Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, beta, acid | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.0147 | 0.0545 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0216 | 0.0147 | 0.0545 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0547 | 0.4567 | 0.3659 |
Brugia malayi | LBP/BPI | 0.0407 | 0.2701 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2701 | 0.1481 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1432 | 0.5301 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0954 | 1 | 1 |
Onchocerca volvulus | 0.0407 | 0.2701 | 0.2701 | |
Onchocerca volvulus | 0.0547 | 0.4567 | 0.4567 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0547 | 0.4567 | 0.3659 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1432 | 0.5301 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1432 | 0.5301 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2701 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.0954 | 1 | 1 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0547 | 0.4567 | 0.3659 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0954 | 1 | 1 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Onchocerca volvulus | 0.0547 | 0.4567 | 0.4567 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0954 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2701 | 0.1481 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4567 | 0.3659 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0547 | 0.4567 | 0.3659 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1432 | 0.5301 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4567 | 0.3659 |
Brugia malayi | hypothetical protein | 0.0547 | 0.4567 | 0.3659 |
Brugia malayi | hypothetical protein | 0.0407 | 0.2701 | 0.1481 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1432 | 0.5301 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4567 | 0.3659 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0547 | 0.4567 | 0.3659 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4567 | 0.3659 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0407 | 0.2701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0547 | 0.4567 | 0.3659 |
Loa Loa (eye worm) | hypothetical protein | 0.0407 | 0.2701 | 0.1481 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0547 | 0.4567 | 0.3659 |
Onchocerca volvulus | 0.0954 | 1 | 1 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0312 | 0.1432 | 0.5301 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0586 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.5012 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 95.2834 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.