TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 350.414 | Formula: C20H22N4O2
H donors: 1 H acceptors: 2 LogP: 1.82 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(o1)CNC(=O)C1CC2C(N1C)c1n(C2)c2c(n1)cccc2
InChi: 1S/C20H22N4O2/c1-12-7-8-14(26-12)10-21-20(25)17-9-13-11-24-16-6-4-3-5-15(16)22-19(24)18(13)23(17)2/h3-8,13,17-18H,9-11H2,1-2H3,(H,21,25)
InChiKey: AQODJJSXRAHXIU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0022	0.0023
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0256	0.2804	0.2788
Brugia malayi	jmjC domain containing protein	0.0059	0.0538	0.0517
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.1424	0.1405
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0399	0.0378
Brugia malayi	glutaminase DH11.1	0.0264	0.2893	0.2878
Brugia malayi	jmjC domain containing protein	0.006	0.0556	0.0535
Schistosoma mansoni	hypothetical protein	0.0039	0.0316	0.0295
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0399	0.04
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0399	0.04
Echinococcus granulosus	expressed conserved protein	0.0089	0.089	0.087
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0556	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0399	0.0378
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.0835	0.9445	1
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain)	0.0069	0.0657	0.0695
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.0556	0.0535
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0016	0.0044	0.0023
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0069	0.0657	0.0636
Schistosoma mansoni	hypothetical protein	0.0067	0.0632	0.0612
Brugia malayi	jmjC domain containing protein	0.0016	0.0044	0.0023
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0884	1	1
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0069	0.0657	0.0636
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.022	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0333	0.0312
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.022	0.0199
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.0835	0.9445	1
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0016	0.0044	0.0023
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.0956	1
Echinococcus granulosus	jumonji domain containing 1A	0.0016	0.0044	0.0023
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0016	0.0044	0.0023
Echinococcus multilocularis	cpg binding protein	0.0029	0.0201	0.018
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0693	0.7809	0.8268
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit beta	0.0023	0.0133	0.0118
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.054	0.0519
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0399	0.04
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.022	0.0199
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0023	0.0133	0.0112
Loa Loa (eye worm)	glutaminase 2	0.0264	0.2893	0.2878
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0632	0.0612
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0017	0.0063	0.0041
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0399	0.04
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.0556	0.0535
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0399	0.0422
Onchocerca volvulus		0.0028	0.0183	0.428
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit beta	0.0069	0.0657	0.0403
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.0884	1	1
Mycobacterium ulcerans	glutaminase	0.0264	0.2893	0.3048
Echinococcus multilocularis	JmjC domain containing protein 4	0.0016	0.0044	0.0023
Echinococcus multilocularis	phd:f box containing protein	0.0016	0.0044	0.0023
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0333	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.0243
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0044	0.0023
Schistosoma mansoni	ribonucleoside-diphosphate reductase small chain	0.0069	0.0657	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0988	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.0243
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0044	0.0023
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.0835	0.9445	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0022	0.0023
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0399	0.04
Echinococcus multilocularis	ribonucleoside diphosphate reductase subunit	0.0069	0.0657	0.0636
Echinococcus granulosus	phd:f box containing protein	0.0016	0.0044	0.0023
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0022	0.0023
Loa Loa (eye worm)	glutaminase	0.0264	0.2893	0.2878
Schistosoma mansoni	hypothetical protein	0.0031	0.022	0.0199
Brugia malayi	jmjC domain containing protein	0.0016	0.0044	0.0023
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.022	0.0199
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0022	0.0023
Mycobacterium ulcerans	transcriptional regulator NrdR	0.0048	0.042	0.0423
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0264	0.0243
Schistosoma mansoni	hypothetical protein	0.0031	0.022	0.0199
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0242	0.0256
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0016	0.0044	0.0023
Brugia malayi	Cell division protein ftsZ	0.0332	0.3676	0.3663
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0693	0.7809	0.8138
Brugia malayi	jmjC domain containing protein	0.0016	0.0044	0.0023
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0022	0.0023
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0069	0.0657	0.0636
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain, putative	0.0069	0.0657	0.0636
Echinococcus multilocularis	lysine specific demethylase 5A	0.0059	0.0538	0.0517
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0016	0.0044	0.0023
Loa Loa (eye worm)	hypothetical protein	0.005	0.0438	0.0418
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0399	0.0378
Echinococcus multilocularis	jumonji domain containing 1A	0.0016	0.0044	0.0023
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0399	0.0378
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.0956	0.0936
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0023	0.0133	0.0112
Schistosoma mansoni	phd/f-box containing protein	0.0016	0.0044	0.0023
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.022	0.0199
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0333	0.033
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.0988	0.0968
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.0884	1	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0017	0.0063	0.0041
Echinococcus granulosus	ribonucleoside diphosphate reductase subunit	0.0069	0.0657	0.0636
Echinococcus granulosus	GPCR family 2	0.0031	0.022	0.0199
Mycobacterium leprae	cell division protein FtsZ	0.0693	0.7809	0.8264
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.0884	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0242	0.0256
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0468	0.0447
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.03	0.3309	0.3504
Schistosoma mansoni	glutaminase	0.0264	0.2893	0.2878
Onchocerca volvulus		0.0047	0.0399	1
Schistosoma mansoni	hypothetical protein	0.0031	0.022	0.0199
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.0884	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0044	0.0023
