TDR Targets

Basic information

Technical information

TDR Targets ID: 1410471
Name: (4,5-diacetyloxy-2-indol-1-yloxan-3-yl) aceta te
MW: 375.373 | Formula: C19H21NO7
H donors: 0 H acceptors: 3 LogP: 1.56 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)OC1C(OC(=O)C)C(COC1n1ccc2c1cccc2)OC(=O)C
InChi: 1S/C19H21NO7/c1-11(21)25-16-10-24-19(18(27-13(3)23)17(16)26-12(2)22)20-9-8-14-6-4-5-7-15(14)20/h4-9,16-19H,10H2,1-3H3
InChiKey: WUXBRHMRVLRHAA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4,5-diacetoxy-2-indol-1-yl-tetrahydropyran-3-yl) acetate
acetic acid [4,5-diacetoxy-2-(1-indolyl)-3-tetrahydropyranyl] ester
acetic acid (4,5-diacetoxy-2-indol-1-yl-tetrahydropyran-3-yl) ester
(4,5-diacetyloxy-2-indol-1-yl-oxan-3-yl) ethanoate
Oprea1_629747
Oprea1_707156
ChemDiv2_001390
EU-0048328
Acetic acid 4,5-diacetoxy-2-indol-1-yl-tetrahydro-pyran-3-yl ester
MLS000035783
SMR000001014
BAS 00058992

