Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | multiple endocrine neoplasia I | No references | |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | putative regulatory protein | 0.0965 | 0.993 | 0.993 |
Wolbachia endosymbiont of Brugia malayi | signal transduction histidine kinase and receiver | 0.0007 | 0.0019 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.003 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.003 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.003 | 1 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0965 | 0.993 | 0.993 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.003 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0965 | 0.993 | 0.993 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0328 | 0.0648 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0972 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.003 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0307 | 1 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0965 | 0.993 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.003 | 1 |
Treponema pallidum | chemotaxis response regulator (cheY) | 0.0007 | 0.0019 | 0.5 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0972 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.003 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.003 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.5056 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.003 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.003 | 1 |
Chlamydia trachomatis | two component regulatory system response regulator/ATPase | 0.0007 | 0.0019 | 0.5 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.5056 | 1 |
Onchocerca volvulus | 0.0035 | 0.0307 | 0.5 | |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0965 | 0.993 | 0.993 |
Treponema pallidum | response regulatory protein (atoC) | 0.0007 | 0.0019 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.003 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.003 | 1 |
Schistosoma mansoni | sensor histidine kinase/response regulator | 0.0007 | 0.0019 | 0.0037 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.003 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.003 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0038 | 0.0074 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0328 | 0.0578 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0709 | 0.1403 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0307 | 0.0608 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0328 | 0.0578 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.003 | 1 |
Wolbachia endosymbiont of Brugia malayi | response regulator | 0.0007 | 0.0019 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.0628 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0965 | 0.993 | 0.993 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.003 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.006 | 0.0044 |
Wolbachia endosymbiont of Brugia malayi | response regulator PleD | 0.0007 | 0.0019 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.006 | 0.0044 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0965 | 0.993 | 0.993 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.003 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0328 | 0.0648 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0965 | 0.993 | 0.993 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.003 | 1 |
Treponema pallidum | protein-glutamate methylesterase (cheB) | 0.0007 | 0.0019 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0307 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.5056 | 1 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0972 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 8.9125 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.