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0022	0.0023
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.1424	0.1405
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0399	0.4038
Schistosoma mansoni	hypothetical protein	0.0031	0.022	0.0199
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.0988	0.0968
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0242	0.0256
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0022	0.0023
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.022	0.0199
Loa Loa (eye worm)	ribonucleotide reductase M2 B	0.0069	0.0657	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.0243
Plasmodium vivax	JmjC domain containing protein	0.0016	0.0044	0.0023
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0264	0.0279
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0333	0.0312
Plasmodium vivax	ribonucleoside-diphosphate reductase small chain, putative	0.0069	0.0657	0.0636
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0399	0.04
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0399	0.0378
Echinococcus granulosus	dnaJ subfamily B	0.0395	0.4396	0.4384
Brugia malayi	Cell division protein ftsZ	0.0342	0.3786	0.3772
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0399	0.0378
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.0973	0.0953
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.0835	0.9445	1
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.022	0.0199
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.0956	0.0936
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0044	0.0023
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.0538	0.0517
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0059	0.0538	0.0517
Treponema pallidum	cell division protein FtsZ	0.0693	0.7809	0.7655
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0059	0.0538	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0399	0.0378
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0022	0.0023
Brugia malayi	ribonucleotide reductase 2	0.0069	0.0657	0.0636
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.0988	0.0968
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0016	0.0044	0.0023
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0022	0.0023
Echinococcus granulosus	JmjC domain containing protein 4	0.0016	0.0044	0.0023
Chlamydia trachomatis	transcriptional repressor NrdR	0.0048	0.042	0.0161
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0399	0.04
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0956	0.0936
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0399	0.04
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.0884	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0044	0.0023
Toxoplasma gondii	ribonucleoside-diphosphate reductase small subunit	0.0069	0.0657	0.0636
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.0884	1	1
Echinococcus multilocularis	protein patched	0.0041	0.0333	0.0312
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN)	0.0023	0.0133	0.0118
Schistosoma mansoni	cpg binding protein	0.0029	0.0201	0.018
Mycobacterium tuberculosis	Probable transcriptional regulatory protein NrdR	0.0048	0.042	0.0445
Echinococcus multilocularis	dnaJ subfamily B	0.0395	0.4396	0.4384
Schistosoma mansoni	phosphatidylserine receptor	0.0016	0.0044	0.0023
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0069	0.0657	0.0636
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.0884	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.022	0.0199
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0264	0.0257
Schistosoma mansoni	cpg binding protein	0.0028	0.0183	0.0162
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0242	0.0256
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0333	0.0312
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0333	0.0312
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0069	0.0657	0.0636
Brugia malayi	CHE-14 protein	0.0041	0.0333	0.0312
Echinococcus granulosus	cpg binding protein	0.0029	0.0201	0.018
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0399	0.0378
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0069	0.0657	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.0243
Echinococcus multilocularis	expressed conserved protein	0.0089	0.089	0.087
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0264	0.0243
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.0835	0.9445	1
Schistosoma mansoni	hypothetical protein	0.0395	0.4396	0.4384
Brugia malayi	jmjC domain containing protein	0.0016	0.0044	0.0023
Echinococcus multilocularis	lysine specific demethylase 6a	0.0016	0.0044	0.0023
Schistosoma mansoni	hypothetical protein	0.0039	0.0316	0.0295
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0183	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0632	0.0612
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0399	0.04
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0264	0.0243
Leishmania major	hypothetical protein, conserved	0.0016	0.0044	0.0023
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0183	0.0162
Plasmodium vivax	ribonucleotide reductase small subunit, putative	0.0023	0.0133	0.0112
Mycobacterium leprae	conserved hypothetical protein	0.0048	0.042	0.0423
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0399	0.4038
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0399	0.0422
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.0556	0.0535
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0399	0.4038
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.0884	1	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0316	0.0295
Schistosoma mansoni	hypothetical protein	0.0039	0.0316	0.0295
Echinococcus granulosus	lysine specific demethylase 6a	0.0016	0.0044	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0044	0.0023
Schistosoma mansoni	protein phosphatase 2C	0.0016	0.0044	0.0023
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0022	0.0023
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.0884	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0399	0.0378
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.0956	0.0936
Echinococcus multilocularis	GPCR, family 2	0.0031	0.022	0.0199
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0069	0.0657	0.0636
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0069	0.0657	0.0636
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.0884	1	1
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0022	0.0023
Trichomonas vaginalis	glutaminase, putative	0.0264	0.2893	0.3048
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0399	0.0378
Schistosoma mansoni	jumonji domain containing protein	0.0016	0.0044	0.0023
Loa Loa (eye worm)	jmjC domain-containing protein	0.0016	0.0044	0.0023
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein)	0.0069	0.0657	0.0695
Schistosoma mansoni	cpg binding protein	0.0029	0.0201	0.018
Schistosoma mansoni	patched 1	0.0041	0.0333	0.0312
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.0884	1	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0693	0.7809	0.8264
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0399	0.04

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1553011

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1410489