Detailed information for compound 1414450

Basic information

Technical information
  • TDR Targets ID: 1414450
  • Name: 3-[(3R,4S)-2-(4-bromophenyl)-4,5-di(phenyl)3, 4-dihydropyrazole-3-carbonyl]-1,3-oxazolidin- 2-one
  • MW: 490.349 | Formula: C25H20BrN3O3
  • H donors: 0 H acceptors: 2 LogP: 5.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)N1N=C([C@H]([C@@H]1C(=O)N1CCOC1=O)c1ccccc1)c1ccccc1
  • InChi: 1S/C25H20BrN3O3/c26-19-11-13-20(14-12-19)29-23(24(30)28-15-16-32-25(28)31)21(17-7-3-1-4-8-17)22(27-29)18-9-5-2-6-10-18/h1-14,21,23H,15-16H2/t21-,23-/m1/s1
  • InChiKey: BMBOMFSMAUFHAD-FYYLOGMGSA-N  


Substructure search Similarity search

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Synonyms

  • 3-[(3R,4S)-2-(4-bromophenyl)-4,5-di(phenyl)3,4-dihydropyrazole-3-carbonyl]oxazolidin-2-one
  • 3-[[(3R,4S)-2-(4-bromophenyl)-4,5-di(phenyl)-3,4-dihydropyrazol-3-yl]-oxomethyl]-2-oxazolidinone
  • 3-[[(3R,4S)-2-(4-bromophenyl)-4,5-di(phenyl)-3,4-dihydropyrazol-3-yl]carbonyl]-1,3-oxazolidin-2-one
  • NCGC00159728-01
  • KUC100712N