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Bacillus anthracis	Anthrax lethal factor	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1049	0.1049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Brugia malayi	cathepsin L precursor	0.0062	0.1049	0.103
Echinococcus multilocularis	cathepsin L cysteine protease	0.0317	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.1049	0.103
Plasmodium vivax	unspecified product	0.0165	0.4678	0.4054
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0322	0.0302
Schistosoma mansoni	cathepsin S (C01 family)	0.0062	0.1049	0.103
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0991	0.0972
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0062	0.1049	0.103
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.1049	0.103
Plasmodium vivax	unspecified product	0.0103	0.2507	0.1628
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1049	0.1049
Onchocerca volvulus	Cathepsin L homolog	0.0317	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.1049	0.103
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.1049	0.103
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0317	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1049	0.1049
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0165	0.4678	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1049	0.1049
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0317	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0165	0.4678	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.1049	0.1049
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0165	0.4678	0.2898
Brugia malayi	Cathepsin L-like precursor	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0317	1	1
Brugia malayi	Cathepsin L-like precursor	0.0317	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0214	0.6371	0.5946
Loa Loa (eye worm)	cathepsin B	0.0103	0.2506	0.2506
Brugia malayi	Cathepsin L-like precursor	0.0317	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0103	0.2506	0.1627
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1049	0.1049
Echinococcus multilocularis	cysteine protease	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2507	0.2507
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0062	0.1049	0.1049
Echinococcus granulosus	cathepsin L cysteine protease	0.0165	0.4678	0.4667
Trypanosoma cruzi	cysteine peptidase, putative	0.0103	0.2507	0.1628
Echinococcus granulosus	cathepsin l1	0.0317	1	1
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0317	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.5759	0.5759
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0165	0.4678	0.4667
Brugia malayi	cathepsin L-like cysteine proteinase	0.0062	0.1049	0.103
Loa Loa (eye worm)	hypothetical protein	0.006	0.0991	0.0991
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0317	1	1
Echinococcus multilocularis	cysteine protease	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Echinococcus granulosus	cathepsin L	0.0062	0.1049	0.103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.1049	0.103
Loa Loa (eye worm)	hypothetical protein	0.0214	0.6371	0.6371
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0322	0.0322
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0317	1	1
Leishmania major	cathepsin L-like protease	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.1049	0.103
Leishmania major	cathepsin L-like protease	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0165	0.4678	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0317	1	1
Leishmania major	cathepsin L-like protease	0.0317	1	1
Brugia malayi	Cathepsin L-like precursor	0.0317	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.1049	0.103
Brugia malayi	cathepsin F-like cysteine proteinase	0.0103	0.2507	0.2491
Plasmodium vivax	vivapain-1	0.0165	0.4678	0.4054
Leishmania major	cathepsin L-like protease	0.0317	1	1
Onchocerca volvulus		0.0062	0.1049	0.103
Entamoeba histolytica	cysteine proteinase, putative	0.0165	0.4678	0.4054
Onchocerca volvulus		0.0317	1	1
Echinococcus granulosus	cysteine protease	0.0165	0.4678	0.4667
Entamoeba histolytica	cysteine proteinase, putative	0.0165	0.4678	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0214	0.6371	0.5946
Onchocerca volvulus	Cathepsin F homolog	0.0317	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0165	0.4678	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0317	1	1
Giardia lamblia	Cathepsin B precursor	0.0103	0.2506	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0062	0.1049	0.103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Onchocerca volvulus		0.0214	0.6371	0.6364
Loa Loa (eye worm)	hypothetical protein	0.0214	0.6371	0.6371
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.1049	0.103
Leishmania major	cysteine peptidase A (CPA)	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0317	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0165	0.4678	0.4667
Loa Loa (eye worm)	ctsf protein	0.0317	1	1
Loa Loa (eye worm)	fibroinase	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1049	0.1049
Trypanosoma cruzi	cysteine peptidase, putative	0.0317	1	1
Plasmodium vivax	vivapain-3	0.0165	0.4678	0.4054
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0317	1	1
Echinococcus multilocularis	cathepsin L	0.0165	0.4678	0.4667
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.1049	0.103
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0317	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0214	0.6371	0.6364
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0317	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0103	0.2506	0.249
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0062	0.1049	0.103
Plasmodium vivax	vivapain-2	0.0317	1	1
Toxoplasma gondii	cathepsin CPL	0.0317	1	1
Onchocerca volvulus		0.0317	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0317	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0322	0.0302
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0021	0.0021
Onchocerca volvulus	Cathepsin L homolog	0.0062	0.1049	0.103
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0103	0.2507	0.2507
Brugia malayi	fibroinase precursor	0.0062	0.1049	0.103
Schistosoma mansoni	cathepsin F (C01 family)	0.0317	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0196	0.5759	0.5262
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Loa Loa (eye worm)	cysteine protease	0.0317	1	1
Entamoeba histolytica	cysteine protease, putative	0.0317	1	1
Leishmania major	cathepsin L-like protease	0.0317	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0317	1	1
Brugia malayi	Cathepsin L-like precursor	0.0103	0.2507	0.2491
Trypanosoma cruzi	cysteine peptidase, putative	0.0165	0.4678	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2507	0.2507
Brugia malayi	Papain family cysteine protease containing protein	0.0165	0.4678	0.4667
Trypanosoma cruzi	cysteine peptidase, putative	0.0317	1	1
Echinococcus granulosus	cathepsin l1	0.0214	0.6371	0.6364
Loa Loa (eye worm)	hypothetical protein	0.0317	1	1
Onchocerca volvulus		0.0317	1	1
Brugia malayi	Cathepsin L-like precursor	0.0214	0.6371	0.6364
Entamoeba histolytica	cysteine proteinase 1, putative	0.0165	0.4678	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0317	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0214	0.6371	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0165	0.4678	0.4054
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0062	0.1049	0.103
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0021	0.0021
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0317	1	1
Onchocerca volvulus		0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0165	0.4678	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0165	0.4678	0.4667
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0317	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0062	0.1049	0.103
Schistosoma mansoni	cathepsin s	0.0103	0.2507	0.2491
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0062	0.1049	0.103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0214	0.6371	0.5946
Plasmodium vivax	vivapain-2	0.0317	1	1
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0317	1	1
Brugia malayi	cathepsin L-like precursor	0.0214	0.6371	0.6364
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0317	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0165	0.4678	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0062	0.1049	0.103
Leishmania major	cathepsin L-like protease	0.0317	1	1
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Leishmania major	cathepsin L-like protease	0.0317	1	1
Schistosoma mansoni	cathepsin C	0.0062	0.1049	0.103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Echinococcus multilocularis	cathepsin b	0.0196	0.5759	0.575
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0991	0.0991
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Leishmania major	cathepsin L-like protease	0.0317	1	1
Toxoplasma gondii	cathepsin B	0.0103	0.2506	0.1627
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0196	0.5759	0.575
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0103	0.2506	0.1627
Onchocerca volvulus		0.0317	1	1
Giardia lamblia	Cathepsin B precursor	0.0103	0.2506	1
Brugia malayi	Cathepsin L-like precursor	0.0214	0.6371	0.6364
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0214	0.6371	0.6371
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0165	0.4678	0.4054
Echinococcus granulosus	cathepsin b	0.0196	0.5759	0.575
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0165	0.4678	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0196	0.5759	0.575
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0991	0.0972
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0062	0.1049	0.1049
Brugia malayi	cathepsin B-like cysteine proteinase	0.0196	0.5759	0.575
Trypanosoma cruzi	cruzipain precursor, putative	0.0103	0.2507	0.1628
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0317	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0165	0.4678	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0317	1	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.2507	0.2507
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0196	0.5759	0.575
Echinococcus granulosus	cathepsin L	0.0165	0.4678	0.4667
Trypanosoma cruzi	cysteine proteinase, putative	0.0165	0.4678	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0317	1	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0103	0.2507	0.2491
Echinococcus granulosus	cathepsin b	0.0196	0.5759	0.575
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0196	0.5759	0.575
Onchocerca volvulus		0.0317	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0214	0.6371	0.6364
Brugia malayi	Papain family cysteine protease containing protein	0.0165	0.4678	0.4667
Echinococcus multilocularis	cathepsin L	0.0062	0.1049	0.103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0317	1	1
Onchocerca volvulus		0.0317	1	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0062	0.1049	0.103
Giardia lamblia	Cathepsin B precursor	0.0103	0.2506	1
Echinococcus multilocularis	cathepsin b	0.0196	0.5759	0.575
Entamoeba histolytica	cysteine protease, putative	0.0165	0.4678	0.4054

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	88.133 uM	PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 0.5012 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.5849 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1546569

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1410471