansoni hypothetical protein 0.0014 0.0054 0.004
Echinococcus granulosus cpg binding protein 0.0037 0.046 0.046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0114 0.1826 0.1814
Giardia lamblia Cathepsin B precursor 0.0114 0.1826 0.2564
Schistosoma mansoni cathepsin S (C01 family) 0.0114 0.1826 0.1814
Schistosoma mansoni chromobox protein 0.0084 0.1301 0.1289
Giardia lamblia Cathepsin B precursor 0.0114 0.1826 0.2564
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0237 0.0184
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0505 0.0415
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0646 0.0633
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1109 0.298
Entamoeba histolytica cysteine protease, putative 0.0301 0.514 0.5113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0193 0.014
Leishmania major cathepsin L-like protease 0.0575 1 1
Giardia lamblia Cysteine protease 0.0114 0.1826 0.2564
Brugia malayi cathepsin Z-like cysteine proteinase 0.0114 0.1826 0.1814
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0114 0.1826 0.1781
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0114 0.1826 0.1781

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.99 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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