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.0205 0.0982 0.0982
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0052 1
Echinococcus multilocularis cysteine protease 0.002 0.0052 0.0052
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.1095 0.1095
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.1993 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.003 0.0103 0.0093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Brugia malayi CXXC zinc finger family protein 0.0035 0.0125 0.0122
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.1993 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0103 0.0101
Leishmania major cathepsin L-like protease 0.0077 0.0338 0.0288
Loa Loa (eye worm) ctsf protein 0.002 0.0052 0.0041
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.1993 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0052 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0046 0.0046
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.024 0.023
Loa Loa (eye worm) hypothetical protein 0.006 0.0253 0.0243
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0281 0.0281
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.032 0.032
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0338 0.0336
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1396 0.162
Brugia malayi Cathepsin L-like precursor 0.002 0.0052 0.0049
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4152 0.4152
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0052 0.0041
Schistosoma mansoni cpg binding protein 0.0037 0.0135 0.0135
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0253 0.0243
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0052 1
Loa Loa (eye worm) cysteine protease 0.002 0.0052 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0276 0.1343 0.1316
Echinococcus granulosus GPCR family 2 0.0019 0.0046 0.0046
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0019 0.0019
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0018 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.032 0.0316
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.1717 0.8607 1
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.002 0.0049 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0135 0.0135
Brugia malayi MH2 domain containing protein 0.0144 0.0677 0.0675
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0135 0.0135
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0058 0.0242 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0052 0.0057
Brugia malayi Pre-SET motif family protein 0.0252 0.1221 0.1219
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0052 0.0052
Leishmania major cathepsin L-like protease 0.0077 0.0338 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0288 0.0237
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.024 0.024
Onchocerca volvulus Cathepsin L homolog 0.002 0.0052 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0018 0.0018
Loa Loa (eye worm) fibroinase 0.002 0.0052 0.0041
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0103 0.0052
Brugia malayi mbt repeat family protein 0.0058 0.024 0.0238
Loa Loa (eye worm) hypothetical protein 0.0066 0.0281 0.027
Onchocerca volvulus 0.002 0.0052 0.0245
Onchocerca volvulus 0.002 0.0052 0.0245
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0041
Brugia malayi Cathepsin L-like precursor 0.002 0.0052 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Onchocerca volvulus 0.002 0.0052 0.0245
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0103 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0103 0.0101
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.1993 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.032 0.032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.032 0.0316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0052 0.0057
Echinococcus granulosus cathepsin l1 0.0014 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Loa Loa (eye worm) MBCTL1 0.0066 0.0281 0.027
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0052 0.0052
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.1717 0.8607 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0305 0.0302
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0007
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.024 0.1613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Schistosoma mansoni hypothetical protein 0.0014 0.0019 0.0019
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0002 0.0002
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0058 0.0242 0.024
Echinococcus granulosus cysteine protease 0.001 0.0002 0.0002
Mycobacterium leprae conserved hypothetical protein 0.0276 0.1343 0.1512
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0281 0.0281
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.1095 0.1095
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0046
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0058 0.0242 0.0242
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0527 0.2606 0.2604
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0052 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.1221 0.1212
Echinococcus multilocularis cathepsin L 0.001 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0052 0.0057
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.1993 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0052 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0052 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0052 0.0057
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0052 0.0049
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0135 0.0135
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.024 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0253 0.0251
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0052 0.0052
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0046 0.0046
Echinococcus granulosus cathepsin L 0.001 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Onchocerca volvulus 0.002 0.0052 0.0245
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0019 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0018 0.0018
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.1717 0.8607 1
Brugia malayi hypothetical protein 0.002 0.0049 0.0047
Schistosoma mansoni cpg binding protein 0.0037 0.0135 0.0135
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0338 0.0336
Onchocerca volvulus Cathepsin F homolog 0.002 0.0052 0.0245
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0135 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Brugia malayi mbt repeat family protein 0.0058 0.024 0.0238
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0125 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Onchocerca volvulus 0.0035 0.0125 0.0774
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0103 0.0101
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.1993 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2441 0.2441
Onchocerca volvulus 0.002 0.0052 0.0245
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.024 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0052 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Brugia malayi Cathepsin L-like precursor 0.002 0.0052 0.0049
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.1993 1 1
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0058 0.0242 0.024
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0677 0.0667
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.002 0.0052 0.0049
Echinococcus multilocularis geminin 0.0205 0.0982 0.0982
Plasmodium vivax vivapain-2 0.002 0.0052 0.0049
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0338 0.0336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0046
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0281 0.0281
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0002 0.0002
Echinococcus multilocularis GPCR, family 2 0.0019 0.0046 0.0046
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0058 0.0242 0.0191
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0677 0.0667
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0058 0.0242 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Brugia malayi Cathepsin L-like precursor 0.0014 0.0018 0.0016
Echinococcus multilocularis cpg binding protein 0.0037 0.0135 0.0135
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0135 0.0135
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0052 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0052 0.0057
Brugia malayi cathepsin L-like precursor 0.0014 0.0018 0.0016
Schistosoma mansoni cpg binding protein 0.0035 0.0125 0.0125
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0058 0.0242 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0046 0.0035
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0058 0.0242 0.0231
Chlamydia trachomatis transcriptional repressor NrdR 0.0276 0.1343 0.1128
Onchocerca volvulus 0.0287 0.1396 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0255 0.0253
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4152 0.4152
Schistosoma mansoni hypothetical protein 0.0205 0.0982 0.0982
Leishmania major hypothetical protein, conserved 0.003 0.0103 0.0052
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0157 0.0155
Plasmodium vivax vivapain-2 0.002 0.0052 0.0049
Brugia malayi ribonucleotide reductase 2 0.0058 0.0242 0.024
Onchocerca volvulus 0.002 0.0052 0.0245
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.002 0.0049 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0052 0.0057
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0052 0.0049
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0125 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Brugia malayi hypothetical protein 0.003 0.0103 0.0101
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0058 0.0242 0.0242
Echinococcus granulosus cathepsin l1 0.002 0.0052 0.0052
Entamoeba histolytica cysteine protease, putative 0.002 0.0052 1
Leishmania major cathepsin L-like protease 0.0077 0.0338 0.0288
Brugia malayi Cathepsin L-like precursor 0.002 0.0052 0.0049
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.1993 1 1
Onchocerca volvulus 0.002 0.0052 0.0245
Loa Loa (eye worm) hypothetical protein 0.0058 0.024 0.023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0046 0.0044
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.032 0.0269
Mycobacterium ulcerans transcriptional regulator NrdR 0.0276 0.1343 0.1512
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4152 0.4152
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.1717 0.8607 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0135 0.0125
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0052 0.0052
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.032 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Onchocerca volvulus 0.0058 0.024 0.1613
Echinococcus granulosus cpg binding protein 0.0037 0.0135 0.0135
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.024 0.024
Schistosoma mansoni hypothetical protein 0.0205 0.0982 0.0982
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0281 0.0281
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0052 0.0049
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.1993 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0157 0.0147
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.002 0.0049 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0328 0.0328
Echinococcus multilocularis cysteine protease 0.002 0.0052 0.0052
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0018 0.3182
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0058 0.0242 0.024
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.032 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0058 0.0242 0.024
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.1993 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0052 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0135 0.0135
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.1993 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.032 0.0093
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.024 0.024
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.024 0.024
Onchocerca volvulus Cathepsin L homolog 0.002 0.0052 0.0245
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0135 0.0135
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0058 0.0242 0.0242
Brugia malayi Cathepsin L-like precursor 0.0014 0.0018 0.0016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.032 0.0316
Brugia malayi Pre-SET motif family protein 0.0037 0.0135 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0052 0.0057
Schistosoma mansoni hypothetical protein 0.0494 0.2441 0.2441
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0338 0.0336
Plasmodium vivax SET domain protein, putative 0.0037 0.0135 0.0133
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0046 0.0044
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0058 0.0242 0.024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.032 0.032
Onchocerca volvulus 0.0037 0.0135 0.0852
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0052 0.0049
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0011 0.0011
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0018 0.0018
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0052 0.0041
Schistosoma mansoni hypothetical protein 0.0041 0.0157 0.0157
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.1993 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.001 0.0008
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0058 0.0242 0.0191
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0253 0.0251
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0007
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0617 0.3062 0.3372
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0281 0.0281
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0281 0.0278
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0338 0.0336
Brugia malayi Cathepsin L-like precursor 0.002 0.0052 0.0049
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0103 0.0101
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.1717 0.8607 1
Schistosoma mansoni hypothetical protein 0.035 0.1716 0.1716
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2441 0.2441
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0058 0.0242 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0052 0.0057
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0135 0.0084
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0103 0.0101
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0019 0.0046 0.0046

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (binding) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 141.2538 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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