Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bacillus anthracis | Anthrax lethal factor | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | multiple endocrine neoplasia I | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0342 | 0.0608 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0365 | 0.0578 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.079 | 0.1403 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0365 | 0.0578 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0042 | 0.0074 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0033 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0033 | 1 |
Schistosoma mansoni | sensor histidine kinase/response regulator | 0.0007 | 0.0026 | 0.0046 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0033 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0033 | 1 |
Treponema pallidum | response regulatory protein (atoC) | 0.0007 | 0.0026 | 0.5 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.5632 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0342 | 1 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0873 | 1 | 1 |
Treponema pallidum | protein-glutamate methylesterase (cheB) | 0.0007 | 0.0026 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0365 | 0.0648 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0866 | 0.9917 | 0.9917 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0033 | 1 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0866 | 0.9917 | 0.9917 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0033 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0033 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0066 | 0.0044 |
Wolbachia endosymbiont of Brugia malayi | response regulator PleD | 0.0007 | 0.0026 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0066 | 0.0044 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.0699 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0866 | 0.9917 | 0.9917 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0033 | 1 |
Wolbachia endosymbiont of Brugia malayi | response regulator | 0.0007 | 0.0026 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0033 | 1 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0873 | 1 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0342 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0033 | 1 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0866 | 0.9917 | 1 |
Treponema pallidum | chemotaxis response regulator (cheY) | 0.0007 | 0.0026 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0033 | 1 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0873 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0365 | 0.0648 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0866 | 0.9917 | 0.9917 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0033 | 1 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0866 | 0.9917 | 0.9917 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0033 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0866 | 0.9917 | 0.9917 |
Wolbachia endosymbiont of Brugia malayi | signal transduction histidine kinase and receiver | 0.0007 | 0.0026 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0033 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0033 | 1 |
Onchocerca volvulus | 0.0035 | 0.0342 | 0.5 | |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0866 | 0.9917 | 0.9917 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.5632 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0033 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.5632 | 1 |
Chlamydia trachomatis | two component regulatory system response regulator/ATPase | 0.0007 | 0.0026 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0033 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0033 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0079 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.